| (S)-nicotine | multiple interactions | ISO | RGD:1319341 | 6480464 | Nicotine inhibits the reaction [E2F4 protein binds to CDC6 promoter]; more ... | CTD | PMID:16862215 |
| 17alpha-ethynylestradiol | affects expression | ISO | RGD:1319342 | 6480464 | Ethinyl Estradiol affects the expression of CDC6 mRNA | CTD | PMID:17555576 |
| 17alpha-ethynylestradiol | increases expression | ISO | RGD:1319342 | 6480464 | Ethinyl Estradiol results in increased expression of CDC6 mRNA | CTD | PMID:17942748 |
| 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1319342 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDC6 mRNA | CTD | PMID:17942748 |
| 17beta-estradiol | increases expression | ISO | RGD:1319341 | 6480464 | Estradiol results in increased expression of CDC6 mRNA | CTD | PMID:16474171 more ... |
| 17beta-estradiol | increases expression | ISO | RGD:1319341 | 6480464 | Estradiol results in increased expression of CDC6 mRNA | CTD | PMID:16474171 more ... |
| 17beta-estradiol | increases expression | ISO | RGD:1319341 | 6480464 | Estradiol results in increased expression of CDC6 mRNA | CTD | PMID:16474171 PMID:17268063 |
| 17beta-estradiol | increases expression | ISO | RGD:1319341 | 6480464 | Estradiol results in increased expression of CDC6 mRNA | CTD | PMID:17268063 PMID:16474171 |
| 17beta-estradiol | affects expression | ISO | RGD:1319342 | 6480464 | Estradiol affects the expression of CDC6 mRNA | CTD | PMID:15598610 |
| 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one | increases expression | ISO | RGD:1319341 | 6480464 | Metribolone results in increased expression of CDC6 mRNA | CTD | PMID:19318562 |
| 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1319342 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of CDC6 mRNA | CTD | PMID:15667827 PMID:17942748 |
| 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1319342 | 6480464 | Tetrachlorodibenzodioxin affects the expression of CDC6 mRNA | CTD | PMID:21570461 |
| 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1319341 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CDC6 mRNA | CTD | PMID:21632981 |
| 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1319342 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of CDC6 mRNA | CTD | PMID:17942748 PMID:15667827 |
| 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1319342 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CDC6 mRNA | CTD | PMID:16102516 |
| 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1319342 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDC6 mRNA | CTD | PMID:17942748 |
| 2-butoxyethanol | increases expression | ISO | RGD:1319342 | 6480464 | n-butoxyethanol results in increased expression of CDC6 mRNA | CTD | PMID:19812364 |
| 3-methylcholanthrene | increases expression | ISO | RGD:1319342 | 6480464 | Methylcholanthrene results in increased expression of CDC6 mRNA | CTD | PMID:20713471 |
| 4,4'-diaminodiphenylmethane | decreases expression | ISO | RGD:1319342 | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of CDC6 mRNA | CTD | PMID:18648102 |
| 5-fluorouracil | affects expression | ISO | RGD:1319341 | 6480464 | Fluorouracil affects the expression of CDC6 mRNA | CTD | PMID:16557594 |
| 5-fluorouracil | decreases expression | ISO | RGD:1319342 | 6480464 | Fluorouracil results in decreased expression of CDC6 mRNA | CTD | PMID:19272435 |
| 5-fluorouracil | multiple interactions | ISO | RGD:1319341 | 6480464 | [Leucovorin co-treated with Fluorouracil] results in increased expression of CDC6 mRNA | CTD | PMID:15342418 |
| 5-fluorouracil | increases expression | ISO | RGD:1319341 | 6480464 | Fluorouracil results in increased expression of CDC6 mRNA | CTD | PMID:16709241 |
| 5-fluorouracil | decreases expression | ISO | RGD:1319341 | 6480464 | Fluorouracil results in decreased expression of CDC6 mRNA | CTD | PMID:17039268 |
| 5-formyltetrahydrofolic acid | multiple interactions | ISO | RGD:1319341 | 6480464 | [Leucovorin co-treated with Fluorouracil] results in increased expression of CDC6 mRNA | CTD | PMID:15342418 |
| afimoxifene | multiple interactions | ISO | RGD:1319341 | 6480464 | 4-hydroxytamoxifen inhibits the reaction [Estrogens results in increased expression of CDC6 mRNA]; more ... | CTD | PMID:21233418 |
| aflatoxin B1 | affects expression | ISO | RGD:1319341 | 6480464 | Aflatoxin B1 affects the expression of CDC6 protein | CTD | PMID:20106945 |
| aflatoxin B1 | increases expression | ISO | RGD:1319341 | 6480464 | Aflatoxin B1 results in increased expression of CDC6 mRNA | CTD | PMID:22100608 |
| aflatoxin B1 | decreases expression | ISO | RGD:1319341 | 6480464 | Aflatoxin B1 results in decreased expression of CDC6 mRNA | CTD | PMID:21641981 |
| all-trans-retinoic acid | decreases expression | ISO | RGD:1319341 | 6480464 | Tretinoin results in decreased expression of CDC6 mRNA | CTD | PMID:16249480 |
| all-trans-retinoic acid | decreases expression | ISO | RGD:1319341 | 6480464 | Tretinoin results in decreased expression of CDC6 mRNA | CTD | PMID:15498508 PMID:16249480 |
| all-trans-retinoic acid | decreases expression | ISO | RGD:1319341 | 6480464 | Tretinoin results in decreased expression of CDC6 mRNA | CTD | PMID:16249480 PMID:15498508 |
| ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of CDC6 protein | CTD | PMID:16483693 |
| atropine | multiple interactions | ISO | RGD:1319341 | 6480464 | [Parathion co-treated with Atropine] results in increased expression of CDC6 mRNA | CTD | PMID:17390078 |
| benzo[a]pyrene | increases expression | ISO | RGD:1319342 | 6480464 | Benzo(a)pyrene results in increased expression of CDC6 mRNA | CTD | PMID:20713471 |
| benzo[a]pyrene | decreases expression | ISO | RGD:1319341 | 6480464 | Benzo(a)pyrene results in decreased expression of CDC6 mRNA | CTD | PMID:16120219 |
| bicalutamide | decreases expression | ISO | RGD:1319341 | 6480464 | bicalutamide results in decreased expression of CDC6 mRNA; more ... | CTD | PMID:15887248 |
| bisphenol A | increases expression | ISO | RGD:1319341 | 6480464 | bisphenol A results in increased expression of CDC6 mRNA | CTD | PMID:16474171 PMID:17268063 |
| bisphenol A | increases expression | ISO | RGD:1319341 | 6480464 | bisphenol A results in increased expression of CDC6 mRNA | CTD | PMID:17268063 PMID:16474171 |
| calcitriol | decreases expression | ISO | RGD:1319341 | 6480464 | Calcitriol results in decreased expression of CDC6 mRNA | CTD | PMID:21592394 |
| calcitriol | multiple interactions | ISO | RGD:1319341 | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of CDC6 mRNA | CTD | PMID:21592394 |
| cefaloridine | increases expression | EXP | | 6480464 | Cephaloridine results in increased expression of CDC6 mRNA | CTD | PMID:18500788 |
| chlorpyrifos | decreases expression | ISO | RGD:1319342 | 6480464 | Chlorpyrifos results in decreased expression of CDC6 mRNA | CTD | PMID:20350560 |
| choline | multiple interactions | ISO | RGD:1319342 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CDC6 gene | CTD | PMID:20938992 |
| cisplatin | increases phosphorylation | ISO | RGD:1319342 | 6480464 | Cisplatin results in increased phosphorylation of CDC6 protein | CTD | PMID:22006019 |
| cobalt dichloride | decreases expression | ISO | RGD:1319341 | 6480464 | cobaltous chloride results in decreased expression of CDC6 mRNA | CTD | PMID:19376846 |
| coumestrol | multiple interactions | ISO | RGD:1319341 | 6480464 | [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CDC6 mRNA; more ... | CTD | PMID:19167446 |
| coumestrol | increases expression | ISO | RGD:1319341 | 6480464 | Coumestrol results in increased expression of CDC6 mRNA | CTD | PMID:19167446 |
| cyclosporin A | increases expression | ISO | RGD:1319341 | 6480464 | Cyclosporine results in increased expression of CDC6 mRNA | CTD | PMID:20106945 |
| dasatinib (anhydrous) | decreases expression | ISO | RGD:1319341 | 6480464 | dasatinib results in decreased expression of CDC6 mRNA | CTD | PMID:20579391 |
| diarsenic trioxide | multiple interactions | ISO | RGD:1319341 | 6480464 | 9-methoxy-2-methylellipticinium acetate inhibits the reaction [arsenic trioxide results in increased expression of CDC6 protein]; more ... | CTD | PMID:20862710 |
| diarsenic trioxide | increases expression | ISO | RGD:1319341 | 6480464 | arsenic trioxide results in increased expression of CDC6 mRNA; more ... | CTD | PMID:20862710 |
| dibutyl phthalate | decreases expression | ISO | RGD:1319342 | 6480464 | Dibutyl Phthalate results in decreased expression of CDC6 mRNA | CTD | PMID:21266533 |
| dibutyl phthalate | decreases expression | ISO | RGD:1319342 | 6480464 | Dibutyl Phthalate results in decreased expression of CDC6 mRNA | CTD | PMID:17361019 PMID:21266533 |
| disodium selenite | decreases expression | ISO | RGD:1319341 | 6480464 | Sodium Selenite results in decreased expression of CDC6 mRNA | CTD | PMID:16705456 |
| etoposide | decreases expression | ISO | RGD:1319341 | 6480464 | Etoposide results in decreased expression of CDC6 mRNA | CTD | PMID:16120219 |
| folic acid | multiple interactions | ISO | RGD:1319342 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CDC6 gene | CTD | PMID:20938992 |
| genistein | increases expression | ISO | RGD:1319341 | 6480464 | Genistein results in increased expression of CDC6 mRNA | CTD | PMID:16474171 |
| ketamine | decreases expression | EXP | | 6480464 | Ketamine results in decreased expression of CDC6 mRNA | CTD | PMID:20080153 |
| L-ascorbic acid | multiple interactions | ISO | RGD:1319341 | 6480464 | [Quercetin co-treated with Ascorbic Acid] results in increased expression of CDC6 mRNA | CTD | PMID:17639512 |
| L-methionine | multiple interactions | ISO | RGD:1319342 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CDC6 gene | CTD | PMID:20938992 |
| lead diacetate | decreases expression | ISO | RGD:1319342 | 6480464 | lead acetate results in decreased expression of CDC6 mRNA | CTD | PMID:20542052 |
| lithium chloride | decreases expression | ISO | RGD:1319341 | 6480464 | Lithium Chloride results in decreased expression of CDC6 mRNA; more ... | CTD | PMID:17440966 |
| lithium chloride | increases expression | ISO | RGD:1319341 | 6480464 | Lithium Chloride results in increased expression of CDC6 mRNA | CTD | PMID:22493441 |
| lucanthone | decreases expression | ISO | RGD:1319341 | 6480464 | Lucanthone results in decreased expression of CDC6 mRNA | CTD | PMID:21148553 |
| N-nitrosodiethylamine | multiple interactions | ISO | RGD:1319342 | 6480464 | RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CDC6 mRNA] | CTD | PMID:17854601 |
| N-nitrosodiethylamine | increases expression | ISO | RGD:1319342 | 6480464 | Diethylnitrosamine results in increased expression of CDC6 mRNA | CTD | PMID:17854601 |
| N-nitrosodimethylamine | decreases expression | ISO | RGD:1319341 | 6480464 | Dimethylnitrosamine results in decreased expression of CDC6 mRNA | CTD | PMID:19031421 |
| ozone | increases expression | ISO | RGD:1319342 | 6480464 | Ozone results in increased expression of CDC6 mRNA | CTD | PMID:19555225 |
| paracetamol | increases expression | ISO | RGD:1319342 | 6480464 | Acetaminophen results in increased expression of CDC6 mRNA | CTD | PMID:18544908 |
| paracetamol | increases expression | ISO | RGD:1319341 | 6480464 | Acetaminophen results in increased expression of CDC6 mRNA | CTD | PMID:22230336 |
| parathion | multiple interactions | ISO | RGD:1319341 | 6480464 | [Parathion co-treated with Atropine] results in increased expression of CDC6 mRNA | CTD | PMID:17390078 |
| parathion | increases expression | ISO | RGD:1319341 | 6480464 | Parathion results in increased expression of CDC6 mRNA | CTD | PMID:17622325 |
| phenobarbital | multiple interactions | ISO | RGD:1319342 | 6480464 | NR1I3 protein affects the reaction [Phenobarbital results in increased expression of CDC6 mRNA] | CTD | PMID:19482888 |
| phenobarbital | increases expression | ISO | RGD:1319342 | 6480464 | Phenobarbital results in increased expression of CDC6 mRNA | CTD | PMID:19482888 PMID:23091169 |
| phenobarbital | increases expression | ISO | RGD:1319342 | 6480464 | Phenobarbital results in increased expression of CDC6 mRNA | CTD | PMID:19482888 |
| pirinixic acid | multiple interactions | ISO | RGD:1319341 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CDC6 mRNA | CTD | PMID:19710929 |
| piroxicam | increases expression | ISO | RGD:1319341 | 6480464 | Piroxicam results in increased expression of CDC6 mRNA | CTD | PMID:21858171 |
| progesterone | increases expression | ISO | RGD:1319341 | 6480464 | Progesterone results in increased expression of CDC6 mRNA | CTD | PMID:18070364 |
| quercetin | multiple interactions | ISO | RGD:1319341 | 6480464 | [Quercetin co-treated with Ascorbic Acid] results in increased expression of CDC6 mRNA | CTD | PMID:17639512 |
| quercetin | increases expression | ISO | RGD:1319341 | 6480464 | Quercetin results in increased expression of CDC6 mRNA | CTD | PMID:21632981 |
| quercetin | decreases expression | ISO | RGD:1319341 | 6480464 | Quercetin results in decreased expression of CDC6 mRNA | CTD | PMID:15309432 |
| quinolin-8-ol | decreases expression | ISO | RGD:1319341 | 6480464 | Oxyquinoline results in decreased expression of CDC6 mRNA | CTD | PMID:21632981 |
| resveratrol | decreases expression | ISO | RGD:1319341 | 6480464 | resveratrol results in decreased expression of CDC6 mRNA | CTD | PMID:15767336 |
| resveratrol | multiple interactions | ISO | RGD:1319341 | 6480464 | [Coumestrol co-treated with resveratrol] results in increased expression of CDC6 mRNA | CTD | PMID:19167446 |
| silver(1+) nitrate | increases expression | ISO | RGD:1319341 | 6480464 | Silver Nitrate results in increased expression of CDC6 mRNA; more ... | CTD | PMID:22831968 |
| simvastatin | decreases expression | ISO | RGD:1319341 | 6480464 | Simvastatin results in decreased expression of CDC6 mRNA | CTD | PMID:17428261 |
| succimer | multiple interactions | ISO | RGD:1319342 | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CDC6 mRNA | CTD | PMID:21641980 |
| tamibarotene | decreases expression | ISO | RGD:1319341 | 6480464 | Am 80 results in decreased expression of CDC6 mRNA; more ... | CTD | PMID:15498508 |
| tamoxifen | affects expression | ISO | RGD:1319342 | 6480464 | Tamoxifen affects the expression of CDC6 mRNA | CTD | PMID:17555576 |
| testosterone | multiple interactions | ISO | RGD:1319341 | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of CDC6 mRNA | CTD | PMID:21592394 |
| testosterone | decreases expression | ISO | RGD:1319341 | 6480464 | Testosterone results in decreased expression of CDC6 mRNA | CTD | PMID:21592394 |
| tetrachloromethane | increases expression | ISO | RGD:1319342 | 6480464 | Carbon Tetrachloride results in increased expression of CDC6 mRNA | CTD | PMID:17484886 |
| thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of CDC6 mRNA | CTD | PMID:22659510 |
| tocopherol | increases expression | ISO | RGD:1319342 | 6480464 | Tocopherols results in increased expression of CDC6 mRNA | CTD | PMID:17056531 |
| trans-resveratrol | decreases expression | ISO | RGD:1319341 | 6480464 | resveratrol results in decreased expression of CDC6 mRNA | CTD | PMID:15767336 |
| trans-resveratrol | multiple interactions | ISO | RGD:1319341 | 6480464 | [Coumestrol co-treated with resveratrol] results in increased expression of CDC6 mRNA | CTD | PMID:19167446 |
| trimellitic anhydride | increases expression | ISO | RGD:1319342 | 6480464 | trimellitic anhydride results in increased expression of CDC6 mRNA | CTD | PMID:19042947 |
| troglitazone | decreases expression | ISO | RGD:1319341 | 6480464 | troglitazone results in decreased expression of CDC6 mRNA | CTD | PMID:19140230 |
| valproic acid | affects expression | ISO | RGD:1319342 | 6480464 | Valproic Acid affects the expression of CDC6 mRNA | CTD | PMID:17963808 |