Elane (elastase, neutrophil expressed) - Rat Genome Database

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Gene: Elane (elastase, neutrophil expressed) Mus musculus
Analyze
Symbol: Elane
Name: elastase, neutrophil expressed
RGD ID: 1624045
MGI Page MGI
Description: Exhibits serine-type endopeptidase activity. Involved in several processes, including acute inflammatory response to antigenic stimulus; response to fungus; and response to lipopolysaccharide. Localizes to cytoplasm. Human ortholog(s) of this gene implicated in cyclic hematopoiesis; periodontitis; polycythemia vera; severe congenital neutropenia; and severe congenital neutropenia 1. Orthologous to human ELANE (elastase, neutrophil expressed).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: El; Ela2; elastase 2, neutrophil; elastase-2; F430011M15Rik; leukocyte elastase; N; NE; neutrophil elastase
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,722,146 - 79,724,050 (+)NCBIGRCm39mm39
GRCm39 Ensembl1079,722,081 - 79,724,049 (+)Ensembl
GRCm381079,886,312 - 79,888,216 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,886,247 - 79,888,215 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,349,057 - 79,350,961 (+)NCBIGRCm37mm9NCBIm37
MGSCv361079,289,464 - 79,291,246 (+)NCBImm8
Celera1080,901,123 - 80,903,026 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Belaaouaj A, etal., Nat Med. 1998 May;4(5):615-8.
2. Chen HM, etal., Shock. 1999 Dec;12(6):462-7.
3. Cho HK and Jeon IS, J Korean Med Sci. 2014 Mar;29(3):452-5. doi: 10.3346/jkms.2014.29.3.452. Epub 2014 Feb 27.
4. Chung MC, etal., FEMS Immunol Med Microbiol. 2008 Dec;54(3):309-18. doi: 10.1111/j.1574-695X.2008.00480.x.
5. Crinnion JN, etal., Cardiovasc Surg. 1994 Dec;2(6):749-53.
6. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
7. Guo L, etal., Dig Dis Sci. 1995 Oct;40(10):2177-83.
8. Harada N, etal., Shock. 2008 Oct;30(4):379-87. doi: 10.1097/SHK.0b013e3181673e2c.
9. Hayakawa M, etal., Surgery. 2011 Feb;149(2):221-30. doi: 10.1016/j.surg.2010.06.010. Epub 2010 Jul 23.
10. Hayama T, etal., Transplant Proc. 2006 Sep;38(7):2201-2.
11. Hirahashi J, etal., Circulation. 2009 Sep 29;120(13):1255-65. Epub 2009 Sep 14.
12. Honore S, etal., Shock. 2004 Aug;22(2):131-6.
13. Horwitz M, etal., Nat Genet. 1999 Dec;23(4):433-6.
14. Jo YJ, etal., Int Immunopharmacol. 2008 Jul;8(7):959-66. doi: 10.1016/j.intimp.2008.02.014. Epub 2008 Mar 27.
15. Kaynar AM, etal., Am J Respir Cell Mol Biol. 2008 Jul;39(1):53-60. doi: 10.1165/rcmb.2007-0315OC. Epub 2008 Feb 14.
16. Kono T, etal., Mol Cell Biochem. 2008 Apr;311(1-2):87-92. doi: 10.1007/s11010-007-9698-9. Epub 2007 Dec 30.
17. Kuraki T, etal., Am J Respir Crit Care Med. 2002 Aug 15;166(4):496-500.
18. Kurnikova M, etal., Pediatr Blood Cancer. 2011 Aug;57(2):332-5. doi: 10.1002/pbc.23104. Epub 2011 Mar 21.
19. Liu W, etal., J Lab Clin Med. 1998 Nov;132(5):432-9.
20. Marchetti M, etal., Blood. 2008 Nov 15;112(10):4061-8. doi: 10.1182/blood-2008-06-164087. Epub 2008 Sep 3.
21. Matayoshi H, etal., Brain Res. 2009 Mar 9;1259:98-106. doi: 10.1016/j.brainres.2008.12.070. Epub 2009 Jan 10.
22. Mori H, etal., Eur J Cardiothorac Surg. 2007 Nov;32(5):791-5. Epub 2007 Sep 20.
23. Oliveira C, etal., Br J Pharmacol. 2010 Oct;161(4):899-910. doi: 10.1111/j.1476-5381.2010.00924.x.
24. OMIM Disease Annotation Pipeline
25. Pipeline to import KEGG annotations from KEGG into RGD
26. Prufer S, etal., Immunobiology. 2014 Feb;219(2):87-96. doi: 10.1016/j.imbio.2013.08.010. Epub 2013 Aug 30.
27. RGD automated import pipeline
28. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. RGD automated import pipeline for gene-chemical interactions
30. Shimakura A, etal., Brain Res. 2000 Mar 6;858(1):55-60.
31. Skokowa J, etal., Blood. 2009 Oct 1;114(14):3044-51. doi: 10.1182/blood-2008-11-188755. Epub 2009 Jul 20.
32. Song JS, etal., Exp Lung Res. 2009 Dec;35(10):817-29. doi: 10.3109/01902140902912527.
33. Takahasi H, etal., J Trauma. 2000 Jul;49(1):86-91.
34. Taoka Y, etal., Brain Res. 1998 Jul 20;799(2):264-9.
35. Toda Y, etal., Int J Mol Med. 2007 Feb;19(2):237-43.
36. Tsuji M, etal., Arch Oral Biol. 2009 Dec;54(12):1128-35. doi: 10.1016/j.archoralbio.2009.10.003. Epub 2009 Nov 12.
37. Yamamoto H, etal., Eur J Pharmacol. 2000 Dec 8;409(2):179-83.
38. Yang YL, etal., J Biomed Sci. 2008 Jul;15(4):499-507. doi: 10.1007/s11373-008-9238-y. Epub 2008 Feb 19.
39. Ye Y, etal., J Clin Immunol. 2011 Dec;31(6):936-45. doi: 10.1007/s10875-011-9572-0. Epub 2011 Jul 29.
Additional References at PubMed
PMID:8035830   PMID:9021140   PMID:9611252   PMID:9925946   PMID:10051312   PMID:10187779   PMID:10349636   PMID:10714686   PMID:10984455   PMID:11007483   PMID:11042159   PMID:11076861  
PMID:11217851   PMID:11451907   PMID:11907569   PMID:11961105   PMID:11994507   PMID:12189154   PMID:12384420   PMID:12412016   PMID:12466851   PMID:12477932   PMID:14565940   PMID:14633606  
PMID:14636558   PMID:14975240   PMID:15010367   PMID:15034066   PMID:15078883   PMID:15131125   PMID:15489334   PMID:15601827   PMID:15614130   PMID:15661916   PMID:15840647   PMID:15963783  
PMID:16045796   PMID:16141072   PMID:16141073   PMID:16182289   PMID:16373690   PMID:16602821   PMID:16754715   PMID:16872848   PMID:16920981   PMID:17200183   PMID:17272511   PMID:17442971  
PMID:17878334   PMID:18023421   PMID:18178964   PMID:18292580   PMID:18536720   PMID:18568075   PMID:18772136   PMID:18802098   PMID:19039769   PMID:19088179   PMID:19393318   PMID:19833730  
PMID:20081861   PMID:20676107   PMID:20709801   PMID:20921524   PMID:20965700   PMID:20974816   PMID:21098233   PMID:21160041   PMID:21285438   PMID:21464320   PMID:21849484   PMID:21860019  
PMID:21873635   PMID:21911460   PMID:21979170   PMID:22159717   PMID:22163282   PMID:22197976   PMID:22213227   PMID:22241891   PMID:22441751   PMID:22461690   PMID:22683734   PMID:22711877  
PMID:22862945   PMID:22863787   PMID:22927440   PMID:23024281   PMID:23227233   PMID:23404144   PMID:23532733   PMID:23562077   PMID:23975926   PMID:24321240   PMID:24335230   PMID:24599360  
PMID:24857755   PMID:24929239   PMID:25092677   PMID:25166912   PMID:25195861   PMID:25274309   PMID:25278585   PMID:25497734   PMID:25666548   PMID:25743626   PMID:25915831   PMID:26047922  
PMID:26064906   PMID:26185250   PMID:26649828   PMID:26712312   PMID:27551156   PMID:27573815   PMID:27942017   PMID:28192517   PMID:28202548   PMID:28300553   PMID:28512253   PMID:28964716  
PMID:29383685   PMID:29401615   PMID:29539421   PMID:29853539   PMID:29922273   PMID:30092349   PMID:30148763   PMID:30262472   PMID:30455353   PMID:30632166   PMID:31108101   PMID:31284755  
PMID:31472960   PMID:31612267   PMID:31685810   PMID:32002713   PMID:32243431   PMID:32294409   PMID:32299910   PMID:32371889   PMID:32415172   PMID:32633320   PMID:33214666  


Genomics

Comparative Map Data
Elane
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,722,146 - 79,724,050 (+)NCBIGRCm39mm39
GRCm39 Ensembl1079,722,081 - 79,724,049 (+)Ensembl
GRCm381079,886,312 - 79,888,216 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,886,247 - 79,888,215 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,349,057 - 79,350,961 (+)NCBIGRCm37mm9NCBIm37
MGSCv361079,289,464 - 79,291,246 (+)NCBImm8
Celera1080,901,123 - 80,903,026 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
ELANE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl19851,014 - 856,247 (+)EnsemblGRCh38hg38GRCh38
GRCh3819850,997 - 856,250 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3719852,303 - 856,243 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3619803,291 - 807,246 (+)NCBINCBI36hg18NCBI36
Build 3419803,290 - 807,244NCBI
Celera19777,442 - 781,374 (+)NCBI
Cytogenetic Map19p13.3NCBI
HuRef19621,154 - 625,109 (+)NCBIHuRef
CHM1_119851,610 - 855,840 (+)NCBICHM1_1
Elane
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.279,817,251 - 9,819,174 (-)NCBI
Rnor_6.0 Ensembl712,638,322 - 12,640,232 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0712,638,320 - 12,640,168 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0712,808,042 - 12,809,890 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,329,642 - 11,331,490 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1711,329,643 - 11,331,467 (-)NCBI
Celera77,992,002 - 7,993,850 (-)NCBICelera
Cytogenetic Map7q11NCBI
ELANE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.119820,455 - 828,181 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v019276,499 - 280,598 (-)NCBIMhudiblu_PPA_v0panPan3
ELANE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,789,044 - 57,790,932 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,788,062 - 57,790,932 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,591,060 - 57,592,948 (-)NCBI
ROS_Cfam_1.02058,531,328 - 58,533,216 (-)NCBI
UMICH_Zoey_3.12057,586,105 - 57,588,011 (-)NCBI
UNSW_CanFamBas_1.02058,065,758 - 58,067,646 (-)NCBI
UU_Cfam_GSD_1.02058,268,788 - 58,270,676 (-)NCBI
ELANE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,509,344 - 77,516,027 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,513,769 - 77,516,118 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,480,250 - 77,485,906 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ELANE
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16599,392 - 604,925 (+)NCBI
ChlSab1.1 Ensembl6601,217 - 604,725 (+)Ensembl


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357740Obsty3_mobesity 3 (mouse)Not determined108359714116355075Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101023252187565233Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101282830784243920Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101282830784243920Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101282830784243920Mouse
1357893Lvrq4_mliver weight QTL 4 (mouse)Not determined101282830784243920Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1282830784243920Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1282830784243920Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1282830784243920Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1282830784243920Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101282830784243920Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018383585125739363Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1019000000129800000Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021532255114381325Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102300000091200000Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024800000121200000Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039300000129800000Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039300000129800000Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1045000000116100000Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045600000120800000Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4684430782655287Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104950223383502378Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined105001240884012633Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined105001240884012633Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined105001240884012633Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined105001244384012618Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined105001244384012618Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105125566085255809Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105125566085255809Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105161730482655287Mouse
14746991Manh68_mmandible shape 68 (mouse)105244466786444667Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105868113592681262Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059500000122500000Mouse
13208560Wght9_mweight 9 (mouse)1060000000121000000Mouse
26884424Zlq9_mzygomatic length QTL 9, 16 week (mouse)1064100000116100000Mouse
1302060El3_mepilepsy 3 (mouse)Not determined106565510499655287Mouse
1300533Aem3_manti-erythrocyte autoantibody modifier 3 (mouse)Not determined106565510499655287Mouse
1301737Insq9_minsulin QTL 9 (mouse)Not determined106565510499655287Mouse
1302035Lmb4_mlupus in MRL and B6 F2 cross (mouse)Not determined106701240892422811Mouse
26884447Sklq9_mskull length QTL 9, 10 week (mouse)1067500000111900000Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1068000000125000000Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069900000132500000Mouse
11039497Ltpr5a_mLeishmania tropica response 5a (mouse)1073671039107671185Mouse
4142107Obrq12_mobesity resistance QTL 12 (mouse)Not determined7415138482655287Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1074151384125680038Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1074151384125680038Mouse
1300975Fembrs3_mfemur breaking strength 3 (mouse)Not determined1075502706109502905Mouse
4142137Femwf3_mfemur work to failure 3 (mouse)Not determined75502706109502905Mouse
1357632Vtbt9_mvertebral trabecular bone trait 9 (mouse)Not determined1075502706109502905Mouse
11251717Siim1_mstress induced immobility 1 (mouse)1078545406112545406Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:158
Count of miRNA genes:155
Interacting mature miRNAs:158
Transcripts:ENSMUST00000046091
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000046091   ⟹   ENSMUSP00000038925
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1079,886,247 - 79,888,215 (+)Ensembl
RefSeq Acc Id: NM_015779   ⟹   NP_056594
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391079,722,146 - 79,724,050 (+)NCBI
GRCm381079,886,312 - 79,888,216 (+)ENTREZGENE
MGSCv371079,349,057 - 79,350,961 (+)RGD
Celera1080,901,123 - 80,903,026 (+)RGD
cM Map10 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_056594   ⟸   NM_015779
- Peptide Label: precursor
- UniProtKB: Q3UP87 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000038925   ⟸   ENSMUST00000046091
Protein Domains
Peptidase S1

Promoters
RGD ID:8672570
Promoter ID:EPDNEW_M14316
Type:multiple initiation site
Name:Elane_1
Description:Mus musculus elastase, neutrophil expressed , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381079,886,312 - 79,886,372EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2679229 AgrOrtholog
Ensembl Genes ENSMUSG00000020125 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000038925 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000046091 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
KEGG Report mmu:50701 UniProtKB/Swiss-Prot
MGD MGI:2679229 ENTREZGENE
NCBI Gene 50701 ENTREZGENE
Pfam Trypsin UniProtKB/Swiss-Prot
PharmGKB ELA2 RGD
PhenoGen Elane PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
SMART Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
UniProt ELNE_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A6H698 UniProtKB/Swiss-Prot
  Q61515 UniProtKB/Swiss-Prot