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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | increases expression | ISO | RGD:62234 | 6480464 | Ethinyl Estradiol results in increased expression of ROBO1 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:62234 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ROBO1 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:735617 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ROBO1 mRNA | CTD | PMID:20106945 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:62234 | 6480464 | Tetrachlorodibenzodioxin affects the expression of ROBO1 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:735617 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ROBO1 mRNA | CTD | PMID:20106945 PMID:21632981 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:62234 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ROBO1 mRNA | CTD | PMID:17586704 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:62234 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ROBO1 mRNA | CTD | PMID:17942748 | 3-methylcholanthrene | decreases expression | ISO | RGD:62234 | 6480464 | Methylcholanthrene results in decreased expression of ROBO1 mRNA | CTD | PMID:20713471 | 5-aza-2'-deoxycytidine | affects methylation | ISO | RGD:735617 | 6480464 | decitabine affects the methylation of ROBO1 promoter | CTD | PMID:17671114 | aflatoxin B1 | decreases expression | ISO | RGD:62234 | 6480464 | Aflatoxin B1 results in decreased expression of ROBO1 mRNA | CTD | PMID:19770486 | aflatoxin B1 | decreases expression | ISO | RGD:735617 | 6480464 | Aflatoxin B1 results in decreased expression of ROBO1 mRNA | CTD | PMID:22100608 | all-trans-retinoic acid | decreases expression | ISO | RGD:735617 | 6480464 | Tretinoin results in decreased expression of ROBO1 mRNA | CTD | PMID:21934132 | atrazine | multiple interactions | ISO | RGD:735617 | 6480464 | [Atrazine co-treated with Arsenates] results in increased expression of ROBO1 mRNA | CTD | PMID:18585445 | benzo[a]pyrene | decreases expression | ISO | RGD:735617 | 6480464 | Benzo(a)pyrene results in decreased expression of ROBO1 mRNA | CTD | PMID:20106945 | benzo[a]pyrene | decreases expression | ISO | RGD:735617 | 6480464 | Benzo(a)pyrene results in decreased expression of ROBO1 mRNA | CTD | PMID:20106945 PMID:21632981 | benzo[a]pyrene | decreases expression | ISO | RGD:62234 | 6480464 | Benzo(a)pyrene results in decreased expression of ROBO1 mRNA | CTD | PMID:19770486 | benzo[a]pyrene | multiple interactions | ISO | RGD:62234 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of ROBO1 mRNA | CTD | PMID:21715664 | copper(2+) sulfate | increases expression | ISO | RGD:735617 | 6480464 | Copper Sulfate results in increased expression of ROBO1 mRNA | CTD | PMID:19549813 | diarsenic trioxide | decreases expression | ISO | RGD:735617 | 6480464 | arsenic trioxide results in decreased expression of ROBO1 mRNA | CTD | PMID:15725085 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of ROBO1 mRNA | CTD | PMID:21266533 | etoposide | affects response to substance | ISO | RGD:735617 | 6480464 | ROBO1 protein affects the susceptibility to Etoposide | CTD | PMID:16217747 | lead(0) | increases expression | ISO | RGD:735617 | 6480464 | Lead results in increased expression of ROBO1 mRNA | CTD | PMID:19921347 | nickel dichloride | increases expression | ISO | RGD:735617 | 6480464 | nickel chloride results in increased expression of ROBO1 mRNA | CTD | PMID:17312168 | paracetamol | affects expression | ISO | RGD:62234 | 6480464 | Acetaminophen affects the expression of ROBO1 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | RGD:735617 | 6480464 | Acetaminophen results in increased expression of ROBO1 mRNA | CTD | PMID:22230336 | phenobarbital | increases expression | ISO | RGD:62234 | 6480464 | Phenobarbital results in increased expression of ROBO1 mRNA | CTD | PMID:19270015 | phenobarbital | affects expression | ISO | RGD:62234 | 6480464 | Phenobarbital affects the expression of ROBO1 mRNA | CTD | PMID:23091169 | quercetin | decreases expression | ISO | RGD:735617 | 6480464 | Quercetin results in decreased expression of ROBO1 mRNA | CTD | PMID:21632981 | trichloroethene | increases expression | ISO | RGD:62234 | 6480464 | Trichloroethylene results in increased expression of ROBO1 mRNA | CTD | PMID:15363585 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Axon guidance |
| Pathway Interaction Database | Posttranslational regulation of adherens junction stability and dissassembly (PID:200117) |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Axon guidance |
| Pathway Interaction Database | Posttranslational regulation of adherens junction stability and dissassembly (PID:200117) |
References - curated| 1. |
Brose K, etal., Cell 1999 Mar 19;96(6):795-806. |
| 2. |
Kidd T, etal., Cell 1998 Jan 23;92(2):205-15. |
| 3. |
Liu Z, etal., Mol Cell Neurosci 2004 Jun;26(2):232-40. |
| 4. |
Marillat V, etal., J Comp Neurol. 2002 Jan 7;442(2):130-55. |
| 5. |
MGD data from the GO Consortium |
| 6. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 7. |
RGD automated data pipeline |
| 8. |
RGD automated import pipeline for gene-chemical interactions |
| 9. |
Tamada A, etal., Neural Dev. 2008 Nov 5;3:29. |
| 10. |
Tsujiuchi T, etal., Mol Carcinog. 2004 Aug;40(4):241-6. |
| 11. |
Wehrle R, etal., Eur J Neurosci. 2005 Nov;22(9):2134-44. |
References - uncurated
RGD Disease Portals| Robo1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Robo1 (Rattus norvegicus) |
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| ROBO1 (Homo sapiens) |
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| Robo1 (Mus musculus) |
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Position Markers| D11Rat80 |
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| D11Got12 |
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| D11Got11 |
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| BF386615 |
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| BF386668 |
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| BF390471 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_022188 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06067004 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06067005 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06067006 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06067007 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06067008 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06067009 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06067010 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06067011 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06067012 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06067013 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06067014 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06067015 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06067016 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067492 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067493 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067494 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067495 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067496 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067497 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067498 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067499 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067500 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067501 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067502 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067503 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067504 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067505 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067506 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067507 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067508 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067509 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067510 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067511 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067512 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067513 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067514 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067515 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067516 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067517 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067518 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067519 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067520 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067521 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067522 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067523 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01067524 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF041082 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_022188 | |||||||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_071524 | |||||||||||||||||||||||||
| Peptide Label: | precursor | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_071524 | (Get FASTA) |
| GenBank Protein | AAC39960 | (Get FASTA) |
| O55005 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000029614 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000044134 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000042384 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 58946 | ENTREZGENE |
| Gene3D-CATH | Ig-like_fold | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000029614 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 2206 | ENTREZGENE |
| InterPro | FN_III | UniProtKB/Swiss-Prot |
| Ig-like | UniProtKB/Swiss-Prot | |
| Ig-like_fold | UniProtKB/Swiss-Prot | |
| Ig_I-set | UniProtKB/Swiss-Prot | |
| Ig_sub2 | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:58946 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | fn3 | UniProtKB/Swiss-Prot |
| I-set | UniProtKB/Swiss-Prot | |
| PROSITE | FN3 | UniProtKB/Swiss-Prot |
| IG_LIKE | UniProtKB/Swiss-Prot | |
| SMART | FN3 | UniProtKB/Swiss-Prot |
| IGc2 | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | FN_III-like | UniProtKB/Swiss-Prot |
| Transposagen | Robo1 |
Transposagen |
| UniGene | Rn.44468 | ENTREZGENE |
| UniProt | F1LQI2_RAT | UniProtKB/TrEMBL |
| ROBO1_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2013-04-17 | Robo1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | LOC683548 | similar to roundabout homolog 1 | Data Merged | 9333 | PROVISIONAL |
| 2006-11-19 | LOC683548 | similar to roundabout homolog 1 | Symbol and Name status set to provisional | 1724 | PROVISIONAL | ||
| 2002-06-10 | Robo1 | roundabout homolog 1 (Drosophila) | Name updated | 1488 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_product | member of the subfamily of immunoglobulin superfamily proteins | 61733 |
| More on Robo1 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 61941 |
| Created: | 2001-04-11 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-28 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




