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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:L-leucine
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Accession:CHEBI:15603 term browser browse the term
Definition:The L-enantiomer of leucine.
Synonyms:related_synonym: (2S)-2-amino-4-methylpentanoic acid;   (2S)-alpha-2-Amino-4-methylvaleric acid;   (2S)-alpha-Leucine;   (S)-leucine;   2-Amino-4-methylvaleric acid;   Formula=C6H13NO2;   InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1;   InChIKey=ROHFNLRQFUQHCH-YFKPBYRVSA-N;   L;   L-Leucin;   L-Leuzin;   LEUCINE;   Leu;   SMILES=CC(C)C[C@H](N)C(O)=O
 alt_id: CHEBI:10866;   CHEBI:13131;   CHEBI:21348;   CHEBI:43646;   CHEBI:43695;   CHEBI:43733;   CHEBI:43814;   CHEBI:6260
 xref: Beilstein:1721722;   CAS:61-90-5;   DrugBank:DB00149;   Drug_Central:1557;   ECMDB:ECMDB00687;   Gmelin:50204;   HMDB:HMDB0000687;   KEGG:C00123;   KEGG:D00030;   KNApSAcK:C00001377
 xref_mesh: MESH:D007930
 xref: MetaCyc:LEU;   PDBeChem:LEU_LFOH;   PMID:17609475;   PMID:22735334;   PMID:24206068;   PMID:24333966;   PMID:8798704;   Reaxys:1721722;   Wikipedia:Leucine;   YMDB:YMDB00387
 cyclic_relationship: is_conjugate_acid_of CHEBI:32619;   is_conjugate_base_of CHEBI:32620;   is_enantiomer_of CHEBI:28225;   is_tautomer_of CHEBI:57427


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L-leucine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg5 autophagy related 5 multiple interactions EXP Leucine inhibits the reaction [alpinetin promotes the reaction [Dextran Sulfate results in increased expression of ATG5 mRNA]] CTD PMID:31676321 NCBI chr10:44,144,325...44,240,295
Ensembl chr10:44,144,354...44,240,287 		JBrowse link
G Atg7 autophagy related 7 multiple interactions EXP Leucine inhibits the reaction [alpinetin promotes the reaction [Dextran Sulfate results in increased expression of ATG7 mRNA]] CTD PMID:31676321 NCBI chr 6:114,620,075...114,837,565
Ensembl chr 6:114,620,058...114,837,575 		JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions EXP Leucine inhibits the reaction [[Dextran Sulfate co-treated with alpinetin] results in increased expression of BECN1 protein] CTD PMID:31676321 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP Leucine inhibits the reaction [alpinetin inhibits the reaction [Dextran Sulfate results in increased cleavage of CASP3 protein]] CTD PMID:31676321 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Leucine; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Leucine] CTD PMID:22689575 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions EXP Leucine inhibits the reaction [[Dextran Sulfate co-treated with alpinetin] results in increased expression of and results in increased lipidation of MAP1LC3B protein] CTD PMID:31676321 NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Leucine inhibits the reaction [alpinetin inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]] CTD PMID:31676321 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Slc3a2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 affects import ISO SLC3A2 protein affects the import of Leucine CTD PMID:28786956 NCBI chr19:8,684,931...8,700,733
Ensembl chr19:8,684,246...8,700,733 		JBrowse link
G Slc7a8 solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 affects import ISO SLC7A8 protein affects the import of Leucine CTD PMID:28786956 NCBI chr14:54,959,672...55,019,343
Ensembl chr14:54,959,666...55,019,403 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP Leucine inhibits the reaction [[Dextran Sulfate co-treated with alpinetin] results in decreased expression of SQSTM1 protein] CTD PMID:31676321 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
aloxistatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Capn1 calpain 1 multiple interactions ISO aloxistatin inhibits the reaction [CAPN1 protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form] CTD PMID:30910806 NCBI chr19:6,038,573...6,065,855
Ensembl chr19:6,038,573...6,065,927 		JBrowse link
G Capn7 calpain 7 multiple interactions ISO aloxistatin inhibits the reaction [CAPN7 protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form] CTD PMID:30910806 NCBI chr14:31,058,582...31,093,944
Ensembl chr14:31,058,595...31,093,943 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [aloxistatin co-treated with pepstatin] inhibits the reaction [[vistusertib co-treated with Chloroquine] results in increased activity of CASP3 protein]
[Swainsonine co-treated with aloxistatin] results in increased cleavage of CASP3 protein		 CTD PMID:26853465 PMID:33186601 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO aloxistatin inhibits the reaction [syringic acid analog results in increased secretion of CASP9 protein] CTD PMID:34523043 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Ctsb cathepsin B multiple interactions ISO [aloxistatin co-treated with pepstatin] results in decreased expression of CTSB protein; aloxistatin inhibits the reaction [CTSB protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form] CTD PMID:30910806 PMID:32186374 NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372 		JBrowse link
G Ctsd cathepsin D multiple interactions ISO [aloxistatin co-treated with pepstatin] results in decreased expression of CTSD protein CTD PMID:32186374 NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775 		JBrowse link
G Ctsl cathepsin L multiple interactions ISO aloxistatin inhibits the reaction [CTSL protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form] CTD PMID:30910806 NCBI chr13:64,509,704...64,518,586
Ensembl chr13:64,507,151...64,518,704 		JBrowse link
G Ddx3x DEAD box helicase 3, X-linked multiple interactions ISO aloxistatin inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of DDX3X protein] CTD PMID:30821613 NCBI chr  X:13,147,261...13,160,222
Ensembl chr  X:13,147,209...13,160,291 		JBrowse link
G Eif4a1 eukaryotic translation initiation factor 4A1 multiple interactions ISO aloxistatin inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of EIF4A1 protein] CTD PMID:30821613 NCBI chr11:69,557,762...69,563,249
Ensembl chr11:69,557,762...69,563,249 		JBrowse link
G Eif4h eukaryotic translation initiation factor 4H multiple interactions ISO aloxistatin inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of EIF4H protein] CTD PMID:30821613 NCBI chr 5:134,648,726...134,668,263
Ensembl chr 5:134,648,575...134,668,344 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO aloxistatin inhibits the reaction [syringic acid analog results in increased secretion of GAPDH protein] CTD PMID:34523043 NCBI chr 6:125,138,812...125,143,450
Ensembl chr 6:125,138,678...125,143,430 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 multiple interactions ISO [aloxistatin co-treated with pepstatin] results in increased expression of LAMP2 protein CTD PMID:32186374 NCBI chr  X:37,488,524...37,545,337
Ensembl chr  X:37,490,234...37,545,331 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases lipidation		 ISO
EXP		 [aloxistatin co-treated with pepstatin] inhibits the reaction [Biological Factors deficiency results in increased degradation of MAP1LC3B protein modified form]; [aloxistatin co-treated with pepstatin] inhibits the reaction [Biological Factors deficiency results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] inhibits the reaction [Dronabinol results in increased degradation of MAP1LC3B protein modified form]; [aloxistatin co-treated with pepstatin] inhibits the reaction [Dronabinol results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] promotes the reaction [ABTL0812 results in increased expression of and results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] promotes the reaction [Brefeldin A results in increased expression of and results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] promotes the reaction [N-((1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl)octanamide results in increased expression of and results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] results in decreased degradation of MAP1LC3B protein modified form; aloxistatin promotes the reaction [indatraline results in increased lipidation of MAP1LC3B protein]
aloxistatin results in increased lipidation of MAP1LC3B protein
[aloxistatin co-treated with pepstatin] inhibits the reaction [Biological Factors deficiency results in increased degradation of MAP1LC3B protein modified form]; [aloxistatin co-treated with pepstatin] inhibits the reaction [Biological Factors deficiency results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] inhibits the reaction [Dronabinol results in increased degradation of MAP1LC3B protein modified form]; [aloxistatin co-treated with pepstatin] inhibits the reaction [Dronabinol results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] results in increased expression of MAP1LC3B protein		 CTD PMID:26483381 PMID:27635674 PMID:32397857 PMID:33124469 NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression		 ISO
EXP		 [aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 protein; aloxistatin promotes the reaction [indatraline results in increased expression of SQSTM1 protein]; aloxistatin promotes the reaction [Sertraline results in increased expression of SQSTM1 protein]
aloxistatin results in increased expression of SQSTM1 protein
[aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 protein; [Dronabinol co-treated with aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 protein; [HU 211 co-treated with aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 protein		 CTD PMID:26483381 PMID:32186374 PMID:32773031 PMID:33124469 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
Leu-enkephalin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dpp3 dipeptidylpeptidase 3 increases cleavage
multiple interactions		 ISO DPP3 protein results in increased cleavage of Enkephalin, Leucine
spinorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]; tynorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]		 CTD PMID:10873616 NCBI chr19:4,957,257...4,978,315
Ensembl chr19:4,957,257...4,978,315 		JBrowse link
G Oprd1 opioid receptor, delta 1 increases activity ISO Enkephalin, Leucine results in increased activity of OPRD1 protein CTD PMID:26476280 NCBI chr 4:131,834,980...131,872,042
Ensembl chr 4:131,838,037...131,871,797 		JBrowse link
G Oprm1 opioid receptor, mu 1 increases activity ISO Enkephalin, Leucine results in increased activity of OPRM1 protein CTD PMID:26476280 NCBI chr10:6,708,593...6,988,209
Ensembl chr10:6,708,506...6,988,198 		JBrowse link
methyl L-leucinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnf tumor necrosis factor multiple interactions ISO leucine methyl ester inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:21748807 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
N-formyl-L-methionyl-L-leucyl-L-phenylalanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase multiple interactions ISO ADA protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides] CTD PMID:10947063 NCBI chr 2:163,565,703...163,592,154
Ensembl chr 2:163,568,504...163,592,159 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 increases phosphorylation
multiple interactions		 ISO
EXP		 N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of AKT1 protein
cyclosporin H inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of AKT1 protein]; epsilon-viniferin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of AKT1 protein]		 CTD PMID:15925284 PMID:16621998 PMID:34144024 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Leukotriene C4]; ALOX5 protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]; N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of ALOX5 protein; SB 203580 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of ALOX5 protein] CTD PMID:9495842 PMID:10779545 PMID:11116075 NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139 		JBrowse link
G Arf1 ADP-ribosylation factor 1 affects localization ISO N-Formylmethionine Leucyl-Phenylalanine affects the localization of ARF1 protein CTD PMID:10931844 NCBI chr11:59,102,237...59,119,042
Ensembl chr11:59,102,238...59,119,096 		JBrowse link
G Arf6 ADP-ribosylation factor 6 multiple interactions
affects localization		 ISO 1-Butanol inhibits the reaction [ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 1-Butanol inhibits the reaction [ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 2,3-Diphosphoglycerate inhibits the reaction [ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 2,3-Diphosphoglycerate inhibits the reaction [ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]; ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]
N-Formylmethionine Leucyl-Phenylalanine affects the localization of ARF6 protein		 CTD PMID:10931844 NCBI chr12:69,418,924...69,422,754
Ensembl chr12:69,418,924...69,420,557 		JBrowse link
G Bax BCL2-associated X protein increases activity ISO N-Formylmethionine Leucyl-Phenylalanine results in increased activity of BAX protein CTD PMID:20130848 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO Melatonin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of CASP3 protein] CTD PMID:20130848 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity		 ISO Melatonin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of CASP9 protein] CTD PMID:20130848 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cd38 CD38 antigen increases cleavage
multiple interactions		 ISO N-Formylmethionine Leucyl-Phenylalanine results in increased cleavage of CD38 protein
SB 203580 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased cleavage of CD38 protein]		 CTD PMID:15494208 NCBI chr 5:44,026,153...44,069,714
Ensembl chr 5:44,025,895...44,069,717 		JBrowse link
G Cd63 CD63 antigen multiple interactions
increases expression		 ISO Mustard Gas promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of CD63 protein]; Quercetin affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of CD63 protein]; SB 203580 inhibits the reaction [Mustard Gas promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of CD63 protein]] CTD PMID:19887118 PMID:22036725 NCBI chr10:128,731,577...128,748,691
Ensembl chr10:128,736,858...128,748,691 		JBrowse link
G Ctsg cathepsin G multiple interactions
increases secretion		 ISO cyclosporin H inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of CTSG protein]; epsilon-viniferin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of CTSG protein]; honokiol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of CTSG protein] CTD PMID:25980585 PMID:34144024 NCBI chr14:56,337,342...56,340,031
Ensembl chr14:56,337,338...56,340,031 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 increases expression
increases secretion
multiple interactions		 ISO N-Formylmethionine Leucyl-Phenylalanine results in increased expression of CXCL8 mRNA; N-Formylmethionine Leucyl-Phenylalanine results in increased expression of CXCL8 protein
N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of CXCL8 protein
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of CXCL8 protein]; nimesulide inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of CXCL8 protein]; nordy inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of CXCL8 mRNA]; nordy inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of CXCL8 protein]		 CTD PMID:11566077 PMID:12946449 PMID:17459229 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cybb cytochrome b-245, beta polypeptide increases activity
multiple interactions		 EXP N-Formylmethionine Leucyl-Phenylalanine results in increased activity of CYBB protein
diphenyleneiodonium inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of CYBB protein]; Genistein inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of CYBB protein]		 CTD PMID:29183754 NCBI chr  X:9,301,493...9,354,005
Ensembl chr  X:9,301,491...9,354,010 		JBrowse link
G Elane elastase, neutrophil expressed multiple interactions
increases secretion		 ISO 2-(2-fluorobenzamido)benzoate ethyl ester inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of ELANE protein]; [Cytochalasin B co-treated with N-Formylmethionine Leucyl-Phenylalanine] results in increased secretion of ELANE protein; pirinixic acid analog inhibits the reaction [[Cytochalasin B co-treated with N-Formylmethionine Leucyl-Phenylalanine] results in increased secretion of ELANE protein] CTD PMID:19686721 PMID:21457779 NCBI chr10:79,722,146...79,724,050
Ensembl chr10:79,722,081...79,724,049 		JBrowse link
G Enpp3 ectonucleotide pyrophosphatase/phosphodiesterase 3 increases expression
multiple interactions		 ISO N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ENPP3 protein
Quercetin affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ENPP3 protein]		 CTD PMID:19887118 NCBI chr10:24,649,712...24,712,093
Ensembl chr10:24,648,304...24,718,721 		JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase multiple interactions
increases phosphorylation		 ISO 1-Butanol inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine co-treated with dihydrocytochalasin B] results in increased activity of FGR protein]
N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of FGR protein		 CTD PMID:11078731 PMID:25980585 NCBI chr 4:132,701,406...132,729,204
Ensembl chr 4:132,701,406...132,729,221 		JBrowse link
G Fpr1 formyl peptide receptor 1 multiple interactions ISO N-Formylmethionine Leucyl-Phenylalanine binds to and results in increased activity of FPR1 protein CTD PMID:17520823 NCBI chr17:18,096,733...18,104,201
Ensembl chr17:18,096,733...18,104,202 		JBrowse link
G Gusb glucuronidase, beta increases secretion
multiple interactions		 ISO N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of GUSB protein
epigallocatechin gallate inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of GUSB protein]		 CTD PMID:9545557 PMID:11944907 NCBI chr 5:130,011,278...130,031,890
Ensembl chr 5:130,017,852...130,031,890 		JBrowse link
G Hck hemopoietic cell kinase increases phosphorylation ISO N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of HCK protein CTD PMID:25980585 NCBI chr 2:152,950,388...152,993,361
Ensembl chr 2:152,950,388...152,993,361 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 ISO N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of IL1B protein]; nimesulide inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of IL1B protein] CTD PMID:12946449 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il3 interleukin 3 increases response to substance EXP IL3 protein results in increased susceptibility to N-Formylmethionine Leucyl-Phenylalanine CTD PMID:11145705 NCBI chr11:54,155,911...54,158,105
Ensembl chr11:54,156,129...54,158,103 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of IL6 protein]; nimesulide inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of IL6 protein] CTD PMID:12946449 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Itga2b integrin alpha 2b multiple interactions ISO ITGA2B protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein] CTD PMID:11116075 NCBI chr11:102,344,134...102,360,570
Ensembl chr11:102,344,123...102,360,948 		JBrowse link
G Itgam integrin alpha M multiple interactions
increases expression 		ISO 2-(2-fluorobenzamido)benzoate ethyl ester inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]; dimemorfan inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]; Foropafant inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]; KT 5720 inhibits the reaction [2-(2-fluorobenzamido)benzoate ethyl ester inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [2-(2-fluorobenzamido)benzoate ethyl ester inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Rolipram inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]; plaunotol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]; Rolipram inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]; Staurosporine inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]
fMLP increases expression of ITGAM protein on neutrophils and monocytes
[N-formyl-methionyl-leucyl-phenylalanine cotreated with midazolam] decreases expression of ITGAM protein on neutrophils		 CTD
RGD		 PMID:10215738 PMID:11116075 PMID:15774851 PMID:18500357 PMID:21457779 More... RGD:329901666, RGD:329853762 NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663 		JBrowse link
G Itgb2 integrin beta 2 increases expression
multiple interactions		 EXP
ISO		 N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]; acteoside inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]; crenatoside inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]; plaunotol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]		 CTD PMID:10215738 PMID:16393473 PMID:21664406 NCBI chr10:77,366,164...77,401,542
Ensembl chr10:77,366,086...77,401,542 		JBrowse link
G Itgb3 integrin beta 3 increases expression EXP N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB3 protein CTD PMID:21664406 NCBI chr11:104,498,826...104,561,302
Ensembl chr11:104,498,826...104,561,302 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase multiple interactions
increases phosphorylation		 ISO AG 1879 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of LYN protein]; honokiol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of LYN protein] CTD PMID:25980585 NCBI chr 4:3,676,865...3,791,613
Ensembl chr 4:3,678,115...3,813,122 		JBrowse link
G Lyz2 lysozyme 2 increases secretion ISO N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of LYZ protein CTD PMID:9545557 NCBI chr10:117,113,446...117,118,177
Ensembl chr10:117,113,236...117,118,226 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO
EXP		 cyclosporin H inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein]; epsilon-viniferin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein]; Grape Seed Proanthocyanidins inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein]; honokiol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein]; N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK1 protein; nordy inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Pentoxifylline inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; PLD1 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Qingdai compound inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein]; Resveratrol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein]
N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK1 protein; resveratrol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein]
RAC2 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein]		 CTD PMID:11145705 PMID:11427526 PMID:15494208 PMID:16212921 PMID:16621998 More... NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 multiple interactions
increases phosphorylation		 ISO
EXP		 N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK14 protein; Omeprazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK14 protein] CTD PMID:16621998 PMID:17406807 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO
EXP		 cyclosporin H inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein]; epsilon-viniferin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein]; Grape Seed Proanthocyanidins inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein]; honokiol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein]; N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK3 protein; nordy inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Pentoxifylline inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; PLD1 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Qingdai compound inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein]; Resveratrol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein]
N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Resveratrol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein]
RAC2 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein]		 CTD PMID:11145705 PMID:11427526 PMID:15494208 PMID:16212921 PMID:16621998 More... NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK8 protein; nordy inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK8 protein]
MAPK8 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Reactive Oxygen Species]; N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK8 protein		 CTD PMID:17377739 PMID:17560994 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mmp8 matrix metallopeptidase 8 increases expression EXP N-Formylmethionine Leucyl-Phenylalanine results in increased expression of MMP8 protein CTD PMID:32367270 NCBI chr 9:7,558,430...7,568,487
Ensembl chr 9:7,558,457...7,568,486 		JBrowse link
G Mpo myeloperoxidase multiple interactions
increases activity
increases secretion
increases expression		 EXP
ISO		 carvedilol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of MPO protein]
N-Formylmethionine Leucyl-Phenylalanine results in increased activity of MPO protein
N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of MPO protein
carvedilol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of MPO protein]; diphenyleneiodonium inhibits the reaction [manganese chloride promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of MPO protein]]; manganese chloride promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of MPO protein]; Sodium Azide inhibits the reaction [manganese chloride promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of MPO protein]]; wortmannin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of MPO protein]		 CTD PMID:16601795 PMID:17159805 PMID:18987595 PMID:22906169 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions
affects localization		 ISO AG 1879 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of NCF1 protein]; bisindolylmaleimide I inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of NCF1 protein]; honokiol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of NCF1 protein] CTD PMID:25980585 NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479 		JBrowse link
G Pecam1 platelet/endothelial cell adhesion molecule 1 increases expression EXP N-Formylmethionine Leucyl-Phenylalanine results in increased expression of PECAM1 protein CTD PMID:21664406 NCBI chr11:106,545,039...106,606,107
Ensembl chr11:106,545,043...106,641,454 		JBrowse link
G Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) multiple interactions ISO PLA2G4A protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased metabolism of Leukotriene B4] CTD PMID:11741884 NCBI chr 1:149,705,369...149,837,041
Ensembl chr 1:149,705,369...149,837,041 		JBrowse link
G Pla2g5 phospholipase A2, group V increases activity
multiple interactions
increases secretion		 ISO N-Formylmethionine Leucyl-Phenylalanine results in increased activity of PLA2G5 protein
PLA2G5 protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Arachidonic Acid]; PLA2G5 protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Leukotriene C4]
N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of PLA2G5 protein		 CTD PMID:9495842 PMID:11741884 NCBI chr 4:138,526,558...138,590,784
Ensembl chr 4:138,526,555...138,590,793 		JBrowse link
G Plcg2 phospholipase C, gamma 2 multiple interactions
increases phosphorylation		 ISO AG 1879 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of PLCG2 protein]; honokiol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of PLCG2 protein] CTD PMID:25980585 NCBI chr 8:118,225,014...118,361,881
Ensembl chr 8:118,225,030...118,361,881 		JBrowse link
G Pld1 phospholipase D1 multiple interactions ISO PLD1 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; PLD1 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
PLD1 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Reactive Oxygen Species]		 CTD PMID:11427526 PMID:17560994 NCBI chr 3:27,992,636...28,187,388
Ensembl chr 3:27,992,844...28,187,511 		JBrowse link
G Ptafr platelet-activating factor receptor multiple interactions ISO PTAFR protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein] CTD PMID:11116075 NCBI chr 4:132,291,378...132,309,994
Ensembl chr 4:132,291,378...132,309,994 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO N-Formylmethionine Leucyl-Phenylalanine results in increased expression of PTGS2 mRNA; N-Formylmethionine Leucyl-Phenylalanine results in increased expression of PTGS2 protein CTD PMID:12946449 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Rac1 Rac family small GTPase 1 increases activity
multiple interactions		 EXP N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC1 protein
6-amino-N-(3-(4-(4-morpholinyl)pyrido(3',2'-4,5)furo(3,2-d)pyrimidin-2-yl)phenyl)-3-pyridinecarboxamide inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC1 protein]; apilimod inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC1 protein]; RHOG gene mutant form inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC1 protein]		 CTD PMID:16621998 PMID:28779020 NCBI chr 5:143,491,236...143,513,786
Ensembl chr 5:143,489,389...143,513,791 		JBrowse link
G Rac2 Rac family small GTPase 2 increases activity
multiple interactions		 EXP N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC2 protein
6-amino-N-(3-(4-(4-morpholinyl)pyrido(3',2'-4,5)furo(3,2-d)pyrimidin-2-yl)phenyl)-3-pyridinecarboxamide inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC2 protein]; apilimod inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC2 protein]; RAC2 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein]; RAC2 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein]; RHOG gene mutant form inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC2 protein]		 CTD PMID:11145705 PMID:16621998 PMID:28779020 NCBI chr15:78,443,369...78,456,983
Ensembl chr15:78,443,367...78,456,983 		JBrowse link
G Rhog ras homolog family member G multiple interactions
affects response to substance		 EXP RHOG gene mutant form inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC1 protein]; RHOG gene mutant form inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC2 protein]
RHOG protein affects the susceptibility to N-Formylmethionine Leucyl-Phenylalanine		 CTD PMID:16621998 NCBI chr 7:101,888,330...101,899,325
Ensembl chr 7:101,888,330...101,905,261 		JBrowse link
G Sell selectin, lymphocyte increases expression EXP N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELL protein CTD PMID:21664406 NCBI chr 1:163,889,556...163,908,354
Ensembl chr 1:163,889,551...163,911,750 		JBrowse link
G Selp selectin, platelet multiple interactions
increases expression		 ISO ALOX5 protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]; Foropafant inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]; ITGA2B protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]; MK-886 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]; PTAFR protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]; SR 121566 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]; zileuton inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein] CTD PMID:11116075 NCBI chr 1:163,942,833...163,977,595
Ensembl chr 1:163,942,833...163,977,595 		JBrowse link
G Src Rous sarcoma oncogene increases phosphorylation
multiple interactions		 ISO N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of SRC protein
AG 1879 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of SRC protein]; cyclosporin H inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of SRC protein]; epsilon-viniferin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of SRC protein]; honokiol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of SRC protein]		 CTD PMID:25980585 PMID:34144024 NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782 		JBrowse link
G Tec tec protein tyrosine kinase multiple interactions
affects localization		 ISO AG 1879 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of TEC protein]; honokiol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of TEC protein] CTD PMID:25980585 NCBI chr 5:72,913,061...73,025,997
Ensembl chr 5:72,913,059...73,025,826 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO [N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides; Cyclosporine inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides]; Tacrolimus inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides]
N-Formylmethionine Leucyl-Phenylalanine results in increased expression of TNF protein		 CTD PMID:11121130 PMID:12946449 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfaip6 tumor necrosis factor alpha induced protein 6 decreases response to substance ISO TNFAIP6 protein modified form results in decreased susceptibility to N-Formylmethionine Leucyl-Phenylalanine CTD PMID:12401803 NCBI chr 2:51,928,125...51,946,693
Ensembl chr 2:51,928,021...51,946,698 		JBrowse link
G Vav1 vav 1 oncogene increases phosphorylation ISO N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of VAV1 protein CTD PMID:25980585 NCBI chr17:57,586,080...57,636,236
Ensembl chr17:57,586,100...57,635,031 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression
increases secretion		 ISO Masoprocol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of VEGFA mRNA]; Masoprocol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of VEGFA protein]; nordy inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of VEGFA mRNA]; nordy inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of VEGFA protein]
N-Formylmethionine Leucyl-Phenylalanine results in increased expression of VEGFA mRNA; N-Formylmethionine Leucyl-Phenylalanine results in increased expression of VEGFA protein		 CTD PMID:17377739 PMID:17459229 PMID:17520823 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
orlistat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd12 abhydrolase domain containing 12 decreases activity ISO orlistat results in decreased activity of ABHD12 protein CTD PMID:18657971 NCBI chr 2:150,674,413...150,746,705
Ensembl chr 2:150,674,413...150,746,661 		JBrowse link
G Abhd16a abhydrolase domain containing 16A decreases activity ISO orlistat results in decreased activity of ABHD16A protein CTD PMID:18657971 NCBI chr17:35,308,210...35,321,963
Ensembl chr17:35,308,239...35,321,963 		JBrowse link
G Acaca acetyl-Coenzyme A carboxylase alpha multiple interactions
decreases expression		 ISO Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ACACA mRNA]
Orlistat results in decreased expression of ACACA mRNA		 CTD PMID:32347045 PMID:33476690 NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477 		JBrowse link
G Ache acetylcholinesterase decreases activity ISO Orlistat results in decreased activity of ACHE protein CTD PMID:33844597 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728 		JBrowse link
G Acot8 acyl-CoA thioesterase 8 decreases expression ISO Orlistat results in decreased expression of ACOT8 protein CTD PMID:30667213 NCBI chr 2:164,634,688...164,662,132
Ensembl chr 2:164,634,685...164,646,802 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO orlistat inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein]
Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ protein]		 CTD PMID:25087745 PMID:33476690 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in decreased expression of PTEN protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased abundance of Malondialdehyde]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased abundance of Triglycerides]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of CCND1 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of CD34 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of FASN protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of IL6 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of PCNA protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of PTGS2 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of SREBF1 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of TNF protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of MAPK1 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of MAPK3 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of RPS6 protein] CTD PMID:32045588 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [1,1,1,2,2-pentafluoro-7-phenylheptan-3-one co-treated with Orlistat] inhibits the reaction [APP protein modified form results in increased secretion of Arachidonic Acid] CTD PMID:28721267 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO orlistat results in increased expression of ATF4 mRNA CTD PMID:17283163 NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742 		JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO Orlistat inhibits the reaction [Dietary Fats results in increased expression of BAX mRNA] CTD PMID:32450208 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO Orlistat inhibits the reaction [Dietary Fats results in decreased expression of BCL2 mRNA] CTD PMID:32450208 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
multiple interactions		 ISO
EXP		 orlistat results in increased activity of CASP3 protein
orlistat results in increased cleavage of CASP3 protein
Orlistat inhibits the reaction [Dietary Fats results in increased expression of CASP3 mRNA]		 CTD PMID:17283163 PMID:20805790 PMID:21723078 PMID:32450208 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO orlistat analog results in increased cleavage of and results in increased activity of CASP8 protein; orlistat results in increased cleavage of and results in increased activity of CASP8 protein
Orlistat inhibits the reaction [Dietary Fats results in increased expression of CASP8 mRNA]		 CTD PMID:18796435 PMID:20577697 PMID:32450208 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions		 EXP
ISO		 orlistat results in increased activity of CASP9 protein
Orlistat inhibits the reaction [Dietary Fats results in increased expression of CASP9 mRNA]		 CTD PMID:20805790 PMID:32450208 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cat catalase multiple interactions
decreases expression		 ISO Orlistat inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; Orlistat inhibits the reaction [Dietary Fats results in decreased expression of CAT mRNA]; Orlistat inhibits the reaction [Dietary Fats results in decreased expression of CAT protein]
Orlistat results in decreased expression of CAT protein		 CTD PMID:25087745 PMID:30667213 PMID:32450208 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cck cholecystokinin decreases secretion
multiple interactions		 ISO orlistat results in decreased secretion of CCK protein
[[orlistat results in decreased abundance of Fatty Acids, Nonesterified] which results in decreased secretion of CCK protein] which results in decreased secretion of PNLIP protein; orlistat inhibits the reaction [Fats results in increased secretion of CCK protein]; orlistat inhibits the reaction [Olive Oil results in increased secretion of CCK protein]		 CTD PMID:11408251 PMID:18303078 PMID:18647814 NCBI chr 9:121,318,890...121,324,728
Ensembl chr 9:121,318,890...121,324,760 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Orlistat results in decreased expression of CCNA2 protein CTD PMID:30667213 NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299 		JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions		 ISO Orlistat results in increased expression of CCND1 protein
Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of CCND1 protein]		 CTD PMID:30667213 PMID:32045588 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Ccne1 cyclin E1 increases expression ISO Orlistat results in increased expression of CCNE1 protein CTD PMID:30667213 NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959 		JBrowse link
G Cd34 CD34 antigen multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of CD34 protein] CTD PMID:32045588 NCBI chr 1:194,621,239...194,643,587
Ensembl chr 1:194,621,127...194,643,587 		JBrowse link
G Cdk1 cyclin dependent kinase 1 decreases expression ISO Orlistat results in decreased expression of CDK1 protein CTD PMID:30667213 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Orlistat results in decreased expression of CDK2 protein CTD PMID:30667213 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900 		JBrowse link
G Cdk4 cyclin dependent kinase 4 decreases expression ISO Orlistat results in decreased expression of CDK4 protein CTD PMID:30667213 NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression ISO Orlistat results in increased expression of CDKN1A protein CTD PMID:30667213 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B increases expression ISO orlistat results in increased expression of CDKN1B protein CTD PMID:15138278 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO Orlistat promotes the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA protein] CTD PMID:33476690 NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353 		JBrowse link
G Cel carboxyl ester lipase decreases activity ISO orlistat results in decreased activity of CEL protein CTD PMID:11592731 PMID:12381337 NCBI chr 2:28,445,831...28,453,415
Ensembl chr 2:28,445,807...28,453,415 		JBrowse link
G Clps colipase, pancreatic multiple interactions ISO orlistat inhibits the reaction [[PNLIP protein co-treated with CLPS protein] results in increased hydrolysis of Olive Oil] CTD PMID:15158758 NCBI chr17:28,777,184...28,779,740
Ensembl chr17:28,777,123...28,779,740 		JBrowse link
G Cpb2 carboxypeptidase B2 decreases expression ISO orlistat results in decreased expression of CPB2 protein CTD PMID:16959692 NCBI chr14:75,479,727...75,520,995
Ensembl chr14:75,479,727...75,520,995 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver decreases expression ISO Orlistat results in decreased expression of CPT1A protein CTD PMID:30667213 NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 decreases expression ISO Orlistat results in decreased expression of CPT2 protein CTD PMID:30667213 NCBI chr 4:107,761,179...107,780,786
Ensembl chr 4:107,761,178...107,780,807 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO orlistat inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA] CTD PMID:21088047 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Dagla diacylglycerol lipase, alpha decreases activity ISO orlistat results in decreased activity of DAGLA protein CTD PMID:16466961 NCBI chr19:10,222,629...10,282,323
Ensembl chr19:10,222,629...10,282,241 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO orlistat results in increased expression of DDIT3 mRNA CTD PMID:17283163 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO orlistat results in increased expression of DDIT4 mRNA CTD PMID:18796435 NCBI chr10:59,785,497...59,787,592
Ensembl chr10:59,785,491...59,787,656 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation
multiple interactions		 ISO
EXP		 orlistat analog results in increased phosphorylation of EIF2A protein; orlistat results in increased phosphorylation of EIF2A protein
Cycloheximide inhibits the reaction [orlistat results in increased phosphorylation of EIF2A protein]
orlistat promotes the reaction [EIF2AK3 protein results in increased phosphorylation of EIF2A protein]		 CTD PMID:17283163 PMID:20577697 NCBI chr 3:58,433,252...58,464,922
Ensembl chr 3:58,433,242...58,464,922 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases response to substance		 EXP orlistat promotes the reaction [EIF2AK3 protein results in increased phosphorylation of EIF2A protein]
EIF2AK3 gene mutant form results in increased susceptibility to orlistat		 CTD PMID:17283163 NCBI chr 6:70,821,468...70,882,225
Ensembl chr 6:70,821,499...70,882,229 		JBrowse link
G Eif4e eukaryotic translation initiation factor 4E increases phosphorylation ISO orlistat results in increased phosphorylation of EIF4E protein CTD PMID:18796435 NCBI chr 3:138,231,952...138,265,457
Ensembl chr 3:138,231,940...138,265,457 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 affects localization
decreases expression
affects response to substance		 ISO orlistat affects the localization of ERBB2 protein
orlistat results in decreased expression of ERBB2 mRNA; orlistat results in decreased expression of ERBB2 protein
ERBB2 protein affects the susceptibility to orlistat		 CTD PMID:15870086 NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signalling 1 multiple interactions ISO orlistat affects the reaction [ERN1 protein affects the splicing of XBP1 mRNA] CTD PMID:17283163 NCBI chr11:106,285,474...106,378,701
Ensembl chr11:106,285,476...106,378,678 		JBrowse link
G Etv4 ets variant 4 increases expression ISO orlistat results in increased expression of ETV4 protein CTD PMID:15870086 NCBI chr11:101,660,573...101,677,963
Ensembl chr11:101,660,568...101,676,197 		JBrowse link
G Fabp1 fatty acid binding protein 1, liver decreases expression ISO Orlistat results in decreased expression of FABP1 protein CTD PMID:30667213 NCBI chr 6:71,176,863...71,182,018
Ensembl chr 6:71,176,811...71,182,007 		JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO Orlistat results in decreased expression of FAS mRNA CTD PMID:32347045 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fasn fatty acid synthase multiple interactions
affects response to substance
affects binding
decreases activity
decreases expression		 ISO
EXP		 [Orlistat results in decreased activity of FASN protein] which results in decreased abundance of Fatty Acids; [Orlistat results in decreased activity of FASN protein] which results in decreased abundance of Phosphatidylcholines; [Orlistat results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholine; [Orlistat results in decreased activity of FASN protein] which results in decreased chemical synthesis of Fatty Acids; [Orlistat results in decreased activity of FASN protein] which results in decreased expression of SKP2 protein; Orlistat binds to and results in decreased activity of FASN protein; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of FASN protein]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FASN mRNA]; Orlistat inhibits the reaction [FASN protein results in decreased susceptibility to Doxorubicin]; Orlistat inhibits the reaction [FASN protein results in decreased susceptibility to Mitoxantrone]
FASN protein affects the susceptibility to orlistat
orlistat analog binds to FASN protein
orlistat analog results in decreased activity of FASN protein; orlistat results in decreased activity of FASN protein
[orlistat results in decreased activity of FASN protein] which affects the abundance of Fatty Acids, Nonesterified; orlistat inhibits the reaction [FASN protein results in increased chemical synthesis of Palmitic Acid]
Orlistat results in decreased expression of FASN protein		 CTD PMID:15026345 PMID:15138278 PMID:15870086 PMID:17012255 PMID:17618296 More... NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373 		JBrowse link
G Gcg glucagon multiple interactions
decreases expression
decreases secretion		 ISO orlistat inhibits the reaction [Dietary Fats results in increased secretion of GCG protein]; orlistat inhibits the reaction [Olive Oil results in increased secretion of GCG protein]
orlistat results in decreased expression of GCG protein
orlistat results in decreased secretion of GCG protein		 CTD PMID:12915676 PMID:18647814 PMID:19837920 NCBI chr 2:62,304,874...62,313,997
Ensembl chr 2:62,304,874...62,313,994 		JBrowse link
G Ghrl ghrelin multiple interactions ISO orlistat inhibits the reaction [Olive Oil results in decreased expression of GHRL protein]; orlistat inhibits the reaction [Triglycerides results in decreased secretion of GHRL protein] CTD PMID:15998659 PMID:17138722 NCBI chr 6:113,693,080...113,696,872
Ensembl chr 6:113,693,080...113,696,841 		JBrowse link
G Gip gastric inhibitory polypeptide decreases expression ISO orlistat results in decreased expression of GIP protein CTD PMID:12915676 NCBI chr11:95,915,358...95,921,657
Ensembl chr11:95,915,371...95,921,657 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO orlistat inhibits the reaction [[Corn Oil co-treated with (5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl)acetic acid] results in increased activity of GPT protein] CTD PMID:29479035 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Orlistat inhibits the reaction [Dietary Fats results in decreased expression of GPX1 mRNA] CTD PMID:32450208 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542 		JBrowse link
G Gpx8 glutathione peroxidase 8 (putative) increases expression ISO orlistat results in increased expression of GPX8 mRNA CTD PMID:18796435 NCBI chr13:113,179,287...113,182,944
Ensembl chr13:113,179,287...113,182,944 		JBrowse link
G Gsr glutathione reductase multiple interactions ISO Orlistat inhibits the reaction [Dietary Fats results in decreased expression of GSR protein] CTD PMID:32450208 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 decreases expression ISO Orlistat results in decreased expression of HBA1 protein modified form CTD PMID:19207292 PMID:19461584 NCBI chr11:32,233,672...32,234,486
Ensembl chr11:32,233,511...32,234,465 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase multiple interactions ISO orlistat inhibits the reaction [Dietary Fats results in increased expression of HMGCR protein] CTD PMID:25087745 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444 		JBrowse link
G Hspa5 heat shock protein 5 increases expression ISO orlistat results in increased expression of HSPA5 mRNA CTD PMID:17283163 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Il10 interleukin 10 increases expression ISO Orlistat results in increased expression of IL10 mRNA CTD PMID:32450208 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Orlistat inhibits the reaction [Dietary Fats results in increased expression of IL1B mRNA] CTD PMID:32450208 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of IL6 protein]; Orlistat inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:21088047 PMID:32045588 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Ins1 insulin I multiple interactions ISO Orlistat inhibits the reaction [Dietary Fats results in increased expression of INS1 protein] CTD PMID:25087745 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Ins2 insulin II increases expression
affects expression
decreases expression
multiple interactions		 ISO orlistat results in increased expression of INS protein
orlistat affects the expression of INS protein
orlistat results in decreased expression of INS protein
[Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of NFE2L2 mRNA; [Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of TGFB1 mRNA; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ACACA mRNA]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ protein]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FASN mRNA]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARD mRNA]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of UCP1 mRNA]; Orlistat promotes the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA protein]		 CTD PMID:10095983 PMID:11274935 PMID:12915676 PMID:33476690 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118 		JBrowse link
G Kdelr3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 increases expression ISO orlistat results in increased expression of KDELR3 mRNA CTD PMID:18796435 NCBI chr15:79,400,609...79,411,940
Ensembl chr15:79,400,612...79,411,940 		JBrowse link
G Kdr kinase insert domain protein receptor decreases expression ISO orlistat results in decreased expression of KDR protein CTD PMID:17012255 NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118 		JBrowse link
G Krt81 keratin 81 increases expression ISO orlistat results in increased expression of KRT81 mRNA CTD PMID:18796435 NCBI chr15:101,356,942...101,361,646
Ensembl chr15:101,356,942...101,361,632 		JBrowse link
G Lcat lecithin cholesterol acyltransferase multiple interactions ISO orlistat inhibits the reaction [Dietary Fats results in decreased expression of LCAT protein] CTD PMID:25087745 NCBI chr 8:106,666,183...106,670,034
Ensembl chr 8:106,666,183...106,670,014 		JBrowse link
G Lep leptin multiple interactions ISO
EXP		 orlistat inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:21332399 PMID:25087745 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Lipf lipase, gastric decreases activity ISO orlistat results in decreased activity of LIPF protein CTD PMID:11408251 PMID:12381337 NCBI chr19:33,938,648...33,954,213
Ensembl chr19:33,938,587...33,954,210 		JBrowse link
G Lpl lipoprotein lipase multiple interactions
decreases activity		 EXP
ISO		 [orlistat results in decreased activity of LPL protein] which affects the uptake of Triglycerides
orlistat inhibits the reaction [[LPL protein results in increased hydrolysis of Triglycerides] which results in increased uptake of Triglycerides]; orlistat inhibits the reaction [LPL protein results in decreased activity of TNF protein]; orlistat inhibits the reaction [very low density lipoprotein triglyceride results in increased activity of LPL protein]
orlistat inhibits the reaction [Dietary Fats results in decreased expression of LPL protein]		 CTD PMID:12388125 PMID:12573449 PMID:15910848 PMID:15994321 PMID:18698144 More... NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of MAPK1 protein] CTD PMID:32045588 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of MAPK3 protein] CTD PMID:32045588 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Met met proto-oncogene multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in decreased expression of PTEN protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased abundance of Malondialdehyde]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased abundance of Triglycerides]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of CCND1 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of CD34 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of FASN protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of IL6 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of PCNA protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of PTGS2 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of SREBF1 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of TNF protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of MAPK1 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of MAPK3 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of RPS6 protein] CTD PMID:32045588 NCBI chr 6:17,463,351...17,573,979
Ensembl chr 6:17,463,799...17,573,979 		JBrowse link
G Napepld N-acyl phosphatidylethanolamine phospholipase D decreases activity ISO orlistat results in decreased activity of NAPEPLD protein CTD PMID:16466961 NCBI chr 5:21,867,899...21,906,620
Ensembl chr 5:21,867,899...21,906,394 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO Orlistat inhibits the reaction [Dietary Fats results in decreased expression of NFE2L2 mRNA]
[Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of NFE2L2 mRNA		 CTD PMID:32450208 PMID:33476690 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO Orlistat inhibits the reaction [Dietary Fats results in increased expression of NOS2 mRNA]; Orlistat inhibits the reaction [Dietary Fats results in increased expression of NOS2 protein] CTD PMID:32450208 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Npy neuropeptide Y increases expression ISO orlistat results in increased expression of NPY protein CTD PMID:15962606 NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO orlistat results in increased activity of NR1I2 protein CTD PMID:20599501 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Orlistat binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:31312845 NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270 		JBrowse link
G Nts neurotensin multiple interactions ISO orlistat inhibits the reaction [Fats results in increased secretion of NTS protein]; orlistat inhibits the reaction [Olive Oil results in increased secretion of NTS protein] CTD PMID:18303078 NCBI chr10:102,317,617...102,326,294
Ensembl chr10:102,317,617...102,326,347 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions
increases cleavage		 ISO [orlistat co-treated with Thapsigargin] results in increased cleavage of PARP1 protein
orlistat results in increased cleavage of PARP1 protein		 CTD PMID:15870086 PMID:17283163 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of PCNA protein] CTD PMID:32045588 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234 		JBrowse link
G Pla2g7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) multiple interactions
decreases activity		 ISO [orlistat co-treated with Ezetimibe] results in decreased activity of PLA2G7 protein; [orlistat co-treated with Fenofibrate] results in decreased activity of PLA2G7 protein
orlistat results in decreased activity of PLA2G7 protein		 CTD PMID:16911813 PMID:18513463 PMID:18657971 NCBI chr17:43,879,009...43,923,093
Ensembl chr17:43,878,989...43,923,092 		JBrowse link
G Pnlip pancreatic lipase decreases activity
multiple interactions
decreases secretion
affects folding		 ISO orlistat results in decreased activity of PNLIP protein
[[orlistat results in decreased abundance of Fatty Acids, Nonesterified] which results in decreased secretion of CCK protein] which results in decreased secretion of PNLIP protein; orlistat inhibits the reaction [[PNLIP protein co-treated with CLPS protein] results in increased hydrolysis of Olive Oil]
orlistat inhibits the reaction [Taurocholic Acid results in increased activity of PNLIP protein]
orlistat results in decreased secretion of PNLIP protein
orlistat affects the folding of PNLIP protein		 CTD PMID:11408251 PMID:11668201 PMID:12381337 PMID:15158758 PMID:19346257 NCBI chr19:58,658,797...58,670,231
Ensembl chr19:58,640,930...58,670,220 		JBrowse link
G Pnliprp2 pancreatic lipase-related protein 2 decreases activity ISO orlistat results in decreased activity of PNLIPRP2 protein
Orlistat results in decreased activity of PNLIPRP2 protein		 CTD PMID:9822688 PMID:17401110 NCBI chr19:58,748,155...58,765,966
Ensembl chr19:58,748,151...58,765,966 		JBrowse link
G Pon1 paraoxonase 1 increases activity ISO orlistat results in increased activity of PON1 protein CTD PMID:11820148 PMID:17134960 NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946 		JBrowse link
G Ppard peroxisome proliferator activator receptor delta multiple interactions ISO Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARD mRNA] CTD PMID:33476690 NCBI chr17:28,451,715...28,520,446
Ensembl chr17:28,451,674...28,520,448 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma increases expression ISO Orlistat results in increased expression of PPARG mRNA CTD PMID:32347045 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 decreases expression ISO Orlistat results in decreased expression of PPT1 protein CTD PMID:30667213 NCBI chr 4:122,729,879...122,752,968
Ensembl chr 4:122,730,035...122,752,968 		JBrowse link
G Ppy pancreatic polypeptide multiple interactions ISO orlistat inhibits the reaction [Triglycerides results in increased secretion of PPY protein] CTD PMID:15998659 NCBI chr11:101,990,757...101,992,145
Ensembl chr11:101,990,756...101,992,145 		JBrowse link
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit multiple interactions EXP
ISO		 orlistat inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased phosphorylation of and results in increased activity of PRKAA1 protein]; orlistat inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of PRKAA1 protein]
orlistat inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]		 CTD PMID:18390901 PMID:19167487 NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380 		JBrowse link
G Pten phosphatase and tensin homolog increases expression
multiple interactions		 ISO Orlistat results in increased expression of PTEN protein
Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in decreased expression of PTEN protein]		 CTD PMID:32045588 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of PTGS2 protein] CTD PMID:32045588 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Pyy peptide YY decreases secretion
multiple interactions		 ISO orlistat results in decreased secretion of PYY protein
orlistat inhibits the reaction [Olive Oil results in increased expression of PYY protein]; orlistat inhibits the reaction [Triglycerides results in increased secretion of PYY protein]		 CTD PMID:15998659 PMID:17138722 PMID:18647814 NCBI chr11:101,997,502...101,998,658
Ensembl chr11:101,997,502...101,998,658 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO orlistat results in decreased phosphorylation of RB1 protein CTD PMID:15138278 NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Orlistat inhibits the reaction [Dietary Fats results in increased expression of RELA mRNA] CTD PMID:32450208 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Rps6 ribosomal protein S6 multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of RPS6 protein] CTD PMID:32045588 NCBI chr 4:86,772,336...86,775,604
Ensembl chr 4:86,772,897...86,775,649 		JBrowse link
G Sec24d SEC24 homolog D, COPII coat complex component increases expression ISO orlistat results in increased expression of SEC24D mRNA CTD PMID:18796435 NCBI chr 3:123,058,451...123,159,290
Ensembl chr 3:123,061,104...123,159,290 		JBrowse link
G Skp2 S-phase kinase-associated protein 2 multiple interactions
decreases expression		 ISO [orlistat results in decreased activity of FASN protein] which results in decreased expression of SKP2 protein
orlistat results in decreased expression of SKP2 protein		 CTD PMID:15138278 NCBI chr15:9,112,070...9,155,512
Ensembl chr15:9,112,073...9,155,512 		JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO orlistat inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression
multiple interactions		 ISO Orlistat results in decreased expression of SREBF1 protein
Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of SREBF1 protein]		 CTD PMID:32045588 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of TGFB1 mRNA CTD PMID:33476690 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of TNF protein]; Orlistat inhibits the reaction [LPL protein results in decreased activity of TNF protein]
Orlistat inhibits the reaction [Dietary Fats results in increased expression of TNF mRNA]		 CTD PMID:15994321 PMID:32045588 PMID:32450208 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 increases response to substance ISO orlistat results in increased susceptibility to TNFSF10 protein CTD PMID:18796435 PMID:21406729 NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576 		JBrowse link
G Trf transferrin multiple interactions ISO [Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of NFE2L2 mRNA; [Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of TGFB1 mRNA; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ACACA mRNA]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ protein]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FASN mRNA]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARD mRNA]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of UCP1 mRNA]; Orlistat promotes the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA protein] CTD PMID:33476690 NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO Orlistat inhibits the reaction [Dietary Fats results in increased expression of TP53 mRNA] CTD PMID:32450208 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Ucp1 uncoupling protein 1 (mitochondrial, proton carrier) multiple interactions ISO Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of UCP1 mRNA] CTD PMID:33476690 NCBI chr 8:84,016,977...84,025,085
Ensembl chr 8:84,016,981...84,025,081 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO orlistat affects the reaction [ERN1 protein affects the splicing of XBP1 mRNA] CTD PMID:17283163 NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22182
    role 22167
      application 21752
        refrigerant 19194
          isobutane 1058
            isobutyl group 167
              leucine 167
                L-leucine 167
                  Ala-Leu-Ala 0
                  Ala-Leu-Ala-Pro 0
                  Ala-Leu-Asp-Asp 0
                  Ala-Leu-Asp-Gly 0
                  Ala-Leu-Leu-Asp 0
                  Ala-Leu-Leu-His 0
                  Ala-Leu-Leu-Ser 0
                  Ala-Leu-Leu-Thr 0
                  Ala-Leu-Thr-Gln 0
                  Ala-Leu-Thr-Pro 0
                  Ala-Leu-Val-Ser 0
                  Asn-Leu 0
                  Asn-Leu-Asp-Asp 0
                  Asn-Leu-Leu-Ser 0
                  Asn-Leu-Phe-Asp 0
                  Asp-Leu-Asp-Gln 0
                  Asp-Leu-Leu-Gln 0
                  Asp-Leu-Leu-Ser 0
                  Asp-Leu-Phe-Val 0
                  Asp-Leu-Thr-Asp 0
                  Asp-Leu-Thr-Ser 0
                  DON-10-leucine 0
                  Gln-Leu 0
                  Gln-Leu-Leu-Pro 0
                  Glu-Glu-Leu 0
                  Glu-Leu 0
                  Glu-Leu-Phe-Ala 0
                  Glu-Val-Thr-Leu-Tyr peptide residue 0
                  Gly-L-Leu-L-Met-NH2 0
                  Gly-Leu 0
                  Ile-Leu-Trp-Trp 0
                  Ile-Leu-Val-Tyr 0
                  L-Leu-L-Met-NH2 0
                  L-Phe-Gly-L-Leu-L-Met-NH2 0
                  L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 0
                  L-leucine derivative + 116
                  L-leucine residue + 0
                  L-leucine-d3 0
                  L-leucino group 0
                  L-leucyl group 0
                  Leu-Ala 0
                  Leu-Ala-Asp 0
                  Leu-Ala-Gly 0
                  Leu-Ala-Ser 0
                  Leu-Arg 0
                  Leu-Asn 0
                  Leu-Asn-His 0
                  Leu-Asp-Gln 0
                  Leu-Asp-Gly 0
                  Leu-Asp-Ser 0
                  Leu-Asp-Tyr 0
                  Leu-Cys 0
                  Leu-FMDP 0
                  Leu-Gly-Pro 0
                  Leu-Gly-Ser 0
                  Leu-Leu 0
                  Leu-Leu-Ala 0
                  Leu-Leu-Asn 0
                  Leu-Leu-Asp 0
                  Leu-Leu-Gly 0
                  Leu-Leu-Ser 0
                  Leu-Leu-Tyr 0
                  Leu-Lys 0
                  Leu-Lys-Asp 0
                  Leu-Met 0
                  Leu-Phe 0
                  Leu-Phe-Asn 0
                  Leu-Phe-Asp 0
                  Leu-Pro 0
                  Leu-Pro-Tyr 0
                  Leu-Ser 0
                  Leu-Ser-Ser-Tyr 0
                  Leu-Thr 0
                  Leu-Thr-Ala 0
                  Leu-Thr-Asp 0
                  Leu-Thr-Gln 0
                  Leu-Thr-Ser 0
                  Leu-Trp 0
                  Leu-Tyr 0
                  Leu-Val 0
                  Leu-Val-Asp 0
                  Leu-Val-Gly 0
                  Leu-Val-Ser 0
                  Leu-enkephalin 3
                  Lys-Leu-Ser 0
                  Lys-Lys-Leu 0
                  N-formyl-L-methionyl-L-leucyl-L-phenylalanine 53
                  Ser-Leu-Ser 0
                  Tyr-Ile-Leu 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22182
    subatomic particle 22174
      composite particle 22174
        hadron 22174
          baryon 22174
            nucleon 22174
              atomic nucleus 22174
                atom 22174
                  main group element atom 22108
                    main group molecular entity 22108
                      s-block molecular entity 21708
                        hydrogen molecular entity 21626
                          hydrides 20762
                            inorganic hydride 18674
                              pnictogen hydride 18654
                                nitrogen hydride 18521
                                  azane 18428
                                    ammonia 18427
                                      organic amino compound 18427
                                        amino acid 16414
                                          alpha-amino acid 14209
                                            L-alpha-amino acid 13304
                                              pyruvate family amino acid 324
                                                L-leucine 167
                                                  Ala-Leu-Ala 0
                                                  Ala-Leu-Ala-Pro 0
                                                  Ala-Leu-Asp-Asp 0
                                                  Ala-Leu-Asp-Gly 0
                                                  Ala-Leu-Leu-Asp 0
                                                  Ala-Leu-Leu-His 0
                                                  Ala-Leu-Leu-Ser 0
                                                  Ala-Leu-Leu-Thr 0
                                                  Ala-Leu-Thr-Gln 0
                                                  Ala-Leu-Thr-Pro 0
                                                  Ala-Leu-Val-Ser 0
                                                  Asn-Leu 0
                                                  Asn-Leu-Asp-Asp 0
                                                  Asn-Leu-Leu-Ser 0
                                                  Asn-Leu-Phe-Asp 0
                                                  Asp-Leu-Asp-Gln 0
                                                  Asp-Leu-Leu-Gln 0
                                                  Asp-Leu-Leu-Ser 0
                                                  Asp-Leu-Phe-Val 0
                                                  Asp-Leu-Thr-Asp 0
                                                  Asp-Leu-Thr-Ser 0
                                                  DON-10-leucine 0
                                                  Gln-Leu 0
                                                  Gln-Leu-Leu-Pro 0
                                                  Glu-Glu-Leu 0
                                                  Glu-Leu 0
                                                  Glu-Leu-Phe-Ala 0
                                                  Glu-Val-Thr-Leu-Tyr peptide residue 0
                                                  Gly-L-Leu-L-Met-NH2 0
                                                  Gly-Leu 0
                                                  Ile-Leu-Trp-Trp 0
                                                  Ile-Leu-Val-Tyr 0
                                                  L-Leu-L-Met-NH2 0
                                                  L-Phe-Gly-L-Leu-L-Met-NH2 0
                                                  L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 0
                                                  L-leucine derivative + 116
                                                  L-leucine residue + 0
                                                  L-leucine-d3 0
                                                  L-leucino group 0
                                                  L-leucyl group 0
                                                  Leu-Ala 0
                                                  Leu-Ala-Asp 0
                                                  Leu-Ala-Gly 0
                                                  Leu-Ala-Ser 0
                                                  Leu-Arg 0
                                                  Leu-Asn 0
                                                  Leu-Asn-His 0
                                                  Leu-Asp-Gln 0
                                                  Leu-Asp-Gly 0
                                                  Leu-Asp-Ser 0
                                                  Leu-Asp-Tyr 0
                                                  Leu-Cys 0
                                                  Leu-FMDP 0
                                                  Leu-Gly-Pro 0
                                                  Leu-Gly-Ser 0
                                                  Leu-Leu 0
                                                  Leu-Leu-Ala 0
                                                  Leu-Leu-Asn 0
                                                  Leu-Leu-Asp 0
                                                  Leu-Leu-Gly 0
                                                  Leu-Leu-Ser 0
                                                  Leu-Leu-Tyr 0
                                                  Leu-Lys 0
                                                  Leu-Lys-Asp 0
                                                  Leu-Met 0
                                                  Leu-Phe 0
                                                  Leu-Phe-Asn 0
                                                  Leu-Phe-Asp 0
                                                  Leu-Pro 0
                                                  Leu-Pro-Tyr 0
                                                  Leu-Ser 0
                                                  Leu-Ser-Ser-Tyr 0
                                                  Leu-Thr 0
                                                  Leu-Thr-Ala 0
                                                  Leu-Thr-Asp 0
                                                  Leu-Thr-Gln 0
                                                  Leu-Thr-Ser 0
                                                  Leu-Trp 0
                                                  Leu-Tyr 0
                                                  Leu-Val 0
                                                  Leu-Val-Asp 0
                                                  Leu-Val-Gly 0
                                                  Leu-Val-Ser 0
                                                  Leu-enkephalin 3
                                                  Lys-Leu-Ser 0
                                                  Lys-Lys-Leu 0
                                                  N-formyl-L-methionyl-L-leucyl-L-phenylalanine 53
                                                  Ser-Leu-Ser 0
                                                  Tyr-Ile-Leu 0
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