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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:iodide
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Accession:CHEBI:16382 term browser browse the term
Definition:A monoatomic iodine that has formula I.
Synonyms:exact_synonym: iodide(1-)
 related_synonym: Formula=I;   I-;   IODIDE ION;   InChI=1S/HI/h1H/p-1;   InChIKey=XMBWDFGMSWQBCA-UHFFFAOYSA-M;   SMILES=[I-];   iodine anion
 alt_id: CHEBI:14460;   CHEBI:49698;   CHEBI:5946
 xref: Beilstein:3587184;   CAS:20461-54-5;   Gmelin:14912;   KEGG:C00708;   PDBeChem:IOD
 cyclic_relationship: is_conjugate_base_of CHEBI:43451



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1,1-dimethyl-4-phenylpiperazinium iodide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions ISO
EXP
Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]
1,1-dimethyl-4-phenylpiperazinium iodide affects binding competes with [Epibatidine binds to Chrna2 protein]
CTD
RGD
PMID:9454827 PMID:15016836 RGD:2303194 NCBI chr15:40,342,317...40,358,601
Ensembl chr15:40,342,317...40,358,601
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions ISO
EXP
Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]
1,1-dimethyl-4-phenylpiperazinium iodide affects binding [Epibatidine binds to Chrna3 protein]
CTD
RGD
PMID:9454827 PMID:15016836 RGD:2303194 NCBI chr 8:55,401,981...55,415,012
Ensembl chr 8:55,401,702...55,415,165
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO
EXP
Dimethylphenylpiperazinium Iodide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]
1,1-dimethyl-4-phenylpiperazinium iodide affects binding to Chrna4 protein; 1,1-dimethyl-4-phenylpiperazinium iodide competes with [Epibatidine binds to Chrna4 protein]
CTD
RGD
PMID:9454827 PMID:14645658 PMID:15016836 RGD:2303194 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions
increases response to substance
increases activity
ISO Dimethylphenylpiperazinium Iodide inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]
CHRNA7 protein mutant form results in increased susceptibility to Dimethylphenylpiperazinium Iodide
Dimethylphenylpiperazinium Iodide results in increased activity of CHRNA7 protein
CTD PMID:10082212 PMID:10216184 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO
EXP
Dimethylphenylpiperazinium Iodide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]
1,1-dimethyl-4-phenylpiperazinium iodide affects binding to Chrnb2 protein; 1,1-dimethyl-4-phenylpiperazinium iodide competes with [Epibatidine binds to Chrnb2 protein]
CTD
RGD
PMID:14645658 PMID:15016836 RGD:2303194 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions ISO Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]; Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]; Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA4 protein] CTD PMID:9454827 NCBI chr 8:55,418,379...55,436,967
Ensembl chr 8:55,418,313...55,437,027
JBrowse link
G Tnf tumor necrosis factor increases activity EXP TNF results in increased activity of Dimethylphenylpiperazinium Iodide CTD PMID:15086448 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
4-DAMP methiodide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm3 cholinergic receptor, muscarinic 3 affects binding IDA 4-DAMP methiodide inhibits response to acetylcholine in rat aortic rings RGD PMID:8075871 RGD:2303390 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
JBrowse link
ecothiopate iodide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Echothiophate Iodide results in decreased activity of ACHE protein CTD PMID:16978018 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Alb albumin affects binding ISO Echothiophate Iodide binds to ALB protein CTD PMID:15525694 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Bche butyrylcholinesterase decreases activity
multiple interactions
ISO Echothiophate Iodide results in decreased activity of BCHE protein
Echothiophate Iodide inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]
CTD PMID:7377577 PMID:16213467 PMID:17698511 PMID:21802514 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 decreases activity ISO Echothiophate Iodide results in decreased activity of NCEH1 protein CTD PMID:16978018 NCBI chr 2:110,074,985...110,135,592
Ensembl chr 2:110,074,957...110,135,588
JBrowse link
iodide salt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aass aminoadipate-semialdehyde synthase increases expression EXP Iodides deficiency results in increased expression of AASS protein CTD PMID:26795019 NCBI chr 4:51,606,461...51,663,136
Ensembl chr 4:51,606,462...51,663,136
JBrowse link
G Actb actin, beta decreases expression EXP Iodides deficiency results in decreased expression of ACTB protein CTD PMID:26795019 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
JBrowse link
G Agxt2 alanine-glyoxylate aminotransferase 2 increases expression EXP Iodides deficiency results in increased expression of AGXT2 protein CTD PMID:26795019 NCBI chr 2:59,336,252...59,377,664
Ensembl chr 2:59,336,283...59,377,926
JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 increases expression EXP Iodides deficiency results in increased expression of AKR1D1 protein CTD PMID:26795019 NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372
JBrowse link
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 increases expression EXP Iodides deficiency results in increased expression of ALDH1L1 protein CTD PMID:26795019 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465
JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 multiple interactions EXP [hexabromocyclododecane co-treated with Iodides deficiency] results in decreased expression of ALDH1L2 protein CTD PMID:26795019 NCBI chr 7:20,254,196...20,305,793
Ensembl chr 7:20,254,233...20,305,776
JBrowse link
G Apmap adipocyte plasma membrane associated protein decreases expression EXP Iodides deficiency results in decreased expression of APMAP protein CTD PMID:26795019 NCBI chr 3:139,409,020...139,437,296
Ensembl chr 3:139,409,022...139,437,341
JBrowse link
G Aqp1 aquaporin 1 affects expression EXP Iodides deficiency affects the expression of AQP1 mRNA CTD PMID:21623536 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
JBrowse link
G Arg1 arginase 1 increases expression EXP Iodides deficiency results in increased expression of ARG1 protein CTD PMID:26795019 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Best1 bestrophin 1 multiple interactions
increases transport
ISO PAR-1-activating peptide promotes the reaction [BEST1 protein results in increased transport of Iodides] CTD PMID:19828819 NCBI chr 1:206,629,340...206,646,085
Ensembl chr 1:206,629,500...206,646,063
JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase multiple interactions EXP [hexabromocyclododecane co-treated with Iodides deficiency] results in decreased expression of BHMT protein CTD PMID:26795019 NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742
JBrowse link
G Ca3 carbonic anhydrase 3 increases expression EXP Iodides deficiency results in increased expression of CA3 protein CTD PMID:26795019 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO 3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone inhibits the reaction [[[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides]; 5-butyl-6-hydroxy-10-chlorobenzo(c)quinolizinium chloride inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]; 5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]; 6-hydroxy-10-chlorobenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]; [[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Brefeldin A inhibits the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Brefeldin A inhibits the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]; fenamic acid inhibits the reaction [[[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides]; geldanamycin promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; geldanamycin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Glyburide inhibits the reaction [[[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides]; miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]; Thapsigargin promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Thapsigargin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]] CTD PMID:18230692 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 increases expression EXP Iodides deficiency results in increased expression of CPS1 protein CTD PMID:26795019 NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033
JBrowse link
G Dmgdh dimethylglycine dehydrogenase increases expression
multiple interactions
EXP Iodides deficiency results in increased expression of DMGDH protein
hexabromocyclododecane inhibits the reaction [Iodides deficiency results in increased expression of DMGDH protein]
CTD PMID:26795019 NCBI chr 2:24,912,600...24,987,533
Ensembl chr 2:24,912,578...24,987,528
JBrowse link
G Eno1 enolase 1 multiple interactions EXP [hexabromocyclododecane co-treated with Iodides deficiency] results in decreased expression of ENO1 protein CTD PMID:26795019 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
JBrowse link
G Etfb electron transfer flavoprotein subunit beta decreases expression EXP Iodides deficiency results in decreased expression of ETFB protein CTD PMID:26795019 NCBI chr 1:93,851,908...93,866,072
Ensembl chr 1:93,851,858...93,866,068
JBrowse link
G Ethe1 ETHE1, persulfide dioxygenase increases expression EXP Iodides deficiency results in increased expression of ETHE1 protein CTD PMID:26795019 NCBI chr 1:80,184,037...80,199,092
Ensembl chr 1:80,183,894...80,199,052
JBrowse link
G Fdps farnesyl diphosphate synthase decreases expression EXP Iodides deficiency results in decreased expression of FDPS protein CTD PMID:26795019 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases expression EXP Iodides deficiency results in increased expression of GOT1 protein CTD PMID:26795019 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases expression EXP Iodides deficiency results in decreased expression of GSTA1 protein CTD PMID:26795019 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases expression EXP Iodides deficiency results in decreased expression of GSTA2 protein CTD PMID:26795019 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 decreases expression EXP Iodides deficiency results in decreased expression of GSTA3 protein CTD PMID:26795019 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 decreases expression EXP Iodides deficiency results in decreased expression of GSTA4 protein CTD PMID:26795019 NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression EXP Iodides deficiency results in decreased expression of GSTP1 protein CTD PMID:26795019 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gstz1 glutathione S-transferase zeta 1 multiple interactions ISO Iodides inhibits the reaction [Dichloroacetic Acid results in decreased activity of GSTZ1 protein] CTD PMID:24632415 NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 decreases expression EXP Iodides deficiency results in decreased expression of HSP90AA1 protein CTD PMID:26795019 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression EXP Iodides deficiency results in decreased expression of HSPA5 protein CTD PMID:26795019 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 decreases expression EXP Iodides deficiency results in decreased expression of HSPA8 protein CTD PMID:26795019 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Iah1 isoamyl acetate hydrolyzing esterase 1 decreases expression EXP Iodides deficiency results in decreased expression of IAH1 protein CTD PMID:26795019 NCBI chr 6:40,865,530...40,872,747
Ensembl chr 6:40,865,502...40,872,978
JBrowse link
G Lep leptin increases expression EXP Iodides deficiency results in increased expression of LEP protein CTD PMID:26795019 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Nit1 nitrilase 1 increases expression EXP Iodides deficiency results in increased expression of NIT1 protein CTD PMID:26795019 NCBI chr13:83,769,888...83,773,324
Ensembl chr13:83,765,941...83,773,332
JBrowse link
G Ogdh oxoglutarate dehydrogenase increases expression EXP Iodides deficiency results in increased expression of OGDH protein CTD PMID:26795019 NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479
JBrowse link
G Pah phenylalanine hydroxylase increases expression EXP Iodides deficiency results in increased expression of PAH protein CTD PMID:26795019 NCBI chr 7:21,933,179...21,998,134
Ensembl chr 7:21,933,179...21,998,130
JBrowse link
G Pc pyruvate carboxylase decreases expression EXP Iodides deficiency results in decreased expression of PC protein CTD PMID:26795019 NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 decreases expression EXP Iodides deficiency results in decreased expression of PDIA3 protein CTD PMID:26795019 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236
JBrowse link
G Pon3 paraoxonase 3 decreases expression EXP Iodides deficiency results in decreased expression of PON3 protein CTD PMID:26795019 NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855
JBrowse link
G Ppia peptidylprolyl isomerase A decreases expression EXP Iodides deficiency results in decreased expression of PPIA protein CTD PMID:26795019 NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601
JBrowse link
G Qprt quinolinate phosphoribosyltransferase decreases expression EXP Iodides deficiency results in decreased expression of QPRT protein CTD PMID:26795019 NCBI chr 1:181,718,189...181,733,486
Ensembl chr 1:181,718,190...181,733,486
JBrowse link
G Sardh sarcosine dehydrogenase increases expression EXP Iodides deficiency results in increased expression of SARDH protein CTD PMID:26795019 NCBI chr 3:10,510,553...10,575,342
Ensembl chr 3:10,510,553...10,573,874
JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha multiple interactions EXP Iodides results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] CTD PMID:16027156 NCBI chr 4:158,122,962...158,146,184
Ensembl chr 4:158,122,962...158,146,181
JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta multiple interactions EXP Iodides results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] CTD PMID:16027156 NCBI chr 1:176,430,063...176,484,451
Ensembl chr 1:176,430,103...176,484,451
JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma multiple interactions EXP Iodides results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] CTD PMID:16027156 NCBI chr 1:176,304,942...176,338,816
Ensembl chr 1:176,304,942...176,338,816
JBrowse link
G Slc22a3 solute carrier family 22 member 3 affects expression EXP Iodides deficiency affects the expression of SLC22A3 mRNA CTD PMID:21623536 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
JBrowse link
G Slc26a4 solute carrier family 26 member 4 affects transport ISO SLC26A4 protein affects the transport of Iodides CTD PMID:22116359 NCBI chr 6:48,107,575...48,153,762
Ensembl chr 6:48,107,588...48,145,703
JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions
affects expression
increases uptake
ISO
EXP
Dexamethasone promotes the reaction [SLC5A5 protein results in increased uptake of Iodides]; perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Iodides]; potassium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Iodides]; thiocyanate inhibits the reaction [SLC5A5 protein results in increased uptake of Iodides]
Iodides deficiency affects the expression of SLC5A5 mRNA
CTD PMID:15671536 PMID:15850642 PMID:15941870 PMID:16234306 PMID:21623536 NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases expression EXP Iodides deficiency results in increased expression of SULT1A1 protein CTD PMID:26795019 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Tf transferrin decreases expression EXP Iodides deficiency results in decreased expression of TF protein CTD PMID:26795019 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
G Tpmt thiopurine S-methyltransferase increases expression EXP Iodides deficiency results in increased expression of TPMT protein CTD PMID:26795019 NCBI chr17:17,644,088...17,662,709
Ensembl chr17:17,644,173...17,662,709
JBrowse link
G Tpo thyroid peroxidase increases oxidation ISO TPO protein results in increased oxidation of Iodides CTD PMID:25595679 NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions
increases expression
ISO
EXP
[Iodides deficiency co-treated with perchlorate] results in increased expression of TSHB protein
Iodides deficiency results in increased expression of TSHB protein
CTD PMID:18178547 PMID:20439182 PMID:26795019 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
JBrowse link
potassium iodide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor decreases expression EXP Potassium Iodide results in decreased expression of AR mRNA CTD PMID:32593569 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Potassium Iodide results in increased expression of BAX protein CTD PMID:32593569 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP Potassium Iodide results in decreased expression of BCL2 protein CTD PMID:32593569 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions
ISO Potassium Iodide results in increased expression of BECN1 mRNA; Potassium Iodide results in increased expression of BECN1 protein
3-methyladenine inhibits the reaction [Potassium Iodide results in increased expression of BECN1 mRNA]; 3-methyladenine inhibits the reaction [Potassium Iodide results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [Potassium Iodide results in increased expression of BECN1 mRNA]; Acetylcysteine inhibits the reaction [Potassium Iodide results in increased expression of BECN1 protein]
CTD PMID:29923297 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bid BH3 interacting domain death agonist increases expression EXP Potassium Iodide results in increased expression of BID protein CTD PMID:32593569 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression EXP Potassium Iodide results in decreased expression of BIRC5 protein CTD PMID:32593569 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Casp3 caspase 3 increases expression EXP Potassium Iodide results in increased expression of CASP3 protein CTD PMID:32593569 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases expression EXP Potassium Iodide results in increased expression of CASP9 protein CTD PMID:32593569 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccnd1 cyclin D1 decreases expression EXP Potassium Iodide results in decreased expression of CCND1 protein CTD PMID:32593569 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdh1 cadherin 1 decreases expression EXP Potassium Iodide results in decreased expression of CDH1 protein CTD PMID:32593569 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 decreases expression EXP Potassium Iodide results in decreased expression of CDH2 protein CTD PMID:32593569 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression EXP Potassium Iodide results in decreased expression of CDK4 protein CTD PMID:32593569 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cldn1 claudin 1 decreases expression EXP Potassium Iodide results in decreased expression of CLDN1 mRNA CTD PMID:32593569 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
JBrowse link
G Cldn5 claudin 5 decreases expression EXP Potassium Iodide results in decreased expression of CLDN5 mRNA CTD PMID:32593569 NCBI chr11:82,212,822...82,214,248 JBrowse link
G Ctnnb1 catenin beta 1 decreases expression EXP Potassium Iodide results in decreased expression of CTNNB1 protein CTD PMID:32593569 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cxadr CXADR, Ig-like cell adhesion molecule decreases expression EXP Potassium Iodide results in decreased expression of CXADR mRNA CTD PMID:32593569 NCBI chr11:16,982,752...17,030,078
Ensembl chr11:16,982,860...17,030,046
JBrowse link
G Cycs cytochrome c, somatic increases expression EXP Potassium Iodide results in increased expression of CYCS protein CTD PMID:32593569 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO [Sodium Fluoride co-treated with Potassium Iodide] results in increased expression of DDIT3 mRNA; Potassium Iodide inhibits the reaction [Sodium Fluoride results in increased expression of DDIT3 protein]
Potassium Iodide results in increased expression of DDIT3 mRNA
CTD PMID:24231001 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO [Sodium Fluoride co-treated with Potassium Iodide] results in increased expression of ERN1 mRNA; Potassium Iodide promotes the reaction [Sodium Fluoride results in increased expression of ERN1 protein] CTD PMID:24231001 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions EXP [bisphenol A co-treated with diisopropanolnitrosamine co-treated with Potassium Iodide] results in increased expression of ESR1 protein; [Potassium Iodide co-treated with diisopropanolnitrosamine] results in increased expression of ESR1 protein CTD PMID:29050248 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G F11r F11 receptor decreases expression EXP Potassium Iodide results in decreased expression of F11R protein CTD PMID:32593569 NCBI chr13:83,873,797...83,897,388
Ensembl chr13:83,873,797...83,897,402
JBrowse link
G Fn1 fibronectin 1 decreases expression EXP Potassium Iodide results in decreased expression of FN1 mRNA CTD PMID:32593569 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fst follistatin increases expression EXP Potassium Iodide results in increased expression of FST protein CTD PMID:32593569 NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression EXP Potassium Iodide results in decreased expression of HMOX1 protein CTD PMID:32593569 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Potassium Iodide inhibits the reaction [Sodium Fluoride results in increased expression of HSPA5 mRNA]; Potassium Iodide inhibits the reaction [Sodium Fluoride results in increased expression of HSPA5 protein] CTD PMID:24231001 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression EXP Potassium Iodide results in decreased expression of ITGB1 protein CTD PMID:32593569 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression EXP Potassium Iodide results in decreased expression of KIT mRNA; Potassium Iodide results in decreased expression of KIT protein CTD PMID:32593569 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
JBrowse link
G Marveld2 MARVEL domain containing 2 decreases expression EXP Potassium Iodide results in decreased expression of MARVELD2 protein CTD PMID:32593569 NCBI chr 2:31,742,652...31,764,150 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression EXP Potassium Iodide results in decreased expression of NFE2L2 protein CTD PMID:32593569 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Ocln occludin decreases expression EXP Potassium Iodide results in decreased expression of OCLN mRNA CTD PMID:32593569 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions EXP Potassium Iodide inhibits the reaction [Propylthiouracil results in increased expression of and results in increased activity of ODC1 protein] CTD PMID:8882155 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression EXP Potassium Iodide results in increased expression of PARP1 protein modified form CTD PMID:32593569 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
decreases expression
EXP [Potassium Iodide co-treated with diisopropanolnitrosamine] results in increased expression of PCNA protein
Potassium Iodide results in decreased expression of PCNA protein
CTD PMID:29050248 PMID:32593569 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
ISO Potassium Iodide inhibits the reaction [arsenic trioxide results in increased expression of PTGS2 mRNA]; Potassium Iodide inhibits the reaction [arsenic trioxide results in increased expression of PTGS2 protein]; Potassium Iodide inhibits the reaction [monomethylarsonous acid results in increased expression of PTGS2 mRNA]
Potassium Iodide results in decreased expression of PTGS2 protein
CTD PMID:18588940 PMID:19014992 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases expression EXP Potassium Iodide results in decreased expression of PTK2 protein; Potassium Iodide results in decreased expression of PTK2 protein modified form CTD PMID:32593569 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP Potassium Iodide results in increased expression of SOD1 protein CTD PMID:32593569 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Potassium Iodide inhibits the reaction [monomethylarsonous acid results in increased expression of SOD2 protein] CTD PMID:18588940 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression
ISO 3-methyladenine inhibits the reaction [Potassium Iodide results in increased expression of SQSTM1 mRNA]; 3-methyladenine inhibits the reaction [Potassium Iodide results in increased expression of SQSTM1 protein]; Acetylcysteine inhibits the reaction [Potassium Iodide results in increased expression of SQSTM1 mRNA]; Acetylcysteine inhibits the reaction [Potassium Iodide results in increased expression of SQSTM1 protein]
Potassium Iodide results in increased expression of SQSTM1 mRNA; Potassium Iodide results in increased expression of SQSTM1 protein
CTD PMID:29923297 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO Potassium Iodide inhibits the reaction [monomethylarsonous acid results in increased phosphorylation of SRC protein] CTD PMID:18588940 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Testin testin gene decreases expression EXP Potassium Iodide results in decreased expression of TESTIN mRNA CTD PMID:32593569 NCBI chr17:3,824,222...3,859,385
Ensembl chr17:3,846,899...3,859,385
JBrowse link
G Tjp1 tight junction protein 1 decreases expression EXP Potassium Iodide results in decreased expression of TJP1 mRNA CTD PMID:32593569 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tp53 tumor protein p53 increases expression EXP Potassium Iodide results in increased expression of TP53 protein CTD PMID:32593569 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions EXP [diisopropanolnitrosamine co-treated with Potassium Iodide] results in increased expression of TSHB protein CTD PMID:29050248 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO Potassium Iodide inhibits the reaction [Sodium Fluoride results in increased splicing of XBP1 mRNA] CTD PMID:24231001 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
sodium iodide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions EXP Sodium Iodide promotes the reaction [perchlorate results in increased activity of CASP3 protein] CTD PMID:11834455 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cftr CF transmembrane conductance regulator affects export ISO CFTR protein affects the export of Sodium Iodide CTD PMID:14502435 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions
increases uptake
increases activity
increases abundance
decreases export
ISO
EXP
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid promotes the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]; dysidenin inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide analog]; mibolerone promotes the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]; Ouabain inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]; perchlorate inhibits the reaction [mibolerone promotes the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]]; perchlorate inhibits the reaction [SLC5A5 protein results in increased abundance of Sodium Iodide]; perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]; perrhenate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide analog]; potassium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]; sodium bromide inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide analog]; sodium chlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide analog]; Sodium Iodide inhibits the reaction [SLC5A5 protein results in increased uptake of perrhenate analog]; Sodium Iodide inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Pertechnetate Tc 99m]; sodium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide analog]; sodium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]; sodium thiocyanate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide analog]
Sodium Iodide results in increased activity of SLC5A5 protein
SLC5A5 protein results in decreased export of Sodium Iodide
CTD PMID:12488351 PMID:12489024 PMID:12541134 PMID:12601449 PMID:14633711 More... NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697
JBrowse link
G Tpo thyroid peroxidase multiple interactions ISO Sodium Iodide inhibits the reaction [Methimazole results in decreased activity of TPO protein] CTD PMID:7626075 NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      molecular entity 19799
        elemental molecular entity 16471
          elemental halogen 9292
            elemental iodine 136
              monoatomic iodine 105
                iodide 105
                  iodide salt + 64
                  potassium iodide 44
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        biochemical role 19368
          metabolite 19344
            eukaryotic metabolite 19033
              animal metabolite 18895
                mammalian metabolite 18895
                  human metabolite 18398
                    iodide 105
                      iodide salt + 64
                      potassium iodide 44
paths to the root