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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:iodide
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Accession:CHEBI:16382 term browser browse the term
Definition:A monoatomic iodine that has formula I.
Synonyms:exact_synonym: iodide(1-)
 related_synonym: Formula=I;   I-;   IODIDE ION;   InChI=1S/HI/h1H/p-1;   InChIKey=XMBWDFGMSWQBCA-UHFFFAOYSA-M;   SMILES=[I-];   iodine anion
 alt_id: CHEBI:14460;   CHEBI:49698;   CHEBI:5946
 xref: Beilstein:3587184;   CAS:20461-54-5;   Gmelin:14912;   KEGG:C00708;   PDBeChem:IOD
 cyclic_relationship: is_conjugate_base_of CHEBI:43451


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1,1-dimethyl-4-phenylpiperazinium iodide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions ISO Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA2 protein] CTD PMID:9454827 NCBI chr15:42,808,897...42,825,179
Ensembl chr15:42,808,897...42,825,179
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions ISO Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA3 protein] CTD PMID:9454827 NCBI chr 8:59,594,007...59,607,122
Ensembl chr 8:59,592,403...59,607,275
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO Dimethylphenylpiperazinium Iodide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA4 protein] CTD PMID:9454827 PMID:14645658 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions
increases response to substance
increases activity
ISO Dimethylphenylpiperazinium Iodide inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]
CHRNA7 protein mutant form results in increased susceptibility to Dimethylphenylpiperazinium Iodide
Dimethylphenylpiperazinium Iodide results in increased activity of CHRNA7 protein
CTD PMID:10082212 PMID:10216184 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO Dimethylphenylpiperazinium Iodide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14645658 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions ISO Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]; Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]; Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA4 protein] CTD PMID:9454827 NCBI chr 8:59,610,489...59,629,073
Ensembl chr 8:59,609,693...59,629,133
JBrowse link
G Tnf tumor necrosis factor increases activity EXP TNF results in increased activity of Dimethylphenylpiperazinium Iodide CTD PMID:15086448 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
ecothiopate iodide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Echothiophate Iodide results in decreased activity of ACHE protein CTD PMID:16978018 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Alb albumin affects binding ISO Echothiophate Iodide binds to ALB protein CTD PMID:15525694 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Bche butyrylcholinesterase decreases activity
multiple interactions
ISO Echothiophate Iodide results in decreased activity of BCHE protein
Echothiophate Iodide inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]
CTD PMID:7377577 PMID:16213467 PMID:17698511 PMID:21802514 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 decreases activity ISO Echothiophate Iodide results in decreased activity of NCEH1 protein CTD PMID:16978018 NCBI chr 2:112,868,834...112,932,622
Ensembl chr 2:112,868,707...112,934,953
JBrowse link
iodide salt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aass aminoadipate-semialdehyde synthase increases expression EXP Iodides deficiency results in increased expression of AASS protein CTD PMID:26795019 NCBI chr 4:50,152,005...50,208,935
Ensembl chr 4:50,152,452...50,200,328
JBrowse link
G Actb actin, beta decreases expression EXP Iodides deficiency results in decreased expression of ACTB protein CTD PMID:26795019 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Agxt2 alanine-glyoxylate aminotransferase 2 increases expression EXP Iodides deficiency results in increased expression of AGXT2 protein CTD PMID:26795019 NCBI chr 2:60,337,667...60,379,144
Ensembl chr 2:60,337,667...60,379,420
JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 increases expression EXP Iodides deficiency results in increased expression of AKR1D1 protein CTD PMID:26795019 NCBI chr 4:65,110,706...65,143,930
Ensembl chr 4:65,110,746...65,143,941
JBrowse link
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 increases expression EXP Iodides deficiency results in increased expression of ALDH1L1 protein CTD PMID:26795019 NCBI chr 4:123,516,553...123,564,067
Ensembl chr 4:123,516,788...123,557,501
JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 multiple interactions EXP [hexabromocyclododecane co-treated with Iodides deficiency] results in decreased expression of ALDH1L2 protein CTD PMID:26795019 NCBI chr 7:26,375,866...26,425,838
Ensembl chr 7:26,375,866...26,425,108
JBrowse link
G Apmap adipocyte plasma membrane associated protein decreases expression EXP Iodides deficiency results in decreased expression of APMAP protein CTD PMID:26795019 NCBI chr 3:146,376,828...146,407,259
Ensembl chr 3:146,376,828...146,407,252
JBrowse link
G Aqp1 aquaporin 1 affects expression EXP Iodides deficiency affects the expression of AQP1 mRNA CTD PMID:21623536 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Arg1 arginase 1 increases expression EXP Iodides deficiency results in increased expression of ARG1 protein CTD PMID:26795019 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Best1 bestrophin 1 multiple interactions
increases transport
ISO PAR-1-activating peptide promotes the reaction [BEST1 protein results in increased transport of Iodides] CTD PMID:19828819 NCBI chr 1:226,033,146...226,049,893
Ensembl chr 1:226,030,875...226,049,929
JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase multiple interactions EXP [hexabromocyclododecane co-treated with Iodides deficiency] results in decreased expression of BHMT protein CTD PMID:26795019 NCBI chr 2:23,236,573...23,256,158
Ensembl chr 2:23,236,575...23,256,158
JBrowse link
G Ca3 carbonic anhydrase 3 increases expression EXP Iodides deficiency results in increased expression of CA3 protein CTD PMID:26795019 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO 3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone inhibits the reaction [[[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides]; 5-butyl-6-hydroxy-10-chlorobenzo(c)quinolizinium chloride inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]; 5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]; 6-hydroxy-10-chlorobenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]; [[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Brefeldin A inhibits the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Brefeldin A inhibits the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]; fenamic acid inhibits the reaction [[[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides]; geldanamycin promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; geldanamycin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Glyburide inhibits the reaction [[[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides]; miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]; Thapsigargin promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Thapsigargin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]] CTD PMID:18230692 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 increases expression EXP Iodides deficiency results in increased expression of CPS1 protein CTD PMID:26795019 NCBI chr 9:74,113,437...74,236,274
Ensembl chr 9:74,124,016...74,236,274
JBrowse link
G Dmgdh dimethylglycine dehydrogenase increases expression
multiple interactions
EXP Iodides deficiency results in increased expression of DMGDH protein
hexabromocyclododecane inhibits the reaction [Iodides deficiency results in increased expression of DMGDH protein]
CTD PMID:26795019 NCBI chr 2:23,289,376...23,370,360
Ensembl chr 2:23,289,374...23,370,477
JBrowse link
G Eno1 enolase 1 multiple interactions EXP [hexabromocyclododecane co-treated with Iodides deficiency] results in decreased expression of ENO1 protein CTD PMID:26795019 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Etfb electron transfer flavoprotein subunit beta decreases expression EXP Iodides deficiency results in decreased expression of ETFB protein CTD PMID:26795019 NCBI chr 1:98,472,776...98,486,940
Ensembl chr 1:98,472,745...98,486,976
JBrowse link
G Ethe1 ETHE1, persulfide dioxygenase increases expression EXP Iodides deficiency results in increased expression of ETHE1 protein CTD PMID:26795019 NCBI chr 1:81,457,008...81,472,061
Ensembl chr 1:81,456,984...81,472,097
JBrowse link
G Fdps farnesyl diphosphate synthase decreases expression EXP Iodides deficiency results in decreased expression of FDPS protein CTD PMID:26795019 NCBI chr 2:188,403,595...188,413,219
Ensembl chr 2:188,392,858...188,413,219
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases expression EXP Iodides deficiency results in increased expression of GOT1 protein CTD PMID:26795019 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases expression EXP Iodides deficiency results in decreased expression of GSTA1 protein CTD PMID:26795019 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases expression EXP Iodides deficiency results in decreased expression of GSTA2 protein CTD PMID:26795019 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta3 glutathione S-transferase alpha 3 decreases expression EXP Iodides deficiency results in decreased expression of GSTA3 protein CTD PMID:26795019 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 decreases expression EXP Iodides deficiency results in decreased expression of GSTA4 protein CTD PMID:26795019 NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression EXP Iodides deficiency results in decreased expression of GSTP1 protein CTD PMID:26795019 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstz1 glutathione S-transferase zeta 1 multiple interactions ISO Iodides inhibits the reaction [Dichloroacetic Acid results in decreased activity of GSTZ1 protein] CTD PMID:24632415 NCBI chr 6:111,176,798...111,187,246
Ensembl chr 6:111,176,798...111,187,244
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 decreases expression EXP Iodides deficiency results in decreased expression of HSP90AA1 protein CTD PMID:26795019 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression EXP Iodides deficiency results in decreased expression of HSPA5 protein CTD PMID:26795019 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 decreases expression EXP Iodides deficiency results in decreased expression of HSPA8 protein CTD PMID:26795019 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Iah1 isoamyl acetate hydrolyzing esterase 1 decreases expression EXP Iodides deficiency results in decreased expression of IAH1 protein CTD PMID:26795019 NCBI chr 6:43,393,113...43,400,330
Ensembl chr 6:43,393,113...43,400,328
JBrowse link
G Lep leptin increases expression EXP Iodides deficiency results in increased expression of LEP protein CTD PMID:26795019 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Nit1 nitrilase 1 increases expression EXP Iodides deficiency results in increased expression of NIT1 protein CTD PMID:26795019 NCBI chr13:89,722,370...89,725,806
Ensembl chr13:89,722,374...89,725,806
JBrowse link
G Ogdh oxoglutarate dehydrogenase increases expression EXP Iodides deficiency results in increased expression of OGDH protein CTD PMID:26795019 NCBI chr14:86,414,924...86,481,903
Ensembl chr14:86,414,949...86,613,327
JBrowse link
G Pah phenylalanine hydroxylase increases expression EXP Iodides deficiency results in increased expression of PAH protein CTD PMID:26795019 NCBI chr 7:28,066,639...28,129,772
Ensembl chr 7:28,066,635...28,129,769
JBrowse link
G Pc pyruvate carboxylase decreases expression EXP Iodides deficiency results in decreased expression of PC protein CTD PMID:26795019 NCBI chr 1:219,759,157...219,859,854
Ensembl chr 1:219,759,183...219,859,848
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 decreases expression EXP Iodides deficiency results in decreased expression of PDIA3 protein CTD PMID:26795019 NCBI chr 3:113,376,983...113,400,707
Ensembl chr 3:113,376,983...113,400,707
JBrowse link
G Pon3 paraoxonase 3 decreases expression EXP Iodides deficiency results in decreased expression of PON3 protein CTD PMID:26795019 NCBI chr 4:30,311,981...30,338,679
Ensembl chr 4:30,311,982...30,338,679
JBrowse link
G Ppia peptidylprolyl isomerase A decreases expression EXP Iodides deficiency results in decreased expression of PPIA protein CTD PMID:26795019 NCBI chr14:86,673,775...86,677,443
Ensembl chr14:86,673,775...86,677,443
JBrowse link
G Qprt quinolinate phosphoribosyltransferase decreases expression EXP Iodides deficiency results in decreased expression of QPRT protein CTD PMID:26795019 NCBI chr 1:198,544,262...198,559,556
Ensembl chr 1:198,544,262...198,559,568
JBrowse link
G Sardh sarcosine dehydrogenase increases expression EXP Iodides deficiency results in increased expression of SARDH protein CTD PMID:26795019 NCBI chr 3:5,737,203...5,802,153
Ensembl chr 3:5,737,200...5,802,129
JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha multiple interactions EXP Iodides results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] CTD PMID:16027156 NCBI chr 4:157,834,339...157,860,472
Ensembl chr 4:157,836,912...157,860,049
JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta multiple interactions EXP Iodides results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] CTD PMID:16027156 NCBI chr 1:191,829,547...191,883,991
Ensembl chr 1:191,829,555...191,884,298
JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma multiple interactions EXP Iodides results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] CTD PMID:16027156 NCBI chr 1:191,704,397...191,738,271
Ensembl chr 1:191,704,311...191,738,268
JBrowse link
G Slc22a3 solute carrier family 22 member 3 affects expression EXP Iodides deficiency affects the expression of SLC22A3 mRNA CTD PMID:21623536 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Slc26a4 solute carrier family 26 member 4 affects transport ISO SLC26A4 protein affects the transport of Iodides CTD PMID:22116359 NCBI chr 6:50,809,103...50,848,443
Ensembl chr 6:50,808,923...50,846,965
JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions
affects expression
increases uptake
ISO
EXP
Dexamethasone promotes the reaction [SLC5A5 protein results in increased uptake of Iodides]; perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Iodides]; potassium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Iodides]; thiocyanate inhibits the reaction [SLC5A5 protein results in increased uptake of Iodides]
Iodides deficiency affects the expression of SLC5A5 mRNA
CTD PMID:15671536 PMID:15850642 PMID:15941870 PMID:16234306 PMID:21623536 NCBI chr16:20,297,414...20,307,401
Ensembl chr16:20,297,414...20,307,400
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases expression EXP Iodides deficiency results in increased expression of SULT1A1 protein CTD PMID:26795019 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Tf transferrin decreases expression EXP Iodides deficiency results in decreased expression of TF protein CTD PMID:26795019 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tpmt thiopurine S-methyltransferase increases expression EXP Iodides deficiency results in increased expression of TPMT protein CTD PMID:26795019 NCBI chr17:18,029,090...18,047,716
Ensembl chr17:18,029,124...18,047,714
JBrowse link
G Tpo thyroid peroxidase increases oxidation ISO TPO protein results in increased oxidation of Iodides CTD PMID:25595679 NCBI chr 6:49,020,918...49,089,855
Ensembl chr 6:49,021,044...49,089,855
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions
increases expression
ISO
EXP
[Iodides deficiency co-treated with perchlorate] results in increased expression of TSHB protein
Iodides deficiency results in increased expression of TSHB protein
CTD PMID:18178547 PMID:20439182 PMID:26795019 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link
potassium iodide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor decreases expression EXP Potassium Iodide results in decreased expression of AR mRNA CTD PMID:32593569 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Potassium Iodide results in increased expression of BAX protein CTD PMID:32593569 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP Potassium Iodide results in decreased expression of BCL2 protein CTD PMID:32593569 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions
ISO Potassium Iodide results in increased expression of BECN1 mRNA; Potassium Iodide results in increased expression of BECN1 protein
3-methyladenine inhibits the reaction [Potassium Iodide results in increased expression of BECN1 mRNA]; 3-methyladenine inhibits the reaction [Potassium Iodide results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [Potassium Iodide results in increased expression of BECN1 mRNA]; Acetylcysteine inhibits the reaction [Potassium Iodide results in increased expression of BECN1 protein]
CTD PMID:29923297 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Bid BH3 interacting domain death agonist increases expression EXP Potassium Iodide results in increased expression of BID protein CTD PMID:32593569 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression EXP Potassium Iodide results in decreased expression of BIRC5 protein CTD PMID:32593569 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Casp3 caspase 3 increases expression EXP Potassium Iodide results in increased expression of CASP3 protein CTD PMID:32593569 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases expression EXP Potassium Iodide results in increased expression of CASP9 protein CTD PMID:32593569 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccnd1 cyclin D1 decreases expression EXP Potassium Iodide results in decreased expression of CCND1 protein CTD PMID:32593569 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdh1 cadherin 1 decreases expression EXP Potassium Iodide results in decreased expression of CDH1 protein CTD PMID:32593569 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh2 cadherin 2 decreases expression EXP Potassium Iodide results in decreased expression of CDH2 protein CTD PMID:32593569 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression EXP Potassium Iodide results in decreased expression of CDK4 protein CTD PMID:32593569 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cldn1 claudin 1 decreases expression EXP Potassium Iodide results in decreased expression of CLDN1 mRNA CTD PMID:32593569 NCBI chr11:77,815,216...77,830,373
Ensembl chr11:77,815,181...77,830,416
JBrowse link
G Cldn5 claudin 5 decreases expression EXP Potassium Iodide results in decreased expression of CLDN5 mRNA CTD PMID:32593569 NCBI chr11:86,356,292...86,357,718
Ensembl chr11:86,356,294...86,357,718
JBrowse link
G Ctnnb1 catenin beta 1 decreases expression EXP Potassium Iodide results in decreased expression of CTNNB1 protein CTD PMID:32593569 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cxadr CXADR, Ig-like cell adhesion molecule decreases expression EXP Potassium Iodide results in decreased expression of CXADR mRNA CTD PMID:32593569 NCBI chr11:16,826,269...16,873,564
Ensembl chr11:16,826,399...16,873,562
JBrowse link
G Cycs cytochrome c, somatic increases expression EXP Potassium Iodide results in increased expression of CYCS protein CTD PMID:32593569 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO [Sodium Fluoride co-treated with Potassium Iodide] results in increased expression of DDIT3 mRNA; Potassium Iodide inhibits the reaction [Sodium Fluoride results in increased expression of DDIT3 protein]
Potassium Iodide results in increased expression of DDIT3 mRNA
CTD PMID:24231001 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO [Sodium Fluoride co-treated with Potassium Iodide] results in increased expression of ERN1 mRNA; Potassium Iodide promotes the reaction [Sodium Fluoride results in increased expression of ERN1 protein] CTD PMID:24231001 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions EXP [bisphenol A co-treated with diisopropanolnitrosamine co-treated with Potassium Iodide] results in increased expression of ESR1 protein; [Potassium Iodide co-treated with diisopropanolnitrosamine] results in increased expression of ESR1 protein CTD PMID:29050248 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G F11r F11 receptor decreases expression EXP Potassium Iodide results in decreased expression of F11R protein CTD PMID:32593569 NCBI chr13:89,826,272...89,850,151
Ensembl chr13:89,826,254...89,850,612
JBrowse link
G Fn1 fibronectin 1 decreases expression EXP Potassium Iodide results in decreased expression of FN1 mRNA CTD PMID:32593569 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fst follistatin increases expression EXP Potassium Iodide results in increased expression of FST protein CTD PMID:32593569 NCBI chr 2:46,537,589...46,544,813
Ensembl chr 2:46,538,700...46,544,457
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression EXP Potassium Iodide results in decreased expression of HMOX1 protein CTD PMID:32593569 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Potassium Iodide inhibits the reaction [Sodium Fluoride results in increased expression of HSPA5 mRNA]; Potassium Iodide inhibits the reaction [Sodium Fluoride results in increased expression of HSPA5 protein] CTD PMID:24231001 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression EXP Potassium Iodide results in decreased expression of ITGB1 protein CTD PMID:32593569 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression EXP Potassium Iodide results in decreased expression of KIT mRNA; Potassium Iodide results in decreased expression of KIT protein CTD PMID:32593569 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610
JBrowse link
G Marveld2 MARVEL domain containing 2 decreases expression EXP Potassium Iodide results in decreased expression of MARVELD2 protein CTD PMID:32593569 NCBI chr 2:30,612,746...30,634,308
Ensembl chr 2:30,612,106...30,634,243
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases expression EXP Potassium Iodide results in decreased expression of NFE2L2 protein CTD PMID:32593569 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Ocln occludin decreases expression EXP Potassium Iodide results in decreased expression of OCLN mRNA CTD PMID:32593569 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions EXP Potassium Iodide inhibits the reaction [Propylthiouracil results in increased expression of and results in increased activity of ODC1 protein] CTD PMID:8882155 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression EXP Potassium Iodide results in increased expression of PARP1 protein modified form CTD PMID:32593569 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
decreases expression
EXP [Potassium Iodide co-treated with diisopropanolnitrosamine] results in increased expression of PCNA protein
Potassium Iodide results in decreased expression of PCNA protein
CTD PMID:29050248 PMID:32593569 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
ISO Potassium Iodide inhibits the reaction [arsenic trioxide results in increased expression of PTGS2 mRNA]; Potassium Iodide inhibits the reaction [arsenic trioxide results in increased expression of PTGS2 protein]; Potassium Iodide inhibits the reaction [monomethylarsonous acid results in increased expression of PTGS2 mRNA]
Potassium Iodide results in decreased expression of PTGS2 protein
CTD PMID:18588940 PMID:19014992 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases expression EXP Potassium Iodide results in decreased expression of PTK2 protein; Potassium Iodide results in decreased expression of PTK2 protein modified form CTD PMID:32593569 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP Potassium Iodide results in increased expression of SOD1 protein CTD PMID:32593569 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Potassium Iodide inhibits the reaction [monomethylarsonous acid results in increased expression of SOD2 protein] CTD PMID:18588940 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression
ISO 3-methyladenine inhibits the reaction [Potassium Iodide results in increased expression of SQSTM1 mRNA]; 3-methyladenine inhibits the reaction [Potassium Iodide results in increased expression of SQSTM1 protein]; Acetylcysteine inhibits the reaction [Potassium Iodide results in increased expression of SQSTM1 mRNA]; Acetylcysteine inhibits the reaction [Potassium Iodide results in increased expression of SQSTM1 protein]
Potassium Iodide results in increased expression of SQSTM1 mRNA; Potassium Iodide results in increased expression of SQSTM1 protein
CTD PMID:29923297 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO Potassium Iodide inhibits the reaction [monomethylarsonous acid results in increased phosphorylation of SRC protein] CTD PMID:18588940 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Testin testin gene decreases expression EXP Potassium Iodide results in decreased expression of TESTIN mRNA CTD PMID:32593569 NCBI chr17:4,194,796...4,225,376
Ensembl chr17:4,212,890...4,225,376
JBrowse link
G Tjp1 tight junction protein 1 decreases expression EXP Potassium Iodide results in decreased expression of TJP1 mRNA CTD PMID:32593569 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tp53 tumor protein p53 increases expression EXP Potassium Iodide results in increased expression of TP53 protein CTD PMID:32593569 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions EXP [diisopropanolnitrosamine co-treated with Potassium Iodide] results in increased expression of TSHB protein CTD PMID:29050248 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO Potassium Iodide inhibits the reaction [Sodium Fluoride results in increased splicing of XBP1 mRNA] CTD PMID:24231001 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
sodium iodide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions EXP Sodium Iodide promotes the reaction [perchlorate results in increased activity of CASP3 protein] CTD PMID:11834455 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cftr CF transmembrane conductance regulator affects export ISO CFTR protein affects the export of Sodium Iodide CTD PMID:14502435 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions
increases uptake
increases activity
increases abundance
decreases export
ISO
EXP
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid promotes the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]; dysidenin inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide analog]; mibolerone promotes the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]; Ouabain inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]; perchlorate inhibits the reaction [mibolerone promotes the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]]; perchlorate inhibits the reaction [SLC5A5 protein results in increased abundance of Sodium Iodide]; perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]; perrhenate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide analog]; potassium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]; sodium bromide inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide analog]; sodium chlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide analog]; Sodium Iodide inhibits the reaction [SLC5A5 protein results in increased uptake of perrhenate analog]; Sodium Iodide inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Pertechnetate Tc 99m]; sodium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide analog]; sodium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]; sodium thiocyanate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide analog]
Sodium Iodide results in increased activity of SLC5A5 protein
SLC5A5 protein results in decreased export of Sodium Iodide
CTD PMID:12488351 PMID:12489024 PMID:12541134 PMID:12601449 PMID:14633711 PMID:15347726 PMID:15520214 PMID:15522214 PMID:16987991 PMID:17611400 NCBI chr16:20,297,414...20,307,401
Ensembl chr16:20,297,414...20,307,400
JBrowse link
G Tpo thyroid peroxidase multiple interactions ISO Sodium Iodide inhibits the reaction [Methimazole results in decreased activity of TPO protein] CTD PMID:7626075 NCBI chr 6:49,020,918...49,089,855
Ensembl chr 6:49,021,044...49,089,855
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19841
      molecular entity 19839
        elemental molecular entity 16264
          elemental halogen 9255
            elemental iodine 136
              monoatomic iodine 104
                iodide 104
                  iodide salt + 63
                  potassium iodide 44
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      biological role 19792
        biochemical role 19328
          metabolite 19308
            eukaryotic metabolite 18965
              animal metabolite 18770
                mammalian metabolite 18769
                  human metabolite 18267
                    iodide 104
                      iodide salt + 63
                      potassium iodide 44
paths to the root