Hipk2 (homeodomain interacting protein kinase 2) - Rat Genome Database

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Gene: Hipk2 (homeodomain interacting protein kinase 2) Rattus norvegicus
Analyze
Symbol: Hipk2
Name: homeodomain interacting protein kinase 2
RGD ID: 1309349
Description: Predicted to enable several functions, including SMAD binding activity; transcription corepressor activity; and virion binding activity. Predicted to contribute to transcription coactivator activity. Predicted to be involved in several processes, including camera-type eye morphogenesis; protein phosphorylation; and regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to act upstream of or within several processes, including adult walking behavior; cell surface receptor signaling pathway; and positive regulation of macromolecule metabolic process. Predicted to be located in PML body and cytoplasmic stress granule. Predicted to be part of RNA polymerase II transcription regulator complex. Orthologous to human HIPK2 (homeodomain interacting protein kinase 2); PARTICIPATES IN p53 signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding (Ensembl: pseudogene)
RefSeq Status: VALIDATED
Previously known as: homeodomain-interacting protein kinase 2; LOC362342
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8468,399,358 - 68,586,404 (-)NCBIGRCr8
mRatBN7.2467,439,327 - 67,619,223 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl467,440,501 - 67,619,223 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx472,374,290 - 72,554,535 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0468,295,405 - 68,475,651 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0466,693,617 - 66,873,451 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0466,438,390 - 66,625,183 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl466,445,266 - 66,624,912 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0466,249,021 - 66,435,438 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4466,273,623 - 66,455,774 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1466,550,710 - 66,731,896 (-)NCBI
Celera462,453,587 - 62,633,348 (-)NCBICelera
Cytogenetic Map4q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crotonaldehyde  (ISO)
cyclosporin A  (EXP,ISO)
DDE  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
etoposide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
heptachlor  (EXP)
hypochlorous acid  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
menadione  (ISO)
methapyrilene  (EXP,ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
Monobutylphthalate  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel sulfate  (ISO)
niclosamide  (EXP,ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phosgene  (ISO)
pirinixic acid  (EXP,ISO)
progesterone  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
sarin  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
torcetrapib  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
xylitol  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (ISO)
adult walking behavior  (ISO)
anterior/posterior pattern specification  (ISO)
cell population proliferation  (ISO)
DNA damage response, signal transduction by p53 class mediator  (ISO)
embryonic camera-type eye morphogenesis  (ISO)
embryonic retina morphogenesis in camera-type eye  (ISO)
gene expression  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (ISO)
iris morphogenesis  (ISO)
lens induction in camera-type eye  (ISO)
lung morphogenesis  (ISO)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of ubiquitin-dependent protein catabolic process  (ISO)
neuron apoptotic process  (ISO)
neuron differentiation  (ISO)
peptidyl-serine phosphorylation  (ISO)
peptidyl-threonine phosphorylation  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (ISO)
protein phosphorylation  (ISO)
respiratory system process  (ISO)
retina layer formation  (ISO)
SMAD protein signal transduction  (ISO)
smoothened signaling pathway  (ISO)
thyroid gland development  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
voluntary musculoskeletal movement  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9748262   PMID:11078605   PMID:12220523   PMID:12874272   PMID:14647468   PMID:14678985   PMID:14990717   PMID:16407227   PMID:16537918   PMID:16917507   PMID:17159989   PMID:18555800  
PMID:18695000   PMID:19046997   PMID:19448668   PMID:20360400   PMID:20579985   PMID:21628596   PMID:29649627   PMID:32572889   PMID:32572895   PMID:35652392   PMID:36182775  


Genomics

Comparative Map Data
Hipk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8468,399,358 - 68,586,404 (-)NCBIGRCr8
mRatBN7.2467,439,327 - 67,619,223 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl467,440,501 - 67,619,223 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx472,374,290 - 72,554,535 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0468,295,405 - 68,475,651 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0466,693,617 - 66,873,451 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0466,438,390 - 66,625,183 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl466,445,266 - 66,624,912 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0466,249,021 - 66,435,438 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4466,273,623 - 66,455,774 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1466,550,710 - 66,731,896 (-)NCBI
Celera462,453,587 - 62,633,348 (-)NCBICelera
Cytogenetic Map4q23NCBI
HIPK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387139,561,570 - 139,777,998 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7139,561,570 - 139,777,998 (-)EnsemblGRCh38hg38GRCh38
GRCh377139,246,316 - 139,477,797 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367138,907,915 - 138,967,017 (-)NCBINCBI36Build 36hg18NCBI36
Build 347138,714,635 - 138,773,729NCBI
Celera7133,984,493 - 134,199,751 (-)NCBICelera
Cytogenetic Map7q34NCBI
HuRef7133,556,840 - 133,652,889 (-)NCBIHuRef
HuRef7133,710,627 - 133,772,240 (-)NCBIHuRef
CHM1_17139,180,531 - 139,276,601 (-)NCBICHM1_1
CHM1_17139,349,964 - 139,411,836 (-)NCBICHM1_1
T2T-CHM13v2.07140,874,868 - 141,091,290 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27138,590,861 - 138,806,654 (-)NCBI
Hipk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39638,664,447 - 38,853,236 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl638,671,325 - 38,853,099 (-)EnsemblGRCm39 Ensembl
GRCm38638,687,512 - 38,876,331 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl638,694,390 - 38,876,165 (-)EnsemblGRCm38mm10GRCm38
MGSCv37638,647,839 - 38,826,189 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36638,627,513 - 38,805,560 (-)NCBIMGSCv36mm8
Celera638,679,186 - 38,857,094 (-)NCBICelera
Cytogenetic Map6B1NCBI
cM Map617.85NCBI
Hipk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554943,393,049 - 3,554,844 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554943,365,826 - 3,554,735 (+)NCBIChiLan1.0ChiLan1.0
HIPK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26176,362,098 - 176,578,265 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1728,372,353 - 28,588,520 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07131,506,711 - 131,722,943 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17143,991,085 - 144,149,159 (-)NCBIpanpan1.1PanPan1.1panPan2
HIPK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1169,066,957 - 9,256,916 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl169,066,970 - 9,244,526 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha169,964,085 - 10,084,717 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0168,983,758 - 9,176,992 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl168,983,820 - 9,164,843 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1168,991,699 - 9,112,344 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0168,835,993 - 8,956,650 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0168,904,901 - 9,025,581 (+)NCBIUU_Cfam_GSD_1.0
Hipk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511815,285,455 - 15,419,184 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365923,809,452 - 3,934,327 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365923,800,619 - 3,934,347 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HIPK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl189,861,792 - 10,135,065 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1189,940,535 - 10,141,815 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21810,442,421 - 10,474,649 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HIPK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121108,310,782 - 108,533,274 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21108,322,096 - 108,533,226 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660724,978,558 - 5,188,822 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hipk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476519,923,297 - 20,042,840 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476519,912,623 - 20,105,016 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hipk2
485 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:185
Count of miRNA genes:120
Interacting mature miRNAs:154
Transcripts:ENSRNOT00000064891
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711470578881294Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
2317577Eae24Experimental allergic encephalomyelitis QTL 24nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)46699318572752834Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)45664777678882945Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)45664777678882945Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)45664777678882945Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)45664777678882945Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45711443281266970Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)46738666970362197Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)46588210796130297Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)46293350882490359Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)45843213392991462Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711443291360801Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46293326987483707Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45863587778886137Rat

Markers in Region
RH140577  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2467,497,301 - 67,497,486 (+)MAPPERmRatBN7.2
Rnor_6.0466,502,865 - 66,503,049NCBIRnor6.0
Rnor_5.0466,313,489 - 66,313,673UniSTSRnor5.0
RGSC_v3.4466,331,849 - 66,332,033UniSTSRGSC3.4
Celera462,511,619 - 62,511,803UniSTS
RH 3.4 Map4403.33UniSTS
Cytogenetic Map4q22UniSTS
AU049081  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2467,556,687 - 67,556,872 (+)MAPPERmRatBN7.2
Rnor_6.0466,562,386 - 66,562,570NCBIRnor6.0
Rnor_5.0466,372,856 - 66,373,040UniSTSRnor5.0
RGSC_v3.4466,393,262 - 66,393,446UniSTSRGSC3.4
Celera462,570,820 - 62,571,004UniSTS
Cytogenetic Map4q22UniSTS
BF390664  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2467,478,845 - 67,479,046 (+)MAPPERmRatBN7.2
Rnor_6.0466,484,113 - 66,484,313NCBIRnor6.0
Rnor_5.0466,294,737 - 66,294,937UniSTSRnor5.0
RGSC_v3.4466,313,395 - 66,313,595UniSTSRGSC3.4
Celera462,493,117 - 62,493,317UniSTS
RH 3.4 Map4405.51UniSTS
Cytogenetic Map4q22UniSTS
GDB:4585413  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2467,483,715 - 67,483,795 (+)MAPPERmRatBN7.2
Rnor_6.0466,489,281 - 66,489,360NCBIRnor6.0
Rnor_5.0466,299,905 - 66,299,984UniSTSRnor5.0
RGSC_v3.4466,318,265 - 66,318,344UniSTSRGSC3.4
Celera462,498,035 - 62,498,114UniSTS
Cytogenetic Map4q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000064891   ⟹   ENSRNOP00000060564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl467,440,501 - 67,619,223 (-)Ensembl
Rnor_6.0 Ensembl466,445,266 - 66,624,912 (-)Ensembl
RefSeq Acc Id: NM_001108622   ⟹   NP_001102092
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8468,406,234 - 68,586,108 (-)NCBI
mRatBN7.2467,439,327 - 67,619,223 (-)NCBI
Rnor_6.0466,445,266 - 66,624,912 (-)NCBI
Rnor_5.0466,249,021 - 66,435,438 (-)NCBI
RGSC_v3.4466,273,623 - 66,455,774 (-)RGD
Celera462,453,587 - 62,633,348 (-)RGD
Sequence:
RefSeq Acc Id: XM_063286248   ⟹   XP_063142318
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8468,399,358 - 68,586,404 (-)NCBI
RefSeq Acc Id: XM_063286249   ⟹   XP_063142319
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8468,399,358 - 68,586,404 (-)NCBI
RefSeq Acc Id: XM_063286250   ⟹   XP_063142320
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8468,399,358 - 68,586,404 (-)NCBI
RefSeq Acc Id: NP_001102092   ⟸   NM_001108622
- UniProtKB: A6IET2 (UniProtKB/TrEMBL),   A6IET3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060564   ⟸   ENSRNOT00000064891
RefSeq Acc Id: XP_063142320   ⟸   XM_063286250
- Peptide Label: isoform X3
- UniProtKB: A6IET1 (UniProtKB/TrEMBL),   A6IET3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142319   ⟸   XM_063286249
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063142318   ⟸   XM_063286248
- Peptide Label: isoform X1
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZN85-F1-model_v2 AlphaFold D3ZN85 1-1195 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692975
Promoter ID:EPDNEW_R3500
Type:single initiation site
Name:Hipk2_1
Description:homeodomain interacting protein kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0466,624,935 - 66,624,995EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309349 AgrOrtholog
BioCyc Gene G2FUF-45202 BioCyc
Ensembl Genes ENSRNOG00000007034 Ensembl
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  Ser_Thr_dual-spec_kinase UniProtKB/TrEMBL
KEGG Report rno:362342 UniProtKB/TrEMBL
NCBI Gene 362342 ENTREZGENE
PANTHER DUAL SPECIFICITY PROTEIN KINASE UniProtKB/TrEMBL
  HOMEODOMAIN-INTERACTING PROTEIN KINASE 2 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Hipk2 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007034 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Protein kinase-like (PK-like) UniProtKB/TrEMBL
UniProt A6IET1 ENTREZGENE, UniProtKB/TrEMBL
  A6IET2 ENTREZGENE, UniProtKB/TrEMBL
  A6IET3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Hipk2  homeodomain interacting protein kinase 2   Hipk2_predicted  homeodomain interacting protein kinase 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Hipk2_predicted  homeodomain interacting protein kinase 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED