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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chlorpropamide
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Accession:CHEBI:3650 term browser browse the term
Definition:An N-sulfonylurea that is urea in which a hydrogen attached to one of the nitrogens is substituted by 4-chlorobenzenesulfonyl group and a hydrogen attached to the other nitrogen is substituted by propyl group. Chlorpropamide is a hypoglycaemic agent used in the treatment of type 2 (non-insulin-dependent) diabetes mellitus not responding to dietary modification.
Synonyms:related_synonym: 1-(p-chlorobenzenesulfonyl)-3-propylurea;   1-(p-chlorophenylsulfonyl)-3-propylurea;   1-propyl-3-(p-chlorobenzenesulfonyl)urea;   4-chloro-N-((propylamino)carbonyl)benzenesulfonamide;   Formula=C10H13ClN2O3S;   InChI=1S/C10H13ClN2O3S/c1-2-7-12-10(14)13-17(15,16)9-5-3-8(11)4-6-9/h3-6H,2,7H2,1H3,(H2,12,13,14);   InChIKey=RKWGIWYCVPQPMF-UHFFFAOYSA-N;   N-(4-chlorophenylsulfonyl)-N'-propylurea;   N-(p-chlorobenzenesulfonyl)-N'-propylurea;   SMILES=CCCNC(=O)NS(=O)(=O)c1ccc(Cl)cc1;   chlorpropamidum;   clorpropamida;   n-propyl-N'-(p-chlorobenzenesulfonyl)urea;   n-propyl-N'-p-chlorophenylsulfonylcarbamide
 alt_id: CHEBI:108516
 xref: Beilstein:2218363;   CAS:94-20-2;   DrugBank:DB00672;   Drug_Central:622;   HMDB:HMDB0014810;   KEGG:D00271;   LINCS:LSM-6695
 xref_mesh: MESH:D002747
 xref: PMID:10891117;   PMID:2657066;   PMID:3806586;   Patent:GB853555;   Patent:US3349124;   Reaxys:2218363;   Wikipedia:Chlorpropamide


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chlorpropamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 multiple interactions ISO [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to Chlorpropamide CTD PMID:22209866 NCBI chr 1:102,110,708...102,191,287
Ensembl chr 1:102,110,708...102,191,287
JBrowse link
G Avp arginine vasopressin decreases secretion ISO Chlorpropamide results in decreased secretion of AVP protein modified form CTD PMID:5029389 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Chlorpropamide results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Ins2 insulin 2 decreases expression
increases expression
multiple interactions
ISO Chlorpropamide results in decreased expression of INS protein
Chlorpropamide results in increased expression of INS mRNA
Chlorpropamide inhibits the reaction [Glucose results in decreased secretion of INS protein]
CTD PMID:15642492 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 multiple interactions ISO [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to Chlorpropamide CTD PMID:22209866 NCBI chr 1:102,103,093...102,107,134
Ensembl chr 1:102,103,094...102,106,127
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      application 19420
        pharmaceutical 19293
          drug 19293
            hypoglycemic agent 4036
              chlorpropamide 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      carboxylic acid 18108
                                        carboacyl group 17369
                                          univalent carboacyl group 17369
                                            carbamoyl group 17156
                                              carboxamide 17156
                                                monocarboxylic acid amide 14573
                                                  urea 4990
                                                    ureas 4987
                                                      N-sulfonylurea 115
                                                        chlorpropamide 5
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