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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1550582 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SFRP2 mRNA | CTD | PMID:17942748 | 17beta-estradiol | decreases expression | ISO | RGD:1550582 | 6480464 | Estradiol results in decreased expression of SFRP2 mRNA | CTD | PMID:14664709 | 17beta-estradiol | decreases expression | ISO | RGD:1550582 | 6480464 | Estradiol results in decreased expression of SFRP2 mRNA | CTD | PMID:14664709 PMID:17640991 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1550582 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SFRP2 mRNA | CTD | PMID:17942748 | 2-amino-2-deoxy-D-glucopyranose | decreases expression | EXP | | 6480464 | Glucosamine results in decreased expression of SFRP2 mRNA | CTD | PMID:17109745 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | RGD:1550582 | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SFRP2 mRNA | CTD | PMID:20188158 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | RGD:1550582 | 6480464 | [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of SFRP2 mRNA | CTD | PMID:16054899 | 4-hydroperoxycyclophosphamide | decreases expression | ISO | RGD:1550582 | 6480464 | perfosfamide results in decreased expression of SFRP2 mRNA | CTD | PMID:19429390 | 5-aza-2'-deoxycytidine | multiple interactions | ISO | RGD:1345643 | 6480464 | [decitabine affects the methylation of SFRP2 promoter] which affects the expression of SFRP2 mRNA | CTD | PMID:18283316 | 5-aza-2'-deoxycytidine | multiple interactions | ISO | RGD:1345643 | 6480464 | [decitabine affects the methylation of SFRP2 promoter] which affects the expression of SFRP2 mRNA | CTD | PMID:18283316 PMID:18283316 | 5-aza-2'-deoxycytidine | multiple interactions | ISO | RGD:1345643 | 6480464 | [decitabine affects the methylation of SFRP2 protein] which affects the expression of SFRP2 mRNA | CTD | PMID:18404682 PMID:18404682 | 5-aza-2'-deoxycytidine | affects methylation | ISO | RGD:1345643 | 6480464 | decitabine affects the methylation of SFRP2 promoter | CTD | PMID:17848950 PMID:17882284 | 5-aza-2'-deoxycytidine | multiple interactions | ISO | RGD:1345643 | 6480464 | [decitabine co-treated with trichostatin A] results in increased expression of SFRP2 mRNA | CTD | PMID:17923031 | 5-aza-2'-deoxycytidine | decreases methylation | ISO | RGD:1345643 | 6480464 | decitabine results in decreased methylation of SFRP2 promoter | CTD | PMID:19387464 | 5-aza-2'-deoxycytidine | increases expression | ISO | RGD:1345643 | 6480464 | decitabine results in increased expression of SFRP2 mRNA | CTD | PMID:19387464 | 5-aza-2'-deoxycytidine | multiple interactions | ISO | RGD:1345643 | 6480464 | [decitabine affects the methylation of SFRP2 protein] which affects the expression of SFRP2 mRNA; more ... | CTD | PMID:18404682 | 5-aza-2'-deoxycytidine | affects methylation | ISO | RGD:1345643 | 6480464 | decitabine affects the methylation of SFRP2 promoter | CTD | PMID:17882284 PMID:17848950 | aldehydo-D-glucosamine | decreases expression | EXP | | 6480464 | Glucosamine results in decreased expression of SFRP2 mRNA | CTD | PMID:17109745 | all-trans-retinoic acid | decreases expression | ISO | RGD:1345643 | 6480464 | Tretinoin results in decreased expression of SFRP2 mRNA | CTD | PMID:21934132 | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of SFRP2 mRNA | CTD | PMID:20488242 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of SFRP2 mRNA | CTD | PMID:16483693 | aristolochic acid | decreases expression | EXP | | 6480464 | aristolochic acid I results in decreased expression of SFRP2 mRNA | CTD | PMID:17483316 | atrazine | multiple interactions | ISO | RGD:1345643 | 6480464 | [Atrazine co-treated with Arsenates] results in increased expression of SFRP2 mRNA | CTD | PMID:18585445 | benzo[a]pyrene | decreases expression | ISO | RGD:1550582 | 6480464 | Benzo(a)pyrene results in decreased expression of SFRP2 mRNA | CTD | PMID:21569818 | benzo[a]pyrene | increases expression | ISO | RGD:1550582 | 6480464 | Benzo(a)pyrene results in increased expression of SFRP2 mRNA | CTD | PMID:22228805 | beta-D-glucosamine | decreases expression | EXP | | 6480464 | Glucosamine results in decreased expression of SFRP2 mRNA | CTD | PMID:17109745 | bis(2-chloroethyl) sulfide | decreases expression | ISO | RGD:1550582 | 6480464 | Mustard Gas results in decreased expression of SFRP2 mRNA | CTD | PMID:15674843 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SFRP2 mRNA | CTD | PMID:22504913 | bromochloroacetic acid | decreases expression | ISO | RGD:1550582 | 6480464 | bromochloroacetic acid results in decreased expression of SFRP2 protein | CTD | PMID:21296659 | cadmium dichloride | increases expression | ISO | RGD:1345643 | 6480464 | Cadmium Chloride results in increased expression of SFRP2 mRNA | CTD | PMID:12160620 | cisplatin | decreases expression | ISO | RGD:1550582 | 6480464 | Cisplatin results in decreased expression of SFRP2 mRNA | CTD | PMID:21151649 | cyclosporin A | decreases expression | EXP | | 6480464 | Cyclosporine results in decreased expression of SFRP2 mRNA | CTD | PMID:21865292 | cytarabine | increases expression | ISO | RGD:1345643 | 6480464 | Cytarabine results in increased expression of SFRP2 mRNA | CTD | PMID:21198554 | dexamethasone | multiple interactions | ISO | RGD:1550582 | 6480464 | [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of SFRP2 mRNA | CTD | PMID:16054899 | diarsenic trioxide | decreases expression | ISO | RGD:1345643 | 6480464 | arsenic trioxide results in decreased expression of SFRP2 mRNA | CTD | PMID:22521957 | dibutyl phthalate | decreases expression | ISO | RGD:1550582 | 6480464 | Dibutyl Phthalate results in decreased expression of SFRP2 mRNA | CTD | PMID:21266533 | diethylstilbestrol | increases expression | EXP | | 6480464 | Diethylstilbestrol results in increased expression of SFRP2 mRNA | CTD | PMID:21658437 | diuron | increases expression | EXP | | 6480464 | Diuron results in increased expression of SFRP2 mRNA | CTD | PMID:21551480 | doxorubicin | multiple interactions | ISO | RGD:1550582 | 6480464 | [[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of SFRP2 mRNA | CTD | PMID:21040762 | fonofos | increases methylation | ISO | RGD:1345643 | 6480464 | Fonofos results in increased methylation of SFRP2 promoter | CTD | PMID:22847954 | genistein | increases expression | EXP | | 6480464 | Genistein results in increased expression of SFRP2 mRNA | CTD | PMID:17341692 | genistein | decreases expression | EXP | | 6480464 | Genistein results in decreased expression of SFRP2 mRNA | CTD | PMID:22504913 | hydrazine | decreases expression | ISO | RGD:1550582 | 6480464 | hydrazine results in decreased expression of SFRP2 mRNA | CTD | PMID:15282401 | indole-3-methanol | multiple interactions | EXP | | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SFRP2 mRNA | CTD | PMID:22129741 | lithium chloride | decreases expression | ISO | RGD:1345643 | 6480464 | Lithium Chloride results in decreased expression of SFRP2 mRNA | CTD | PMID:20069066 | lithium chloride | multiple interactions | ISO | RGD:1345643 | 6480464 | SFRP2 protein affects the reaction [Lithium Chloride results in increased expression of CTNNB1 mRNA]; more ... | CTD | PMID:20069066 | N-acetyl-L-cysteine | multiple interactions | EXP | | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SFRP2 mRNA | CTD | PMID:22129741 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SFRP2 mRNA | CTD | PMID:22129741 | ochratoxin A | increases expression | EXP | | 6480464 | ochratoxin A results in increased expression of SFRP2 mRNA | CTD | PMID:23358140 | parathion | increases methylation | ISO | RGD:1345643 | 6480464 | Parathion results in increased methylation of SFRP2 promoter | CTD | PMID:22847954 | rosiglitazone | multiple interactions | ISO | RGD:1550582 | 6480464 | [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of SFRP2 mRNA | CTD | PMID:16054899 | terbufos | increases methylation | ISO | RGD:1345643 | 6480464 | terbufos results in increased methylation of SFRP2 promoter | CTD | PMID:22847954 | trichostatin A | multiple interactions | ISO | RGD:1345643 | 6480464 | [decitabine co-treated with trichostatin A] results in increased expression of SFRP2 mRNA | CTD | PMID:17923031 | trichostatin A | multiple interactions | ISO | RGD:1345643 | 6480464 | [trichostatin A affects the methylation of SFRP2 protein] which affects the expression of SFRP2 mRNA | CTD | PMID:18404682 PMID:18404682 | trichostatin A | multiple interactions | ISO | RGD:1345643 | 6480464 | [trichostatin A affects the methylation of SFRP2 protein] which affects the expression of SFRP2 mRNA; more ... | CTD | PMID:18404682 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Wnt signaling pathway |
Disease Annotations
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
References - curated| 1. |
Brophy PD, etal., J Biol Chem 2003 Dec 26;278(52):52401-5. Epub 2003 Oct 15. |
| 2. |
MGD data from the GO Consortium |
| 3. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 4. |
RGD automated import pipeline for gene-chemical interactions |
| 5. |
RGD comprehensive gene curation |
| 6. |
Su Y, etal., Physiol Genomics. 2007 Jun 19;30(1):8-16. Epub 2007 Mar 6. |
| 7. |
Zhang Z, etal., J Mol Cell Cardiol. 2009 Mar;46(3):370-7. Epub 2008 Dec 9. |
References - uncurated
RGD Disease Portals| Sfrp2 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Sfrp2 (Rattus norvegicus) |
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| SFRP2 (Homo sapiens) |
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| Sfrp2 (Mus musculus) |
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Position Markers| RH141998 |
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| UniSTS:471844 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001100700 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06018577 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01018350 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AJ560715 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC161900 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473976 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001100700 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001094170 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001094170 | (Get FASTA) |
| GenBank Protein | AAI61900 | (Get FASTA) |
| CAD90761 | (Get FASTA) | |
| EDM00833 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000009465 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000012659 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000012658 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 310552 | ENTREZGENE |
| Gene3D-CATH | 000.10 | UniProtKB/TrEMBL |
| HomoloGene Group ID | 56438 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:8367121 | IMAGE-MGC_LOAD |
| InterPro | Frizzled/SFRP | UniProtKB/TrEMBL |
| Frizzled_dom | UniProtKB/TrEMBL | |
| Netrin_domain | UniProtKB/TrEMBL | |
| Netrin_module_non-TIMP | UniProtKB/TrEMBL | |
| SFRP2 | UniProtKB/TrEMBL | |
| TIMP-like_OB-fold | UniProtKB/TrEMBL | |
| IPI | IPI00204804 | UniProtKB/TrEMBL |
| KEGG Report | rno:310552 | ENTREZGENE, UniProtKB/TrEMBL |
| MGC_CLONE | MGC:187620 | IMAGE-MGC_LOAD |
| PANTHER | PTHR11309 | UniProtKB/TrEMBL |
| PTHR11309:SF45 | UniProtKB/TrEMBL | |
| Pfam | NTR | UniProtKB/TrEMBL |
| PF01392 | UniProtKB/TrEMBL | |
| PROSITE | NTR | UniProtKB/TrEMBL |
| PS50038 | UniProtKB/TrEMBL | |
| SMART | C345C | UniProtKB/TrEMBL |
| FRI | UniProtKB/TrEMBL | |
| Superfamily-SCOP | Frizzled_Cys-rich | UniProtKB/TrEMBL |
| TIMP_like | UniProtKB/TrEMBL | |
| UniGene | Rn.102416 | ENTREZGENE |
| UniProt | B1WBV2_RAT | UniProtKB/TrEMBL |
| Q80W55_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2005-07-08 | Sfrp2 | secreted frizzled-related protein 2 | Symbol and Name status set to approved | 10779 | APPROVED |
| More on Sfrp2 | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 735163 |
| Created: | 2004-02-05 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




