Gene: Mpl (MPL proto-oncogene, thrombopoietin receptor) Rattus norvegicus
Symbol: Mpl
Name: MPL proto-oncogene, thrombopoietin receptor
Description: ENCODES a protein that exhibits thrombopoietin receptor activity (ortholog); INVOLVED IN definitive hemopoiesis (ortholog); homeostasis of number of cells (ortholog); negative regulation of apoptotic process (ortholog); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; ASSOCIATED WITH Congenital amegakaryocytic thrombocytopenia (ortholog); Familial myelofibrosis (ortholog); Primary Myelofibrosis (ortholog); FOUND IN cell surface (ortholog); Golgi apparatus (ortholog); plasma membrane (ortholog); INTERACTS WITH bisphenol A; 4,4'-diaminodiphenylmethane (ortholog); 5-aza-2'-deoxycytidine (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC366455; myeloproliferative leukemia virus oncogene; thrombopoietin receptor
Latest Assembly: RGSC Genome Assembly v5.0
RGSC Genome Assembly v6.05137,268,412 - 137,290,587-NCBI
Rat Cytogenetic Map5q36 NCBI
RGSC Genome Assembly v5.05141,057,876 - 141,070,834-NCBI
RGSC Genome Assembly v3.45138,921,281 - 138,931,990-NCBI
Rat Celera Assembly5130,519,369 - 130,541,525-NCBI
Genome Assembly 3.15138,922,155 - 138,937,216-NCBI

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Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (RGSC Genome Assembly v5.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
More on Mpl
Entrez Gene
Ensembl Gene
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Vista + UCSC

RGD Object Information
RGD ID: 1311069
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2015-10-01
Status: ACTIVE