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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:monoatomic iodine
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Accession:CHEBI:36897 term browser browse the term
Synonyms:related_synonym: Formula=I;   atomic iodine


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1,1-dimethyl-4-phenylpiperazinium iodide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions ISO
EXP
Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]
1,1-dimethyl-4-phenylpiperazinium iodide affects binding competes with [Epibatidine binds to Chrna2 protein]
CTD PMID:9454827 PMID:15016836 RGD:2303194 NCBI chr15:40,342,317...40,358,601
Ensembl chr15:40,342,317...40,358,601
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions ISO
EXP
Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]
1,1-dimethyl-4-phenylpiperazinium iodide affects binding [Epibatidine binds to Chrna3 protein]
CTD PMID:9454827 PMID:15016836 RGD:2303194 NCBI chr 8:55,401,981...55,415,012
Ensembl chr 8:55,401,702...55,415,165
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO
EXP
Dimethylphenylpiperazinium Iodide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]
1,1-dimethyl-4-phenylpiperazinium iodide affects binding to Chrna4 protein; 1,1-dimethyl-4-phenylpiperazinium iodide competes with [Epibatidine binds to Chrna4 protein]
CTD PMID:9454827 PMID:14645658 PMID:15016836 RGD:2303194 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions
increases response to substance
increases activity
ISO Dimethylphenylpiperazinium Iodide inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]
CHRNA7 protein mutant form results in increased susceptibility to Dimethylphenylpiperazinium Iodide
Dimethylphenylpiperazinium Iodide results in increased activity of CHRNA7 protein
CTD PMID:10082212 PMID:10216184 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO
EXP
Dimethylphenylpiperazinium Iodide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]
1,1-dimethyl-4-phenylpiperazinium iodide affects binding to Chrnb2 protein; 1,1-dimethyl-4-phenylpiperazinium iodide competes with [Epibatidine binds to Chrnb2 protein]
CTD PMID:14645658 PMID:15016836 RGD:2303194 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions ISO Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]; Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]; Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA4 protein] CTD PMID:9454827 NCBI chr 8:55,418,379...55,436,967
Ensembl chr 8:55,418,313...55,437,027
JBrowse link
G Tnf tumor necrosis factor increases activity EXP TNF results in increased activity of Dimethylphenylpiperazinium Iodide CTD PMID:15086448 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
4-DAMP methiodide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm3 cholinergic receptor, muscarinic 3 affects binding IDA 4-DAMP methiodide inhibits response to acetylcholine in rat aortic rings RGD PMID:8075871 RGD:2303390 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
JBrowse link
ecothiopate iodide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Echothiophate Iodide results in decreased activity of ACHE protein CTD PMID:16978018 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Alb albumin affects binding ISO Echothiophate Iodide binds to ALB protein CTD PMID:15525694 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Bche butyrylcholinesterase decreases activity
multiple interactions
ISO Echothiophate Iodide results in decreased activity of BCHE protein
Echothiophate Iodide inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]
CTD PMID:7377577 PMID:16213467 PMID:17698511 PMID:21802514 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 decreases activity ISO Echothiophate Iodide results in decreased activity of NCEH1 protein CTD PMID:16978018 NCBI chr 2:110,074,985...110,135,592
Ensembl chr 2:110,074,957...110,135,588
JBrowse link
iodide salt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aass aminoadipate-semialdehyde synthase increases expression EXP Iodides deficiency results in increased expression of AASS protein CTD PMID:26795019 NCBI chr 4:51,606,461...51,663,136
Ensembl chr 4:51,606,462...51,663,136
JBrowse link
G Actb actin, beta decreases expression EXP Iodides deficiency results in decreased expression of ACTB protein CTD PMID:26795019 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
JBrowse link
G Agxt2 alanine-glyoxylate aminotransferase 2 increases expression EXP Iodides deficiency results in increased expression of AGXT2 protein CTD PMID:26795019 NCBI chr 2:59,336,252...59,377,664
Ensembl chr 2:59,336,283...59,377,926
JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 increases expression EXP Iodides deficiency results in increased expression of AKR1D1 protein CTD PMID:26795019 NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372
JBrowse link
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 increases expression EXP Iodides deficiency results in increased expression of ALDH1L1 protein CTD PMID:26795019 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465
JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 multiple interactions EXP [hexabromocyclododecane co-treated with Iodides deficiency] results in decreased expression of ALDH1L2 protein CTD PMID:26795019 NCBI chr 7:20,254,196...20,305,793
Ensembl chr 7:20,254,233...20,305,776
JBrowse link
G Apmap adipocyte plasma membrane associated protein decreases expression EXP Iodides deficiency results in decreased expression of APMAP protein CTD PMID:26795019 NCBI chr 3:139,409,020...139,437,296
Ensembl chr 3:139,409,022...139,437,341
JBrowse link
G Aqp1 aquaporin 1 affects expression EXP Iodides deficiency affects the expression of AQP1 mRNA CTD PMID:21623536 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
JBrowse link
G Arg1 arginase 1 increases expression EXP Iodides deficiency results in increased expression of ARG1 protein CTD PMID:26795019 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Best1 bestrophin 1 multiple interactions
increases transport
ISO PAR-1-activating peptide promotes the reaction [BEST1 protein results in increased transport of Iodides] CTD PMID:19828819 NCBI chr 1:206,629,340...206,646,085
Ensembl chr 1:206,629,500...206,646,063
JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase multiple interactions EXP [hexabromocyclododecane co-treated with Iodides deficiency] results in decreased expression of BHMT protein CTD PMID:26795019 NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742
JBrowse link
G Ca3 carbonic anhydrase 3 increases expression EXP Iodides deficiency results in increased expression of CA3 protein CTD PMID:26795019 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO 3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone inhibits the reaction [[[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides]; 5-butyl-6-hydroxy-10-chlorobenzo(c)quinolizinium chloride inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]; 5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]; 6-hydroxy-10-chlorobenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]; [[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Brefeldin A inhibits the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Brefeldin A inhibits the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]; fenamic acid inhibits the reaction [[[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides]; geldanamycin promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; geldanamycin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Glyburide inhibits the reaction [[[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides]; miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]; Thapsigargin promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Thapsigargin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]] CTD PMID:18230692 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 increases expression EXP Iodides deficiency results in increased expression of CPS1 protein CTD PMID:26795019 NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033
JBrowse link
G Dmgdh dimethylglycine dehydrogenase increases expression
multiple interactions
EXP Iodides deficiency results in increased expression of DMGDH protein
hexabromocyclododecane inhibits the reaction [Iodides deficiency results in increased expression of DMGDH protein]
CTD PMID:26795019 NCBI chr 2:24,912,600...24,987,533
Ensembl chr 2:24,912,578...24,987,528
JBrowse link
G Eno1 enolase 1 multiple interactions EXP [hexabromocyclododecane co-treated with Iodides deficiency] results in decreased expression of ENO1 protein CTD PMID:26795019 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
JBrowse link
G Etfb electron transfer flavoprotein subunit beta decreases expression EXP Iodides deficiency results in decreased expression of ETFB protein CTD PMID:26795019 NCBI chr 1:93,851,908...93,866,072
Ensembl chr 1:93,851,858...93,866,068
JBrowse link
G Ethe1 ETHE1, persulfide dioxygenase increases expression EXP Iodides deficiency results in increased expression of ETHE1 protein CTD PMID:26795019 NCBI chr 1:80,184,037...80,199,092
Ensembl chr 1:80,183,894...80,199,052
JBrowse link
G Fdps farnesyl diphosphate synthase decreases expression EXP Iodides deficiency results in decreased expression of FDPS protein CTD PMID:26795019 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases expression EXP Iodides deficiency results in increased expression of GOT1 protein CTD PMID:26795019 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases expression EXP Iodides deficiency results in decreased expression of GSTA1 protein CTD PMID:26795019 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases expression EXP Iodides deficiency results in decreased expression of GSTA2 protein CTD PMID:26795019 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 decreases expression EXP Iodides deficiency results in decreased expression of GSTA3 protein CTD PMID:26795019 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 decreases expression EXP Iodides deficiency results in decreased expression of GSTA4 protein CTD PMID:26795019 NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression EXP Iodides deficiency results in decreased expression of GSTP1 protein CTD PMID:26795019 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gstz1 glutathione S-transferase zeta 1 multiple interactions ISO Iodides inhibits the reaction [Dichloroacetic Acid results in decreased activity of GSTZ1 protein] CTD PMID:24632415 NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 decreases expression EXP Iodides deficiency results in decreased expression of HSP90AA1 protein CTD PMID:26795019 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression EXP Iodides deficiency results in decreased expression of HSPA5 protein CTD PMID:26795019 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 decreases expression EXP Iodides deficiency results in decreased expression of HSPA8 protein CTD PMID:26795019 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Iah1 isoamyl acetate hydrolyzing esterase 1 decreases expression EXP Iodides deficiency results in decreased expression of IAH1 protein CTD PMID:26795019 NCBI chr 6:40,865,530...40,872,747
Ensembl chr 6:40,865,502...40,872,978
JBrowse link
G Lep leptin increases expression EXP Iodides deficiency results in increased expression of LEP protein CTD PMID:26795019 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Nit1 nitrilase 1 increases expression EXP Iodides deficiency results in increased expression of NIT1 protein CTD PMID:26795019 NCBI chr13:83,769,888...83,773,324
Ensembl chr13:83,765,941...83,773,332
JBrowse link
G Ogdh oxoglutarate dehydrogenase increases expression EXP Iodides deficiency results in increased expression of OGDH protein CTD PMID:26795019 NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479
JBrowse link
G Pah phenylalanine hydroxylase increases expression EXP Iodides deficiency results in increased expression of PAH protein CTD PMID:26795019 NCBI chr 7:21,933,179...21,998,134
Ensembl chr 7:21,933,179...21,998,130
JBrowse link
G Pc pyruvate carboxylase decreases expression EXP Iodides deficiency results in decreased expression of PC protein CTD PMID:26795019 NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 decreases expression EXP Iodides deficiency results in decreased expression of PDIA3 protein CTD PMID:26795019 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236
JBrowse link
G Pon3 paraoxonase 3 decreases expression EXP Iodides deficiency results in decreased expression of PON3 protein CTD PMID:26795019 NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855
JBrowse link
G Ppia peptidylprolyl isomerase A decreases expression EXP Iodides deficiency results in decreased expression of PPIA protein CTD PMID:26795019 NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601
JBrowse link
G Qprt quinolinate phosphoribosyltransferase decreases expression EXP Iodides deficiency results in decreased expression of QPRT protein CTD PMID:26795019 NCBI chr 1:181,718,189...181,733,486
Ensembl chr 1:181,718,190...181,733,486
JBrowse link
G Sardh sarcosine dehydrogenase increases expression EXP Iodides deficiency results in increased expression of SARDH protein CTD PMID:26795019 NCBI chr 3:10,510,553...10,575,342
Ensembl chr 3:10,510,553...10,573,874
JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha multiple interactions EXP Iodides results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] CTD PMID:16027156 NCBI chr 4:158,122,962...158,146,184
Ensembl chr 4:158,122,962...158,146,181
JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta multiple interactions EXP Iodides results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] CTD PMID:16027156 NCBI chr 1:176,430,063...176,484,451
Ensembl chr 1:176,430,103...176,484,451
JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma multiple interactions EXP Iodides results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] CTD PMID:16027156 NCBI chr 1:176,304,942...176,338,816
Ensembl chr 1:176,304,942...176,338,816
JBrowse link
G Slc22a3 solute carrier family 22 member 3 affects expression EXP Iodides deficiency affects the expression of SLC22A3 mRNA CTD PMID:21623536 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
JBrowse link
G Slc26a4 solute carrier family 26 member 4 affects transport ISO SLC26A4 protein affects the transport of Iodides CTD PMID:22116359 NCBI chr 6:48,107,575...48,153,762
Ensembl chr 6:48,107,588...48,145,703
JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions
affects expression
increases uptake
ISO
EXP
Dexamethasone promotes the reaction [SLC5A5 protein results in increased uptake of Iodides]; perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Iodides]; potassium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Iodides]; thiocyanate inhibits the reaction [SLC5A5 protein results in increased uptake of Iodides]
Iodides deficiency affects the expression of SLC5A5 mRNA
CTD PMID:15671536 PMID:15850642 PMID:15941870 PMID:16234306 PMID:21623536 NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases expression EXP Iodides deficiency results in increased expression of SULT1A1 protein CTD PMID:26795019 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Tf transferrin decreases expression EXP Iodides deficiency results in decreased expression of TF protein CTD PMID:26795019 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
G Tpmt thiopurine S-methyltransferase increases expression EXP Iodides deficiency results in increased expression of TPMT protein CTD PMID:26795019 NCBI chr17:17,644,088...17,662,709
Ensembl chr17:17,644,173...17,662,709
JBrowse link
G Tpo thyroid peroxidase increases oxidation ISO TPO protein results in increased oxidation of Iodides CTD PMID:25595679 NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions
increases expression
ISO
EXP
[Iodides deficiency co-treated with perchlorate] results in increased expression of TSHB protein
Iodides deficiency results in increased expression of TSHB protein
CTD PMID:18178547 PMID:20439182 PMID:26795019 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
JBrowse link
potassium iodide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor decreases expression EXP Potassium Iodide results in decreased expression of AR mRNA CTD PMID:32593569 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Potassium Iodide results in increased expression of BAX protein CTD PMID:32593569 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP Potassium Iodide results in decreased expression of BCL2 protein CTD PMID:32593569 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions
ISO Potassium Iodide results in increased expression of BECN1 mRNA; Potassium Iodide results in increased expression of BECN1 protein
3-methyladenine inhibits the reaction [Potassium Iodide results in increased expression of BECN1 mRNA]; 3-methyladenine inhibits the reaction [Potassium Iodide results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [Potassium Iodide results in increased expression of BECN1 mRNA]; Acetylcysteine inhibits the reaction [Potassium Iodide results in increased expression of BECN1 protein]
CTD PMID:29923297 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bid BH3 interacting domain death agonist increases expression EXP Potassium Iodide results in increased expression of BID protein CTD PMID:32593569 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression EXP Potassium Iodide results in decreased expression of BIRC5 protein CTD PMID:32593569 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Casp3 caspase 3 increases expression EXP Potassium Iodide results in increased expression of CASP3 protein CTD PMID:32593569 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases expression EXP Potassium Iodide results in increased expression of CASP9 protein CTD PMID:32593569 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccnd1 cyclin D1 decreases expression EXP Potassium Iodide results in decreased expression of CCND1 protein CTD PMID:32593569 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdh1 cadherin 1 decreases expression EXP Potassium Iodide results in decreased expression of CDH1 protein CTD PMID:32593569 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 decreases expression EXP Potassium Iodide results in decreased expression of CDH2 protein CTD PMID:32593569 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression EXP Potassium Iodide results in decreased expression of CDK4 protein CTD PMID:32593569 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cldn1 claudin 1 decreases expression EXP Potassium Iodide results in decreased expression of CLDN1 mRNA CTD PMID:32593569 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
JBrowse link
G Cldn5 claudin 5 decreases expression EXP Potassium Iodide results in decreased expression of CLDN5 mRNA CTD PMID:32593569 NCBI chr11:82,212,822...82,214,248 JBrowse link
G Ctnnb1 catenin beta 1 decreases expression EXP Potassium Iodide results in decreased expression of CTNNB1 protein CTD PMID:32593569 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cxadr CXADR, Ig-like cell adhesion molecule decreases expression EXP Potassium Iodide results in decreased expression of CXADR mRNA CTD PMID:32593569 NCBI chr11:16,982,752...17,030,078
Ensembl chr11:16,982,860...17,030,046
JBrowse link
G Cycs cytochrome c, somatic increases expression EXP Potassium Iodide results in increased expression of CYCS protein CTD PMID:32593569 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO [Sodium Fluoride co-treated with Potassium Iodide] results in increased expression of DDIT3 mRNA; Potassium Iodide inhibits the reaction [Sodium Fluoride results in increased expression of DDIT3 protein]
Potassium Iodide results in increased expression of DDIT3 mRNA
CTD PMID:24231001 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO [Sodium Fluoride co-treated with Potassium Iodide] results in increased expression of ERN1 mRNA; Potassium Iodide promotes the reaction [Sodium Fluoride results in increased expression of ERN1 protein] CTD PMID:24231001 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions EXP [bisphenol A co-treated with diisopropanolnitrosamine co-treated with Potassium Iodide] results in increased expression of ESR1 protein; [Potassium Iodide co-treated with diisopropanolnitrosamine] results in increased expression of ESR1 protein CTD PMID:29050248 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G F11r F11 receptor decreases expression EXP Potassium Iodide results in decreased expression of F11R protein CTD PMID:32593569 NCBI chr13:83,873,797...83,897,388
Ensembl chr13:83,873,797...83,897,402
JBrowse link
G Fn1 fibronectin 1 decreases expression EXP Potassium Iodide results in decreased expression of FN1 mRNA CTD PMID:32593569 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fst follistatin increases expression EXP Potassium Iodide results in increased expression of FST protein CTD PMID:32593569 NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression EXP Potassium Iodide results in decreased expression of HMOX1 protein CTD PMID:32593569 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Potassium Iodide inhibits the reaction [Sodium Fluoride results in increased expression of HSPA5 mRNA]; Potassium Iodide inhibits the reaction [Sodium Fluoride results in increased expression of HSPA5 protein] CTD PMID:24231001 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression EXP Potassium Iodide results in decreased expression of ITGB1 protein CTD PMID:32593569 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression EXP Potassium Iodide results in decreased expression of KIT mRNA; Potassium Iodide results in decreased expression of KIT protein CTD PMID:32593569 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
JBrowse link
G Marveld2 MARVEL domain containing 2 decreases expression EXP Potassium Iodide results in decreased expression of MARVELD2 protein CTD PMID:32593569 NCBI chr 2:31,742,652...31,764,150 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases expression EXP Potassium Iodide results in decreased expression of NFE2L2 protein CTD PMID:32593569 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Ocln occludin decreases expression EXP Potassium Iodide results in decreased expression of OCLN mRNA CTD PMID:32593569 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions EXP Potassium Iodide inhibits the reaction [Propylthiouracil results in increased expression of and results in increased activity of ODC1 protein] CTD PMID:8882155 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression EXP Potassium Iodide results in increased expression of PARP1 protein modified form CTD PMID:32593569 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
decreases expression
EXP [Potassium Iodide co-treated with diisopropanolnitrosamine] results in increased expression of PCNA protein
Potassium Iodide results in decreased expression of PCNA protein
CTD PMID:29050248 PMID:32593569 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
ISO Potassium Iodide inhibits the reaction [arsenic trioxide results in increased expression of PTGS2 mRNA]; Potassium Iodide inhibits the reaction [arsenic trioxide results in increased expression of PTGS2 protein]; Potassium Iodide inhibits the reaction [monomethylarsonous acid results in increased expression of PTGS2 mRNA]
Potassium Iodide results in decreased expression of PTGS2 protein
CTD PMID:18588940 PMID:19014992 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases expression EXP Potassium Iodide results in decreased expression of PTK2 protein; Potassium Iodide results in decreased expression of PTK2 protein modified form CTD PMID:32593569 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP Potassium Iodide results in increased expression of SOD1 protein CTD PMID:32593569 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Potassium Iodide inhibits the reaction [monomethylarsonous acid results in increased expression of SOD2 protein] CTD PMID:18588940 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression
ISO 3-methyladenine inhibits the reaction [Potassium Iodide results in increased expression of SQSTM1 mRNA]; 3-methyladenine inhibits the reaction [Potassium Iodide results in increased expression of SQSTM1 protein]; Acetylcysteine inhibits the reaction [Potassium Iodide results in increased expression of SQSTM1 mRNA]; Acetylcysteine inhibits the reaction [Potassium Iodide results in increased expression of SQSTM1 protein]
Potassium Iodide results in increased expression of SQSTM1 mRNA; Potassium Iodide results in increased expression of SQSTM1 protein
CTD PMID:29923297 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO Potassium Iodide inhibits the reaction [monomethylarsonous acid results in increased phosphorylation of SRC protein] CTD PMID:18588940 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Testin testin gene decreases expression EXP Potassium Iodide results in decreased expression of TESTIN mRNA CTD PMID:32593569 NCBI chr17:3,824,222...3,859,385
Ensembl chr17:3,846,899...3,859,385
JBrowse link
G Tjp1 tight junction protein 1 decreases expression EXP Potassium Iodide results in decreased expression of TJP1 mRNA CTD PMID:32593569 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tp53 tumor protein p53 increases expression EXP Potassium Iodide results in increased expression of TP53 protein CTD PMID:32593569 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions EXP [diisopropanolnitrosamine co-treated with Potassium Iodide] results in increased expression of TSHB protein CTD PMID:29050248 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO Potassium Iodide inhibits the reaction [Sodium Fluoride results in increased splicing of XBP1 mRNA] CTD PMID:24231001 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
sodium iodide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions EXP Sodium Iodide promotes the reaction [perchlorate results in increased activity of CASP3 protein] CTD PMID:11834455 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cftr CF transmembrane conductance regulator affects export ISO CFTR protein affects the export of Sodium Iodide CTD PMID:14502435 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions
increases uptake
increases activity
increases abundance
decreases export
ISO
EXP
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid promotes the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]; dysidenin inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide analog]; mibolerone promotes the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]; Ouabain inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]; perchlorate inhibits the reaction [mibolerone promotes the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]]; perchlorate inhibits the reaction [SLC5A5 protein results in increased abundance of Sodium Iodide]; perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]; perrhenate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide analog]; potassium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]; sodium bromide inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide analog]; sodium chlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide analog]; Sodium Iodide inhibits the reaction [SLC5A5 protein results in increased uptake of perrhenate analog]; Sodium Iodide inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Pertechnetate Tc 99m]; sodium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide analog]; sodium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]; sodium thiocyanate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide analog]
Sodium Iodide results in increased activity of SLC5A5 protein
SLC5A5 protein results in decreased export of Sodium Iodide
CTD PMID:12488351 PMID:12489024 PMID:12541134 PMID:12601449 PMID:14633711 More... NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697
JBrowse link
G Tpo thyroid peroxidase multiple interactions ISO Sodium Iodide inhibits the reaction [Methimazole results in decreased activity of TPO protein] CTD PMID:7626075 NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19812
    chemical entity 19812
      molecular entity 19811
        elemental molecular entity 16307
          elemental halogen 9285
            elemental iodine 136
              monoatomic iodine 105
                iodide + 105
                iodine(.) 0
                iodine(1+) 0
paths to the root