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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chlorpropamide
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Accession:CHEBI:3650 term browser browse the term
Definition:An N-sulfonylurea that is urea in which a hydrogen attached to one of the nitrogens is substituted by 4-chlorobenzenesulfonyl group and a hydrogen attached to the other nitrogen is substituted by propyl group. Chlorpropamide is a hypoglycaemic agent used in the treatment of type 2 (non-insulin-dependent) diabetes mellitus not responding to dietary modification.
Synonyms:related_synonym: 1-(p-chlorobenzenesulfonyl)-3-propylurea;   1-(p-chlorophenylsulfonyl)-3-propylurea;   1-propyl-3-(p-chlorobenzenesulfonyl)urea;   4-chloro-N-((propylamino)carbonyl)benzenesulfonamide;   Formula=C10H13ClN2O3S;   InChI=1S/C10H13ClN2O3S/c1-2-7-12-10(14)13-17(15,16)9-5-3-8(11)4-6-9/h3-6H,2,7H2,1H3,(H2,12,13,14);   InChIKey=RKWGIWYCVPQPMF-UHFFFAOYSA-N;   N-(4-chlorophenylsulfonyl)-N'-propylurea;   N-(p-chlorobenzenesulfonyl)-N'-propylurea;   SMILES=CCCNC(=O)NS(=O)(=O)c1ccc(Cl)cc1;   chlorpropamidum;   clorpropamida;   n-propyl-N'-(p-chlorobenzenesulfonyl)urea;   n-propyl-N'-p-chlorophenylsulfonylcarbamide
 alt_id: CHEBI:108516
 xref: Beilstein:2218363;   CAS:94-20-2;   DrugBank:DB00672;   Drug_Central:622;   HMDB:HMDB0014810;   KEGG:D00271;   LINCS:LSM-6695
 xref_mesh: MESH:D002747
 xref: PMID:10891117;   PMID:2657066;   PMID:3806586;   Patent:GB853555;   Patent:US3349124;   Reaxys:2218363;   Wikipedia:Chlorpropamide



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chlorpropamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 multiple interactions ISO [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to Chlorpropamide CTD PMID:22209866 NCBI chr 1:96,598,663...96,679,495
Ensembl chr 1:96,598,647...96,679,510
JBrowse link
G Ace2 angiotensin I converting enzyme 2 decreases expression ISO Chlorpropamide results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Avp arginine vasopressin decreases secretion ISO Chlorpropamide results in decreased secretion of AVP protein modified form CTD PMID:5029389 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Chlorpropamide results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Ins2 insulin 2 decreases expression
increases expression
multiple interactions
ISO Chlorpropamide results in decreased expression of INS protein
Chlorpropamide results in increased expression of INS mRNA
Chlorpropamide inhibits the reaction [Glucose results in decreased secretion of INS protein]
CTD PMID:15642492 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 multiple interactions ISO [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to Chlorpropamide CTD PMID:22209866 NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20050
    role 20001
      application 19737
        pharmaceutical 19610
          drug 19610
            hypoglycemic agent 4147
              chlorpropamide 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    p-block element atom 19948
                      carbon group element atom 19872
                        carbon atom 19863
                          organic molecular entity 19863
                            organic group 18937
                              organic divalent group 18922
                                organodiyl group 18922
                                  carbonyl group 18872
                                    carbonyl compound 18872
                                      carboxylic acid 18556
                                        carboacyl group 17655
                                          univalent carboacyl group 17655
                                            carbamoyl group 17490
                                              carboxamide 17490
                                                monocarboxylic acid amide 15058
                                                  urea 5127
                                                    ureas 5124
                                                      N-sulfonylurea 124
                                                        chlorpropamide 6
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