Aurkb (aurora kinase B) - Rat Genome Database

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Gene: Aurkb (aurora kinase B) Rattus norvegicus
Analyze
Symbol: Aurkb
Name: aurora kinase B
RGD ID: 621625
Description: Enables protein kinase activity. Involved in cleavage furrow formation. Located in midbody. Orthologous to human AURKB (aurora kinase B); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AIM-1; Aim1; ARK-2; aurora 1; aurora- and Ipl1-like midbody-associated protein 1; aurora-B; aurora-related kinase 2; aurora/IPL1-related kinase 2; serine/threonine kinase 12; serine/threonine-protein kinase 12; serine/threonine-protein kinase 5; serine/threonine-protein kinase aurora-B; STK-1; Stk12
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Bmd4
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,243,116 - 54,249,675 (+)NCBIGRCr8
mRatBN7.21053,744,290 - 53,750,831 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1053,745,142 - 53,750,837 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1058,407,027 - 58,412,691 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01057,895,622 - 57,901,286 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01053,403,795 - 53,409,462 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01055,625,860 - 55,632,399 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1055,626,741 - 55,634,991 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01055,368,674 - 55,375,204 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41055,798,710 - 55,804,367 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11055,812,332 - 55,817,990 (+)NCBI
Celera1052,911,399 - 52,917,056 (+)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-methylcholanthrene  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP,ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
aristolochic acids  (EXP)
arsenite(3-)  (ISO)
azathioprine  (ISO)
Bardoxolone methyl  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
butylated hydroxyanisole  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamate ester  (ISO)
catechol  (EXP)
cefaloridine  (EXP)
chlorambucil  (ISO)
chloroacetaldehyde  (ISO)
choline  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clodronic acid  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
D-aspartic acid  (ISO)
diallyl trisulfide  (ISO)
diarylheptanoid  (ISO)
dibenzofuran  (EXP)
dibutyl phthalate  (EXP)
dieldrin  (EXP)
dimethylarsinous acid  (ISO)
dioxygen  (EXP)
doxorubicin  (ISO)
Enterolactone  (ISO)
epoxiconazole  (ISO)
erythromycin estolate  (EXP)
estriol  (ISO)
fenbendazole  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
glycidol  (EXP)
heptachlor  (EXP)
hydrogen peroxide  (ISO)
ifosfamide  (ISO)
indole-3-methanol  (EXP)
irinotecan  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
latrunculin B  (ISO)
leflunomide  (ISO)
lucanthone  (ISO)
LY294002  (ISO)
melphalan  (ISO)
menadione  (ISO)
metformin  (EXP)
methyl isocyanate  (ISO)
methylmercury chloride  (ISO)
miconazole  (ISO)
Muraglitazar  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (ISO)
niclosamide  (ISO)
nocodazole  (ISO)
O-methyleugenol  (EXP)
ochratoxin A  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (EXP)
phenformin  (EXP)
phenobarbital  (ISO)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP)
progesterone  (EXP)
promethazine  (EXP)
propanal  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
Rebamipide  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
rotenone  (EXP,ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
theophylline  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
toxaphene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Gene expression changes are age-dependent and lobe-specific in the brown Norway rat model of prostatic hyperplasia. Bethel CR, etal., Prostate. 2009 Jun 1;69(8):838-50.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Expression of Aurora kinases A and B in normal, hyperplastic, and malignant human endometrium: Aurora B as a predictor for poor prognosis in endometrial carcinoma. Kurai M, etal., Hum Pathol. 2005 Dec;36(12):1281-8.
5. Targeting Aurora kinases for the treatment of prostate cancer. Lee EC, etal., Cancer Res. 2006 May 15;66(10):4996-5002.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. AIM-1: a mammalian midbody-associated protein required for cytokinesis. Terada Y, etal., EMBO J 1998 Feb 2;17(3):667-76.
12. Severe coagulopathy associated with white-lipped green pit viper bite. Yang JY, etal., Hong Kong Med J. 2007 Oct;13(5):392-5.
Additional References at PubMed
PMID:9514916   PMID:11950924   PMID:12477932   PMID:14751927   PMID:15260989   PMID:16103226   PMID:16962097   PMID:17726514   PMID:18195732   PMID:18591255   PMID:19283064   PMID:19465021  
PMID:19468067   PMID:20562830   PMID:20959462   PMID:21397845   PMID:21531765   PMID:21820309   PMID:22024163   PMID:22724069   PMID:23029267   PMID:23036704   PMID:24034696   PMID:28751710  
PMID:31533043   PMID:31563141   PMID:31819079  


Genomics

Comparative Map Data
Aurkb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,243,116 - 54,249,675 (+)NCBIGRCr8
mRatBN7.21053,744,290 - 53,750,831 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1053,745,142 - 53,750,837 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1058,407,027 - 58,412,691 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01057,895,622 - 57,901,286 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01053,403,795 - 53,409,462 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01055,625,860 - 55,632,399 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1055,626,741 - 55,634,991 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01055,368,674 - 55,375,204 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41055,798,710 - 55,804,367 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11055,812,332 - 55,817,990 (+)NCBI
Celera1052,911,399 - 52,917,056 (+)NCBICelera
Cytogenetic Map10q24NCBI
AURKB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38178,204,731 - 8,210,575 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl178,204,733 - 8,210,600 (-)EnsemblGRCh38hg38GRCh38
GRCh37178,108,049 - 8,113,893 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36178,048,774 - 8,054,608 (-)NCBINCBI36Build 36hg18NCBI36
Build 34178,048,781 - 8,054,604NCBI
Celera178,136,501 - 8,142,334 (-)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef178,003,833 - 8,009,723 (-)NCBIHuRef
CHM1_1178,117,184 - 8,123,078 (-)NCBICHM1_1
T2T-CHM13v2.0178,110,914 - 8,116,765 (-)NCBIT2T-CHM13v2.0
Aurkb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391168,936,477 - 68,942,490 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1168,936,473 - 68,942,490 (+)EnsemblGRCm39 Ensembl
GRCm381169,045,624 - 69,051,664 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,045,647 - 69,051,664 (+)EnsemblGRCm38mm10GRCm38
MGSCv371168,859,145 - 68,865,164 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361168,861,838 - 68,867,857 (+)NCBIMGSCv36mm8
Celera1175,989,163 - 75,995,182 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.32NCBI
Aurkb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554678,715,136 - 8,723,932 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554678,715,387 - 8,720,889 (+)NCBIChiLan1.0ChiLan1.0
AURKB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21965,541,318 - 65,548,629 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11770,350,748 - 70,358,057 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01743,447,661 - 43,453,864 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11748,180,066 - 48,186,129 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1748,180,066 - 48,186,129 (+)Ensemblpanpan1.1panPan2
AURKB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1533,014,098 - 33,028,951 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl533,014,102 - 33,033,948 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha533,150,233 - 33,165,558 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0533,117,167 - 33,132,493 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl533,117,171 - 33,132,455 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1533,083,909 - 33,099,234 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0533,039,680 - 33,055,006 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0533,219,643 - 33,234,968 (-)NCBIUU_Cfam_GSD_1.0
Aurkb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560247,961,511 - 47,966,600 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365951,435,852 - 1,440,351 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365951,435,601 - 1,437,423 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AURKB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1253,410,177 - 53,423,225 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11253,410,833 - 53,426,165 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,886,065 - 55,894,911 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AURKB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,571,255 - 7,583,034 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl167,570,538 - 7,582,959 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605913,820,184 - 13,826,795 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aurkb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478610,765,610 - 10,775,112 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478610,769,797 - 10,775,142 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aurkb
30 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:55
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000008492
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
1578762Toxo1Toxoplasma gondii resistance QTL 1brain integrity trait (VT:0010579)percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028)105220003059378278Rat

Markers in Region
RH129726  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21053,750,414 - 53,750,624 (+)MAPPERmRatBN7.2
Rnor_6.01055,631,983 - 55,632,192NCBIRnor6.0
Rnor_5.01055,374,788 - 55,374,997UniSTSRnor5.0
RGSC_v3.41055,803,952 - 55,804,161UniSTSRGSC3.4
Celera1052,916,641 - 52,916,850UniSTS
Cytogenetic Map10q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 27 39 23 18 23 1 1 44 26 40 11 1
Low 14 15 15 1 15 7 9 26 7 1 7
Below cutoff 2 3 3 3 1 4 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008492   ⟹   ENSRNOP00000008492
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1053,745,142 - 53,750,803 (+)Ensembl
Rnor_6.0 Ensembl1055,626,741 - 55,632,398 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000091016   ⟹   ENSRNOP00000072371
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1053,745,189 - 53,750,837 (+)Ensembl
Rnor_6.0 Ensembl1055,627,025 - 55,634,991 (+)Ensembl
RefSeq Acc Id: NM_053749   ⟹   NP_446201
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,244,018 - 54,249,675 (+)NCBI
mRatBN7.21053,745,173 - 53,750,830 (+)NCBI
Rnor_6.01055,626,741 - 55,632,398 (+)NCBI
Rnor_5.01055,368,674 - 55,375,204 (+)NCBI
RGSC_v3.41055,798,710 - 55,804,367 (+)RGD
Celera1052,911,399 - 52,917,056 (+)RGD
Sequence:
RefSeq Acc Id: XM_006246569   ⟹   XP_006246631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,243,125 - 54,249,661 (+)NCBI
mRatBN7.21053,745,020 - 53,750,831 (+)NCBI
Rnor_6.01055,626,579 - 55,632,399 (+)NCBI
Rnor_5.01055,368,674 - 55,375,204 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006246570   ⟹   XP_006246632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,244,253 - 54,249,661 (+)NCBI
mRatBN7.21053,745,455 - 53,750,831 (+)NCBI
Rnor_6.01055,628,353 - 55,632,399 (+)NCBI
Rnor_5.01055,368,674 - 55,375,204 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767758   ⟹   XP_008765980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,243,116 - 54,249,661 (+)NCBI
mRatBN7.21053,744,290 - 53,750,831 (+)NCBI
Rnor_6.01055,625,860 - 55,632,399 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_446201   ⟸   NM_053749
- UniProtKB: Q4V8N1 (UniProtKB/Swiss-Prot),   O55099 (UniProtKB/Swiss-Prot),   A6HFM8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246631   ⟸   XM_006246569
- Peptide Label: isoform X1
- UniProtKB: Q4V8N1 (UniProtKB/Swiss-Prot),   O55099 (UniProtKB/Swiss-Prot),   A6HFM8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246632   ⟸   XM_006246570
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008765980   ⟸   XM_008767758
- Peptide Label: isoform X1
- UniProtKB: Q4V8N1 (UniProtKB/Swiss-Prot),   O55099 (UniProtKB/Swiss-Prot),   A6HFM8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008492   ⟸   ENSRNOT00000008492
RefSeq Acc Id: ENSRNOP00000072371   ⟸   ENSRNOT00000091016
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O55099-F1-model_v2 AlphaFold O55099 1-343 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697307
Promoter ID:EPDNEW_R7829
Type:initiation region
Name:Aurkb_1
Description:aurora kinase B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01055,626,772 - 55,626,832EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621625 AgrOrtholog
BioCyc Gene G2FUF-24597 BioCyc
Ensembl Genes ENSRNOG00000005659 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00065025020 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008492 ENTREZGENE
  ENSRNOT00000008492.7 UniProtKB/Swiss-Prot
  ENSRNOT00000091016.2 UniProtKB/TrEMBL
  ENSRNOT00065043008 UniProtKB/Swiss-Prot
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7454285 IMAGE-MGC_LOAD
InterPro Aur UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114592 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:114286 IMAGE-MGC_LOAD
NCBI Gene 114592 ENTREZGENE
PANTHER PTHR24350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24350:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aurkb PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005659 RatGTEx
  ENSRNOG00065025020 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2R670_RAT UniProtKB/TrEMBL
  A6HFM8 ENTREZGENE, UniProtKB/TrEMBL
  AURKB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4V8N1 ENTREZGENE
UniProt Secondary Q4V8N1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-03-01 Aurkb  aurora kinase B  Stk12  serine/threonine kinase 12  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED
2002-08-07 Stk12  serine/threonine kinase 12      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized at the equator of central spindles during late anaphase and at the midbody during telophase and cytokinesis 730040
gene_expression mRNA and protein accumulates at G2/M phase of cell cycle 730040
gene_process involved in progression of cytokinesis 730040