Arf6 (ADP-ribosylation factor 6) - Rat Genome Database

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Gene: Arf6 (ADP-ribosylation factor 6) Mus musculus
Analyze
Symbol: Arf6
Name: ADP-ribosylation factor 6
RGD ID: 734182
MGI Page MGI
Description: Exhibits protein N-terminus binding activity. Involved in several processes, including hepatocyte apoptotic process; positive regulation of focal adhesion disassembly; and regulation of cellular protein localization. Localizes to endosome and plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system; and respiratory system. Orthologous to human ARF6 (ADP ribosylation factor 6); PARTICIPATES IN E-cadherin signaling pathway; phosphatidylinositol 3-kinase class I signaling pathway; endocytosis pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI788669; AW496366; expressed sequence AI788669; MGC102530
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391269,418,924 - 69,422,754 (+)NCBIGRCm39mm39
GRCm39 Ensembl1269,418,924 - 69,420,557 (+)Ensembl
GRCm381269,372,150 - 69,375,980 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1269,372,150 - 69,373,783 (+)EnsemblGRCm38mm10GRCm38
MGSCv371270,473,137 - 70,476,967 (+)NCBIGRCm37mm9NCBIm37
MGSCv361270,290,793 - 70,292,388 (+)NCBImm8
Celera1270,470,421 - 70,474,282 (+)NCBICelera
Cytogenetic Map12C2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8947846   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12509462   PMID:12810696   PMID:14585928   PMID:14610273   PMID:15489334   PMID:15509780   PMID:15540117  
PMID:15659652   PMID:15692085   PMID:15782199   PMID:15836626   PMID:16141072   PMID:16141073   PMID:16325184   PMID:16415858   PMID:16516854   PMID:16602821   PMID:16707115   PMID:16751103  
PMID:16880525   PMID:17634366   PMID:18026091   PMID:18162163   PMID:18164504   PMID:18286566   PMID:18326492   PMID:18331728   PMID:18708035   PMID:19164586   PMID:19193766   PMID:19327349  
PMID:19442238   PMID:19686593   PMID:19843586   PMID:20080746   PMID:20107045   PMID:20385769   PMID:20493856   PMID:20505075   PMID:20525696   PMID:20547133   PMID:20727515   PMID:21069828  
PMID:21357688   PMID:21825135   PMID:21873635   PMID:21883766   PMID:21911479   PMID:22053287   PMID:22170068   PMID:22351926   PMID:22522702   PMID:22659138   PMID:22790193   PMID:22841714  
PMID:22907437   PMID:23012656   PMID:23517829   PMID:23572513   PMID:23578932   PMID:23621612   PMID:24261326   PMID:24297182   PMID:24457600   PMID:24581425   PMID:24616519   PMID:24835390  
PMID:24952961   PMID:24955982   PMID:25130574   PMID:25144208   PMID:25450674   PMID:25450693   PMID:25490267   PMID:26229970   PMID:26239146   PMID:26277388   PMID:26291245   PMID:26416603  
PMID:26498519   PMID:26683831   PMID:26703465   PMID:26738539   PMID:26884337   PMID:26935419   PMID:27269287   PMID:27330119   PMID:27336679   PMID:27373827   PMID:27622210   PMID:27758770  
PMID:28378742   PMID:28429746   PMID:28495929   PMID:28744553   PMID:28880939   PMID:28919417   PMID:28931526   PMID:29208529   PMID:29222402   PMID:29420262   PMID:30457570   PMID:30674481  
PMID:30944160   PMID:31048499   PMID:31095630   PMID:31439632   PMID:31907062   PMID:31924649   PMID:32059926   PMID:32325033   PMID:32873638  


Genomics

Comparative Map Data
Arf6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391269,418,924 - 69,422,754 (+)NCBIGRCm39mm39
GRCm39 Ensembl1269,418,924 - 69,420,557 (+)Ensembl
GRCm381269,372,150 - 69,375,980 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1269,372,150 - 69,373,783 (+)EnsemblGRCm38mm10GRCm38
MGSCv371270,473,137 - 70,476,967 (+)NCBIGRCm37mm9NCBIm37
MGSCv361270,290,793 - 70,292,388 (+)NCBImm8
Celera1270,470,421 - 70,474,282 (+)NCBICelera
Cytogenetic Map12C2NCBI
ARF6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1449,893,082 - 49,897,054 (+)EnsemblGRCh38hg38GRCh38
GRCh381449,893,082 - 49,897,054 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371450,359,800 - 50,363,772 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361449,429,486 - 49,433,522 (+)NCBINCBI36hg18NCBI36
Build 341449,429,588 - 49,431,484NCBI
Celera1430,226,871 - 30,230,907 (+)NCBI
Cytogenetic Map14q21.3NCBI
HuRef1430,484,292 - 30,488,326 (+)NCBIHuRef
CHM1_11450,297,978 - 50,302,011 (+)NCBICHM1_1
Arf6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2687,853,742 - 87,854,890 (+)NCBI
Rnor_6.0 Ensembl691,697,109 - 91,698,255 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0691,697,109 - 91,698,257 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06101,149,908 - 101,152,127 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4691,337,496 - 91,338,644 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1691,340,951 - 91,342,098 (+)NCBI
Celera686,351,473 - 86,352,621 (+)NCBICelera
Cytogenetic Map6q24NCBI
Arf6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540912,817,496 - 12,818,023 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540912,814,814 - 12,818,142 (-)NCBIChiLan1.0ChiLan1.0
ARF6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11448,788,586 - 48,792,641 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1448,789,329 - 48,789,856 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01430,482,191 - 30,486,741 (+)NCBIMhudiblu_PPA_v0panPan3
ARF6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1826,445,407 - 26,449,430 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl826,445,647 - 26,525,530 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha826,199,039 - 26,203,086 (+)NCBI
ROS_Cfam_1.0826,622,998 - 26,627,047 (+)NCBI
UMICH_Zoey_3.1826,278,479 - 26,282,519 (+)NCBI
UNSW_CanFamBas_1.0826,351,547 - 26,355,590 (+)NCBI
UU_Cfam_GSD_1.0826,669,436 - 26,673,480 (+)NCBI
Arf6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864058,503,422 - 58,507,422 (+)NCBI
SpeTri2.0NW_004936583181,490 - 185,466 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARF6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1179,697,615 - 179,717,844 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11179,697,582 - 179,717,299 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21200,071,305 - 200,075,268 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARF6
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12426,948,794 - 26,952,803 (+)NCBI
ChlSab1.1 Ensembl2426,949,388 - 26,950,074 (+)Ensembl
Arf6
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473118,880,065 - 18,883,456 (-)NCBI

Position Markers
AW496366  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381269,373,369 - 69,373,482UniSTSGRCm38
MGSCv371270,474,356 - 70,474,469UniSTSGRCm37
Celera1270,471,670 - 70,471,784UniSTS
Cytogenetic Map12C2UniSTS
Whitehead/MRC_RH12646.49UniSTS
AI788669  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381269,375,551 - 69,375,699UniSTSGRCm38
MGSCv371270,476,538 - 70,476,686UniSTSGRCm37
Celera1270,473,853 - 70,474,001UniSTS
Cytogenetic Map12C2UniSTS
Whitehead/MRC_RH12639.64UniSTS
MARC_11609-11610:1002740839:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381269,375,068 - 69,375,446UniSTSGRCm38
MGSCv371270,476,055 - 70,476,433UniSTSGRCm37
Celera1270,473,370 - 70,473,748UniSTS
Cytogenetic Map12C2UniSTS
ARF6_719  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381269,372,800 - 69,373,655UniSTSGRCm38
MGSCv371270,473,787 - 70,474,642UniSTSGRCm37
Celera1270,471,101 - 70,471,957UniSTS
Cytogenetic Map12C2UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142234Tmc1m3_mTmc1 modifier 3 (mouse)Not determined12536844076984429Mouse
27226753Femd7_mfemur midshaft diameter 7, 10 week (mouse)12950000084100000Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121161000097210000Mouse
1558978Cplaq10_mcircadian period of locomotor activity 10 (mouse)Not determined121529102578993590Mouse
1301574Lmblgq5_mlimb length QTL 5 (mouse)Not determined121754644680910109Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235235497109969809Mouse
1357479Splwt1_mspleen weight 1 (mouse)Not determined124164639290920752Mouse
1357757Lnopy2_mlens opacity 2 (mouse)Not determined125279985286800022Mouse
1357749Vtbt13_mvertebral trabecular bone trait 13 (mouse)Not determined125308522887085371Mouse
12832727Ahrq1_mairway hyperresponsiveness QTL 1 (mouse)125464912582619165Mouse
4140993Tglq2b_mtriglyceride QTL 2b (mouse)Not determined125529146189291675Mouse
9850127Tglq6_mtriglyceride QTL6 (mouse)Not determined125529146189291675Mouse
27226728Tibl20_mtibia length 20, 16 week (mouse)125910000093900000Mouse
27226776Tibl6_mtibia length 6, 5 week (mouse)126060000092700000Mouse
10043948Pbft6_mpercent body fat 6 (mouse)Not determined126115865395158653Mouse
1301476Pbwg12_mpostnatal body weight growth 12 (mouse)Not determined126199339095993590Mouse
27226797Scvln19_msacral vertebrae length 2, 16 week (mouse)126210000099500000Mouse
10043895Bw20_mbody weight QTL 20 (mouse)Not determined126226147896261478Mouse
1301046Par3_mpulmonary adenoma resistance 3 (mouse)Not determined126390993497910109Mouse
1301337Cdcs8_mcytokine deficiency colitis susceptibility 8 (mouse)Not determined126464230998642455Mouse
1300633Cdcs7_mcytokine deficiency colitis susceptibility 7 (mouse)Not determined126464230998642455Mouse
14746976Manh73_mmandible shape 73 (mouse)126581035799810357Mouse
27226771Tibl14_mtibia length 14, 10 week (mouse)126830000098800000Mouse
27226793Feml10_mfemur length 10, 5 week (mouse)1268300000113400000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:723
Count of miRNA genes:463
Interacting mature miRNAs:539
Transcripts:ENSMUST00000050063
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000050063   ⟹   ENSMUSP00000055862
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1269,372,150 - 69,373,783 (+)Ensembl
RefSeq Acc Id: NM_007481   ⟹   NP_031507
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391269,418,924 - 69,422,754 (+)NCBI
GRCm381269,372,150 - 69,375,980 (+)ENTREZGENE
MGSCv371270,473,137 - 70,476,967 (+)RGD
Celera1270,470,421 - 70,474,282 (+)RGD
cM Map12 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_031507 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH03478 (Get FASTA)   NCBI Sequence Viewer  
  AAH83112 (Get FASTA)   NCBI Sequence Viewer  
  BAA13495 (Get FASTA)   NCBI Sequence Viewer  
  BAE33917 (Get FASTA)   NCBI Sequence Viewer  
  P62331 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_031507   ⟸   NM_007481
- UniProtKB: P62331 (UniProtKB/Swiss-Prot),   Q3U0D7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000055862   ⟸   ENSMUST00000050063

Promoters
RGD ID:8678408
Promoter ID:EPDNEW_M17234
Type:initiation region
Name:Arf6_1
Description:Mus musculus ADP-ribosylation factor 6 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381269,372,165 - 69,372,225EPDNEW
RGD ID:6822729
Promoter ID:MM_KWN:11811
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Liver,   MEF_B4
Transcripts:NM_007481
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361270,472,929 - 70,473,429 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99435 AgrOrtholog
Ensembl Genes ENSMUSG00000044147 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000055862 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000050063 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Arf6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase_ARF/SAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11845 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:99435 ENTREZGENE
NCBI Gene 11845 ENTREZGENE
Pfam Arf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Arf6 PhenoGen
PRINTS SAR1GTPBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ARF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs small_GTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ARF6_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3U0D7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P26438 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Arf6  ADP-ribosylation factor 6  AI788669  expressed sequence AI788669  Data Merged 737654 PROVISIONAL