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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:glipizide
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Accession:CHEBI:5384 term browser browse the term
Definition:An N-sulfonylurea that is glyburide in which the (5-chloro-2-methoxybenzoyl group is replaced by a (5-methylpyrazin-2-yl)carbonyl group. An oral hypoglycemic agent, it is used in the treatment of type 2 diabetes mellitus.
Synonyms:exact_synonym: N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-5-methylpyrazine-2-carboxamide
 related_synonym: 1-cyclohexyl-3-({p-[2-(5-methylpyrazinecarboxamido)ethyl]phenyl}sulfonyl)urea;   Aldiab;   CP 28,720;   CP 28720;   Digrin;   Dipazide;   Formula=C21H27N5O4S;   Glibenese;   Glibetin;   Glican;   Glidiab;   Glipid;   Gluco-Rite;   Glucolip;   Glucotrol;   Glucozide;   Glupitel;   Glupizide;   Glyde;   Glydiazinamide;   InChI=1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28);   InChIKey=ZJJXGWJIGJFDTL-UHFFFAOYSA-N;   K 4024;   Melizide;   Mindiab;   Minidab;   Minidiab;   Minodiab;   N-{4-[beta-(5-methylpyrazine-2-carboxamido)ethyl]benzenesulphonyl}-N'-cyclohexylurea;   Napizide;   Ozidia;   SMILES=Cc1cnc(cn1)C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)NC1CCCCC1;   Sucrazide;   glipizida;   glipizidum
 xref: CAS:29094-61-9;   DrugBank:DB01067;   Drug_Central:1301;   HMDB:HMDB0015200;   KEGG:D00335;   LINCS:LSM-2251
 xref_mesh: MESH:D005913
 xref: PMID:11147395;   PMID:20797618;   PMID:23230096;   PMID:24418334;   PMID:24444583;   PMID:2665487;   PMID:3143256;   PMID:389600;   PMID:3923454;   PMID:7660535;   Patent:DE2012138;   Patent:US3669966;   Reaxys:903495;   Wikipedia:Glipizide


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glipizide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Glipizide inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Glipizide results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Glipizide results in decreased activity of AKR1C2 protein CTD PMID:26362498 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Glipizide results in decreased activity of AKR1C3 protein CTD PMID:26362498 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pharmaceutical 19275
          drug 19275
            hypoglycemic agent 4030
              glipizide 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            carbamoyl group 17134
                                              carboxamide 17134
                                                monocarboxylic acid amide 14553
                                                  urea 4984
                                                    ureas 4982
                                                      N-sulfonylurea 113
                                                        glipizide 3
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