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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:glipizide
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Accession:CHEBI:5384 term browser browse the term
Definition:An N-sulfonylurea that is glyburide in which the (5-chloro-2-methoxybenzoyl group is replaced by a (5-methylpyrazin-2-yl)carbonyl group. An oral hypoglycemic agent, it is used in the treatment of type 2 diabetes mellitus.
Synonyms:exact_synonym: N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-5-methylpyrazine-2-carboxamide
 related_synonym: 1-cyclohexyl-3-({p-[2-(5-methylpyrazinecarboxamido)ethyl]phenyl}sulfonyl)urea;   Aldiab;   CP 28720;   CP-28,720;   Digrin;   Dipazide;   Formula=C21H27N5O4S;   Glibenese;   Glibetin;   Glican;   Glidiab;   Glipid;   Gluco-Rite;   Glucolip;   Glucotrol;   Glucozide;   Glupitel;   Glupizide;   Glyde;   Glydiazinamide;   InChI=1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28);   InChIKey=ZJJXGWJIGJFDTL-UHFFFAOYSA-N;   K 4024;   Melizide;   Mindiab;   Minidab;   Minidiab;   Minodiab;   N-{4-[beta-(5-methylpyrazine-2-carboxamido)ethyl]benzenesulphonyl}-N'-cyclohexylurea;   Napizide;   Ozidia;   SMILES=Cc1cnc(cn1)C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)NC1CCCCC1;   Sucrazide;   glipizida;   glipizidum
 xref: CAS:29094-61-9;   DrugBank:DB01067;   Drug_Central:1301;   HMDB:HMDB0015200;   KEGG:D00335;   LINCS:LSM-2251
 xref_mesh: MESH:D005913
 xref: PMID:11147395;   PMID:20797618;   PMID:23230096;   PMID:24418334;   PMID:24444583;   PMID:2665487;   PMID:3143256;   PMID:389600;   PMID:3923454;   PMID:7660535;   Patent:DE2012138;   Patent:US3669966;   Reaxys:903495;   Wikipedia:Glipizide


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glipizide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 multiple interactions
decreases activity		 ISO Glipizide inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Glipizide results in decreased activity of ABCB11 protein		 CTD PMID:24014644 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958 		JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 decreases activity ISO Glipizide results in decreased activity of AKR1C3 protein CTD PMID:26362498 NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653 		JBrowse link
G Akr1c20 aldo-keto reductase family 1, member C20 decreases activity ISO Glipizide results in decreased activity of AKR1C1 protein CTD PMID:26362498 NCBI chr13:4,536,855...4,573,353
Ensembl chr13:4,536,848...4,573,344 		JBrowse link
G Akr1c21 aldo-keto reductase family 1, member C21 decreases activity ISO Glipizide results in decreased activity of AKR1C2 protein CTD PMID:26362498 NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540 		JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 increases metabolic processing
decreases metabolic processing		 ISO CYP2C9 protein results in increased metabolism of Glipizide
CYP2C9 gene polymorphism results in decreased metabolism of Glipizide		 CTD PMID:10208645 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      application 21744
        pharmaceutical 21187
          drug 21159
            hypoglycemic agent 4276
              glipizide 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            heteroorganic entity 21482
                              organochalcogen compound 20966
                                organooxygen compound 20806
                                  carbon oxoacid 19593
                                    carboxylic acid 19589
                                      carboacyl group 18277
                                        univalent carboacyl group 18277
                                          carbamoyl group 18088
                                            carboxamide 18106
                                              monocarboxylic acid amide 15820
                                                urea 5736
                                                  ureas 5734
                                                    N-sulfonylurea 155
                                                      glipizide 5
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