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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-artemisinic acid | decreases expression | ISO | RGD:731382 | 6480464 | artemisic acid results in decreased expression of KIT mRNA | CTD | PMID:23063590 | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:731382 | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of KIT mRNA | CTD | PMID:22079256 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:731383 | 6480464 | Ethinyl Estradiol results in increased expression of KIT mRNA | CTD | PMID:17942748 | 17beta-estradiol | affects expression | ISO | RGD:731383 | 6480464 | Estradiol affects the expression of KIT mRNA | CTD | PMID:15598610 | 17beta-estradiol | multiple interactions | ISO | RGD:731382 | 6480464 | [Parathion co-treated with Estradiol] results in increased expression of KIT protein | CTD | PMID:17622325 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:731383 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of KIT mRNA | CTD | PMID:16102516 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:731383 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of KIT mRNA | CTD | PMID:16102516 more ... | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:731383 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of KIT mRNA | CTD | PMID:21041162 PMID:16102516 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:731383 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of KIT mRNA | CTD | PMID:16102516 PMID:21041162 | 2-acetamidofluorene | increases expression | EXP | | 6480464 | 2-Acetylaminofluorene results in increased expression of KIT protein | CTD | PMID:15133858 | 5-fluorouracil | affects response to substance | ISO | RGD:731383 | 6480464 | KIT protein mutant form affects the susceptibility to Fluorouracil | CTD | PMID:19100679 | 5-fluorouracil | decreases expression | ISO | RGD:731383 | 6480464 | Fluorouracil results in decreased expression of KIT protein | CTD | PMID:21296659 | acetic acid | affects expression | ISO | RGD:731383 | 6480464 | Acetic Acid affects the expression of KIT protein | CTD | PMID:21296659 | acrolein | increases expression | ISO | RGD:731383 | 6480464 | Acrolein results in increased expression of KIT mRNA | CTD | PMID:18515264 | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of KIT mRNA | CTD | PMID:22459607 | all-trans-retinoic acid | decreases activity | ISO | RGD:731382 | 6480464 | Tretinoin results in decreased activity of KIT protein | CTD | PMID:21159206 | all-trans-retinoic acid | multiple interactions | ISO | RGD:731382 | 6480464 | [Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of KIT protein | CTD | PMID:23284745 | all-trans-retinoic acid | increases expression | ISO | RGD:731382 | 6480464 | Tretinoin results in increased expression of KIT mRNA | CTD | PMID:21934132 | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of KIT mRNA | CTD | PMID:17303670 | all-trans-retinoic acid | increases expression | ISO | RGD:731383 | 6480464 | Tretinoin results in increased expression of KIT mRNA | CTD | PMID:16788091 | alpha-hexachlorocyclohexane | increases expression | EXP | | 6480464 | alpha-hexachlorocyclohexane results in increased expression of KIT mRNA | CTD | PMID:16940010 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of KIT mRNA | CTD | PMID:16483693 | arsenic atom | decreases expression | ISO | RGD:731383 | 6480464 | Arsenic results in decreased expression of KIT mRNA | CTD | PMID:19654921 | atropine | multiple interactions | ISO | RGD:731382 | 6480464 | Atropine inhibits the reaction [Parathion results in increased expression of KIT protein] | CTD | PMID:17390078 | bromochloroacetic acid | decreases expression | ISO | RGD:731383 | 6480464 | bromochloroacetic acid results in decreased expression of KIT protein | CTD | PMID:21296659 | busulfan | decreases expression | ISO | RGD:731383 | 6480464 | Busulfan results in decreased expression of KIT mRNA | CTD | PMID:15388331 | calcitriol | decreases expression | ISO | RGD:731383 | 6480464 | Calcitriol results in decreased expression of KIT mRNA; more ... | CTD | PMID:8931875 | chlorpyrifos | decreases expression | ISO | RGD:731383 | 6480464 | Chlorpyrifos results in decreased expression of KIT mRNA | CTD | PMID:20350560 | cisplatin | increases expression | ISO | RGD:731382 | 6480464 | Cisplatin results in increased expression of KIT protein | CTD | PMID:21618587 | cisplatin | multiple interactions | ISO | RGD:731382 | 6480464 | [Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of KIT protein | CTD | PMID:21342274 | dasatinib (anhydrous) | affects binding | ISO | RGD:731382 | 6480464 | dasatinib binds to KIT protein | CTD | PMID:18180381 | dasatinib (anhydrous) | decreases phosphorylation | ISO | RGD:731382 | 6480464 | dasatinib results in decreased phosphorylation of KIT protein | CTD | PMID:20145167 | DDD | multiple interactions | ISO | RGD:731382 | 6480464 | [Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of KIT mRNA | CTD | PMID:19422813 | DDE | multiple interactions | ISO | RGD:731382 | 6480464 | [Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of KIT mRNA | CTD | PMID:19422813 | dexamethasone | decreases expression | ISO | RGD:731383 | 6480464 | Dexamethasone results in decreased expression of KIT mRNA; more ... | CTD | PMID:10335920 | diarsenic trioxide | decreases expression | ISO | RGD:731382 | 6480464 | arsenic trioxide results in decreased expression of KIT protein modified form | CTD | PMID:19619438 | diarsenic trioxide | decreases phosphorylation | ISO | RGD:731382 | 6480464 | arsenic trioxide results in decreased phosphorylation of KIT protein | CTD | PMID:19950550 | dieldrin | multiple interactions | ISO | RGD:731382 | 6480464 | [Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of KIT mRNA | CTD | PMID:19422813 | genistein | decreases expression | ISO | RGD:731383 | 6480464 | Genistein results in decreased expression of KIT mRNA | CTD | PMID:21048042 | imatinib | multiple interactions | ISO | RGD:731382 | 6480464 | imatinib inhibits the reaction [KIT protein results in increased expression of HMOX1 protein] | CTD | PMID:17420286 | imatinib | decreases expression | ISO | RGD:731383 | 6480464 | imatinib results in decreased expression of KIT protein | CTD | PMID:21295132 | iron atom | decreases expression | ISO | RGD:731382 | 6480464 | Iron deficiency results in decreased expression of KIT mRNA | CTD | PMID:20368581 | LY294002 | multiple interactions | ISO | RGD:731382 | 6480464 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [KIT protein polymorphism results in increased expression of HMOX1 protein] | CTD | PMID:17420286 | N-ethyl-N-nitrosourea | increases mutagenesis | ISO | RGD:731383 | 6480464 | Ethylnitrosourea results in increased mutagenesis of KIT exon | CTD | PMID:15731517 | N-ethyl-N-nitrosourea | increases mutagenesis | ISO | RGD:731383 | 6480464 | Ethylnitrosourea results in increased mutagenesis of KIT gene | CTD | PMID:15820307 | N-methyl-N'-nitro-N-nitrosoguanidine | increases expression | ISO | RGD:731382 | 6480464 | Methylnitronitrosoguanidine results in increased expression of KIT mRNA | CTD | PMID:12634122 | nickel atom | multiple interactions | EXP | | 6480464 | Grape Seed Proanthocyanidins inhibits the reaction [Nickel results in increased expression of KIT protein] | CTD | PMID:21417627 | nickel atom | increases expression | EXP | | 6480464 | Nickel results in increased expression of KIT protein | CTD | PMID:21417627 | paracetamol | increases expression | ISO | RGD:731383 | 6480464 | Acetaminophen results in increased expression of KIT protein; more ... | CTD | PMID:18467506 | parathion | multiple interactions | ISO | RGD:731382 | 6480464 | [Parathion co-treated with Estradiol] results in increased expression of KIT protein | CTD | PMID:17622325 | parathion | increases expression | ISO | RGD:731382 | 6480464 | Parathion results in increased expression of KIT protein | CTD | PMID:17390078 PMID:17622325 | parathion | multiple interactions | ISO | RGD:731382 | 6480464 | Atropine inhibits the reaction [Parathion results in increased expression of KIT protein] | CTD | PMID:17390078 | phosgene | affects expression | ISO | RGD:731383 | 6480464 | Phosgene affects the expression of KIT mRNA | CTD | PMID:16300373 | resveratrol | multiple interactions | EXP | | 6480464 | resveratrol inhibits the reaction [2,5-hexanedione results in decreased expression of KIT protein] | CTD | PMID:17725299 | sirolimus | multiple interactions | ISO | RGD:731382 | 6480464 | KIT protein mutant form promotes the reaction [Sirolimus results in decreased phosphorylation of EIF4EBP1 protein] | CTD | PMID:16597595 | trans-resveratrol | multiple interactions | EXP | | 6480464 | resveratrol inhibits the reaction [2,5-hexanedione results in decreased expression of KIT protein] | CTD | PMID:17725299 | valproic acid | increases expression | ISO | RGD:731382 | 6480464 | Valproic Acid results in increased expression of KIT mRNA | CTD | PMID:19101580 | valproic acid | increases expression | ISO | RGD:731383 | 6480464 | Valproic Acid results in increased expression of KIT mRNA | CTD | PMID:19136453 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Acute myeloid leukemia |
| Cytokine-cytokine receptor interaction | |
| Endocytosis | |
| Hematopoietic cell lineage | |
| Melanogenesis | |
| Pathways in cancer | |
| PI3K-Akt signaling pathway | |
| Pathway Interaction Database | C-MYB transcription factor network (PID:200153) |
| Signaling events mediated by Stem cell factor receptor (c-Kit) (PID:200181) | |
Phenotype Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Acute myeloid leukemia |
| Cytokine-cytokine receptor interaction | |
| Endocytosis | |
| Hematopoietic cell lineage | |
| Melanogenesis | |
| Pathways in cancer | |
| PI3K-Akt signaling pathway | |
| Pathway Interaction Database | C-MYB transcription factor network (PID:200153) |
| Signaling events mediated by Stem cell factor receptor (c-Kit) (PID:200181) | |
Phenotype Annotations
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References - curated| 1. |
Biermann K, etal., J Pathol. 2007 Nov;213(3):311-8. |
| 2. |
Bodek G, etal., Neoplasia. 2005 May;7(5):497-508. |
| 3. |
Chu S, etal., Gynecol Oncol. 2008 Jan;108(1):182-90. Epub 2007 Oct 29. |
| 4. |
Das AV, etal., Dev Biol. 2004 Sep 1;273(1):87-105. |
| 5. |
Diallo R, etal., Verh Dtsch Ges Pathol. 2006;90:177-85. |
| 6. |
Dym M, etal., Biol Reprod. 1995 Jan;52(1):8-19. |
| 7. |
Erdogan G, etal., APMIS. 2007 Mar;115(3):204-9. |
| 8. |
Eroglu A and Sari A, Med Oncol. 2007;24(2):169-74. |
| 9. |
Giebel LB and Spritz RA, Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8696-9. |
| 10. |
GOA data from the GO Consortium |
| 11. |
Hollenbeck ST, etal., J Surg Res 2004 Aug;120(2):288-94. |
| 12. |
Katafuchi T, etal., Learn Mem. 2000 Nov-Dec;7(6):383-92. |
| 13. |
Ko CD, etal., Clin Exp Metastasis. 2003;20(7):593-7. |
| 14. |
Kuang D, etal., Basic Res Cardiol. 2008 May;103(3):265-273. Epub 2007 Dec 17. |
| 15. |
Li G, etal., Eur J Surg Oncol. 2005 Apr;31(3):299-303. |
| 16. |
Lin ZH, etal., Mod Pathol. 2004 Jun;17(6):611-6. |
| 17. |
Maffini MV, etal., Cancer Cell Int. 2008 Apr 29;8:5. |
| 18. |
MGD data from the GO Consortium |
| 19. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 20. |
Nishida T, etal., Nat Genet. 1998 Aug;19(4):323-4. |
| 21. |
Niwa Y, etal., Blood. 1991 Oct 15;78(8):1936-41. |
| 22. |
Orth JM, etal., Biol Reprod. 1997 Sep;57(3):676-83. |
| 23. |
Pan CX, etal., Mod Pathol. 2005 Mar;18(3):320-3. |
| 24. |
Pignon JM, etal., Br J Haematol. 1997 Feb;96(2):374-6. |
| 25. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 26. |
Prasanth SG and Ali S, DNA Cell Biol. 2003 Jul;22(7):447-56. |
| 27. |
Prasanth SG, etal., DNA Cell Biol. 2004 Jan;23(1):35-43. |
| 28. |
Raspollini MR, etal., Ann Oncol. 2004 Apr;15(4):594-7. |
| 29. |
RGD automated data pipeline |
| 30. |
RGD automated import pipeline for gene-chemical interactions |
| 31. |
RGD Automated Pipelines |
| 32. |
Sakuma Y, etal., Cancer Lett. 2008 Jan 18;259(1):119-26. Epub 2007 Nov 14. |
| 33. |
Sandlow JI, etal., Urology. 1997 Mar;49(3):494-500. |
| 34. |
Satake M, etal., J Hepatol. 2003 Jul;39(1):86-92. |
| 35. |
Takeda M, etal., Cell Tissue Res. 2001 Apr;304(1):21-30. |
| 36. |
Tian Q, etal., Am J Pathol. 1999 Jun;154(6):1643-7. |
| 37. |
Tse GM, etal., Mod Pathol. 2004 Jul;17(7):827-31. |
| 38. |
Tsujimura T, etal., Blood 1991 Oct 15;78(8):1942-6. |
| 39. |
Tsujimura T, etal., Int Arch Allergy Immunol. 1995 Apr;106(4):377-85. |
| 40. |
Tsutsui S, etal., Br J Cancer. 2006 Jun 19;94(12):1874-8. Epub 2006 May 23. |
References - uncurated| PubMed | 12163398 |
| 12641831 | |
| 12879016 | |
| 17322067 | |
| 18087173 | |
| 18448842 | |
| 18544282 | |
| 19255573 | |
| 19591228 | |
| 19634669 | |
| 21179204 | |
| 21455098 | |
| 21559359 | |
| 21634019 | |
| 22366471 | |
| 22931954 | |
| 23090426 |
RGD Disease Portals| Kit has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Kit (Rattus norvegicus) |
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| KIT (Homo sapiens) |
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| Kit (Mus musculus) |
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Position Markers| D14Rat13 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_022264 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06078478 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06078479 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01079067 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01079068 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01079069 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01079070 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF228307 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF228308 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF228309 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF228310 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF228311 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF296693 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF296694 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473981 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CS117952 | (Get FASTA) | Search GEO for Microarray Profiles | |
| D12524 | (Get FASTA) | Search GEO for Microarray Profiles | |
| EU247827 | (Get FASTA) | Search GEO for Microarray Profiles | |
| EU247828 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_022264 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_071600 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_071600 | (Get FASTA) |
| GenBank Protein | AAF69130 | (Get FASTA) |
| AAF69131 | (Get FASTA) | |
| AAF69132 | (Get FASTA) | |
| AAF69133 | (Get FASTA) | |
| AAF69134 | (Get FASTA) | |
| AAG48585 | (Get FASTA) | |
| AAG48586 | (Get FASTA) | |
| ABX45067 | (Get FASTA) | |
| ABX45068 | (Get FASTA) | |
| BAA02094 | (Get FASTA) | |
| CAJ15132 | (Get FASTA) | |
| EDL89921 | (Get FASTA) | |
| EDL89922 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000002227 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000003050 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000003050 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 64030 | ENTREZGENE |
| Gene3D-CATH | Ig-like_fold | UniProtKB/TrEMBL |
| HomoloGene Group ID | 187 | ENTREZGENE |
| InterPro | Ig-like | UniProtKB/TrEMBL |
| Ig-like_fold | UniProtKB/TrEMBL | |
| Ig_I-set | UniProtKB/TrEMBL | |
| Ig_sub | UniProtKB/TrEMBL | |
| Ig_sub2 | UniProtKB/TrEMBL | |
| Kinase-like_dom | UniProtKB/TrEMBL | |
| Prot_kinase_cat_dom | UniProtKB/TrEMBL | |
| Protein_kinase_ATP_BS | UniProtKB/TrEMBL | |
| SCGF_receptor | UniProtKB/TrEMBL | |
| Ser-Thr/Tyr_kinase_cat_dom | UniProtKB/TrEMBL | |
| Tyr_kinase_AS | UniProtKB/TrEMBL | |
| Tyr_kinase_cat_dom | UniProtKB/TrEMBL | |
| Tyr_kinase_CSF1/PDGF_rcpt | UniProtKB/TrEMBL | |
| Tyr_kinase_rcpt_3_CS | UniProtKB/TrEMBL | |
| IPI | IPI00205775 | UniProtKB/TrEMBL |
| KEGG Report | rno:64030 | ENTREZGENE, UniProtKB/TrEMBL |
| Pfam | I-set | UniProtKB/TrEMBL |
| Pkinase_Tyr | UniProtKB/TrEMBL | |
| PharmGKB | KIT | RGD |
| PIRSF | SCGF_recepter | UniProtKB/TrEMBL |
| TyrPK_CSF1-R | UniProtKB/TrEMBL | |
| PROSITE | IG_LIKE | UniProtKB/TrEMBL |
| PROTEIN_KINASE_ATP | UniProtKB/TrEMBL | |
| PROTEIN_KINASE_DOM | UniProtKB/TrEMBL | |
| PROTEIN_KINASE_TYR | UniProtKB/TrEMBL | |
| RECEPTOR_TYR_KIN_III | UniProtKB/TrEMBL | |
| SMART | IGc2 | UniProtKB/TrEMBL |
| SM00409 | UniProtKB/TrEMBL | |
| TyrKc | UniProtKB/TrEMBL | |
| Superfamily-SCOP | Kinase_like | UniProtKB/TrEMBL |
| UniGene | Rn.54004 | ENTREZGENE |
| UniProt | Q63116_RAT | UniProtKB/TrEMBL |
| Q9JKS2_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2004-09-10 | Kit | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | c-kit receptor tyrosine kinase | Name updated | 10779 | APPROVED | |
| 2002-08-07 | Kit | c-kit receptor tyrosine kinase | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_disease | deletion of Val-Lys-Gly-Asn sequence is associated with anemia and deficiency in mast cells and melanocytes | 633170 |
| More on Kit | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 620568 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




