GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Kcnj11 | decreases activity | ISO | KCNJ11 (Homo sapiens) | 6480464 | CTD | Tolbutamide results in decreased activity of KCNJ11 protein | PMID:18025464 | Kcnj11 | multiple interactions | ISO | KCNJ11 (Homo sapiens) | 6480464 | CTD | [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to Tolbutamide; Tolbutamide inhibits the reaction [ABCC8 protein mutant form results in increased activity of KCNJ11 protein] | PMID:18025464 PMID:22209866 | |
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