Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:vascular endothelial growth factor signaling pathway
go back to main search page
Accession:PW:0000243 term browser browse the term
Definition:The VEGF family plays key roles in angiogenesis and lymphangiogenesis. Through their receptors, VEGFs can initiate a diverse and complex network of signaling cascades. Deregulation of VEGF-mediated pathways, mostly through upregulation of VEGF expression, has been implicated in a number of conditions, primarily cancer.
Synonyms:related_synonym: Signaling by VEGF;   VEGF signaling pathways;   vascular endothelial growth factor receptor signaling pathway
View Interactive Diagram


show annotations for term's descendants           Sort by:
vascular endothelial growth factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap1 A-kinase anchoring protein 1 ISO PID PID:200188 NCBI chr10:74,118,232...74,151,366
Ensembl chr10:74,119,124...74,138,190 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO
IEA 		PID
KEGG		 PID:200188 rno:04370 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 IEA KEGG rno:04370 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:92,014,859...92,061,420 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 IEA KEGG rno:04370 NCBI chr13:91,475,839...91,758,060
Ensembl chr13:91,475,839...91,748,020 		JBrowse link
G Arf1 ARF GTPase 1 ISO PID PID:200188 NCBI chr10:44,497,543...44,513,994 JBrowse link
G Bad BCL2-associated agonist of cell death IEA KEGG rno:04370 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO PID PID:200188 NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:69,342,813...69,476,931 		JBrowse link
G Calm1 calmodulin 1 ISO PID PID:200188 NCBI chr 6:125,217,191...125,227,855
Ensembl chr 6:125,217,246...125,225,381 		JBrowse link
G Calm2 calmodulin 2 ISO PID PID:200188 NCBI chr 6:12,845,170...12,857,830
Ensembl chr15:64,519,554...64,520,657
Ensembl chr 6:64,519,554...64,520,657 		JBrowse link
G Calm3 calmodulin 3 ISO PID PID:200188 NCBI chr 1:86,718,761...86,725,869
Ensembl chr 1:86,717,321...86,725,960 		JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 ISO PID PID:200188 NCBI chr12:39,451,828...39,505,719
Ensembl chr12:39,451,834...39,514,964 		JBrowse link
G Casp9 caspase 9 IEA KEGG rno:04370 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cav1 caveolin 1 ISO PID PID:200188 NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:46,600,738...46,639,740 		JBrowse link
G Cbl Cbl proto-oncogene ISO PID PID:200188 NCBI chr 8:53,384,656...53,468,067
Ensembl chr 8:53,384,656...53,468,067 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IMP RGD PMID:14693680 RGD:1580560 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Cdc42 cell division cycle 42 ISO
IEA 		PID
KEGG		 PID:200188 rno:04370 NCBI chr 5:154,838,478...154,876,629
Ensembl chr 5:154,839,631...154,876,627 		JBrowse link
G Cdh5 cadherin 5 ISO PID PID:200188 NCBI chr19:821,875...860,931
Ensembl chr19:822,464...860,822 		JBrowse link
G Chp1 calcineurin-like EF-hand protein 1 IEA KEGG rno:04370 NCBI chr 3:126,989,800...127,025,071
Ensembl chr 3:126,989,579...127,042,443 		JBrowse link
G Chp1l1 calcineurin-like EF-hand protein 1 like 1 IEA KEGG rno:04370 NCBI chr 5:73,364,780...73,367,229
Ensembl chr 5:73,363,560...73,367,249 		JBrowse link
G Chp2 calcineurin-like EF hand protein 2 IEA KEGG rno:04370 NCBI chr 1:186,189,090...186,203,663
Ensembl chr 1:186,185,151...186,203,667 		JBrowse link
G Ctnna1 catenin alpha 1 ISO PID PID:200188 NCBI chr18:27,002,330...27,135,009
Ensembl chr18:26,999,820...27,135,007 		JBrowse link
G Ctnnb1 catenin beta 1 ISO PID PID:200188 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Dnm2 dynamin 2 ISO PID PID:200188 NCBI chr 8:28,254,344...28,336,297
Ensembl chr 8:28,254,529...28,336,295 		JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 ISS RGD PMID:14597660 RGD:1334466 NCBI chr19:69,765,276...69,804,681 JBrowse link
G Egln2 egl-9 family hypoxia-inducible factor 2 TAS
ISS 		RGD PMID:12876291 PMID:14597660 RGD:727754, RGD:1334466 NCBI chr 1:91,579,205...91,586,985
Ensembl chr 1:91,579,206...91,587,385 		JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 ISS RGD PMID:14597660 RGD:1334466 NCBI chr 6:77,385,549...77,411,015
Ensembl chr 6:77,385,549...77,411,015 		JBrowse link
G Fbxw11 F-box and WD repeat domain containing 11 ISO PID PID:200188 NCBI chr10:17,737,181...17,834,834
Ensembl chr10:17,720,444...17,834,834 		JBrowse link
G Fes FES proto-oncogene, tyrosine kinase ISO PID PID:200188 NCBI chr 1:143,746,945...143,756,181
Ensembl chr 1:143,746,945...143,756,181 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 IMP
ISO 		PID
RGD		 PMID:15785231 PMID:16633338 PID:200109 PID:200188, RGD:1626621, RGD:2298727 NCBI chr12:12,333,050...12,504,750
Ensembl chr12:12,333,430...12,504,750 		JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 IMP
ISO 		This is VGFR-3 PID
RGD		 PMID:11683876 PID:200109, RGD:727326 NCBI chr10:34,414,834...34,455,878
Ensembl chr10:34,414,733...34,456,645 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase ISO PID
RGD		 PMID:17658244 PID:200188, RGD:2298729 NCBI chr20:44,322,635...44,514,498
Ensembl chr20:44,322,361...44,515,479 		JBrowse link
G Gab1 GRB2-associated binding protein 1 ISO PID PID:200188 NCBI chr19:44,035,693...44,143,617
Ensembl chr19:44,035,063...44,143,617 		JBrowse link
G Grb10 growth factor receptor bound protein 10 ISO PID PID:200188 NCBI chr14:90,708,653...90,816,399
Ensembl chr14:90,708,653...90,816,387 		JBrowse link
G Grb2 growth factor receptor bound protein 2 ISO PID PID:200188 NCBI chr10:101,380,354...101,448,138
Ensembl chr10:101,380,356...101,448,138 		JBrowse link
G Hgs hepatocyte growth factor-regulated tyrosine kinase substrate ISO PID PID:200188 NCBI chr10:106,237,988...106,256,174
Ensembl chr10:106,237,824...106,256,174 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha IMP RGD PMID:18614764 RGD:2301848 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Hras HRas proto-oncogene, GTPase IEA KEGG rno:04370 NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:205,725,975...205,729,590 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISO PID PID:200188 NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 ISO PID PID:200188 NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:22,931,070...22,935,926 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 IEA KEGG rno:04370 NCBI chr12:26,430,640...26,432,301
Ensembl chr12:26,430,640...26,432,301 		JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 ISO PID PID:200188 NCBI chr 1:144,088,788...144,178,989
Ensembl chr 1:144,088,793...144,179,043 		JBrowse link
G Itgav integrin subunit alpha V ISO PID PID:200188 NCBI chr 3:89,245,382...89,333,512
Ensembl chr 3:89,245,095...89,333,511 		JBrowse link
G Itgb3 integrin subunit beta 3 ISO PID PID:200188 NCBI chr10:90,009,927...90,067,787
Ensembl chr10:90,009,900...90,067,800 		JBrowse link
G Kdr kinase insert domain receptor IMP
IEA
ISO 		VEGFR-2 KEGG
PID
RGD		 PMID:9442048 PMID:18614764 PMID:17658244 PMID:16633338 PMID:15785231 More... PID:200109 PID:200188 rno:04370, RGD:729081, RGD:2301848, RGD:2298729, RGD:2298727, RGD:1626621, RGD:2292019 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192 		JBrowse link
G Kras KRAS proto-oncogene, GTPase IEA KEGG rno:04370 NCBI chr 4:179,916,255...179,949,613
Ensembl chr 4:179,919,802...179,949,320 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 ISO
IEA 		PID
KEGG		 PID:200188 rno:04370 NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 ISO
IEA 		PID
KEGG		 PID:200188 rno:04370 NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:9,241,310...9,260,940 		JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 ISO PID PID:200188 NCBI chr10:46,107,639...46,128,986
Ensembl chr10:46,106,548...46,129,004 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 ISO PID PID:200188 NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,872,546...95,987,721 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO
IEA 		PID
KEGG		 PID:200188 rno:04370 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk11 mitogen-activated protein kinase 11 ISO
IEA 		PID
KEGG		 PID:200188 rno:04370 NCBI chr 7:122,098,120...122,105,023
Ensembl chr 7:122,098,121...122,105,038 		JBrowse link
G Mapk12 mitogen-activated protein kinase 12 IEA KEGG rno:04370 NCBI chr 7:122,085,647...122,096,307
Ensembl chr 7:122,085,913...122,096,307 		JBrowse link
G Mapk13 mitogen activated protein kinase 13 IEA KEGG rno:04370 NCBI chr20:6,836,979...6,847,197
Ensembl chr20:6,837,013...6,847,191 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 ISO
IEA 		PID
KEGG		 PID:200188 rno:04370 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 ISO
IEA 		PID
KEGG		 PID:200188 rno:04370 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 ISO
IEA 		PID
KEGG		 PID:200188 rno:04370 NCBI chr13:45,066,027...45,112,326
Ensembl chr13:45,066,031...45,112,326 		JBrowse link
G Mapkapk3 MAPK activated protein kinase 3 IEA KEGG rno:04370 NCBI chr 8:116,808,429...116,842,228
Ensembl chr 8:116,808,429...116,842,228 		JBrowse link
G Myof myoferlin ISO PID PID:200188 NCBI chr 1:245,086,109...245,234,768
Ensembl chr 1:245,086,109...245,234,768 		JBrowse link
G Nck1 NCK adaptor protein 1 ISO PID
RGD		 PMID:17658244 PID:200188, RGD:2298729 NCBI chr 8:109,897,723...109,958,247
Ensembl chr 8:109,897,724...109,958,247 		JBrowse link
G Nck2 NCK adaptor protein 2 ISO PID PID:200188 NCBI chr 9:53,206,006...53,332,417
Ensembl chr 9:53,231,381...53,332,394 		JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase ISO PID PID:200188 NCBI chr 8:82,264,751...82,349,642
Ensembl chr 8:82,264,649...82,349,633 		JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 IEA KEGG rno:04370 NCBI chr19:52,108,982...52,196,418
Ensembl chr19:52,109,483...52,196,418 		JBrowse link
G Nfatc2 nuclear factor of activated T-cells 2 IEA KEGG rno:04370 NCBI chr 3:177,615,189...177,747,493
Ensembl chr 3:177,618,314...177,747,380 		JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 IEA KEGG rno:04370 NCBI chr19:50,870,464...50,944,992
Ensembl chr19:50,870,489...50,944,992 		JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 IEA KEGG rno:04370 NCBI chr15:33,256,912...33,284,522
Ensembl chr15:33,274,153...33,285,582 		JBrowse link
G Nos3 nitric oxide synthase 3 ISO
IEA 		PID
KEGG		 PID:200188 rno:04370 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664 		JBrowse link
G Nras NRAS proto-oncogene, GTPase IEA KEGG rno:04370 NCBI chr 2:193,271,399...193,282,023
Ensembl chr 2:193,271,430...193,278,543 		JBrowse link
G Nrp1 neuropilin 1 ISS
ISO 		PID
RGD		 PMID:15563310 PMID:16633338 PID:200109, RGD:1334463, RGD:2298727 NCBI chr19:73,256,557...73,411,705
Ensembl chr19:73,256,557...73,411,702 		JBrowse link
G Nrp2 neuropilin 2 ISO PID PID:200109 NCBI chr 9:71,616,602...71,731,869
Ensembl chr 9:71,616,657...71,731,871 		JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 ISO PID PID:200188 NCBI chr11:82,212,896...82,273,803
Ensembl chr11:82,212,951...82,273,803 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 ISO PID PID:200188 NCBI chr10:13,610,000...13,687,226
Ensembl chr10:13,610,063...13,679,181 		JBrowse link
G Pgf placental growth factor TAS
ISO 		RGD PMID:7706320 PMID:16633338 RGD:633657, RGD:2298727 NCBI chr 6:110,547,165...110,557,747
Ensembl chr 6:110,547,153...110,557,747 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO
IEA 		PID
KEGG		 PID:200188 rno:04370 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta IEA KEGG rno:04370 NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:108,474,019...108,579,331 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta IEA KEGG rno:04370 NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:165,377,994...165,403,968 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO
IEA 		PID
KEGG		 PID:200188 rno:04370 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 IEA KEGG rno:04370 NCBI chr16:18,699,389...18,708,045
Ensembl chr16:18,699,448...18,709,665 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 IEA KEGG rno:04370 NCBI chr 5:134,936,790...135,009,303
Ensembl chr 5:134,934,857...135,007,762 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 IEA KEGG rno:04370 NCBI chr10:53,631,469...53,699,550
Ensembl chr10:53,631,476...53,699,539 		JBrowse link
G Pla2g10 phospholipase A2, group X IEA KEGG rno:04370 NCBI chr10:2,104,927...2,117,998
Ensembl chr10:2,104,927...2,116,172 		JBrowse link
G Pla2g12a phospholipase A2, group XIIA IEA KEGG rno:04370 NCBI chr 2:221,110,722...221,126,966
Ensembl chr 2:221,110,685...221,126,964 		JBrowse link
G Pla2g12b phospholipase A2, group XIIB IEA KEGG rno:04370 NCBI chr20:27,910,620...27,931,734
Ensembl chr20:27,913,259...27,932,148 		JBrowse link
G Pla2g1b phospholipase A2 group IB IEA KEGG rno:04370 NCBI chr12:46,802,932...46,814,511
Ensembl chr12:46,802,939...46,813,693 		JBrowse link
G Pla2g2a phospholipase A2 group IIA IEA KEGG rno:04370 NCBI chr 5:156,359,725...156,362,302
Ensembl chr 5:156,359,725...156,362,297 		JBrowse link
G Pla2g2c phospholipase A2, group IIC IEA KEGG rno:04370 NCBI chr 5:156,241,142...156,262,368
Ensembl chr 5:156,242,451...156,264,676 		JBrowse link
G Pla2g2d phospholipase A2, group IID IEA KEGG rno:04370 NCBI chr 5:156,299,374...156,305,816
Ensembl chr 5:156,297,777...156,305,812 		JBrowse link
G Pla2g2f phospholipase A2, group IIF IEA KEGG rno:04370 NCBI chr 5:156,270,077...156,276,464
Ensembl chr 5:156,270,077...156,295,516 		JBrowse link
G Pla2g3 phospholipase A2, group III IEA KEGG rno:04370 NCBI chr14:82,589,908...82,597,542
Ensembl chr14:82,591,862...82,597,542 		JBrowse link
G Pla2g4a phospholipase A2 group 4A IEA KEGG rno:04370 NCBI chr13:64,427,921...64,572,352
Ensembl chr13:64,427,916...64,589,641 		JBrowse link
G Pla2g4b phospholipase A2 group IVB IEA KEGG rno:04370 NCBI chr 3:127,458,022...127,467,637
Ensembl chr 3:127,459,273...127,467,637 		JBrowse link
G Pla2g4e phospholipase A2, group IVE IEA KEGG rno:04370 NCBI chr 3:127,586,318...127,652,369
Ensembl chr 3:127,587,027...127,651,868 		JBrowse link
G Pla2g4f phospholipase A2, group IVF IEA KEGG rno:04370 NCBI chr 3:127,702,603...127,720,429
Ensembl chr 3:127,703,841...127,718,348 		JBrowse link
G Pla2g5 phospholipase A2, group V IEA KEGG rno:04370 NCBI chr 5:156,324,628...156,393,065
Ensembl chr 5:156,324,629...156,381,926 		JBrowse link
G Pla2g6 phospholipase A2 group VI IEA KEGG rno:04370 NCBI chr 7:112,731,803...112,771,978
Ensembl chr 7:112,731,803...112,771,609 		JBrowse link
G Plcg1 phospholipase C, gamma 1 ISO
IEA 		KEGG
PID
RGD		 PMID:17658244 PID:200188 rno:04370, RGD:2298729 NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:169,804,846...169,836,050 		JBrowse link
G Plcg2 phospholipase C, gamma 2 IEA KEGG rno:04370 NCBI chr19:62,456,196...62,592,684
Ensembl chr19:62,453,259...62,592,684 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha IEA KEGG rno:04370 NCBI chr 2:227,839,058...228,113,560
Ensembl chr 2:227,839,062...228,113,554 		JBrowse link
G Ppp3cb protein phosphatase 3 catalytic subunit beta IEA KEGG rno:04370 NCBI chr15:3,809,182...3,854,204
Ensembl chr15:3,809,262...3,854,203 		JBrowse link
G Ppp3cc protein phosphatase 3 catalytic subunit gamma IEA KEGG rno:04370 NCBI chr15:51,699,586...51,771,763
Ensembl chr15:51,700,255...51,771,538 		JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha IEA KEGG rno:04370 NCBI chr14:95,758,333...95,808,015 JBrowse link
G Ppp3r2 protein phosphatase 3, regulatory subunit B, beta IEA KEGG rno:04370 NCBI chr 5:68,822,387...68,823,382
Ensembl chr 5:68,822,387...68,823,818 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 ISO PID PID:200188 NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 ISO PID PID:200188 NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:125,042,179...125,108,324 		JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 ISO PID PID:200188 NCBI chr12:46,248,971...46,259,487
Ensembl chr12:46,249,010...46,259,482 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha ISO PID PID:200188 NCBI chr19:41,059,843...41,083,189
Ensembl chr19:41,059,843...41,086,494 		JBrowse link
G Prkag1 protein kinase AMP-activated non-catalytic subunit gamma 1 ISO PID PID:200188 NCBI chr 7:131,842,058...131,859,484
Ensembl chr 7:131,842,060...131,859,503 		JBrowse link
G Prkca protein kinase C, alpha ISO
IEA 		KEGG
PID
RGD		 PMID:17658244 PID:200188 rno:04370, RGD:2298729 NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572 		JBrowse link
G Prkcb protein kinase C, beta ISO
IEA 		KEGG
RGD		 PMID:17658244 rno:04370, RGD:2298729 NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:186,263,447...186,594,740 		JBrowse link
G Prkcd protein kinase C, delta IMP
ISO 		PID
RGD		 PMID:15541367 PID:200188, RGD:2298730 NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839 		JBrowse link
G Prkcg protein kinase C, gamma IEA KEGG rno:04370 NCBI chr 1:74,748,272...74,777,611
Ensembl chr 1:74,748,272...74,774,814 		JBrowse link
G Prkcz protein kinase C, zeta ISO RGD PMID:17658244 RGD:2298729 NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:171,101,774...171,212,674 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IEA KEGG rno:04370 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Ptk2 protein tyrosine kinase 2 ISO
IEA 		KEGG
RGD		 PMID:17658244 rno:04370, RGD:2298729 NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:107,015,733...107,172,091 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta ISO PID PID:200188 NCBI chr15:44,536,275...44,656,754
Ensembl chr15:44,531,249...44,656,806 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 ISO PID PID:200188 NCBI chr12:41,026,079...41,085,577
Ensembl chr12:41,043,785...41,085,577 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 ISO PID PID:200188 NCBI chr 4:159,212,320...159,237,069
Ensembl chr 4:159,212,320...159,237,069 		JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J ISO PID PID:200188 NCBI chr 3:96,861,785...97,017,702
Ensembl chr 3:96,861,785...97,017,656 		JBrowse link
G Pxn paxillin ISO
IEA 		PID
KEGG		 PID:200188 rno:04370 NCBI chr12:46,721,546...46,768,706
Ensembl chr12:46,721,546...46,768,697 		JBrowse link
G Rac1 Rac family small GTPase 1 IEA KEGG rno:04370 NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109 		JBrowse link
G Rac2 Rac family small GTPase 2 IEA KEGG rno:04370 NCBI chr 7:111,981,825...112,009,201
Ensembl chr 7:111,996,742...112,009,267 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO
IEA 		PID
KEGG		 PID:200188 rno:04370 NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813 		JBrowse link
G RGD1560225 similar to nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 IEA KEGG rno:04370
G RGD1565588 similar to calcium binding protein P22 IEA KEGG rno:04370
G Rhoa ras homolog family member A ISO PID PID:200188 NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 ISO PID PID:200188 NCBI chr18:1,387,360...1,509,218
Ensembl chr18:1,387,360...1,509,147 		JBrowse link
G Sh2d2a SH2 domain containing 2A ISO
IEA 		KEGG
PID
RGD		 PMID:17658244 PID:200188 rno:04370, RGD:2298729 NCBI chr 2:175,610,127...175,616,685
Ensembl chr 2:175,609,874...175,616,685 		JBrowse link
G Shb SH2 domain containing adaptor protein B ISO PID PID:200188 NCBI chr 5:64,473,694...64,581,072
Ensembl chr 5:64,473,694...64,581,072 		JBrowse link
G Shc2 SHC adaptor protein 2 IEA KEGG rno:04370 NCBI chr 7:10,717,320...10,739,539
Ensembl chr 7:10,717,320...10,739,539 		JBrowse link
G Sphk1 sphingosine kinase 1 IEA KEGG rno:04370 NCBI chr10:102,257,413...102,263,086
Ensembl chr10:102,258,975...102,263,082 		JBrowse link
G Sphk2 sphingosine kinase 2 IEA KEGG rno:04370 NCBI chr 1:105,317,332...105,324,985
Ensembl chr 1:105,317,333...105,321,637 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO
IEA 		PID
KEGG		 PID:200188 rno:04370 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462 		JBrowse link
G Vcl vinculin ISO PID PID:200188 NCBI chr15:3,315,069...3,404,891
Ensembl chr15:3,315,069...3,405,163 		JBrowse link
G Vegfa vascular endothelial growth factor A IDA
IEA
IMP
ISO 		KEGG
RGD		 PMID:12181492 PMID:16160062 PMID:18614764 PMID:16633338 PMID:18221855 More... rno:04370, RGD:625593, RGD:2301956, RGD:2301848, RGD:2298727, RGD:2292019, RGD:1626621 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
G Vegfb vascular endothelial growth factor B ISS
ISO 		RGD PMID:15563310 PMID:16633338 RGD:1334463, RGD:2298727 NCBI chr 1:213,601,570...213,607,254
Ensembl chr 1:213,600,966...213,607,152 		JBrowse link
G Vegfc vascular endothelial growth factor C IMP
ISO 		PID
RGD		 PMID:11683876 PMID:16633338 PID:200109, RGD:727326, RGD:2298727 NCBI chr16:44,445,293...44,560,887
Ensembl chr16:44,445,293...44,560,887 		JBrowse link
G Vegfd vascular endothelial growth factor D IMP
ISO 		This is the VEGF-D PID
RGD		 PMID:11683876 PMID:16633338 PID:200109, RGD:727326, RGD:2298727 NCBI chr  X:33,704,582...33,740,305
Ensembl chr  X:33,706,055...33,740,167 		JBrowse link
G Vtn vitronectin ISO PID PID:200188 NCBI chr10:63,892,782...63,895,862
Ensembl chr10:63,892,766...63,895,860 		JBrowse link
altered vascular endothelial growth factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flt4 Fms related receptor tyrosine kinase 4 ISS RGD PMID:15563310 RGD:1334463 NCBI chr10:34,414,834...34,455,878
Ensembl chr10:34,414,733...34,456,645 		JBrowse link
altered vascular endothelial growth factor signaling pathway involving proteins affecting its expression term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdr kinase insert domain receptor IMP RGD PMID:18221855 RGD:2292019 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO RGD PMID:18221855 RGD:2292019 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
altered vascular endothelial growth factor signaling pathway involving the main players term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flt4 Fms related receptor tyrosine kinase 4 ISS RGD PMID:15563310 RGD:1334463 NCBI chr10:34,414,834...34,455,878
Ensembl chr10:34,414,733...34,456,645 		JBrowse link
G Kdr kinase insert domain receptor IMP RGD PMID:18221855 RGD:2292019 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO RGD PMID:18221855 RGD:2292019 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      growth factor signaling pathway 523
        vascular endothelial growth factor signaling pathway 137
          altered vascular endothelial growth factor signaling pathway + 3
Path 2
Term Annotations click to browse term
  pathway 6091
    regulatory pathway 3864
      homeostasis pathway 1772
        cardiovascular system homeostasis pathway 422
          vascular endothelial growth factor signaling pathway 137
            altered vascular endothelial growth factor signaling pathway + 3
paths to the root