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Gene: Best1 (bestrophin 1) Rattus norvegicus
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Symbol: Best1
Name: bestrophin 1
Description: Predicted to have chloride channel activity and identical protein binding activity. Predicted to be involved in detection of light stimulus involved in visual perception; regulation of calcium ion transport; and transepithelial chloride transport. Predicted to localize to the basolateral plasma membrane and chloride channel complex. Human ortholog(s) of this gene implicated in bestrophinopathy; macular degeneration; retinitis pigmentosa 50; and vitelliform macular dystrophy. Orthologous to human BEST1 (bestrophin 1); PARTICIPATES IN retinitis pigmentosa pathway; INTERACTS WITH acrylamide; bisphenol A; copper atom.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: bestrophin-1; LOC293735; vitelliform macular dystrophy (Best disease, bestrophin); vitelliform macular dystrophy 2 homolog; vitelliform macular dystrophy 2 homolog (human); Vmd2
Orthologs:
Homo sapiens (human) : BEST1 (bestrophin 1)  HGNC  Alliance
Mus musculus (house mouse) : Best1 (bestrophin 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Best1 (bestrophin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : BEST1 (bestrophin 1)
Canis lupus familiaris (dog) : BEST1 (bestrophin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Best1 (bestrophin 1)
Sus scrofa (pig) : BEST1 (bestrophin 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01226,033,146 - 226,049,893 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1226,030,875 - 226,049,929 (-)Ensembl
Rnor_5.01232,981,264 - 232,998,090 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41212,432,811 - 212,449,374 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11212,591,240 - 212,607,804 (-)NCBI
Celera1204,125,034 - 204,141,598 (-)NCBICelera
Cytogenetic Map1q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Best1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1311656
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.