Slc26a4 (solute carrier family 26 member 4) - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Slc26a4 (solute carrier family 26 member 4) Rattus norvegicus
Analyze
Symbol: Slc26a4
Name: solute carrier family 26 member 4
RGD ID: 3293
Description: Enables chloride:bicarbonate antiporter activity and iodide transmembrane transporter activity. Involved in inorganic anion transport. Located in apical plasma membrane. Human ortholog(s) of this gene implicated in Pendred Syndrome; autosomal recessive nonsyndromic deafness 4; and goiter. Orthologous to human SLC26A4 (solute carrier family 26 member 4); PARTICIPATES IN thyroid hormone biosynthetic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; amiloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Pds; Pendred syndrome homolog; pendred syndrome homolog (human); pendrin; sodium-independent chloride/iodide transporter; solute carrier family 26 (anion exchanger), member 4; solute carrier family 26, member 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2648,107,575 - 48,153,762 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl648,107,588 - 48,145,703 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx648,413,592 - 48,453,234 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0648,728,513 - 48,768,155 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0648,168,792 - 48,208,193 (-)NCBIRnor_WKY
Rnor_6.0650,809,103 - 50,848,443 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl650,808,923 - 50,846,965 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0659,479,842 - 59,520,531 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4649,389,212 - 49,427,000 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1649,392,337 - 49,430,126 (-)NCBI
Celera647,310,126 - 47,347,924 (-)NCBICelera
Cytogenetic Map6q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
aflatoxin B1  (ISO)
amiloride  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP,ISO)
ceric oxide  (ISO)
chloroprene  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
dibenzo[a,l]pyrene  (ISO)
diiodine  (EXP)
formic acid  (ISO)
fulvestrant  (ISO)
furosemide  (EXP)
gentamycin  (EXP)
graphene oxide  (ISO)
iodide salt  (ISO)
manganese(II) chloride  (EXP)
monosodium L-glutamate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (EXP)
nickel atom  (ISO)
omega-6 fatty acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perchlorate  (EXP)
phenobarbital  (ISO)
potassium bromate  (EXP)
progesterone  (ISO)
quartz  (EXP)
rifampicin  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
sodium nitrate  (EXP)
testosterone  (EXP)
tetraphene  (ISO)
titanium dioxide  (EXP,ISO)
trimellitic anhydride  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. SLC26A4 gene is frequently involved in nonsyndromic hearing impairment with enlarged vestibular aqueduct in Caucasian populations. Albert S, etal., Eur J Hum Genet. 2006 Jun;14(6):773-9.
2. Screening of SLC26A4 (PDS) gene in Pendred's syndrome: a large spectrum of mutations in France and phenotypic heterogeneity. Blons H, etal., Clin Genet. 2004 Oct;66(4):333-40.
3. Iodide excess regulates its own efflux: a possible involvement of pendrin. Calil-Silveira J, etal., Am J Physiol Cell Physiol. 2016 Apr 1;310(7):C576-82. doi: 10.1152/ajpcell.00210.2015. Epub 2016 Jan 20.
4. Pendred syndrome, DFNB4, and PDS/SLC26A4 identification of eight novel mutations and possible genotype-phenotype correlations. Campbell C, etal., Hum Mutat. 2001 May;17(5):403-11.
5. [Screening of SLC26A4 (PDS) gene mutation in cochlear implant recipients with inner ear malformation]. Chen DY, etal., Zhonghua Yi Xue Za Zhi. 2007 Oct 30;87(40):2820-4.
6. Efficient molecular genetic diagnosis of enlarged vestibular aqueducts in East Asians. Choi BY, etal., Genet Test Mol Biomarkers. 2009 Oct;13(5):679-87. doi: 10.1089/gtmb.2009.0054.
7. Mouse model of enlarged vestibular aqueducts defines temporal requirement of Slc26a4 expression for hearing acquisition. Choi BY, etal., J Clin Invest. 2011 Nov;121(11):4516-25. doi: 10.1172/JCI59353. Epub 2011 Oct 3.
8. Distinct and novel SLC26A4/Pendrin mutations in Chinese and U.S. patients with nonsyndromic hearing loss. Dai P, etal., Physiol Genomics. 2009 Aug 7;38(3):281-90. doi: 10.1152/physiolgenomics.00047.2009. Epub 2009 Jun 9.
9. Targeted disruption of mouse Pds provides insight about the inner-ear defects encountered in Pendred syndrome. Everett LA, etal., Hum Mol Genet. 2001 Jan 15;10(2):153-61.
10. Expression pattern of the mouse ortholog of the Pendred's syndrome gene (Pds) suggests a key role for pendrin in the inner ear. Everett LA, etal., Proc Natl Acad Sci U S A 1999 Aug 17;96(17):9727-32.
11. Regulated expression of pendrin in rat kidney in response to chronic NH4Cl or NaHCO3 loading. Frische S, etal., Am J Physiol Renal Physiol 2003 Mar;284(3):F584-93.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Immunocytochemical localization of pendrin in intercalated cell subtypes in rat and mouse kidney. Kim YH, etal., Am J Physiol Renal Physiol 2002 Oct;283(4):F744-54.
15. SLC26A4 targeted to the endolymphatic sac rescues hearing and balance in Slc26a4 mutant mice. Li X, etal., PLoS Genet. 2013 Jul;9(7):e1003641. doi: 10.1371/journal.pgen.1003641. Epub 2013 Jul 11.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. Origins and frequencies of SLC26A4 (PDS) mutations in east and south Asians: global implications for the epidemiology of deafness. Park HJ, etal., J Med Genet. 2003 Apr;40(4):242-8.
20. Regulation of the apical Cl-/HCO-3 exchanger pendrin in rat cortical collecting duct in metabolic acidosis. Petrovic S, etal., Am J Physiol Renal Physiol 2003 Jan;284(1):F103-12.
21. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
22. Two missense mutations in SLC26A4 gene: a molecular and functional study. Rebeh IB, etal., Clin Genet. 2010 Jul;78(1):74-80. doi: 10.1111/j.1399-0004.2009.01360.x. Epub 2009 Dec 2.
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion. Royaux IE, etal., Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4221-6. doi: 10.1073/pnas.071516798.
27. Pendrin: an apical Cl-/OH-/HCO3- exchanger in the kidney cortex. Soleimani M, etal., Am J Physiol Renal Physiol. 2001 Feb;280(2):F356-64. doi: 10.1152/ajprenal.2001.280.2.F356.
28. Screening the SLC26A4 gene in probands with deafness and goiter (Pendred syndrome) ascertained from a large group of students of the schools for the deaf in Turkey. Tekin M, etal., Clin Genet. 2003 Oct;64(4):371-4.
29. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
30. Distribution and frequencies of PDS (SLC26A4) mutations in Pendred syndrome and nonsyndromic hearing loss associated with enlarged vestibular aqueduct: a unique spectrum of mutations in Japanese. Tsukamoto K, etal., Eur J Hum Genet. 2003 Dec;11(12):916-22.
31. The renal physiology of pendrin (SLC26A4) and its role in hypertension. Wall SM Novartis Found Symp. 2006;273:231-9; discussion 239-43, 261-4.
32. Loss of cochlear HCO3- secretion causes deafness via endolymphatic acidification and inhibition of Ca2+ reabsorption in a Pendred syndrome mouse model. Wangemann P, etal., Am J Physiol Renal Physiol. 2007 May;292(5):F1345-53. Epub 2007 Feb 13.
33. Pendrin is an iodide-specific apical porter responsible for iodide efflux from thyroid cells. Yoshida A, etal., J Clin Endocrinol Metab. 2002 Jul;87(7):3356-61.
Additional References at PubMed
PMID:11459928   PMID:12388412   PMID:15292050   PMID:15385584   PMID:16144965   PMID:16260629   PMID:16928804   PMID:17182533   PMID:17409310   PMID:18459119   PMID:18508879   PMID:19056867  
PMID:21082674   PMID:22178794   PMID:22431001   PMID:23376485   PMID:23933130   PMID:26173457   PMID:26932931   PMID:34326480  


Genomics

Comparative Map Data
Slc26a4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2648,107,575 - 48,153,762 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl648,107,588 - 48,145,703 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx648,413,592 - 48,453,234 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0648,728,513 - 48,768,155 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0648,168,792 - 48,208,193 (-)NCBIRnor_WKY
Rnor_6.0650,809,103 - 50,848,443 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl650,808,923 - 50,846,965 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0659,479,842 - 59,520,531 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4649,389,212 - 49,427,000 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1649,392,337 - 49,430,126 (-)NCBI
Celera647,310,126 - 47,347,924 (-)NCBICelera
Cytogenetic Map6q16NCBI
SLC26A4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387107,660,828 - 107,717,809 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl7107,660,828 - 107,717,809 (+)EnsemblGRCh38hg38GRCh38
GRCh377107,301,273 - 107,358,254 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367107,088,316 - 107,145,490 (+)NCBINCBI36Build 36hg18NCBI36
Build 347106,895,030 - 106,952,201NCBI
Celera7102,106,401 - 102,163,591 (+)NCBICelera
Cytogenetic Map7q22.3NCBI
HuRef7101,661,478 - 101,718,643 (+)NCBIHuRef
CHM1_17107,235,048 - 107,292,246 (+)NCBICHM1_1
T2T-CHM13v2.07108,976,971 - 109,033,936 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27106,662,192 - 106,719,369 (+)NCBI
Slc26a4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391231,569,813 - 31,610,054 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1231,569,826 - 31,609,968 (-)EnsemblGRCm39 Ensembl
GRCm381231,519,814 - 31,560,055 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1231,519,827 - 31,559,969 (-)EnsemblGRCm38mm10GRCm38
MGSCv371232,204,684 - 32,244,834 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361232,105,578 - 32,145,728 (-)NCBIMGSCv36mm8
Celera1232,968,822 - 33,008,973 (-)NCBICelera
Cytogenetic Map12A2NCBI
Slc26a4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541012,009,102 - 12,059,637 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541012,008,067 - 12,057,147 (+)NCBIChiLan1.0ChiLan1.0
SLC26A4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17112,363,119 - 112,418,633 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7112,364,126 - 112,415,637 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0799,640,703 - 99,698,109 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SLC26A4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11812,894,347 - 12,941,669 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1812,894,669 - 12,943,212 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1812,536,263 - 12,586,953 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01813,163,396 - 13,214,301 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1813,165,741 - 13,213,145 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11812,980,322 - 13,030,889 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01812,900,588 - 12,950,775 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01813,129,256 - 13,179,537 (-)NCBIUU_Cfam_GSD_1.0
Slc26a4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511855,311,980 - 55,358,504 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647916,435,739 - 16,481,332 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647916,435,779 - 16,483,139 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC26A4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9107,365,814 - 107,431,062 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19107,365,121 - 107,431,065 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29118,119,384 - 118,183,897 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC26A4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12176,578,035 - 76,631,725 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2176,578,665 - 76,633,165 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604227,231,539 - 27,289,239 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc26a4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473922,047,704 - 22,100,154 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473922,047,771 - 22,100,130 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc26a4
314 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:208
Count of miRNA genes:146
Interacting mature miRNAs:172
Transcripts:ENSRNOT00000010350
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63207442872227641Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63330954957730294Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63330954981132889Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63443413777102317Rat
1354632Scl29Serum cholesterol level QTL 293.74blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)63509870971636405Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)63569161857730540Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat

Markers in Region
RH129484  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2648,107,670 - 48,107,873 (+)MAPPERmRatBN7.2
Rnor_6.0650,809,199 - 50,809,401NCBIRnor6.0
Rnor_5.0659,479,938 - 59,480,140UniSTSRnor5.0
RGSC_v3.4649,389,295 - 49,389,497UniSTSRGSC3.4
Celera647,310,209 - 47,310,411UniSTS
RH 3.4 Map6301.99UniSTS
Cytogenetic Map6q16UniSTS
Slc26a4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2648,135,806 - 48,135,960 (+)MAPPERmRatBN7.2
Rnor_6.0650,836,894 - 50,837,047NCBIRnor6.0
Rnor_5.0659,508,427 - 59,508,580UniSTSRnor5.0
RGSC_v3.4649,417,106 - 49,417,259UniSTSRGSC3.4
Celera647,338,030 - 47,338,183UniSTS
Cytogenetic Map6q16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 23 4 1
Low 1 26 10 8 31 2 10 8
Below cutoff 2 17 15 9 11 9 3 3 35 10 27 2 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000087300   ⟹   ENSRNOP00000070261
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl648,107,588 - 48,145,703 (-)Ensembl
Rnor_6.0 Ensembl650,808,923 - 50,846,965 (-)Ensembl
RefSeq Acc Id: NM_019214   ⟹   NP_062087
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2648,107,588 - 48,145,703 (-)NCBI
Rnor_6.0650,809,116 - 50,846,788 (-)NCBI
Rnor_5.0659,479,842 - 59,520,531 (-)NCBI
RGSC_v3.4649,389,212 - 49,427,000 (-)RGD
Celera647,310,126 - 47,347,924 (-)RGD
Sequence:
RefSeq Acc Id: XM_008764576   ⟹   XP_008762798
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2648,107,575 - 48,146,262 (-)NCBI
Rnor_6.0650,809,103 - 50,847,191 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008764577   ⟹   XP_008762799
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2648,107,575 - 48,144,028 (-)NCBI
Rnor_6.0650,809,103 - 50,843,550 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594054   ⟹   XP_017449543
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2648,107,575 - 48,146,457 (-)NCBI
Rnor_6.0650,809,103 - 50,848,443 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039111842   ⟹   XP_038967770
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2648,107,575 - 48,153,762 (-)NCBI
RefSeq Acc Id: XM_039111843   ⟹   XP_038967771
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2648,107,575 - 48,141,486 (-)NCBI
RefSeq Acc Id: XM_039111844   ⟹   XP_038967772
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2648,124,068 - 48,146,264 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_062087   ⟸   NM_019214
- UniProtKB: Q9R154 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008762798   ⟸   XM_008764576
- Peptide Label: isoform X1
- UniProtKB: Q9R154 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008762799   ⟸   XM_008764577
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017449543   ⟸   XM_017594054
- Peptide Label: isoform X1
- UniProtKB: Q9R154 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070261   ⟸   ENSRNOT00000087300
RefSeq Acc Id: XP_038967770   ⟸   XM_039111842
- Peptide Label: isoform X1
- UniProtKB: Q9R154 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038967771   ⟸   XM_039111843
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038967772   ⟸   XM_039111844
- Peptide Label: isoform X4
Protein Domains
STAS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R154-F1-model_v2 AlphaFold Q9R154 1-780 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3293 AgrOrtholog
BioCyc Gene G2FUF-37915 BioCyc
Ensembl Genes ENSRNOG00000058692 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000070261 ENTREZGENE
  ENSRNOP00000070261.1 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000087300 ENTREZGENE
  ENSRNOT00000087300.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.750.24 UniProtKB/Swiss-Prot
InterPro S04_transporter_CS UniProtKB/Swiss-Prot
  SLC26A/SulP_dom UniProtKB/Swiss-Prot
  SLC26A/SulP_fam UniProtKB/Swiss-Prot
  STAS_dom UniProtKB/Swiss-Prot
  STAS_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:29440 UniProtKB/Swiss-Prot
NCBI Gene 29440 ENTREZGENE
PANTHER PTHR11814 UniProtKB/Swiss-Prot
  PTHR11814:SF33 UniProtKB/Swiss-Prot
Pfam STAS UniProtKB/Swiss-Prot
  Sulfate_transp UniProtKB/Swiss-Prot
PhenoGen Slc26a4 PhenoGen
PROSITE SLC26A UniProtKB/Swiss-Prot
  STAS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52091 UniProtKB/Swiss-Prot
TIGR TC220020
TIGRFAMs sulP UniProtKB/Swiss-Prot
UniProt Q9R154 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc26a4  solute carrier family 26 member 4  Slc26a4  solute carrier family 26 (anion exchanger), member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc26a4  solute carrier family 26 (anion exchanger), member 4  Slc26a4  solute carrier family 26, member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Slc26a4  solute carrier family 26, member 4  Slc26a4  Solute carrier family 26 member 4  Name updated 70584 APPROVED
2002-06-10 Slc26a4  solute carrier family 26, member 4      Name updated 70584 APPROVED
2001-12-10 Slc26a4  Solute carrier family 26 member 4      Symbol and Name updated to reflect Human and Mouse nomenclature 69665 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in the cortex of the kidney 634144
gene_function participates as an exchanger in acid-base regulation in the cortical collecting duct (CCD) 634144
gene_regulation expression is regulated by the apical Cl(-)/HCO(3)(-) exchanger 634144