Fbxw11 (F-box and WD repeat domain containing 11) - Rat Genome Database
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Gene: Fbxw11 (F-box and WD repeat domain containing 11) Rattus norvegicus
Analyze
Symbol: Fbxw11
Name: F-box and WD repeat domain containing 11
RGD ID: 1309121
Description: Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular protein metabolic process; microtubule cytoskeleton organization; and transport along microtubule. Predicted to localize to several cellular components, including kinetochore; microtubule cytoskeleton; and neuronal cell body. Orthologous to human FBXW11 (F-box and WD repeat domain containing 11); PARTICIPATES IN Hedgehog signaling pathway; mTOR signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH bisphenol A; cadmium dichloride; gentamycin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: F-box and WD-40 domain protein 11; F-box/WD repeat-containing protein 11; LOC303024
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21017,232,735 - 17,330,584 (+)NCBI
Rnor_6.0 Ensembl1017,542,374 - 17,640,718 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01017,542,374 - 17,640,718 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01017,430,246 - 17,528,590 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41017,502,480 - 17,600,199 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11017,503,612 - 17,599,012 (+)NCBI
Celera1016,877,301 - 16,974,446 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

Additional References at PubMed
PMID:11158290   PMID:11896578   PMID:14673179   PMID:16880511   PMID:16885022   PMID:18782782   PMID:18929646   PMID:19028597   PMID:19966869   PMID:20347421   PMID:21399614  


Genomics

Comparative Map Data
Fbxw11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21017,232,735 - 17,330,584 (+)NCBI
Rnor_6.0 Ensembl1017,542,374 - 17,640,718 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01017,542,374 - 17,640,718 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01017,430,246 - 17,528,590 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41017,502,480 - 17,600,199 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11017,503,612 - 17,599,012 (+)NCBI
Celera1016,877,301 - 16,974,446 (+)NCBICelera
Cytogenetic Map10q12NCBI
FBXW11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5171,861,549 - 172,006,873 (-)EnsemblGRCh38hg38GRCh38
GRCh385171,861,549 - 172,006,638 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375171,288,553 - 171,433,877 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh375171,288,553 - 171,433,642 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365171,221,161 - 171,366,482 (-)NCBINCBI36hg18NCBI36
Celera5167,321,013 - 167,466,463 (-)NCBI
Cytogenetic Map5q35.1NCBI
HuRef5166,384,918 - 166,530,978 (-)NCBIHuRef
CHM1_15170,721,014 - 170,866,350 (-)NCBICHM1_1
Fbxw11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391132,592,555 - 32,696,816 (+)NCBIGRCm39mm39
GRCm381132,642,555 - 32,746,816 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1132,642,724 - 32,746,816 (+)EnsemblGRCm38mm10GRCm38
MGSCv371132,542,875 - 32,646,816 (+)NCBIGRCm37mm9NCBIm37
MGSCv361132,542,875 - 32,646,816 (+)NCBImm8
Celera1135,097,954 - 35,164,258 (+)NCBICelera
Cytogenetic Map11A4NCBI
Fbxw11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540824,687,493 - 24,834,345 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540824,703,477 - 24,834,522 (-)NCBIChiLan1.0ChiLan1.0
FBXW11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15174,124,499 - 174,271,971 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5174,124,499 - 174,271,977 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05167,207,643 - 167,354,730 (-)NCBIMhudiblu_PPA_v0panPan3
FBXW11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl440,238,737 - 40,361,125 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1440,238,695 - 40,363,445 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Fbxw11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366093,256,658 - 3,341,918 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBXW11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1652,212,655 - 52,337,913 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11652,212,401 - 52,337,893 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21656,561,220 - 56,654,277 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FBXW11
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12374,015,964 - 74,154,285 (-)NCBI
ChlSab1.1 Ensembl2374,015,964 - 74,154,062 (-)Ensembl
Fbxw11
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473317,985,546 - 18,121,398 (+)NCBI

Position Markers
D10Rat182  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01017,555,386 - 17,555,534NCBIRnor6.0
Rnor_5.01017,443,258 - 17,443,406UniSTSRnor5.0
RGSC_v3.41017,515,123 - 17,515,458RGDRGSC3.4
RGSC_v3.41017,515,215 - 17,515,363UniSTSRGSC3.4
RGSC_v3.11017,516,172 - 17,516,507RGD
Celera1016,890,021 - 16,890,169UniSTS
RH 2.0 Map10183.0RGD
SHRSP x BN Map1017.15RGD
Cytogenetic Map10q12UniSTS
RH142282  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01017,640,513 - 17,640,682NCBIRnor6.0
Rnor_5.01017,528,385 - 17,528,554UniSTSRnor5.0
RGSC_v3.41017,599,994 - 17,600,163UniSTSRGSC3.4
Celera1016,974,241 - 16,974,410UniSTS
Cytogenetic Map10q12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10129592136Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135538813Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138594330Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142669970Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)10144902893Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1076442166221621Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10483563820170031Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10521719917555534Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10521719919591669Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)10546011921524070Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10546011921524070Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10546011921524070Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10546011921524070Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10546011921524070Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10587753664401490Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10622909575983805Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10622928936185929Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10642907599492409Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10752145052521450Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109841807108540162Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101263951357639513Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101263951357639513Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101263951357639513Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101482789492423564Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014827894107857673Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014827894110992275Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101537547462469074Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101646873661468736Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11712154262121542Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11712154262121542Rat
737823Alc12Alcohol consumption QTL 124.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)101755538619743866Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:219
Count of miRNA genes:169
Interacting mature miRNAs:180
Transcripts:ENSRNOT00000064079
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 41 57 41 19 41 8 11 74 35 35 11 8
Low 2 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000064079   ⟹   ENSRNOP00000059948
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1017,542,374 - 17,640,718 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000079698   ⟹   ENSRNOP00000069447
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1017,579,284 - 17,640,693 (+)Ensembl
RefSeq Acc Id: NM_001106993   ⟹   NP_001100463
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21017,232,779 - 17,330,584 (+)NCBI
Rnor_6.01017,542,374 - 17,640,718 (+)NCBI
Rnor_5.01017,430,246 - 17,528,590 (+)NCBI
RGSC_v3.41017,502,480 - 17,600,199 (+)RGD
Celera1016,877,301 - 16,974,446 (+)RGD
Sequence:
RefSeq Acc Id: XM_006246093   ⟹   XP_006246155
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21017,232,735 - 17,330,564 (+)NCBI
Rnor_6.01017,542,812 - 17,640,698 (+)NCBI
Rnor_5.01017,430,246 - 17,528,590 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006246094   ⟹   XP_006246156
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21017,232,735 - 17,330,564 (+)NCBI
Rnor_6.01017,542,812 - 17,640,698 (+)NCBI
Rnor_5.01017,430,246 - 17,528,590 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597238   ⟹   XP_017452727
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21017,232,957 - 17,330,564 (+)NCBI
Rnor_6.01017,542,812 - 17,640,698 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597239   ⟹   XP_017452728
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01017,542,524 - 17,640,693 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597240   ⟹   XP_017452729
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21017,232,735 - 17,330,564 (+)NCBI
Rnor_6.01017,542,812 - 17,640,698 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597241   ⟹   XP_017452730
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21017,232,735 - 17,330,564 (+)NCBI
Rnor_6.01017,542,812 - 17,640,698 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597242   ⟹   XP_017452731
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01017,599,435 - 17,640,698 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597243   ⟹   XP_017452732
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21017,232,957 - 17,330,564 (+)NCBI
Rnor_6.01017,542,812 - 17,640,698 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597244   ⟹   XP_017452733
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21017,232,957 - 17,330,564 (+)NCBI
Rnor_6.01017,542,812 - 17,640,698 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597245   ⟹   XP_017452734
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21017,232,739 - 17,330,564 (+)NCBI
Rnor_6.01017,542,812 - 17,640,698 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597246   ⟹   XP_017452735
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01017,542,508 - 17,640,693 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085889   ⟹   XP_038941817
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21017,232,735 - 17,330,564 (+)NCBI
RefSeq Acc Id: XM_039085890   ⟹   XP_038941818
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21017,232,957 - 17,330,564 (+)NCBI
RefSeq Acc Id: XM_039085891   ⟹   XP_038941819
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21017,242,468 - 17,330,565 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001100463   ⟸   NM_001106993
- UniProtKB: D3ZXC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246155   ⟸   XM_006246093
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006246156   ⟸   XM_006246094
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017452735   ⟸   XM_017597246
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_017452728   ⟸   XM_017597239
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017452727   ⟸   XM_017597238
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017452732   ⟸   XM_017597243
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_017452733   ⟸   XM_017597244
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_017452729   ⟸   XM_017597240
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017452730   ⟸   XM_017597241
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_017452734   ⟸   XM_017597245
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_017452731   ⟸   XM_017597242
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: ENSRNOP00000069447   ⟸   ENSRNOT00000079698
RefSeq Acc Id: ENSRNOP00000059948   ⟸   ENSRNOT00000064079
RefSeq Acc Id: XP_038941817   ⟸   XM_039085889
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038941818   ⟸   XM_039085890
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038941819   ⟸   XM_039085891
- Peptide Label: isoform X11
Protein Domains
F-box   WD_REPEATS_REGION

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309121 AgrOrtholog
Ensembl Genes ENSRNOG00000004395 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000059948 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000069447 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064079 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000079698 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro Beta-TrCP_D UniProtKB/TrEMBL
  F-box_dom UniProtKB/TrEMBL
  F-box_dom_like UniProtKB/TrEMBL
  G-protein_beta_WD-40_rep UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
KEGG Report rno:303024 UniProtKB/TrEMBL
NCBI Gene 303024 ENTREZGENE
Pfam Beta-TrCP_D UniProtKB/TrEMBL
  F-box-like UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
PhenoGen Fbxw11 PhenoGen
PRINTS GPROTEINBRPT UniProtKB/TrEMBL
PROSITE FBOX UniProtKB/TrEMBL
  WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
SMART Beta-TrCP_D UniProtKB/TrEMBL
  FBOX UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF81383 UniProtKB/TrEMBL
  WD40_like UniProtKB/TrEMBL
UniProt A0A0G2JVE0_RAT UniProtKB/TrEMBL
  D3ZXC6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-25 Fbxw11  F-box and WD repeat domain containing 11  Fbxw11  F-box and WD-40 domain protein 11   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Fbxw11  F-box and WD-40 domain protein 11   Fbxw11_predicted  F-box and WD-40 domain protein 11 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Fbxw11_predicted  F-box and WD-40 domain protein 11 (predicted)      Symbol and Name status set to approved 70820 APPROVED