Gene: Mpl (MPL proto-oncogene, thrombopoietin receptor) Rattus norvegicus
Symbol: Mpl
Name: MPL proto-oncogene, thrombopoietin receptor
Description: ENCODES a protein that exhibits thrombopoietin receptor activity (ortholog); INVOLVED IN cellular response to hypoxia; platelet aggregation; positive regulation of lymphocyte proliferation; PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; ASSOCIATED WITH Fibrosis; Thrombocytopenia; Congenital Amegakaryocytic Thrombocytopenia (ortholog); FOUND IN cell surface; neuron projection; neuronal cell body; INTERACTS WITH bisphenol A; 4,4'-diaminodiphenylmethane (ortholog); 5-aza-2'-deoxycytidine (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC366455; myeloproliferative leukemia virus oncogene; thrombopoietin receptor
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05137,268,412 - 137,290,587 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.05141,057,876 - 141,070,834 (-)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.45138,921,281 - 138,931,990 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15138,922,155 - 138,937,216 (-)NCBI
Celera5130,519,369 - 130,541,525 (-)NCBI
Cytogenetic Map5q36NCBImapview

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
More on Mpl
Entrez Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 1311069
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2016-05-10
Status: ACTIVE