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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N-sulfonylurea
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Accession:CHEBI:76983 term browser browse the term
Definition:A urea in which one of the hydrogens attached to a nitrogen of the urea group is replaced by a sulfonyl group. The N-sulfonylurea moiety is a key group in various herbicides, as well as in a number of antidiabetic drugs used in the management of type 2 diabetis mellitus.
Synonyms:related_synonym: Formula=CN2O3SR4;   N-sulfonylureas;   SMILES=[*]S(=O)(=O)N([*])C(=O)N([*])[*];   sulfonylurea;   sulfonylureas
 xref: PMID:23237384;   PMID:23594109;   PMID:23609875;   Wikipedia:Sulfonylurea


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acetohexamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO Acetohexamide binds to ALB protein; Acetohexamide binds to ALB protein modified form CTD PMID:20435530 PMID:20829128 PMID:20956006 PMID:20974553 PMID:21612784 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Dhrs3 dehydrogenase/reductase 3 increases metabolic processing ISO DHRS3 protein results in increased metabolism of Acetohexamide CTD PMID:25451588 NCBI chr 4:144,618,712...144,654,214
Ensembl chr 4:144,619,397...144,654,779 		JBrowse link
bensulfuron-methyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO methyl bensulfuron results in increased activity of NR1I2 protein CTD PMID:22206814 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
chlorpropamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP-binding cassette, sub-family C member 8 multiple interactions ISO [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to Chlorpropamide CTD PMID:22209866 NCBI chr 7:45,753,952...45,829,441
Ensembl chr 7:45,753,947...45,829,457 		JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression ISO Chlorpropamide results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416 		JBrowse link
G Avp arginine vasopressin decreases secretion ISO Chlorpropamide results in decreased secretion of AVP protein modified form CTD PMID:5029389 NCBI chr 2:130,422,540...130,424,508
Ensembl chr 2:130,422,540...130,424,474 		JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression ISO Chlorpropamide results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Ins2 insulin II decreases expression
increases expression
multiple interactions		 ISO Chlorpropamide results in decreased expression of INS protein
Chlorpropamide results in increased expression of INS mRNA
Chlorpropamide inhibits the reaction [Glucose results in decreased secretion of INS protein]		 CTD PMID:15642492 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118 		JBrowse link
G Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 multiple interactions ISO [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to Chlorpropamide CTD PMID:22209866 NCBI chr 7:45,746,545...45,750,215
Ensembl chr 7:45,743,377...45,750,188 		JBrowse link
gliclazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP-binding cassette, sub-family C member 8 multiple interactions ISO [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in increased susceptibility to Gliclazide CTD PMID:22209866 NCBI chr 7:45,753,952...45,829,441
Ensembl chr 7:45,753,947...45,829,457 		JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 decreases activity ISO Gliclazide results in decreased activity of AKR1C3 protein CTD PMID:26362498 NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653 		JBrowse link
G Alb albumin affects binding
multiple interactions		 ISO Gliclazide binds to ALB protein
Gliclazide inhibits the reaction [[Streptozocin co-treated with Cholesterol, Dietary] results in increased secretion of ALB protein]		 CTD PMID:14871415 PMID:20974553 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO Gliclazide inhibits the reaction [Glucose results in decreased expression of BCL2 protein] CTD PMID:18088078 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression		 ISO Gliclazide inhibits the reaction [Glucose results in increased expression of CASP3 protein]
Gliclazide results in decreased expression of CASP3 mRNA
Gliclazide inhibits the reaction [Acetic Acid results in increased expression of CASP3 protein]		 CTD PMID:18088078 PMID:32045587 PMID:33652124 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Cat catalase multiple interactions ISO Gliclazide inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in decreased activity of CAT protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein]; Gliclazide inhibits the reaction [Streptozocin results in decreased activity of CAT protein] CTD PMID:20307516 PMID:20643114 PMID:21439372 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A multiple interactions EXP Gliclazide inhibits the reaction [Hydrogen Peroxide results in increased expression of CDKN1A mRNA] CTD PMID:12646174 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked multiple interactions ISO Gliclazide inhibits the reaction [Streptozocin results in decreased activity of G6PD protein] CTD PMID:28330423 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC mRNA]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC protein] CTD PMID:21439372 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767 		JBrowse link
G Glo1 glyoxalase 1 multiple interactions ISO Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of GLO1 protein] CTD PMID:21439372 NCBI chr17:30,811,835...30,831,633
Ensembl chr17:30,803,910...30,845,845 		JBrowse link
G Gsr glutathione reductase multiple interactions ISO Gliclazide inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in decreased activity of GSR protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of GSR protein] CTD PMID:20307516 PMID:21439372 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions ISO Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GSTM3 mRNA] CTD PMID:21439372 NCBI chr 3:107,803,240...107,806,002
Ensembl chr 3:107,803,137...107,806,002 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP
ISO		 Gliclazide inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]
Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of HMOX1 protein]		 CTD PMID:12646174 PMID:21439372 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Gliclazide inhibits the reaction [[Streptozocin co-treated with Cholesterol, Dietary] results in increased expression of ICAM1 protein]; Gliclazide inhibits the reaction [Acetic Acid results in increased expression of ICAM1 protein] CTD PMID:14871415 PMID:32045587 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Gliclazide inhibits the reaction [Acetic Acid results in decreased expression of IL10 protein] CTD PMID:32045587 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Gliclazide inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in increased expression of IL1B protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of IL1B protein]; Gliclazide inhibits the reaction [Streptozocin results in increased expression of IL1B protein] CTD PMID:20307516 PMID:20643114 PMID:21439372 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Gliclazide inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in increased expression of IL6 protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of IL6 protein]; Gliclazide inhibits the reaction [Acetic Acid results in increased expression of IL6 protein]; Gliclazide inhibits the reaction [Streptozocin results in increased expression of IL6 protein] CTD PMID:20307516 PMID:20643114 PMID:21439372 PMID:32045587 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Ins1 insulin I multiple interactions ISO Gliclazide inhibits the reaction [Streptozocin results in decreased expression of and results in decreased secretion of INS1 protein]; Gliclazide inhibits the reaction [Streptozocin results in decreased expression of INS1 protein] CTD PMID:28330423 PMID:28625491 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 multiple interactions ISO [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in increased susceptibility to Gliclazide CTD PMID:22209866 NCBI chr 7:45,746,545...45,750,215
Ensembl chr 7:45,743,377...45,750,188 		JBrowse link
G Keap1 kelch-like ECH-associated protein 1 multiple interactions ISO Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 mRNA]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 protein] CTD PMID:21439372 NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO Gliclazide inhibits the reaction [Acetic Acid results in increased phosphorylation of MAPK1 protein] CTD PMID:32045587 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO Gliclazide inhibits the reaction [Acetic Acid results in increased phosphorylation of MAPK3 protein] CTD PMID:32045587 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Gliclazide inhibits the reaction [Acetic Acid results in increased phosphorylation of MAPK8 protein] CTD PMID:32045587 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Gliclazide inhibits the reaction [Acetic Acid results in increased activity of MPO protein] CTD PMID:32045587 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO Gliclazide inhibits the reaction [[Streptozocin co-treated with Cholesterol, Dietary] results in increased expression of NCF1 protein] CTD PMID:14871415 NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of NFE2L2 mRNA]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of NFE2L2 protein] CTD PMID:21439372 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell increases expression ISO Gliclazide results in increased expression of NOS3 protein CTD PMID:14871415 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO Gliclazide inhibits the reaction [Acetic Acid results in decreased expression of PPARG protein] CTD PMID:32045587 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Gliclazide inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in increased expression of RELA protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of RELA protein]; Gliclazide inhibits the reaction [Streptozocin results in increased expression of RELA protein] CTD PMID:20307516 PMID:20643114 PMID:21439372 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO Gliclazide inhibits the reaction [[Streptozocin co-treated with Cholesterol, Dietary] results in decreased expression of SOD2 protein] CTD PMID:14871415 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 ISO Gliclazide inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in increased expression of TNF protein]; Gliclazide inhibits the reaction [Streptozocin results in increased expression of TNF protein]
Gliclazide results in decreased expression of TNF protein		 CTD PMID:20307516 PMID:20643114 PMID:21439372 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 multiple interactions EXP Gliclazide inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFAIP3 mRNA] CTD PMID:12646174 NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405 		JBrowse link
G Trp53 transformation related protein 53 increases expression ISO Gliclazide results in increased expression of TP53 mRNA CTD PMID:33652124 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
glimepiride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 decreases activity
multiple interactions		 ISO glimepiride results in decreased activity of ABCB11 protein
glimepiride inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]		 CTD PMID:20829430 PMID:23956101 PMID:24014644 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958 		JBrowse link
G Abcc8 ATP-binding cassette, sub-family C member 8 multiple interactions ISO [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to glimepiride CTD PMID:22209866 NCBI chr 7:45,753,952...45,829,441
Ensembl chr 7:45,753,947...45,829,457 		JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 decreases activity ISO glimepiride results in decreased activity of AKR1C3 protein CTD PMID:26362498 NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653 		JBrowse link
G Akr1c20 aldo-keto reductase family 1, member C20 decreases activity ISO glimepiride results in decreased activity of AKR1C1 protein CTD PMID:26362498 NCBI chr13:4,536,855...4,573,353
Ensembl chr13:4,536,848...4,573,344 		JBrowse link
G Capn1 calpain 1 increases expression ISO glimepiride results in increased expression of CAPN1 mRNA CTD PMID:33652124 NCBI chr19:6,038,573...6,065,855
Ensembl chr19:6,038,573...6,065,927 		JBrowse link
G Capn10 calpain 10 increases expression ISO glimepiride results in increased expression of CAPN10 mRNA CTD PMID:33652124 NCBI chr 1:92,862,130...92,875,670
Ensembl chr 1:92,862,098...92,875,663 		JBrowse link
G Capn2 calpain 2 increases expression ISO glimepiride results in increased expression of CAPN2 mRNA CTD PMID:33652124 NCBI chr 1:182,294,818...182,345,175
Ensembl chr 1:182,294,825...182,345,173 		JBrowse link
G Casp3 caspase 3 increases expression
increases activity		 ISO glimepiride results in increased expression of CASP3 mRNA
glimepiride results in increased activity of CASP3 protein		 CTD PMID:33652124 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G H2-M3 histocompatibility 2, M region locus 3 affects expression ISO glimepiride affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr17:37,581,094...37,585,380
Ensembl chr17:37,581,111...37,585,375 		JBrowse link
G Ins1 insulin I multiple interactions ISO [Plant Extracts co-treated with glimepiride] inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; glimepiride inhibits the reaction [Streptozocin results in decreased expression of INS1 protein] CTD PMID:26721197 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Ins2 insulin II decreases expression ISO glimepiride results in decreased expression of INS protein CTD PMID:15642492 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118 		JBrowse link
G Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 multiple interactions ISO [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to glimepiride CTD PMID:22209866 NCBI chr 7:45,746,545...45,750,215
Ensembl chr 7:45,743,377...45,750,188 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions		 ISO glimepiride results in increased activity of NR1I2 protein
[glimepiride results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA		 CTD PMID:25455453 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family, member 1b2 multiple interactions ISO glimepiride affects the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin]; glimepiride affects the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein] CTD PMID:23121773 NCBI chr 6:141,575,178...141,632,372
Ensembl chr 6:141,575,244...141,632,372 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions ISO glimepiride inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin]; glimepiride inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein] CTD PMID:23121773 NCBI chr 7:99,307,011...99,360,547
Ensembl chr 7:99,307,011...99,360,547 		JBrowse link
G Trp53 transformation related protein 53 increases expression ISO glimepiride results in increased expression of TP53 mRNA CTD PMID:33652124 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
glipizide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 multiple interactions
decreases activity		 ISO Glipizide inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Glipizide results in decreased activity of ABCB11 protein		 CTD PMID:24014644 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958 		JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 decreases activity ISO Glipizide results in decreased activity of AKR1C3 protein CTD PMID:26362498 NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653 		JBrowse link
G Akr1c20 aldo-keto reductase family 1, member C20 decreases activity ISO Glipizide results in decreased activity of AKR1C1 protein CTD PMID:26362498 NCBI chr13:4,536,855...4,573,353
Ensembl chr13:4,536,848...4,573,344 		JBrowse link
G Akr1c21 aldo-keto reductase family 1, member C21 decreases activity ISO Glipizide results in decreased activity of AKR1C2 protein CTD PMID:26362498 NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540 		JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 increases metabolic processing
decreases metabolic processing		 ISO CYP2C9 protein results in increased metabolism of Glipizide
CYP2C9 gene polymorphism results in decreased metabolism of Glipizide		 CTD PMID:10208645 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388 		JBrowse link
glyburide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 multiple interactions
increases expression
decreases activity		 ISO
EXP		 [Glyburide results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; Glyburide inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
[Bile Acids and Salts co-treated with Glyburide] results in decreased expression of ABCB11 mRNA
Glyburide results in increased expression of ABCB11 mRNA
[Glyburide results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; [Glyburide results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium		 CTD PMID:11343252 PMID:15465654 PMID:15618715 PMID:19853032 PMID:20147439 More... NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958 		JBrowse link
G Abcb4 ATP-binding cassette, sub-family B member 4 increases expression ISO Glyburide results in increased expression of ABCB4 mRNA CTD PMID:27765674 NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231 		JBrowse link
G Abcc1 ATP-binding cassette, sub-family C member 1 decreases activity ISO Glyburide results in decreased activity of ABCC1 protein CTD PMID:15652236 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601 		JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 increases expression ISO
EXP		 Glyburide results in increased expression of ABCC2 mRNA CTD PMID:27765674 PMID:35708773 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
G Abcc3 ATP-binding cassette, sub-family C member 3 increases expression ISO Glyburide results in increased expression of ABCC3 mRNA CTD PMID:27765674 NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823 		JBrowse link
G Abcc4 ATP-binding cassette, sub-family C member 4 increases expression EXP Glyburide results in increased expression of ABCC4 mRNA CTD PMID:35708773 NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631 		JBrowse link
G Abcc8 ATP-binding cassette, sub-family C member 8 increases response to substance
affects binding
multiple interactions		 ISO ABCC8 protein results in increased susceptibility to Glyburide
Glyburide binds to ABCC8 protein; Glyburide binds to ABCC8 protein mutant form
Adenosine Triphosphate deficiency inhibits the reaction [Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein]]; Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein mutant form]; Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein]; resveratrol inhibits the reaction [Glyburide binds to ABCC8 protein]		 CTD PMID:17138562 PMID:19095654 NCBI chr 7:45,753,952...45,829,441
Ensembl chr 7:45,753,947...45,829,457 		JBrowse link
G Abcc9 ATP-binding cassette, sub-family C member 9 affects binding
decreases activity
multiple interactions		 EXP Glyburide binds to ABCC9 protein mutant form
Glyburide results in decreased activity of ABCC9 protein
[Glyburide results in decreased activity of ABCC9 protein] which results in increased expression of XDH protein; Estradiol inhibits the reaction [Glyburide binds to ABCC9 protein mutant form]; Glyburide inhibits the reaction [[Oligomycins co-treated with Deoxyglucose] results in increased activity of [KCNJ11 protein binds to ABCC9 protein]]; resveratrol inhibits the reaction [Glyburide binds to ABCC9 protein]		 CTD PMID:17138562 PMID:19095654 PMID:22622455 PMID:28842488 NCBI chr 6:142,533,592...142,648,472
Ensembl chr 6:142,533,588...142,648,041 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) decreases export
multiple interactions
increases export		 ISO ABCG2 protein polymorphism results in decreased export of Glyburide
3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of Glyburide]; 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester promotes the reaction [ABCG2 protein polymorphism results in decreased export of Glyburide]; Genistein inhibits the reaction [ABCG2 protein results in increased export of Glyburide]; Genistein promotes the reaction [ABCG2 protein polymorphism results in decreased export of Glyburide]		 CTD PMID:26850786 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression ISO Glyburide results in increased expression of ABCG5 mRNA CTD PMID:27765674 NCBI chr17:84,965,602...84,990,439
Ensembl chr17:84,965,662...84,990,439 		JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression ISO Glyburide results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416 		JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions ISO Glyburide promotes the reaction [Isoproterenol results in increased expression of ACTA2 protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of ACTA2 protein]] CTD PMID:35305975 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990 		JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGER protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGER protein] CTD PMID:36999408 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910 		JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions ISO Glyburide inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein] CTD PMID:10799337 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions ISO
EXP		 Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of AIF1 protein]
Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of AIF1 protein]		 CTD PMID:32375810 PMID:32522579 PMID:32860822 NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044 		JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 decreases activity ISO Glyburide results in decreased activity of AKR1C3 protein CTD PMID:26362498 NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653 		JBrowse link
G Akr1c20 aldo-keto reductase family 1, member C20 decreases activity ISO Glyburide results in decreased activity of AKR1C1 protein CTD PMID:26362498 NCBI chr13:4,536,855...4,573,353
Ensembl chr13:4,536,848...4,573,344 		JBrowse link
G Akr1c21 aldo-keto reductase family 1, member C21 decreases activity ISO Glyburide results in decreased activity of AKR1C2 protein CTD PMID:26362498 NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO Glyburide inhibits the reaction [sodium bisulfide results in increased phosphorylation of AKT1 protein]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of AKT1 protein] CTD PMID:21800153 PMID:33724628 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Alb albumin affects binding ISO Glyburide binds to ALB protein CTD PMID:20974553 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Apoa1 apolipoprotein A-I multiple interactions ISO Glyburide promotes the reaction [1,2-linoleoylphosphatidylcholine results in increased secretion of APOA1 protein]; Glyburide promotes the reaction [Clofibrate results in increased secretion of APOA1 protein] CTD PMID:19717637 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764 		JBrowse link
G Arg1 arginase, liver multiple interactions ISO
EXP		 Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of ARG1 mRNA]
Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of ARG1 mRNA]		 CTD PMID:32522579 PMID:32860822 PMID:34052309 NCBI chr10:24,791,105...24,803,368
Ensembl chr10:24,791,119...24,803,382 		JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of BAX protein] CTD PMID:33724628 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO Glyburide inhibits the reaction [sodium bisulfide results in increased expression of BCL2 protein]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein] CTD PMID:21800153 PMID:33724628 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Capn2 calpain 2 increases expression ISO Glyburide results in increased expression of CAPN2 mRNA CTD PMID:33652124 NCBI chr 1:182,294,818...182,345,175
Ensembl chr 1:182,294,825...182,345,173 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO
EXP		 [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased cleavage of CASP1 protein]; Glyburide inhibits the reaction [2,5-hexanedione results in increased cleavage of CASP1 protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased cleavage of CASP1 protein]; Glyburide inhibits the reaction [Paraquat results in increased expression of CASP1 protein]
Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased cleavage of CASP1 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased cleavage of CASP1 protein]; Glyburide inhibits the reaction [Ozone results in increased cleavage of CASP1 protein]		 CTD PMID:25338942 PMID:32167222 PMID:32375810 PMID:32522579 PMID:32860822 More... NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression		 ISO Glyburide inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]; Glyburide inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]; Glyburide promotes the reaction [Isoproterenol results in increased activity of CASP3 protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased activity of CASP3 protein]]
Glyburide results in increased activity of CASP3 protein
Glyburide results in increased expression of CASP3 mRNA		 CTD PMID:16310184 PMID:33652124 PMID:35305975 PMID:36504472 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Cat catalase multiple interactions EXP
ISO		 Glyburide inhibits the reaction [Streptozocin results in decreased expression of CAT protein]
[Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of CAT protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of CAT protein]; Glyburide inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of CAT protein]; Glyburide promotes the reaction [Isoproterenol results in decreased activity of CAT protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in decreased activity of CAT protein]]		 CTD PMID:23716880 PMID:24760747 PMID:26700463 PMID:26748309 PMID:28757134 More... NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator multiple interactions
decreases activity		 ISO
EXP		 Glyburide binds to and results in decreased activity of CFTR protein; Glyburide inhibits the reaction [1-Octanol results in increased activity of CFTR protein]; Glyburide inhibits the reaction [[[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides]; Glyburide inhibits the reaction [Colforsin results in increased activity of CFTR protein]
Glyburide results in decreased activity of CFTR protein
Glyburide inhibits the reaction [[Phenylephrine co-treated with 5-butyl-6-hydroxy-10-chlorobenzo(c)quinolizinium chloride] results in increased activity of CFTR protein]
Glyburide inhibits the reaction [CFTR protein affects the transport of Bicarbonates]; Glyburide inhibits the reaction [CFTR protein affects the transport of Chlorides]		 CTD PMID:14502435 PMID:14967738 PMID:15131065 PMID:15236628 PMID:15371258 More... NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767 		JBrowse link
G Col1a1 collagen, type I, alpha 1 decreases expression EXP Glyburide results in decreased expression of COL1A1 mRNA CTD PMID:35708773 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868 		JBrowse link
G Cp ceruloplasmin multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased expression of CP protein] CTD PMID:26748309 NCBI chr 3:20,011,097...20,063,914
Ensembl chr 3:20,011,218...20,063,309 		JBrowse link
G Cst3 cystatin C multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of CST3 protein] CTD PMID:33387473 NCBI chr 2:148,713,642...148,717,432
Ensembl chr 2:148,713,642...148,717,612 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [Glyburide co-treated with Isoproterenol] results in increased expression of CTNNB1 mRNA; Glyburide promotes the reaction [Isoproterenol results in increased expression of CTNNB1 protein]; pyrvinium inhibits the reaction [[Glyburide co-treated with Isoproterenol] results in increased expression of CTNNB1 mRNA]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of CTNNB1 protein]] CTD PMID:35305975 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Cybb cytochrome b-245, beta polypeptide multiple interactions EXP Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CYBB protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYBB protein] CTD PMID:32375810 PMID:34052309 NCBI chr  X:9,301,493...9,354,005
Ensembl chr  X:9,301,491...9,354,010 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Glyburide inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Glyburide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:10799337 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of EDN1 mRNA]]; Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of EDN1 protein]] CTD PMID:27890915 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO Glyburide promotes the reaction [Isoproterenol results in increased expression of FN1 protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of FN1 protein]] CTD PMID:35305975 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359 		JBrowse link
G Fth1 ferritin heavy polypeptide 1 multiple interactions EXP Glyburide inhibits the reaction [Lipopolysaccharides results in increased expression of FTH1 mRNA] CTD PMID:27246103 NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased activity of G6PC1 protein] CTD PMID:25641191 NCBI chr11:101,258,542...101,268,729
Ensembl chr11:101,258,387...101,268,729 		JBrowse link
G G6pc3 glucose 6 phosphatase, catalytic, 3 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased activity of G6PC3 protein] CTD PMID:31345080 NCBI chr11:102,080,525...102,084,907
Ensembl chr11:102,080,446...102,084,907 		JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased activity of G6PD protein] CTD PMID:25641191 PMID:31345080 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased activity of GPT protein] CTD PMID:29223569 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Gsdmd gasdermin D multiple interactions ISO Glyburide inhibits the reaction [2,5-hexanedione results in increased cleavage of GSDMD protein] CTD PMID:32522579 PMID:32860822 NCBI chr15:75,733,990...75,739,257
Ensembl chr15:75,734,176...75,739,257 		JBrowse link
G Gsr glutathione reductase multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased activity of GSR protein]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of GSR protein] CTD PMID:26748309 PMID:33724628 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; Glyburide inhibits the reaction [Streptozocin results in increased expression of HMOX1 mRNA] CTD PMID:30817903 PMID:36999408 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Ifng interferon gamma multiple interactions EXP Glyburide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Glyburide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11907163 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IGF1 protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IGF1 protein] CTD PMID:36999408 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Il12b interleukin 12b multiple interactions EXP Glyburide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein]; Glyburide inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B protein] CTD PMID:11907163 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO Glyburide promotes the reaction [Isoproterenol results in increased expression of IL17A protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of IL17A protein]] CTD PMID:35305975 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO
EXP		 Glyburide inhibits the reaction [Paraquat results in increased expression of IL18 protein]
Glyburide inhibits the reaction [Ozone results in increased expression of IL18 protein]; Glyburide inhibits the reaction [Paraquat results in increased secretion of IL18 protein]		 CTD PMID:25338942 PMID:32167222 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il1b interleukin 1 beta affects secretion
multiple interactions		 EXP
ISO		 Glyburide affects the secretion of IL1B protein
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of IL1B protein]; Glyburide inhibits the reaction [Paraquat results in increased expression of IL1B protein]; Glyburide inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]; Glyburide inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; Glyburide promotes the reaction [Isoproterenol results in increased expression of IL1B protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of IL1B protein]]
Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IL1B protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B protein]; Glyburide inhibits the reaction [Ozone results in increased expression of IL1B protein]; Glyburide inhibits the reaction [Paraquat results in increased secretion of IL1B protein]		 CTD PMID:15578659 PMID:25338942 PMID:30817903 PMID:32167222 PMID:32375810 More... NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO		 Glyburide inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
Glyburide inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Glyburide inhibits the reaction [Streptozocin results in increased expression of IL6 protein]		 CTD PMID:24760747 PMID:24849676 PMID:26748309 PMID:30817903 PMID:33724628 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Ins1 insulin I multiple interactions
increases secretion		 EXP
ISO		 Glyburide inhibits the reaction [Nanotubes, Carbon inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Glyburide inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein]
Glyburide results in increased secretion of INS1 protein
Glyburide inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; Glyburide inhibits the reaction [Streptozocin results in increased expression of INS1 protein]; Glyburide inhibits the reaction [Streptozocin results in increased secretion of INS1 protein]		 CTD PMID:26700463 PMID:26748309 PMID:29658312 PMID:30445784 PMID:30582900 More... NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Ins2 insulin II multiple interactions
increases response to substance
increases secretion
increases expression
decreases expression		 ISO [Glyburide co-treated with Glucose] results in increased expression of INS protein; Glyburide inhibits the reaction [Glucose results in decreased secretion of INS protein]; IRS1 protein polymorphism inhibits the reaction [Glyburide results in increased secretion of INS protein]
Glyburide results in increased susceptibility to INS protein
Glyburide results in increased expression of INS mRNA
Glyburide results in decreased expression of INS protein		 CTD PMID:3116364 PMID:10430617 PMID:11305519 PMID:15642492 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of IRAK1 protein] CTD PMID:36504472 NCBI chr  X:73,057,520...73,067,527
Ensembl chr  X:73,057,520...73,067,524 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO IRS1 protein polymorphism inhibits the reaction [Glyburide results in increased secretion of INS protein] CTD PMID:10430617 NCBI chr 1:82,210,826...82,269,160
Ensembl chr 1:82,210,822...82,269,137 		JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased expression of IRS2 protein] CTD PMID:33724628 NCBI chr 8:11,034,681...11,058,929
Ensembl chr 8:11,034,681...11,058,458 		JBrowse link
G Itgam integrin alpha M multiple interactions ISO Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of ITGAM protein] CTD PMID:32522579 PMID:32860822 NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663 		JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO Glyburide results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602 		JBrowse link
G Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 multiple interactions
decreases response to substance		 EXP Glyburide inhibits the reaction [2,4-Dinitrophenol promotes the reaction [KCNJ11 protein results in increased transport of Potassium]]; Glyburide inhibits the reaction [[Oligomycins co-treated with Deoxyglucose] results in increased activity of [KCNJ11 protein binds to ABCC9 protein]]
KCNJ11 protein mutant form results in decreased susceptibility to Glyburide		 CTD PMID:15949470 PMID:28842488 NCBI chr 7:45,746,545...45,750,215
Ensembl chr 7:45,743,377...45,750,188 		JBrowse link
G Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 decreases activity
decreases response to substance		 ISO Glyburide results in decreased activity of KCNJ8 protein
KCNJ8 protein mutant form results in decreased susceptibility to Glyburide		 CTD PMID:20050851 PMID:28842488 NCBI chr 6:142,510,563...142,517,340
Ensembl chr 6:142,510,563...142,517,340 		JBrowse link
G Kcnk18 potassium channel, subfamily K, member 18 multiple interactions ISO Glyburide inhibits the reaction [KCNK18 protein results in increased transport of Potassium] CTD PMID:12754259 NCBI chr19:59,208,080...59,225,802
Ensembl chr19:59,207,646...59,225,806 		JBrowse link
G Keap1 kelch-like ECH-associated protein 1 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased expression of KEAP1 mRNA] CTD PMID:30817903 NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657 		JBrowse link
G Lyz2 lysozyme 2 decreases secretion
increases secretion		 ISO Glyburide results in decreased secretion of LYZ protein
Glyburide results in increased secretion of LYZ protein		 CTD PMID:15194485 PMID:15234967 NCBI chr10:117,113,446...117,118,177
Ensembl chr10:117,113,236...117,118,226 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases expression		 ISO Quercetin promotes the reaction [Glyburide results in increased expression of MAPK1 protein modified form] CTD PMID:20860660 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases expression		 ISO Quercetin promotes the reaction [Glyburide results in increased expression of MAPK3 protein modified form] CTD PMID:20860660 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mbp myelin basic protein multiple interactions ISO Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of MBP protein] CTD PMID:32522579 PMID:32860822 NCBI chr18:82,492,883...82,603,762
Ensembl chr18:82,493,271...82,603,762 		JBrowse link
G Mir146 microRNA 146 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of MIR146A mRNA] CTD PMID:36504472 NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Glyburide inhibits the reaction [Paraquat results in increased activity of MPO protein]; Glyburide promotes the reaction [Isoproterenol results in increased activity of MPO protein] CTD PMID:25338942 PMID:35305975 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Mrc1 mannose receptor, C type 1 multiple interactions ISO Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of MRC1 mRNA] CTD PMID:32522579 PMID:32860822 NCBI chr 2:14,234,225...14,336,834
Ensembl chr 2:14,234,203...14,336,868 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NCF1 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NCF1 protein] CTD PMID:32375810 PMID:34052309 NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479 		JBrowse link
G Nefl neurofilament, light polypeptide multiple interactions ISO Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of NEFL protein] CTD PMID:32522579 PMID:32860822 NCBI chr14:68,321,312...68,326,544
Ensembl chr14:68,321,312...68,326,544 		JBrowse link
G Nfatc1 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 multiple interactions EXP Glyburide inhibits the reaction [Lipopolysaccharides affects the localization of NFATC1 protein]; Glyburide inhibits the reaction [Lipopolysaccharides promotes the reaction [NFATC1 protein binds to NOS2 promoter]] CTD PMID:27246103 NCBI chr18:80,649,418...80,756,286
Ensembl chr18:80,649,420...80,756,286 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]; Glyburide inhibits the reaction [Streptozocin results in increased expression of NFE2L2 mRNA] CTD PMID:30817903 PMID:36999408 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NFKB1 protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NFKB1 protein] CTD PMID:36999408 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO
EXP		 [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NLRP3 protein]; Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of NLRP3 protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NLRP3 protein]; Glyburide inhibits the reaction [Paraquat results in increased expression of NLRP3 protein]
Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NLRP3 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NLRP3 protein]; Glyburide inhibits the reaction [Ozone results in increased expression of NLRP3 protein]		 CTD PMID:25338942 PMID:32167222 PMID:32375810 PMID:32522579 PMID:32860822 More... NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP
ISO		 Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA]; Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 protein]; Glyburide inhibits the reaction [Lipopolysaccharides promotes the reaction [NFATC1 protein binds to NOS2 promoter]]; Glyburide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Glyburide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Glyburide inhibits the reaction [Pinacidil inhibits the reaction [Rotenone results in increased expression of and results in increased activity of NOS2 protein]]; KN 93 inhibits the reaction [Glyburide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of NOS2 mRNA]		 CTD PMID:16257489 PMID:27246103 PMID:32375810 PMID:32522579 PMID:32860822 More... NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nppb natriuretic peptide type B multiple interactions ISO Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]]; Glyburide inhibits the reaction [natakalim inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]] CTD PMID:27890915 NCBI chr 4:148,070,264...148,071,662
Ensembl chr 4:148,070,245...148,071,662 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression ISO Glyburide results in decreased expression of NR1H4 mRNA CTD PMID:28391356 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of PCK1 mRNA] CTD PMID:20363216 NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066 		JBrowse link
G Pklr pyruvate kinase liver and red blood cell multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased expression of PKLR mRNA] CTD PMID:20363216 NCBI chr 3:89,043,429...89,054,122
Ensembl chr 3:89,043,449...89,054,091 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased expression of PPARG mRNA]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of PPARG protein] CTD PMID:29223569 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of PTGS2 mRNA] CTD PMID:30817903 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO Glyburide inhibits the reaction [Paraquat results in increased expression of PYCARD protein] CTD PMID:25338942 NCBI chr 7:127,590,545...127,593,039
Ensembl chr 7:127,588,880...127,593,039 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of RELA mRNA]; Glyburide inhibits the reaction [Streptozocin results in increased expression of RELA protein] CTD PMID:33724628 PMID:36504472 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 decreases expression
multiple interactions		 ISO
EXP		 Glyburide results in decreased expression of SLC10A1 mRNA
[Bile Acids and Salts co-treated with Glyburide] results in decreased expression of SLC10A1 mRNA		 CTD PMID:27765674 PMID:28391356 PMID:35708773 NCBI chr12:80,999,959...81,015,479
Ensembl chr12:80,999,957...81,015,479 		JBrowse link
G Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased expression of SLC2A2 protein] CTD PMID:33724628 NCBI chr 3:28,752,052...28,782,510
Ensembl chr 3:28,752,052...28,785,508 		JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] CTD PMID:29223569 PMID:33724628 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014 		JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 multiple interactions EXP Glyburide promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC6A3 protein] CTD PMID:16725203 NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family, member 1b2 multiple interactions ISO Glyburide inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin] CTD PMID:23121773 NCBI chr 6:141,575,178...141,632,372
Ensembl chr 6:141,575,244...141,632,372 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions ISO Glyburide inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin] CTD PMID:23121773 NCBI chr 7:99,307,011...99,360,547
Ensembl chr 7:99,307,011...99,360,547 		JBrowse link
G Snca synuclein, alpha multiple interactions EXP Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased phosphorylation of SNCA protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] promotes the reaction [SNCA protein binds to SNCA protein]]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of SNCA protein] CTD PMID:32375810 PMID:34052309 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839 		JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of SOD1 protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of SOD1 protein] CTD PMID:36999408 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Glyburide promotes the reaction [Isoproterenol results in increased expression of TGFB1 protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of TGFB1 protein]] CTD PMID:35305975 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Glyburide promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein] CTD PMID:16725203 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of TLR4 protein] CTD PMID:36504472 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Glyburide inhibits the reaction [Pinacidil inhibits the reaction [Rotenone results in increased secretion of TNF protein]]
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of TNF mRNA]; Glyburide inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]; Glyburide inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Glyburide promotes the reaction [Isoproterenol results in increased expression of TNF protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of TNF protein]]		 CTD PMID:16257489 PMID:24760747 PMID:26748309 PMID:30817903 PMID:32375810 More... NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnni3 troponin I, cardiac 3 multiple interactions ISO Glyburide promotes the reaction [Isoproterenol results in increased expression of TNNI3 protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of TNNI3 protein]] CTD PMID:35305975 NCBI chr 7:4,521,304...4,526,228
Ensembl chr 7:4,521,304...4,527,228 		JBrowse link
G Traf6 TNF receptor-associated factor 6 multiple interactions ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of TRAF6 protein] CTD PMID:36504472 NCBI chr 2:101,508,765...101,532,013
Ensembl chr 2:101,508,774...101,532,014 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions
increases expression		 ISO Glyburide inhibits the reaction [Streptozocin results in increased expression of TP53 mRNA]; Glyburide inhibits the reaction [Streptozocin results in increased expression of TP53 protein]
Glyburide results in increased expression of TP53 mRNA		 CTD PMID:30817903 PMID:33387473 PMID:33652124 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 decreases activity ISO
EXP		 Glyburide results in decreased activity of TRPM4 protein CTD PMID:16966582 PMID:17188667 NCBI chr 7:44,952,579...44,983,495
Ensembl chr 7:44,952,056...44,983,204 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP [Glyburide results in decreased activity of ABCC9 protein] which results in increased expression of XDH protein CTD PMID:22622455 NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191 		JBrowse link
metsulfuron methyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor multiple interactions ISO metsulfuron methyl binds to and results in increased activity of AHR protein CTD PMID:14636698 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
G Odc1 ornithine decarboxylase, structural 1 decreases expression ISO metsulfuron methyl results in decreased expression of ODC1 mRNA CTD PMID:15519604 NCBI chr12:17,594,906...17,601,503
Ensembl chr12:17,594,795...17,601,506 		JBrowse link
tolazamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ins1 insulin I increases response to substance ISO Tolazamide results in increased susceptibility to INS1 protein CTD PMID:6337899 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
tolbutamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A decreases activity
multiple interactions		 ISO Tolbutamide results in decreased activity of ABCB1 protein
Tolbutamide inhibits the reaction [ABCB1 protein results in increased uptake of quinidinium]		 CTD PMID:32305507 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcc8 ATP-binding cassette, sub-family C member 8 multiple interactions ISO [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to Tolbutamide; ABCC8 gene SNP inhibits the reaction [Tolbutamide results in increased secretion of INS protein]; Tolbutamide inhibits the reaction [ABCC8 protein mutant form results in increased activity of KCNJ11 protein] CTD PMID:9568693 PMID:18025464 PMID:22209866 NCBI chr 7:45,753,952...45,829,441
Ensembl chr 7:45,753,947...45,829,457 		JBrowse link
G Alb albumin affects binding ISO Tolbutamide binds to ALB protein CTD PMID:19596536 PMID:20435530 PMID:20956006 PMID:20974553 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO Tolbutamide results in increased expression of CCND1 protein CTD PMID:16718685 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Ccnd3 cyclin D3 increases expression ISO Tolbutamide results in increased expression of CCND3 protein CTD PMID:16718685 NCBI chr17:47,815,976...47,910,614
Ensembl chr17:47,815,976...47,910,616 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO GJA1 promotes the reaction [Tolbutamide results in increased expression of CDKN1A protein] CTD PMID:16718685 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B increases expression ISO Tolbutamide results in increased expression of CDKN1B protein CTD PMID:16718685 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476 		JBrowse link
G Cyp2c23 cytochrome P450, family 2, subfamily c, polypeptide 23 increases metabolic processing
multiple interactions		 EXP CYP2C23 protein results in increased metabolism of Tolbutamide
[CYP2C23 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide		 CTD PMID:30503582 NCBI chr19:43,993,461...44,017,695
Ensembl chr19:43,993,461...44,017,647 		JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 increases hydroxylation ISO CYP2C8 protein results in increased hydroxylation of Tolbutamide CTD PMID:15843491 NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157 		JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 increases metabolic processing
multiple interactions
increases hydroxylation		 ISO CYP2C19 protein results in increased metabolism of Tolbutamide
[CYP2C19 protein results in increased hydroxylation of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide		 CTD PMID:18511451 PMID:30500380 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519 		JBrowse link
G Cyp2c39 cytochrome P450, family 2, subfamily c, polypeptide 39 multiple interactions
increases metabolic processing		 EXP [CYP2C39 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide CTD PMID:30503582 NCBI chr19:39,335,790...39,558,012
Ensembl chr19:39,499,306...39,556,973 		JBrowse link
G Cyp2c40 cytochrome P450, family 2, subfamily c, polypeptide 40 increases metabolic processing
multiple interactions		 EXP CYP2C40 protein results in increased metabolism of Tolbutamide
[CYP2C40 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide		 CTD PMID:30503582 NCBI chr19:39,755,517...39,801,258
Ensembl chr19:39,755,515...39,801,258 		JBrowse link
G Cyp2c50 cytochrome P450, family 2, subfamily c, polypeptide 50 increases metabolic processing
multiple interactions		 EXP CYP2C50 protein results in increased metabolism of Tolbutamide
[CYP2C50 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide		 CTD PMID:30503582 NCBI chr19:40,078,123...40,102,399
Ensembl chr19:40,078,132...40,102,394 		JBrowse link
G Cyp2c52-ps cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene increases metabolic processing ISO CYP2C18 results in increased metabolism of Tolbutamide CTD PMID:15301741 NCBI chr19:38,965,106...38,992,071
Ensembl chr19:38,965,091...38,991,733 		JBrowse link
G Cyp2c54 cytochrome P450, family 2, subfamily c, polypeptide 54 increases metabolic processing
multiple interactions		 EXP CYP2C54 protein results in increased metabolism of Tolbutamide
[CYP2C54 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide		 CTD PMID:30503582 NCBI chr19:40,026,383...40,062,289
Ensembl chr19:40,026,384...40,062,271 		JBrowse link
G Cyp2c55 cytochrome P450, family 2, subfamily c, polypeptide 55 multiple interactions
increases metabolic processing		 EXP [CYP2C55 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide CTD PMID:30503582 NCBI chr19:38,995,384...39,031,134
Ensembl chr19:38,995,463...39,031,137 		JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 decreases hydroxylation
increases metabolic processing
multiple interactions
increases hydroxylation
increases hydrolysis
affects hydroxylation
affects metabolic processing
decreases metabolic processing
increases chemical synthesis		 ISO
EXP		 CYP2C9 gene SNP results in decreased hydroxylation of Tolbutamide
CYP2C65 protein results in increased metabolism of Tolbutamide
[CYP2C65 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide
CYP2C9 protein results in increased hydroxylation of Tolbutamide
[CYP2C9 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide; Acetone promotes the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; acetonitrile promotes the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; CYP2C9 gene mutant form inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; CYP2C9 protein binds to and affects the metabolism of Tolbutamide; Fenitrothion inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; Malathion inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; phenthoate inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; pranlukast inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]; profenofos inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased hydrolysis of Tolbutamide]; Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]; Ticlopidine inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]; Tolbutamide inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; zafirlukast inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]
CYP2C9 protein affects the hydroxylation of Tolbutamide
CYP2C9 gene polymorphism affects the metabolism of Tolbutamide; CYP2C9 gene SNP affects the metabolism of Tolbutamide; CYP2C9 protein affects the metabolism of Tolbutamide
CYP2C9 gene polymorphism results in decreased metabolism of Tolbutamide
CYP2C9 protein results in increased chemical synthesis of Tolbutamide metabolite		 CTD PMID:2025243 PMID:9110362 PMID:9170147 PMID:9522436 PMID:10208645 More... NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388 		JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 multiple interactions
increases metabolic processing		 EXP [CYP2C66 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide CTD PMID:30503582 NCBI chr19:39,102,342...39,175,200
Ensembl chr19:39,102,342...39,175,516 		JBrowse link
G Cyp2c67 cytochrome P450, family 2, subfamily c, polypeptide 67 increases metabolic processing
multiple interactions		 EXP CYP2C67 protein results in increased metabolism of Tolbutamide
[CYP2C67 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide		 CTD PMID:30503582 NCBI chr19:39,597,288...39,637,497
Ensembl chr19:39,597,286...39,637,495 		JBrowse link
G Cyp2c68 cytochrome P450, family 2, subfamily c, polypeptide 68 multiple interactions
increases metabolic processing		 EXP [CYP2C68 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide CTD PMID:30503582 NCBI chr19:39,677,280...39,729,545
Ensembl chr19:39,677,278...39,729,498 		JBrowse link
G Cyp2c69 cytochrome P450, family 2, subfamily c, polypeptide 69 multiple interactions
increases metabolic processing		 EXP [CYP2C69 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide CTD PMID:30503582 NCBI chr19:39,831,104...39,875,213
Ensembl chr19:39,831,258...39,875,243 		JBrowse link
G Cyp2c70 cytochrome P450, family 2, subfamily c, polypeptide 70 increases metabolic processing
multiple interactions		 EXP CYP2C70 protein results in increased metabolism of Tolbutamide
[CYP2C70 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide		 CTD PMID:30503582 NCBI chr19:40,141,805...40,175,730
Ensembl chr19:40,141,797...40,175,777 		JBrowse link
G Gcg glucagon increases secretion ISO Tolbutamide results in increased secretion of GCG protein CTD PMID:15919803 NCBI chr 2:62,304,874...62,313,997
Ensembl chr 2:62,304,874...62,313,994 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions
increases expression		 ISO GJA1 promotes the reaction [Tolbutamide results in increased expression of CDKN1A protein]; Tolbutamide promotes the reaction [Bucladesine results in increased expression of GJA1 protein]
Tolbutamide results in increased expression of GJA1 protein		 CTD PMID:11741589 PMID:16718685 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609 		JBrowse link
G Hk1 hexokinase 1 increases expression EXP Tolbutamide results in increased expression of HK1 protein CTD PMID:11835228 NCBI chr10:62,104,634...62,215,699
Ensembl chr10:62,104,634...62,215,687 		JBrowse link
G Ins1 insulin I affects secretion
multiple interactions		 EXP Tolbutamide affects the secretion of INS1 protein
[Tolbutamide co-treated with FR900359] inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Tolbutamide inhibits the reaction [arsenite inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Tolbutamide inhibits the reaction [dimethylarsinous acid inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Tolbutamide inhibits the reaction [methylarsonite inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Tolbutamide promotes the reaction [Glucose results in increased secretion of INS1 protein]		 CTD PMID:9366569 PMID:31332465 PMID:37217659 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Ins2 insulin II multiple interactions
increases secretion		 ISO ABCC8 gene SNP inhibits the reaction [Tolbutamide results in increased secretion of INS protein] CTD PMID:9032110 PMID:9568693 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118 		JBrowse link
G Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 multiple interactions
decreases activity		 ISO [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to Tolbutamide; Tolbutamide inhibits the reaction [ABCC8 protein mutant form results in increased activity of KCNJ11 protein]
Tolbutamide results in decreased activity of KCNJ11 protein		 CTD PMID:18025464 PMID:22209866 NCBI chr 7:45,746,545...45,750,215
Ensembl chr 7:45,743,377...45,750,188 		JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 decreases expression ISO Tolbutamide results in decreased expression of MKI67 protein CTD PMID:16718685 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090 		JBrowse link
G Pdcd4 programmed cell death 4 decreases expression
increases expression		 ISO Tolbutamide results in decreased expression of PDCD4 mRNA
Tolbutamide results in increased expression of PDCD4 mRNA		 CTD PMID:21873647 NCBI chr19:53,880,662...53,926,024
Ensembl chr19:53,880,662...53,918,291 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO Tolbutamide results in decreased phosphorylation of RB1 protein CTD PMID:16718685 NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262 		JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 increases expression EXP Tolbutamide results in increased expression of SLC2A1 mRNA; Tolbutamide results in increased expression of SLC2A1 protein CTD PMID:2682625 PMID:11835228 NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180 		JBrowse link
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 decreases expression ISO Tolbutamide results in decreased expression of TNFAIP3 mRNA CTD PMID:21873647 NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405 		JBrowse link
G Tpd52 tumor protein D52 decreases expression
increases expression		 ISO Tolbutamide results in decreased expression of TPD52 mRNA
Tolbutamide results in increased expression of TPD52 mRNA		 CTD PMID:21873647 NCBI chr 3:8,991,590...9,069,824
Ensembl chr 3:8,990,653...9,069,783 		JBrowse link
G Trp53 transformation related protein 53 increases expression ISO Tolbutamide results in increased expression of TP53 mRNA CTD PMID:16426753 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Ugdh UDP-glucose dehydrogenase decreases expression ISO Tolbutamide results in decreased expression of UGDH protein CTD PMID:4270849 NCBI chr 5:65,570,550...65,593,185
Ensembl chr 5:65,570,564...65,593,292 		JBrowse link
torasemide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen increases expression ISO Torsemide results in increased expression of AGT protein modified form CTD PMID:18154949 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 affects expression ISO Torsemide affects the expression of CYP11B2 protein CTD PMID:18001696 NCBI chr15:74,722,467...74,728,080
Ensembl chr15:74,722,859...74,728,167 		JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 increases metabolic processing
multiple interactions		 ISO CYP2C8 protein results in increased metabolism of Torsemide
Torsemide inhibits the reaction [Amiodarone results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Fluoxetine results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Isoniazid results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Nortriptyline results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Phenelzine results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Verapamil results in decreased activity of CYP2C8 protein]		 CTD PMID:15304522 NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157 		JBrowse link
G Cyp2c52-ps cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene affects metabolic processing ISO CYP2C11 protein affects the metabolism of Torsemide CTD PMID:15890479 NCBI chr19:38,965,106...38,992,071
Ensembl chr19:38,965,091...38,991,733 		JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 increases hydroxylation
increases metabolic processing		 ISO CYP2C9 protein results in increased hydroxylation of Torsemide
CYP2C9 protein results in increased metabolism of Torsemide		 CTD PMID:9110362 PMID:19082874 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388 		JBrowse link
G Nppa natriuretic peptide type A decreases expression ISO Torsemide results in decreased expression of NPPA protein CTD PMID:18154949 NCBI chr 4:148,085,179...148,086,531
Ensembl chr 4:148,085,179...148,086,536 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions ISO Torsemide inhibits the reaction [Aldosterone binds to NR3C2 protein] CTD PMID:7954537 NCBI chr 8:77,626,422...77,971,641
Ensembl chr 8:77,626,070...77,971,641 		JBrowse link
G Ren1 renin 1 structural increases expression ISO Torsemide results in increased expression of REN protein CTD PMID:7954537 NCBI chr 1:133,278,412...133,288,058
Ensembl chr 1:133,278,248...133,288,063 		JBrowse link
G Slc12a2 solute carrier family 12, member 2 decreases activity
multiple interactions		 ISO Torsemide results in decreased activity of SLC12A2 protein
Torsemide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]		 CTD PMID:29959396 NCBI chr18:58,011,505...58,079,893
Ensembl chr18:58,011,750...58,079,893 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 affects expression
decreases expression		 ISO Torsemide affects the expression of TGFB1 protein
Torsemide results in decreased expression of TGFB1 protein		 CTD PMID:18001696 PMID:18154949 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
triflusulfuron-methyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO [prochloraz co-treated with Chlorpyrifos co-treated with triflusulfuron-methyl] results in increased expression of CYP19A1 mRNA CTD PMID:25233012 NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22210
    role 22195
      application 21777
        agrochemical 16972
          fertilizer 14254
            urea 5748
              ureas 5746
                N-sulfonylurea 155
                  1-(4-chlorobenzenesulfonyl)-3-(2-oxopropyl)urea 0
                  3-[(2-adamantylamino)-oxomethyl]-1-methylsulfonyl-1-pentylurea 0
                  3-chloro-N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-1-methyl-4-(5-methyl-5,6-dihydro-1,4,2-dioxazin-3-yl)-1H-pyrazole-5-sulfonamide + 0
                  4'-hydroxy torasemide 0
                  5-chloro-N-(2-\{4-[(cyclohexylcarbamoyl)aminosulfonyl]phenyl\}-2-hydroxypropyl)-2-methoxybenzamide 0
                  5-chloro-N-(2-\{4-[(cyclohexylcarbamoyl)aminosulfonyl]phenyl\}propyl)-2-methoxybenzamide 0
                  Cinosulfuron 0
                  acetohexamide 2
                  azimsulfuron 0
                  bensulfuron + 1
                  bensulfuron-methyl 1
                  chlorimuron + 0
                  chlorimuron-ethyl 0
                  chlorimuron-ethyl(1-) 0
                  chlorpropamide 6
                  chlorsulfuron 0
                  ethametsulfuron + 0
                  ethametsulfuron-methyl 0
                  flucarbazone 0
                  gliclazide 33
                  glimepiride 16
                  glipizide 5
                  glyburide 102
                  hydroxy torasemide 0
                  iofensulfuron 0
                  metsulfuron methyl 2
                  nicosulfuron 0
                  orthosulfamuron 0
                  rimsulfuron 0
                  sulfometuron + 0
                  sulfometuron methyl 0
                  thiencarbazone + 0
                  thiencarbazone-methyl 0
                  thifensulfuron + 0
                  thifensulfuron-methyl 0
                  tolazamide 1
                  tolbutamide 36
                  torasemide + 10
                  torasemide carboxylic acid 0
                  triasulfuron 0
                  tribenuron + 0
                  tribenuron methyl 0
                  triflusulfuron + 1
                  triflusulfuron-methyl 1
                  tritosulfuron 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22210
    subatomic particle 22202
      composite particle 22202
        hadron 22202
          baryon 22202
            nucleon 22202
              atomic nucleus 22202
                atom 22202
                  main group element atom 22136
                    p-block element atom 22136
                      carbon group element atom 21936
                        carbon atom 21861
                          organic molecular entity 21861
                            heteroorganic entity 21517
                              organochalcogen compound 21006
                                organooxygen compound 20847
                                  carbon oxoacid 19634
                                    carboxylic acid 19630
                                      carboacyl group 18294
                                        univalent carboacyl group 18294
                                          carbamoyl group 18107
                                            carboxamide 18107
                                              monocarboxylic acid amide 15844
                                                urea 5748
                                                  ureas 5746
                                                    N-sulfonylurea 155
                                                      1-(4-chlorobenzenesulfonyl)-3-(2-oxopropyl)urea 0
                                                      3-[(2-adamantylamino)-oxomethyl]-1-methylsulfonyl-1-pentylurea 0
                                                      3-chloro-N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-1-methyl-4-(5-methyl-5,6-dihydro-1,4,2-dioxazin-3-yl)-1H-pyrazole-5-sulfonamide + 0
                                                      4'-hydroxy torasemide 0
                                                      5-chloro-N-(2-\{4-[(cyclohexylcarbamoyl)aminosulfonyl]phenyl\}-2-hydroxypropyl)-2-methoxybenzamide 0
                                                      5-chloro-N-(2-\{4-[(cyclohexylcarbamoyl)aminosulfonyl]phenyl\}propyl)-2-methoxybenzamide 0
                                                      Cinosulfuron 0
                                                      acetohexamide 2
                                                      azimsulfuron 0
                                                      bensulfuron + 1
                                                      bensulfuron-methyl 1
                                                      chlorimuron + 0
                                                      chlorimuron-ethyl 0
                                                      chlorimuron-ethyl(1-) 0
                                                      chlorpropamide 6
                                                      chlorsulfuron 0
                                                      ethametsulfuron + 0
                                                      ethametsulfuron-methyl 0
                                                      flucarbazone 0
                                                      gliclazide 33
                                                      glimepiride 16
                                                      glipizide 5
                                                      glyburide 102
                                                      hydroxy torasemide 0
                                                      iofensulfuron 0
                                                      metsulfuron methyl 2
                                                      nicosulfuron 0
                                                      orthosulfamuron 0
                                                      rimsulfuron 0
                                                      sulfometuron + 0
                                                      sulfometuron methyl 0
                                                      thiencarbazone + 0
                                                      thiencarbazone-methyl 0
                                                      thifensulfuron + 0
                                                      thifensulfuron-methyl 0
                                                      tolazamide 1
                                                      tolbutamide 36
                                                      torasemide + 10
                                                      torasemide carboxylic acid 0
                                                      triasulfuron 0
                                                      tribenuron + 0
                                                      tribenuron methyl 0
                                                      triflusulfuron + 1
                                                      triflusulfuron-methyl 1
                                                      tritosulfuron 0
paths to the root