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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69099
Species: Mus musculus
RGD Object: Gene
Symbol: Kcnj11
Name: potassium inwardly rectifying channel, subfamily J, member 11
Acc ID: CHEBI:27999
Term: tolbutamide
Definition: An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.
Chemical ID: MESH:D014044
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnj11decreases activityISOKCNJ11 (Homo sapiens)6480464CTDTolbutamide results in decreased activity of KCNJ11 proteinPMID:18025464
Kcnj11multiple interactionsISOKCNJ11 (Homo sapiens)6480464CTD[KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to Tolbutamide; Tolbutamide inhibits the reaction [ABCC8 protein mutant form results in increased activity of KCNJ11 protein]PMID:18025464 PMID:22209866
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