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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:gliclazide
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Accession:CHEBI:31654 term browser browse the term
Definition:A N-sulfonylurea that has formula C15H21N3O3S.
Synonyms:exact_synonym: N-(hexahydrocyclopenta[c]pyrrol-2(1H)-ylcarbamoyl)-4-methylbenzenesulfonamide
 related_synonym: 1-(3-azabicyclo(3.3.0)oct-3-yl)-3-(p-tolylsulfonyl)urea;   1-(hexahydrocyclopenta(c)pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)urea;   Formula=C15H21N3O3S;   Glimicron;   InChI=1S/C15H21N3O3S/c1-11-5-7-14(8-6-11)22(20,21)17-15(19)16-18-9-12-3-2-4-13(12)10-18/h5-8,12-13H,2-4,9-10H2,1H3,(H2,16,17,19);   InChIKey=BOVGTQGAOIONJV-UHFFFAOYSA-N;   SMILES=Cc1ccc(cc1)S(=O)(=O)NC(=O)NN1CC2CCCC2C1
 xref: Beilstein:1657836;   CAS:21187-98-4;   DrugBank:DB01120;   Drug_Central:1299;   HMDB:HMDB0015252;   KEGG:D01599;   LINCS:LSM-5096
 xref_mesh: MESH:D005907
 xref: PMID:10048179;   PMID:14871415;   PMID:16631804;   PMID:22118706;   PMID:22183301;   PMID:22411174;   PMID:22732450;   PMID:9226746;   Reaxys:1657836;   Wikipedia:Gliclazide

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gliclazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 multiple interactions ISO [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in increased susceptibility to Gliclazide CTD PMID:22209866 NCBI chr 1:102,110,708...102,191,287
Ensembl chr 1:102,110,708...102,191,287 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Gliclazide results in decreased activity of AKR1C3 protein CTD PMID:26362498 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021 		JBrowse link
G Alb albumin affects binding
multiple interactions		 ISO
EXP		 Gliclazide binds to ALB protein
Gliclazide inhibits the reaction [[Streptozocin co-treated with Cholesterol, Dietary] results in increased secretion of ALB protein]		 CTD PMID:14871415 PMID:20974553 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Gliclazide inhibits the reaction [Glucose results in decreased expression of BCL2 protein] CTD PMID:18088078 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP		 Gliclazide inhibits the reaction [Glucose results in increased expression of CASP3 protein]
Gliclazide inhibits the reaction [Acetic Acid results in increased expression of CASP3 protein]		 CTD PMID:18088078 PMID:32045587 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cat catalase multiple interactions EXP Gliclazide inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in decreased activity of CAT protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein]; Gliclazide inhibits the reaction [Streptozocin results in decreased activity of CAT protein] CTD PMID:20307516 PMID:20643114 PMID:21439372 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Gliclazide inhibits the reaction [Hydrogen Peroxide results in increased expression of CDKN1A mRNA] CTD PMID:12646174 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP Gliclazide inhibits the reaction [Streptozocin results in decreased activity of G6PD protein] CTD PMID:28330423 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions EXP Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC mRNA]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC protein] CTD PMID:21439372 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468 		JBrowse link
G Glo1 glyoxalase 1 multiple interactions EXP Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of GLO1 protein] CTD PMID:21439372 NCBI chr20:9,273,589...9,291,608
Ensembl chr20:9,273,594...9,291,610 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Gliclazide inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in decreased activity of GSR protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of GSR protein] CTD PMID:20307516 PMID:21439372 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions EXP Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GSTM3 mRNA] CTD PMID:21439372 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO
EXP		 Gliclazide inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]
Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of HMOX1 protein]		 CTD PMID:12646174 PMID:21439372 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP Gliclazide inhibits the reaction [[Streptozocin co-treated with Cholesterol, Dietary] results in increased expression of ICAM1 protein]; Gliclazide inhibits the reaction [Acetic Acid results in increased expression of ICAM1 protein] CTD PMID:14871415 PMID:32045587 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP Gliclazide inhibits the reaction [Acetic Acid results in decreased expression of IL10 protein] CTD PMID:32045587 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Gliclazide inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in increased expression of IL1B protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of IL1B protein]; Gliclazide inhibits the reaction [Streptozocin results in increased expression of IL1B protein] CTD PMID:20307516 PMID:20643114 PMID:21439372 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Gliclazide inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in increased expression of IL6 protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of IL6 protein]; Gliclazide inhibits the reaction [Acetic Acid results in increased expression of IL6 protein]; Gliclazide inhibits the reaction [Streptozocin results in increased expression of IL6 protein] CTD PMID:20307516 PMID:20643114 PMID:21439372 PMID:32045587 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 multiple interactions ISO [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in increased susceptibility to Gliclazide CTD PMID:22209866 NCBI chr 1:102,103,093...102,107,134
Ensembl chr 1:102,103,094...102,106,127 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions EXP Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 mRNA]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 protein] CTD PMID:21439372 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Gliclazide inhibits the reaction [Acetic Acid results in increased phosphorylation of MAPK1 protein] CTD PMID:32045587 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Gliclazide inhibits the reaction [Acetic Acid results in increased phosphorylation of MAPK3 protein] CTD PMID:32045587 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP Gliclazide inhibits the reaction [Acetic Acid results in increased phosphorylation of MAPK8 protein] CTD PMID:32045587 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Gliclazide inhibits the reaction [Acetic Acid results in increased activity of MPO protein] CTD PMID:32045587 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP Gliclazide inhibits the reaction [[Streptozocin co-treated with Cholesterol, Dietary] results in increased expression of NCF1 protein] CTD PMID:14871415 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of NFE2L2 mRNA]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of NFE2L2 protein] CTD PMID:21439372 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nos3 nitric oxide synthase 3 increases expression EXP Gliclazide results in increased expression of NOS3 protein CTD PMID:14871415 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP Gliclazide inhibits the reaction [Acetic Acid results in decreased expression of PPARG protein] CTD PMID:32045587 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Gliclazide inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in increased expression of RELA protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of RELA protein]; Gliclazide inhibits the reaction [Streptozocin results in increased expression of RELA protein] CTD PMID:20307516 PMID:20643114 PMID:21439372 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP Gliclazide inhibits the reaction [[Streptozocin co-treated with Cholesterol, Dietary] results in decreased expression of SOD2 protein] CTD PMID:14871415 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 EXP Gliclazide inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in increased expression of TNF protein]; Gliclazide inhibits the reaction [Streptozocin results in increased expression of TNF protein]
Gliclazide results in decreased expression of TNF protein		 CTD PMID:20307516 PMID:20643114 PMID:21439372 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 multiple interactions ISO Gliclazide inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFAIP3 mRNA] CTD PMID:12646174 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      chemical role 19250
        antioxidant 14252
          radical scavenger 5242
            gliclazide 31
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic group 18593
                              organic divalent group 18584
                                organodiyl group 18584
                                  carbonyl group 18499
                                    carbonyl compound 18499
                                      carboxylic acid 18151
                                        carboacyl group 17410
                                          univalent carboacyl group 17410
                                            carbamoyl group 17208
                                              carboxamide 17208
                                                monocarboxylic acid amide 14600
                                                  urea 5020
                                                    ureas 5018
                                                      N-sulfonylurea 120
                                                        gliclazide 31
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