Gene: Itpr1 (inositol 1,4,5-trisphosphate receptor, type 1) Rattus norvegicus
Symbol: Itpr1
Name: inositol 1,4,5-trisphosphate receptor, type 1
Description: ENCODES a protein that exhibits inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; protein C-terminus binding; protein complex binding; INVOLVED IN cellular response to cAMP; cellular response to hypoxia; negative regulation of neuron death; PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH Asthma; Heart Arrest; Huntington Disease; FOUND IN cytoplasm; dendrite; endoplasmic reticulum membrane; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: I145TR; inositol 1,4,5-triphosphate receptor 1; inositol 1,4,5-triphosphate receptor type 1; inositol 1,4,5-triphosphate receptor, type 1; inositol 1,4,5-trisphosphate receptor type 1; inositol 145-triphosphate receptor type 1; InsP3R; InsP3R1; IP-3-R; IP3 receptor; IP3R 1; IP3R1; P400; type 1 inositol 1,4,5-trisphosphate receptor; type 1 InsP3 receptor
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04140,247,297 - 140,580,749 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.04204,714,729 - 205,047,901 (+)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.44143,705,360 - 144,030,051NCBIRGSC3.4rn4RGSC3.4
Celera4129,839,611 - 130,162,657 (+)NCBI
Cytogenetic Map4q41NCBImapview
RH 3.4 Map4 RGD

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Itpr1
Entrez Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 2933
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2016-10-11
Status: ACTIVE