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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:glipizide
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Accession:CHEBI:5384 term browser browse the term
Definition:An N-sulfonylurea that is glyburide in which the (5-chloro-2-methoxybenzoyl group is replaced by a (5-methylpyrazin-2-yl)carbonyl group. An oral hypoglycemic agent, it is used in the treatment of type 2 diabetes mellitus.
Synonyms:exact_synonym: N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-5-methylpyrazine-2-carboxamide
 related_synonym: 1-cyclohexyl-3-({p-[2-(5-methylpyrazinecarboxamido)ethyl]phenyl}sulfonyl)urea;   Aldiab;   CP 28720;   CP-28,720;   Digrin;   Dipazide;   Formula=C21H27N5O4S;   Glibenese;   Glibetin;   Glican;   Glidiab;   Glipid;   Gluco-Rite;   Glucolip;   Glucotrol;   Glucozide;   Glupitel;   Glupizide;   Glyde;   Glydiazinamide;   InChI=1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28);   InChIKey=ZJJXGWJIGJFDTL-UHFFFAOYSA-N;   K 4024;   Melizide;   Mindiab;   Minidab;   Minidiab;   Minodiab;   N-{4-[beta-(5-methylpyrazine-2-carboxamido)ethyl]benzenesulphonyl}-N'-cyclohexylurea;   Napizide;   Ozidia;   SMILES=Cc1cnc(cn1)C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)NC1CCCCC1;   Sucrazide;   glipizida;   glipizidum
 xref: CAS:29094-61-9;   DrugBank:DB01067;   Drug_Central:1301;   HMDB:HMDB0015200;   KEGG:D00335;   LINCS:LSM-2251
 xref_mesh: MESH:D005913
 xref: PMID:11147395;   PMID:20797618;   PMID:23230096;   PMID:24418334;   PMID:24444583;   PMID:2665487;   PMID:3143256;   PMID:389600;   PMID:3923454;   PMID:7660535;   Patent:DE2012138;   Patent:US3669966;   Reaxys:903495;   Wikipedia:Glipizide


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glipizide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Glipizide inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Glipizide results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Glipizide results in decreased activity of AKR1C2 protein CTD PMID:26362498 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Glipizide results in decreased activity of AKR1C3 protein CTD PMID:26362498 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases metabolic processing
decreases metabolic processing
ISO CYP2C9 protein results in increased metabolism of Glipizide
CYP2C9 gene polymorphism results in decreased metabolism of Glipizide
CTD PMID:10208645 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G RGD1564865 similar to 20-alpha-hydroxysteroid dehydrogenase decreases activity ISO Glipizide results in decreased activity of AKR1C1 protein CTD PMID:26362498 NCBI chr17:65,847,580...65,881,488
Ensembl chr17:65,835,634...65,881,488
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        pharmaceutical 19319
          drug 19319
            hypoglycemic agent 4135
              glipizide 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        carboacyl group 17482
                                          univalent carboacyl group 17482
                                            carbamoyl group 17298
                                              carboxamide 17298
                                                monocarboxylic acid amide 15014
                                                  urea 5112
                                                    ureas 5109
                                                      N-sulfonylurea 123
                                                        glipizide 5
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