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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:torasemide
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Accession:CHEBI:9637 term browser browse the term
Definition:An N-sulfonylurea obtained by formal condensation of [(3-methylphenyl)amino]pyridine-3-sulfonic acid with the free amino group of N-isopropylurea. It is a potent loop diuretic used for the treatment of hypertension and edema in patients with congestive heart failure.
Synonyms:exact_synonym: 4-(3-methylanilino)-N-(propan-2-ylcarbamoyl)pyridine-3-sulfonamide
 related_synonym: 1-Isopropyl-3-((4-m-toluidino-3-pyridyl)sulfonyl)urea;   AC-4464;   AC4464;   BM 02015;   BM-02.015;   BM02.015;   BM02015;   Demadex;   Formula=C16H20N4O3S;   InChI=1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21);   InChIKey=NGBFQHCMQULJNZ-UHFFFAOYSA-N;   JDL 464;   Luprac;   N-(((1-Methylethyl)amino)carbonyl)-4-((3-methylphenyl)amino)-3-pyridinesulfonamide;   N-(isopropylcarbamoyl)-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide;   N-[(propan-2-yl)carbamoyl]-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide;   SMILES=C=1(C(NC=2C=C(C=CC2)C)=CC=NC1)S(NC(NC(C)C)=O)(=O)=O;   Torem;   Torsemide;   Unat;   torasemida;   torasemidum
 xref: CAS:56211-40-6;   DrugBank:DB00214;   Drug_Central:2708;   HMDB:HMDB0014359;   KEGG:D00382;   LINCS:LSM-2662
 xref_mesh: MESH:C026116
 xref: PMID:21391491;   PMID:21906812;   PMID:22030290;   PMID:22364690;   PMID:22407343;   PMID:23013124;   PMID:23237447;   PMID:23792294;   PMID:23837587;   PMID:23877845;   PMID:24040049;   PMID:24243991;   PMID:24367917;   PMID:24432564;   PMID:24554915;   PMID:28891228;   PMID:29488197;   PMID:30649675;   PMID:30827731;   PMID:31124957;   PMID:31436024;   PMID:31699358;   PMID:31809955;   PMID:32098657;   PMID:32302808;   PMID:32411731;   Reaxys:498515;   Wikipedia:Torasemide

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torasemide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen increases expression EXP Torsemide results in increased expression of AGT protein modified form CTD PMID:18154949 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 affects expression EXP Torsemide affects the expression of CYP11B2 protein CTD PMID:18001696 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 affects metabolic processing
increases metabolic processing
increases hydroxylation		 EXP
ISO		 CYP2C11 protein affects the metabolism of Torsemide
CYP2C9 protein results in increased metabolism of Torsemide
CYP2C9 protein results in increased hydroxylation of Torsemide		 CTD PMID:9110362 PMID:15890479 PMID:19082874 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases metabolic processing
multiple interactions		 ISO CYP2C8 protein results in increased metabolism of Torsemide
Torsemide inhibits the reaction [Amiodarone results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Fluoxetine results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Isoniazid results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Nortriptyline results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Phenelzine results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Verapamil results in decreased activity of CYP2C8 protein]		 CTD PMID:15304522 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Nppa natriuretic peptide A decreases expression EXP Torsemide results in decreased expression of NPPA protein CTD PMID:18154949 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions EXP Torsemide inhibits the reaction [Aldosterone binds to NR3C2 protein] CTD PMID:7954537 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695 		JBrowse link
G Ren renin increases expression EXP Torsemide results in increased expression of REN protein CTD PMID:7954537 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151 		JBrowse link
G Slc12a2 solute carrier family 12 member 2 decreases activity
multiple interactions		 ISO Torsemide results in decreased activity of SLC12A2 protein
Torsemide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]		 CTD PMID:29959396 NCBI chr18:52,917,124...52,985,281
Ensembl chr18:52,917,124...52,985,261 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
affects expression		 EXP Torsemide results in decreased expression of TGFB1 protein
Torsemide affects the expression of TGFB1 protein		 CTD PMID:18001696 PMID:18154949 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      application 19465
        pesticide 16525
          avicide 4091
            4-aminopyridine 41
              torasemide 9
                4'-hydroxy torasemide 0
                hydroxy torasemide 0
                torasemide carboxylic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic group 18537
                              organic divalent group 18528
                                organodiyl group 18528
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18113
                                        carboacyl group 17377
                                          univalent carboacyl group 17377
                                            carbamoyl group 17164
                                              carboxamide 17164
                                                monocarboxylic acid amide 14583
                                                  urea 4994
                                                    ureas 4991
                                                      N-sulfonylurea 116
                                                        torasemide 9
                                                          4'-hydroxy torasemide 0
                                                          hydroxy torasemide 0
                                                          torasemide carboxylic acid 0
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