CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: pyruvate family amino acid
Accession: CHEBI:26463
browse the term
Definition: An L-alpha-amino acid which is biosynthesised from pyruvate (i.e. alanine, valine, and leucine). A closed class.
Synonyms: related_synonym: pyruvate family amino acids
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Gria3
glutamate ionotropic receptor AMPA type subunit 3
affects response to substance
ISO
GRIA3 protein affects the susceptibility to 5-fluorowillardiine
CTD
PMID:15264227
NCBI chr X:127,561,843...127,829,763
Ensembl chr X:127,562,660...127,829,753
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Ctsd
cathepsin D
multiple interactions
EXP
alliin affects the reaction [Isoproterenol affects the activity of CTSD protein]
CTD
PMID:17623887
NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
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Fasn
fatty acid synthase
multiple interactions
ISO
alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of FASN mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of FASN protein]
CTD
PMID:29305303
NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
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Fgf2
fibroblast growth factor 2
decreases secretion multiple interactions
ISO
alliin results in decreased secretion of FGF2 protein alliin promotes the reaction [FGF2 protein results in increased expression of TP53 protein]
CTD
PMID:16351512
NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
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Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
multiple interactions
EXP ISO
alliin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein] alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR protein]
CTD
PMID:16640830 PMID:29305303
NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
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Lcat
lecithin cholesterol acyltransferase
multiple interactions
EXP
alliin inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein]
CTD
PMID:16640830
NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813
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Srebf1
sterol regulatory element binding transcription factor 1
multiple interactions
ISO
alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF1 mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF1 protein]
CTD
PMID:29305303
NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
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Srebf2
sterol regulatory element binding transcription factor 2
multiple interactions
ISO
alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF2 mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF2 protein]
CTD
PMID:29305303
NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
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Tp53
tumor protein p53
multiple interactions
ISO
alliin promotes the reaction [FGF2 protein results in increased expression of TP53 protein]
CTD
PMID:16351512
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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Vegfa
vascular endothelial growth factor A
decreases secretion
ISO
alliin results in decreased secretion of VEGFA protein
CTD
PMID:16351512
NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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Capn1
calpain 1
multiple interactions
ISO
aloxistatin inhibits the reaction [CAPN1 protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form]
CTD
PMID:30910806
NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322
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Capn7
calpain 7
multiple interactions
ISO
aloxistatin inhibits the reaction [CAPN7 protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form]
CTD
PMID:30910806
NCBI chr16:7,435,541...7,472,483
Ensembl chr16:7,435,634...7,471,807
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Casp3
caspase 3
multiple interactions
ISO EXP
[aloxistatin co-treated with pepstatin] inhibits the reaction [[vistusertib co-treated with Chloroquine] results in increased activity of CASP3 protein] [Swainsonine co-treated with aloxistatin] results in increased cleavage of CASP3 protein
CTD
PMID:26853465 PMID:33186601
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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Ctsb
cathepsin B
multiple interactions
ISO
[aloxistatin co-treated with pepstatin] results in decreased expression of CTSB protein; aloxistatin inhibits the reaction [CTSB protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form]
CTD
PMID:30910806 PMID:32186374
NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
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Ctsd
cathepsin D
multiple interactions
ISO
[aloxistatin co-treated with pepstatin] results in decreased expression of CTSD protein
CTD
PMID:32186374
NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
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Ctsl
cathepsin L
multiple interactions
ISO
aloxistatin inhibits the reaction [CTSL protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form]
CTD
PMID:30910806
NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279
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Ddx3x
DEAD-box helicase 3, X-linked
multiple interactions
ISO
aloxistatin inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of DDX3X protein]
CTD
PMID:30821613
NCBI chr X:10,400,363...10,414,010
Ensembl chr X:10,400,366...10,413,995
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Eif4a1
eukaryotic translation initiation factor 4A1
multiple interactions
ISO
aloxistatin inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of EIF4A1 protein]
CTD
PMID:30821613
NCBI chr10:56,271,257...56,276,764
Ensembl chr10:56,271,257...56,276,764
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Eif4h
eukaryotic translation initiation factor 4H
multiple interactions
ISO
aloxistatin inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of EIF4H protein]
CTD
PMID:30821613
NCBI chr12:25,093,119...25,109,805
Ensembl chr12:25,093,149...25,109,799
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Lamp2
lysosomal-associated membrane protein 2
multiple interactions
ISO
[aloxistatin co-treated with pepstatin] results in increased expression of LAMP2 protein
CTD
PMID:32186374
NCBI chr X:124,722,628...124,766,079
Ensembl chr X:124,722,628...124,766,044
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Map1lc3b
microtubule-associated protein 1 light chain 3 beta
multiple interactions
ISO
[aloxistatin co-treated with pepstatin] inhibits the reaction [Biological Factors deficiency results in increased degradation of MAP1LC3B protein modified form]; [aloxistatin co-treated with pepstatin] inhibits the reaction [Biological Factors deficiency results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] inhibits the reaction [Dronabinol results in increased degradation of MAP1LC3B protein modified form]; [aloxistatin co-treated with pepstatin] inhibits the reaction [Dronabinol results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] results in decreased degradation of MAP1LC3B protein modified form
CTD
PMID:27635674
NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
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Sqstm1
sequestosome 1
multiple interactions
ISO
[aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 protein [aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 protein; [Dronabinol co-treated with aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 protein; [HU 211 co-treated with aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 protein
CTD
PMID:32186374 PMID:32773031
NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
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Dek
DEK proto-oncogene
multiple interactions
ISO
DEK protein results in increased chemical synthesis of and results in increased secretion of Alanine
CTD
PMID:28558019
NCBI chr17:17,965,872...17,987,836
Ensembl chr17:17,965,881...17,987,834
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Idh2
isocitrate dehydrogenase (NADP(+)) 2
decreases abundance multiple interactions
ISO
IDH2 protein mutant form results in decreased abundance of Alanine Triazines inhibits the reaction [IDH2 protein mutant form results in decreased abundance of Alanine]
CTD
PMID:27469509
NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
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Atg5
autophagy related 5
multiple interactions
ISO
Leucine inhibits the reaction [alpinetin promotes the reaction [Dextran Sulfate results in increased expression of ATG5 mRNA]]
CTD
PMID:31676321
NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
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Atg7
autophagy related 7
multiple interactions
ISO
Leucine inhibits the reaction [alpinetin promotes the reaction [Dextran Sulfate results in increased expression of ATG7 mRNA]]
CTD
PMID:31676321
NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
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Becn1
beclin 1
multiple interactions
ISO
Leucine inhibits the reaction [[Dextran Sulfate co-treated with alpinetin] results in increased expression of BECN1 protein]
CTD
PMID:31676321
NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
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Casp3
caspase 3
multiple interactions
ISO
Leucine inhibits the reaction [alpinetin inhibits the reaction [Dextran Sulfate results in increased cleavage of CASP3 protein]]
CTD
PMID:31676321
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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Egf
epidermal growth factor
multiple interactions
EXP
[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Leucine; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Leucine]
CTD
PMID:22689575
NCBI chr 2:68,820,616...68,895,537
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Map1lc3b
microtubule-associated protein 1 light chain 3 beta
multiple interactions
ISO
Leucine inhibits the reaction [[Dextran Sulfate co-treated with alpinetin] results in increased expression of and results in increased lipidation of MAP1LC3B protein]
CTD
PMID:31676321
NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
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Mpo
myeloperoxidase
multiple interactions
ISO
Leucine inhibits the reaction [alpinetin inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]]
CTD
PMID:31676321
NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
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Sqstm1
sequestosome 1
multiple interactions
ISO
Leucine inhibits the reaction [[Dextran Sulfate co-treated with alpinetin] results in decreased expression of SQSTM1 protein]
CTD
PMID:31676321
NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
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Alad
aminolevulinate dehydratase
decreases activity
EXP
Selenocysteine analog results in decreased activity of ALAD protein
CTD
PMID:14630126
NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
Selenocysteine inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of FOS protein]; Selenocysteine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of FOS protein]
CTD
PMID:14572605
NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
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Gsta2
glutathione S-transferase alpha 2
increases expression
EXP
Selenocysteine results in increased expression of GSTA2 mRNA
CTD
PMID:12034368
NCBI chr 8:85,640,081...85,645,621
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Gsta3
glutathione S-transferase alpha 3
increases expression
EXP
Selenocysteine results in increased expression of GSTA3 mRNA
CTD
PMID:12034368
NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
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Gsta5
glutathione S-transferase alpha 5
increases expression
EXP
Selenocysteine results in increased expression of GSTA5 mRNA
CTD
PMID:12034368
NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
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Gstp1
glutathione S-transferase pi 1
increases expression
EXP
Selenocysteine results in increased expression of GSTP1 mRNA
CTD
PMID:12034368
NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
Selenocysteine inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of RELA protein]; Selenocysteine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of RELA protein]
CTD
PMID:14572605
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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Klrc1
killer cell lectin like receptor C1
decreases expression
ISO
ledipasvir co-treated with sofosbuvir decreases expression of NCR1 protein in natural killer cells
RGD
PMID:31218578
RGD:40400920
NCBI chr 4:163,453,435...163,463,718
Ensembl chr 4:163,458,528...163,463,718
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Ncr1
natural cytotoxicity triggering receptor 1
affects expression
ISO
ledipasvir co-treated sofosbuvir with affects expression of NCR1 protein in natural killer cells
RGD
PMID:31218578
RGD:40400920
NCBI chr 1:73,178,917...73,226,504
Ensembl chr 1:73,179,013...73,226,777
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Dpp3
dipeptidylpeptidase 3
increases cleavage multiple interactions
ISO
DPP3 protein results in increased cleavage of Enkephalin, Leucine spinorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]; tynorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]
CTD
PMID:10873616
NCBI chr 1:220,166,124...220,189,762
Ensembl chr 1:220,166,127...220,188,541
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Oprd1
opioid receptor, delta 1
increases activity
ISO
Enkephalin, Leucine results in increased activity of OPRD1 protein
CTD
PMID:26476280
NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063
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Oprm1
opioid receptor, mu 1
increases activity
ISO
Enkephalin, Leucine results in increased activity of OPRM1 protein
CTD
PMID:26476280
NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
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Cyp2c6v1
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1
decreases expression
ISO
metalaxyl results in decreased expression of CYP2C19 protein
CTD
PMID:32194361
NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
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Cyp7a1
cytochrome P450 family 7 subfamily A member 1
decreases expression
ISO
metalaxyl results in decreased expression of CYP7A1 protein
CTD
PMID:32194361
NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
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Ncoa2
nuclear receptor coactivator 2
multiple interactions
ISO
N-benzoylalanine promotes the reaction [THRA protein binds to NCOA2 protein]; N-benzoylalanine promotes the reaction [THRB protein binds to NCOA2 protein]
CTD
PMID:31566444
NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
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Thra
thyroid hormone receptor alpha
multiple interactions
ISO
N-benzoylalanine promotes the reaction [THRA protein binds to NCOA2 protein]
CTD
PMID:31566444
NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
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Thrb
thyroid hormone receptor beta
multiple interactions affects binding
ISO
N-benzoylalanine promotes the reaction [THRB protein binds to NCOA2 protein] N-benzoylalanine binds to THRB protein
CTD
PMID:31566444
NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
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Abhd12
abhydrolase domain containing 12, lysophospholipase
decreases activity
ISO
orlistat results in decreased activity of ABHD12 protein
CTD
PMID:18657971
NCBI chr 3:146,630,298...146,690,375
Ensembl chr 3:146,630,299...146,690,375
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Abhd16a
abhydrolase domain containing 16A, phospholipase
decreases activity
ISO
orlistat results in decreased activity of ABHD16A protein
CTD
PMID:18657971
NCBI chr20:5,080,070...5,094,935
Ensembl chr20:5,080,070...5,094,935
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Acot8
acyl-CoA thioesterase 8
decreases expression
ISO
Orlistat results in decreased expression of ACOT8 protein
CTD
PMID:30667213
NCBI chr 3:161,260,837...161,272,495
Ensembl chr 3:161,259,735...161,272,460
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Adipoq
adiponectin, C1Q and collagen domain containing
multiple interactions
EXP
orlistat inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein]
CTD
PMID:25087745
NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
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App
amyloid beta precursor protein
multiple interactions
ISO
[1,1,1,2,2-pentafluoro-7-phenylheptan-3-one co-treated with Orlistat] inhibits the reaction [APP protein modified form results in increased secretion of Arachidonic Acid]
CTD
PMID:28721267
NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
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Atf4
activating transcription factor 4
increases expression
ISO
orlistat results in increased expression of ATF4 mRNA
CTD
PMID:17283163
NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
EXP
Orlistat inhibits the reaction [Dietary Fats results in increased expression of BAX mRNA]
CTD
PMID:32450208
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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Bcl2
BCL2, apoptosis regulator
multiple interactions
EXP
Orlistat inhibits the reaction [Dietary Fats results in decreased expression of BCL2 mRNA]
CTD
PMID:32450208
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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Casp3
caspase 3
increases activity multiple interactions increases cleavage
ISO EXP
orlistat results in increased activity of CASP3 protein Orlistat inhibits the reaction [Dietary Fats results in increased expression of CASP3 mRNA] orlistat results in increased cleavage of CASP3 protein
CTD
PMID:17283163 PMID:20805790 PMID:21723078 PMID:32450208
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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Casp8
caspase 8
multiple interactions
ISO EXP
orlistat analog results in increased cleavage of and results in increased activity of CASP8 protein; orlistat results in increased cleavage of and results in increased activity of CASP8 protein Orlistat inhibits the reaction [Dietary Fats results in increased expression of CASP8 mRNA]
CTD
PMID:18796435 PMID:20577697 PMID:32450208
NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
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Casp9
caspase 9
increases activity multiple interactions
ISO EXP
orlistat results in increased activity of CASP9 protein Orlistat inhibits the reaction [Dietary Fats results in increased expression of CASP9 mRNA]
CTD
PMID:20805790 PMID:32450208
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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Cat
catalase
multiple interactions decreases expression
EXP ISO
Orlistat inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; Orlistat inhibits the reaction [Dietary Fats results in decreased expression of CAT mRNA]; Orlistat inhibits the reaction [Dietary Fats results in decreased expression of CAT protein] Orlistat results in decreased expression of CAT protein
CTD
PMID:25087745 PMID:30667213 PMID:32450208
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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Cck
cholecystokinin
multiple interactions decreases secretion
ISO
[[orlistat results in decreased abundance of Fatty Acids, Nonesterified] which results in decreased secretion of CCK protein] which results in decreased secretion of PNLIP protein; orlistat inhibits the reaction [Fats results in increased secretion of CCK protein]; orlistat inhibits the reaction [Olive Oil results in increased secretion of CCK protein] orlistat results in decreased secretion of CCK protein
CTD
PMID:11408251 PMID:18303078 PMID:18647814
NCBI chr 8:130,120,525...130,127,515
Ensembl chr 8:130,120,523...130,127,392
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Ccna2
cyclin A2
decreases expression
ISO
Orlistat results in decreased expression of CCNA2 protein
CTD
PMID:30667213
NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
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Ccnd1
cyclin D1
increases expression
ISO
Orlistat results in increased expression of CCND1 protein
CTD
PMID:30667213
NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
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Ccne1
cyclin E1
increases expression
ISO
Orlistat results in increased expression of CCNE1 protein
CTD
PMID:30667213
NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
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Cdk1
cyclin-dependent kinase 1
decreases expression
ISO
Orlistat results in decreased expression of CDK1 protein
CTD
PMID:30667213
NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
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Cdk2
cyclin dependent kinase 2
decreases expression
ISO
Orlistat results in decreased expression of CDK2 protein
CTD
PMID:30667213
NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
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Cdk4
cyclin-dependent kinase 4
decreases expression
ISO
Orlistat results in decreased expression of CDK4 protein
CTD
PMID:30667213
NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
Orlistat results in increased expression of CDKN1A protein
CTD
PMID:30667213
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
increases expression
ISO
orlistat results in increased expression of CDKN1B protein
CTD
PMID:15138278
NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
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Cel
carboxyl ester lipase
decreases activity
ISO
orlistat results in decreased activity of CEL protein
CTD
PMID:11592731 PMID:12381337
NCBI chr 3:7,134,021...7,141,522
Ensembl chr 3:7,134,021...7,141,522
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Clps
colipase
multiple interactions
ISO
orlistat inhibits the reaction [[PNLIP protein co-treated with CLPS protein] results in increased hydrolysis of Olive Oil]
CTD
PMID:15158758
NCBI chr20:5,803,447...5,806,107
Ensembl chr20:5,803,383...5,806,097
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Cpb2
carboxypeptidase B2
decreases expression
ISO
orlistat results in decreased expression of CPB2 protein
CTD
PMID:16959692
NCBI chr15:57,290,849...57,339,762
Ensembl chr15:57,290,849...57,339,760
G
Cpt1a
carnitine palmitoyltransferase 1A
decreases expression
ISO
Orlistat results in decreased expression of CPT1A protein
CTD
PMID:30667213
NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
G
Cpt2
carnitine palmitoyltransferase 2
decreases expression
ISO
Orlistat results in decreased expression of CPT2 protein
CTD
PMID:30667213
NCBI chr 5:127,505,646...127,523,016
Ensembl chr 5:127,505,614...127,523,089
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Cyp3a62
cytochrome P450, family 3, subfamily a, polypeptide 62
increases expression
ISO
Orlistat results in increased expression of CYP3A4 mRNA; Orlistat results in increased expression of CYP3A4 protein
CTD
PMID:20599501
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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Dagla
diacylglycerol lipase, alpha
decreases activity
ISO
orlistat results in decreased activity of DAGLA protein
CTD
PMID:16466961
NCBI chr 1:226,297,013...226,353,712
Ensembl chr 1:226,297,016...226,353,611
G
Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
orlistat results in increased expression of DDIT3 mRNA
CTD
PMID:17283163
NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
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Ddit4
DNA-damage-inducible transcript 4
increases expression
ISO
orlistat results in increased expression of DDIT4 mRNA
CTD
PMID:18796435
NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
G
Eif2a
eukaryotic translation initiation factor 2A
increases phosphorylation multiple interactions
ISO
orlistat results in increased phosphorylation of EIF2A protein orlistat promotes the reaction [EIF2AK3 protein results in increased phosphorylation of EIF2A protein] Cycloheximide inhibits the reaction [orlistat results in increased phosphorylation of EIF2A protein] orlistat analog results in increased phosphorylation of EIF2A protein; orlistat results in increased phosphorylation of EIF2A protein
CTD
PMID:17283163 PMID:20577697
NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
G
Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
increases response to substance multiple interactions
ISO
EIF2AK3 gene mutant form results in increased susceptibility to orlistat orlistat promotes the reaction [EIF2AK3 protein results in increased phosphorylation of EIF2A protein]
CTD
PMID:17283163
NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
G
Eif4e
eukaryotic translation initiation factor 4E
increases phosphorylation
ISO
orlistat results in increased phosphorylation of EIF4E protein
CTD
PMID:18796435
NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631
G
Erbb2
erb-b2 receptor tyrosine kinase 2
affects response to substance affects localization decreases expression
ISO
ERBB2 protein affects the susceptibility to orlistat orlistat affects the localization of ERBB2 protein orlistat results in decreased expression of ERBB2 mRNA; orlistat results in decreased expression of ERBB2 protein
CTD
PMID:15870086
NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
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Ern1
endoplasmic reticulum to nucleus signaling 1
multiple interactions
ISO
orlistat affects the reaction [ERN1 protein affects the splicing of XBP1 mRNA]
CTD
PMID:17283163
NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
G
Etv4
ETS variant transcription factor 4
increases expression
ISO
orlistat results in increased expression of ETV4 protein
CTD
PMID:15870086
NCBI chr10:89,685,058...89,700,300
Ensembl chr10:89,685,058...89,700,283
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Fabp1
fatty acid binding protein 1
decreases expression
ISO
Orlistat results in decreased expression of FABP1 protein
CTD
PMID:30667213
NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
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Fasn
fatty acid synthase
affects binding decreases expression decreases activity multiple interactions affects response to substance
ISO
orlistat analog binds to FASN protein Orlistat results in decreased expression of FASN protein orlistat results in decreased activity of FASN protein [orlistat results in decreased activity of FASN protein] which affects the abundance of Fatty Acids, Nonesterified; orlistat inhibits the reaction [FASN protein results in increased chemical synthesis of Palmitic Acid] orlistat analog results in decreased activity of FASN protein; orlistat results in decreased activity of FASN protein [orlistat results in decreased activity of FASN protein] which results in decreased abundance of Fatty Acids; [orlistat results in decreased activity of FASN protein] which results in decreased abundance of Phosphatidylcholines; [orlistat results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholine; [orlistat results in decreased activity of FASN protein] which results in decreased chemical synthesis of Fatty Acids; [orlistat results in decreased activity of FASN protein] which results in decreased expression of SKP2 protein; orlistat binds to and results in decreased activity of FASN protein; orlistat inhibits the reaction [FASN protein results in decreased susceptibility to Doxorubicin]; orlistat inhibits the reaction [FASN protein results in decreased susceptibility to Mitoxantrone] FASN protein affects the susceptibility to orlistat
CTD
PMID:15026345 PMID:15138278 PMID:15870086 PMID:17012255 PMID:17618296 PMID:17847090 PMID:18281512 PMID:18710210 PMID:18723500 PMID:20148945 PMID:20577697 PMID:21213365 PMID:30667213
NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
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Gcg
glucagon
multiple interactions decreases secretion decreases expression
ISO
orlistat inhibits the reaction [Dietary Fats results in increased secretion of GCG protein]; orlistat inhibits the reaction [Olive Oil results in increased secretion of GCG protein] orlistat results in decreased secretion of GCG protein orlistat results in decreased expression of GCG protein
CTD
PMID:12915676 PMID:18647814 PMID:19837920
NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650
G
Ghrl
ghrelin and obestatin prepropeptide
multiple interactions
ISO
orlistat inhibits the reaction [Olive Oil results in decreased expression of GHRL protein]; orlistat inhibits the reaction [Triglycerides results in decreased secretion of GHRL protein]
CTD
PMID:15998659 PMID:17138722
NCBI chr 4:145,674,157...145,678,066
Ensembl chr 4:145,674,157...145,678,066
G
Gip
gastric inhibitory polypeptide
decreases expression
ISO
orlistat results in decreased expression of GIP protein
CTD
PMID:12915676
NCBI chr10:83,835,080...83,848,399
Ensembl chr10:83,840,303...83,848,396
G
Gpt
glutamic--pyruvic transaminase
multiple interactions
EXP
orlistat inhibits the reaction [[Corn Oil co-treated with (5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl)acetic acid] results in increased activity of GPT protein]
CTD
PMID:29479035
NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
G
Gpx1
glutathione peroxidase 1
multiple interactions
EXP
Orlistat inhibits the reaction [Dietary Fats results in decreased expression of GPX1 mRNA]
CTD
PMID:32450208
NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
G
Gpx8
glutathione peroxidase 8
increases expression
ISO
orlistat results in increased expression of GPX8 mRNA
CTD
PMID:18796435
NCBI chr 2:44,903,337...44,907,046
Ensembl chr 2:44,903,337...44,907,030
G
Gsr
glutathione-disulfide reductase
multiple interactions
EXP
Orlistat inhibits the reaction [Dietary Fats results in decreased expression of GSR protein]
CTD
PMID:32450208
NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
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Hba-a2
hemoglobin alpha, adult chain 2
decreases expression
ISO
orlistat results in decreased expression of HBA1 protein modified form
CTD
PMID:19207292 PMID:19461584
NCBI chr10:15,589,364...15,590,207
Ensembl chr10:15,589,364...15,590,220
G
Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
multiple interactions
EXP
orlistat inhibits the reaction [Dietary Fats results in increased expression of HMGCR protein]
CTD
PMID:25087745
NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
G
Hspa5
heat shock protein family A (Hsp70) member 5
increases expression
ISO
orlistat results in increased expression of HSPA5 mRNA
CTD
PMID:17283163
NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
G
Il10
interleukin 10
increases expression
EXP
Orlistat results in increased expression of IL10 mRNA
CTD
PMID:32450208
NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
G
Il1b
interleukin 1 beta
multiple interactions
EXP
Orlistat inhibits the reaction [Dietary Fats results in increased expression of IL1B mRNA]
CTD
PMID:32450208
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
G
Il6
interleukin 6
multiple interactions
ISO
orlistat inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
CTD
PMID:21088047
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
G
Ins2
insulin 2
decreases expression affects expression increases expression
ISO
orlistat results in decreased expression of INS protein orlistat affects the expression of INS protein orlistat results in increased expression of INS protein
CTD
PMID:10095983 PMID:11274935 PMID:12915676
NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
G
Kdelr3
KDEL endoplasmic reticulum protein retention receptor 3
increases expression
ISO
orlistat results in increased expression of KDELR3 mRNA
CTD
PMID:18796435
NCBI chr 7:120,749,680...120,760,163
Ensembl chr 7:120,749,752...120,760,160
G
Kdr
kinase insert domain receptor
decreases expression
ISO
orlistat results in decreased expression of KDR protein
CTD
PMID:17012255
NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
G
Krt81
keratin 81
increases expression
ISO
orlistat results in increased expression of KRT81 mRNA
CTD
PMID:18796435
NCBI chr 7:143,107,901...143,113,006
Ensembl chr 7:143,107,901...143,112,960
G
Lcat
lecithin cholesterol acyltransferase
multiple interactions
EXP
orlistat inhibits the reaction [Dietary Fats results in decreased expression of LCAT protein]
CTD
PMID:25087745
NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813
G
Lep
leptin
multiple interactions
ISO EXP
orlistat inhibits the reaction [Dietary Fats results in increased expression of LEP protein]
CTD
PMID:21332399 PMID:25087745
NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
G
Lipf
lipase F, gastric type
decreases activity
ISO
orlistat results in decreased activity of LIPF protein
CTD
PMID:11408251 PMID:12381337
NCBI chr 1:252,284,464...252,302,811
Ensembl chr 1:252,284,464...252,302,811
G
Lpl
lipoprotein lipase
decreases activity multiple interactions
ISO EXP
orlistat results in decreased activity of LPL protein [orlistat results in decreased activity of LPL protein] which affects the uptake of Triglycerides orlistat inhibits the reaction [[LPL protein results in increased hydrolysis of Triglycerides] which results in increased uptake of Triglycerides]; orlistat inhibits the reaction [LPL protein results in decreased activity of TNF protein]; orlistat inhibits the reaction [very low density lipoprotein triglyceride results in increased activity of LPL protein] orlistat inhibits the reaction [Dietary Fats results in decreased expression of LPL protein]
CTD
PMID:12388125 PMID:12573449 PMID:15910848 PMID:15994321 PMID:18698144 PMID:25087745
NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
G
Napepld
N-acyl phosphatidylethanolamine phospholipase D
decreases activity
EXP
orlistat results in decreased activity of NAPEPLD protein
CTD
PMID:16466961
NCBI chr 4:9,965,323...10,004,650
Ensembl chr 4:9,966,891...10,002,247
G
Nfe2l2
nuclear factor, erythroid 2-like 2
multiple interactions
EXP
Orlistat inhibits the reaction [Dietary Fats results in decreased expression of NFE2L2 mRNA]
CTD
PMID:32450208
NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
G
Nos2
nitric oxide synthase 2
multiple interactions
EXP
Orlistat inhibits the reaction [Dietary Fats results in increased expression of NOS2 mRNA]; Orlistat inhibits the reaction [Dietary Fats results in increased expression of NOS2 protein]
CTD
PMID:32450208
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
G
Npy
neuropeptide Y
increases expression
ISO
orlistat results in increased expression of NPY protein
CTD
PMID:15962606
NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097 Ensembl chr 4:79,557,854...79,565,097
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity
ISO
orlistat results in increased activity of NR1I2 protein
CTD
PMID:20599501
NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
G
Nr1i3
nuclear receptor subfamily 1, group I, member 3
multiple interactions
ISO
Orlistat binds to and results in increased activity of NR1I3 protein alternative form
CTD
PMID:31312845
NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
G
Nts
neurotensin
multiple interactions
ISO
Orlistat inhibits the reaction [Fats results in increased secretion of NTS protein]; Orlistat inhibits the reaction [Olive Oil results in increased secretion of NTS protein]
CTD
PMID:18303078
NCBI chr 7:44,111,594...44,120,998
Ensembl chr 7:44,111,151...44,121,130
G
Parp1
poly (ADP-ribose) polymerase 1
multiple interactions increases cleavage
ISO
[orlistat co-treated with Thapsigargin] results in increased cleavage of PARP1 protein orlistat results in increased cleavage of PARP1 protein
CTD
PMID:15870086 PMID:17283163
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
G
Pla2g7
phospholipase A2 group VII
decreases activity multiple interactions
ISO
orlistat results in decreased activity of PLA2G7 protein [orlistat co-treated with Ezetimibe] results in decreased activity of PLA2G7 protein; [orlistat co-treated with Fenofibrate] results in decreased activity of PLA2G7 protein
CTD
PMID:16911813 PMID:18513463 PMID:18657971
NCBI chr 9:19,935,754...19,978,013
Ensembl chr 9:19,935,768...19,978,013
G
Pnlip
pancreatic lipase
decreases secretion multiple interactions affects folding decreases activity
ISO EXP
orlistat results in decreased secretion of PNLIP protein [[orlistat results in decreased abundance of Fatty Acids, Nonesterified] which results in decreased secretion of CCK protein] which results in decreased secretion of PNLIP protein; orlistat inhibits the reaction [[PNLIP protein co-treated with CLPS protein] results in increased hydrolysis of Olive Oil] orlistat affects the folding of PNLIP protein orlistat inhibits the reaction [Taurocholic Acid results in increased activity of PNLIP protein] orlistat results in decreased activity of PNLIP protein
CTD
PMID:11408251 PMID:11668201 PMID:12381337 PMID:15158758 PMID:19346257
NCBI chr 1:279,798,187...279,811,372
Ensembl chr 1:279,798,187...279,811,372
G
Pnliprp2
pancreatic lipase related protein 2
decreases activity
ISO EXP
orlistat results in decreased activity of PNLIPRP2 protein Orlistat results in decreased activity of PNLIPRP2 protein
CTD
PMID:9822688 PMID:17401110
NCBI chr 1:279,896,973...279,927,600
Ensembl chr 1:279,896,973...279,927,600
G
Pon1
paraoxonase 1
increases activity
ISO
orlistat results in increased activity of PON1 protein
CTD
PMID:11820148 PMID:17134960
NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
G
Ppt1
palmitoyl-protein thioesterase 1
decreases expression
ISO
Orlistat results in decreased expression of PPT1 protein
CTD
PMID:30667213
NCBI chr 5:140,538,260...140,558,163
Ensembl chr 5:140,538,260...140,558,162
G
Ppy
pancreatic polypeptide
multiple interactions
ISO
orlistat inhibits the reaction [Triglycerides results in increased secretion of PPY protein]
CTD
PMID:15998659
NCBI chr10:90,041,582...90,043,316
Ensembl chr10:90,041,591...90,042,877
G
Prkaa1
protein kinase AMP-activated catalytic subunit alpha 1
multiple interactions
EXP ISO
orlistat inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein] orlistat inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased phosphorylation of and results in increased activity of PRKAA1 protein]; orlistat inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of PRKAA1 protein]
CTD
PMID:18390901 PMID:19167487
NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
G
Pyy
peptide YY
decreases secretion multiple interactions
ISO
orlistat results in decreased secretion of PYY protein orlistat inhibits the reaction [Olive Oil results in increased expression of PYY protein]; orlistat inhibits the reaction [Triglycerides results in increased secretion of PYY protein]
CTD
PMID:15998659 PMID:17138722 PMID:18647814
NCBI chr10:90,047,989...90,049,155
Ensembl chr10:90,047,993...90,049,112
G
Rb1
RB transcriptional corepressor 1
decreases phosphorylation
ISO
orlistat results in decreased phosphorylation of RB1 protein
CTD
PMID:15138278
NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP
Orlistat inhibits the reaction [Dietary Fats results in increased expression of RELA mRNA]
CTD
PMID:32450208
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
G
Sec24d
SEC24 homolog D, COPII coat complex component
increases expression
ISO
orlistat results in increased expression of SEC24D mRNA
CTD
PMID:18796435
NCBI chr 2:227,455,704...227,562,801
Ensembl chr 2:227,455,722...227,562,319
G
Skp2
S-phase kinase associated protein 2
multiple interactions decreases expression
ISO
[orlistat results in decreased activity of FASN protein] which results in decreased expression of SKP2 protein orlistat results in decreased expression of SKP2 protein
CTD
PMID:15138278
NCBI chr 2:58,506,146...58,534,211
Ensembl chr 2:58,506,151...58,534,211
G
Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
orlistat inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
G
Tnf
tumor necrosis factor
multiple interactions
ISO EXP
orlistat inhibits the reaction [LPL protein results in decreased activity of TNF protein] Orlistat inhibits the reaction [Dietary Fats results in increased expression of TNF mRNA]
CTD
PMID:15994321 PMID:32450208
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
G
Tnfsf10
TNF superfamily member 10
increases response to substance
ISO
orlistat results in increased susceptibility to TNFSF10 protein
CTD
PMID:18796435 PMID:21406729
NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
G
Tp53
tumor protein p53
multiple interactions
EXP
Orlistat inhibits the reaction [Dietary Fats results in increased expression of TP53 mRNA]
CTD
PMID:32450208
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
G
Xbp1
X-box binding protein 1
multiple interactions
ISO
orlistat affects the reaction [ERN1 protein affects the splicing of XBP1 mRNA]
CTD
PMID:17283163
NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
G
Abcb11
ATP binding cassette subfamily B member 11
decreases activity multiple interactions
ISO
Ritonavir results in decreased activity of ABCB11 protein Ritonavir inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD
PMID:20829430 PMID:22646477 PMID:23956101 PMID:24014644 PMID:28437613
NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
G
Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions
ISO
hyperforin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; hypericin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; kaempferol inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; Quercetin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]
CTD
PMID:15266218
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
G
Abcb4
ATP binding cassette subfamily B member 4
decreases expression decreases activity
ISO
Ritonavir results in decreased expression of ABCB4 Ritonavir results in decreased activity of ABCB4 protein
CTD
PMID:26626330 PMID:28437613
NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
G
Acss2
acyl-CoA synthetase short-chain family member 2
affects expression
EXP
Ritonavir affects the expression of ACSS2 mRNA
CTD
PMID:17719200
NCBI chr 3:151,032,925...151,075,856
Ensembl chr 3:151,032,952...151,075,856
G
Adipoq
adiponectin, C1Q and collagen domain containing
decreases expression multiple interactions
ISO
Ritonavir results in decreased expression of ADIPOQ mRNA; Ritonavir results in decreased expression of ADIPOQ protein rosiglitazone inhibits the reaction [Ritonavir results in decreased secretion of ADIPOQ protein] diphenyleneiodonium inhibits the reaction [Ritonavir results in decreased expression of ADIPOQ protein]
CTD
PMID:15865214 PMID:17668557
NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
G
Alb
albumin
affects binding
ISO
Ritonavir binds to ALB protein
CTD
PMID:15814459 PMID:16336266
NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
G
Bak1
BCL2-antagonist/killer 1
increases expression
ISO
Ritonavir results in increased expression of BAK1 protein
CTD
PMID:19386116
NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
G
Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
Ritonavir results in decreased expression of BCL2 protein
CTD
PMID:19386116
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
G
Bcl2l1
Bcl2-like 1
decreases expression
ISO
Ritonavir results in decreased expression of BCL2L1 mRNA
CTD
PMID:16174765
NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
G
Birc5
baculoviral IAP repeat-containing 5
decreases expression
ISO
Ritonavir results in decreased expression of BIRC5 mRNA; Ritonavir results in decreased expression of BIRC5 protein
CTD
PMID:16174765 PMID:21270666
NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
G
Casp1
caspase 1
decreases expression
ISO
Ritonavir results in decreased expression of CASP1 protein
CTD
PMID:10551732
NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
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Casp3
caspase 3
decreases activity
ISO
Ritonavir results in decreased activity of CASP3 protein
CTD
PMID:10551732
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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Ccl2
C-C motif chemokine ligand 2
multiple interactions increases expression increases secretion decreases expression
ISO
diphenyleneiodonium inhibits the reaction [Ritonavir results in increased expression of CCL2 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased secretion of CCL2 protein] Ritonavir results in decreased expression of CCL2
CTD
PMID:17668557 PMID:20884875 PMID:26626330
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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Ccl20
C-C motif chemokine ligand 20
decreases expression
ISO
Ritonavir results in decreased expression of CCL20
CTD
PMID:26626330
NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
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Ccl3
C-C motif chemokine ligand 3
decreases expression increases expression
ISO
Ritonavir results in decreased expression of CCL3 Ritonavir results in increased expression of CCL3 protein
CTD
PMID:17668557 PMID:26626330
NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
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Ccl4
C-C motif chemokine ligand 4
decreases expression
ISO
Ritonavir results in decreased expression of CCL4
CTD
PMID:26626330
NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
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Ccna2
cyclin A2
decreases expression
ISO
Ritonavir results in decreased expression of CCNA2 mRNA
CTD
PMID:19386116
NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
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Ccnb1
cyclin B1
decreases expression
ISO
Ritonavir results in decreased expression of CCNB1 mRNA
CTD
PMID:19386116
NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
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Ccnd1
cyclin D1
decreases expression
ISO
Ritonavir results in decreased expression of CCND1 protein
CTD
PMID:16551874 PMID:21270666
NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
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Ccnd2
cyclin D2
decreases expression
ISO
Ritonavir results in decreased expression of CCND2 mRNA
CTD
PMID:16174765 PMID:19386116
NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
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Ccne2
cyclin E2
decreases expression
ISO
Ritonavir results in decreased expression of CCNE2 mRNA
CTD
PMID:19386116
NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
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Cdk2
cyclin dependent kinase 2
decreases expression
ISO
Ritonavir results in decreased expression of CDK2 mRNA; Ritonavir results in decreased expression of CDK2 protein
CTD
PMID:16551874 PMID:19386116
NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
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Cdk4
cyclin-dependent kinase 4
decreases expression
ISO
Ritonavir results in decreased expression of CDK4 mRNA; Ritonavir results in decreased expression of CDK4 protein
CTD
PMID:16551874 PMID:19386116
NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
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Cdk5
cyclin-dependent kinase 5
decreases expression
ISO
Ritonavir results in decreased expression of CDK5 mRNA
CTD
PMID:19386116
NCBI chr 4:7,282,945...7,287,427
Ensembl chr 4:7,282,948...7,288,383
G
Cdk6
cyclin-dependent kinase 6
decreases expression
ISO
Ritonavir results in decreased expression of CDK6 mRNA; Ritonavir results in decreased expression of CDK6 protein
CTD
PMID:16551874 PMID:19386116
NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression multiple interactions
ISO
Ritonavir results in increased expression of CDKN1A mRNA; Ritonavir results in increased expression of CDKN1A protein manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Ritonavir results in increased expression of CDKN1A protein]
CTD
PMID:19386116 PMID:20884875
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
increases expression
ISO
Ritonavir results in increased expression of CDKN1B mRNA
CTD
PMID:19386116
NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
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Cdkn2b
cyclin-dependent kinase inhibitor 2B
increases expression
ISO
Ritonavir results in increased expression of CDKN2B mRNA
CTD
PMID:19386116
NCBI chr 5:107,834,353...107,857,428
Ensembl chr 5:107,845,951...107,858,104
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Cebpa
CCAAT/enhancer binding protein alpha
multiple interactions
ISO
Ritonavir inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of CEBPA protein]
CTD
PMID:11101056
NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
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Ciita
class II, major histocompatibility complex, transactivator
increases expression
ISO
Ritonavir results in increased expression of CIITA
CTD
PMID:26626330
NCBI chr10:5,212,621...5,260,641
Ensembl chr10:5,213,350...5,260,608
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Crot
carnitine O-octanoyltransferase
decreases expression
EXP
Ritonavir results in decreased expression of CROT mRNA
CTD
PMID:17719200
NCBI chr 4:22,079,837...22,116,265
Ensembl chr 4:22,081,604...22,116,265
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Cxcl1
C-X-C motif chemokine ligand 1
decreases expression
ISO
Ritonavir results in decreased expression of CXCL1
CTD
PMID:26626330
NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
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Cxcl10
C-X-C motif chemokine ligand 10
decreases expression
ISO
Ritonavir results in decreased expression of CXCL10
CTD
PMID:26626330
NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
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Cxcl12
C-X-C motif chemokine ligand 12
decreases expression
ISO
Ritonavir results in decreased expression of CXCL12
CTD
PMID:26626330
NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
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Cxcl2
C-X-C motif chemokine ligand 2
decreases expression
ISO
Ritonavir results in decreased expression of CXCL2
CTD
PMID:26626330
NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
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Cxcl3
C-X-C motif chemokine ligand 3
decreases expression
ISO
Ritonavir results in decreased expression of CXCL1
CTD
PMID:26626330
NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
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Cxcl6
C-X-C motif chemokine ligand 6
decreases expression
ISO
Ritonavir results in decreased expression of CXCL6
CTD
PMID:26626330
NCBI chr14:18,860,201...18,920,839
Ensembl chr14:18,860,264...18,862,407
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Cyb5r3
cytochrome b5 reductase 3
affects expression
EXP
Ritonavir affects the expression of CYB5R3 mRNA
CTD
PMID:17719200
NCBI chr 7:124,024,003...124,041,564
Ensembl chr 7:124,023,995...124,041,594
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
ISO
Ritonavir results in increased expression of CYP1A1 mRNA
CTD
PMID:11918509
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases expression decreases expression
ISO EXP
Ritonavir results in increased expression of CYP1A2 mRNA Ritonavir results in decreased expression of CYP1A2 mRNA
CTD
PMID:11918509 PMID:17719200
NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
increases activity increases expression
ISO
Ritonavir results in increased activity of CYP2B6 protein Ritonavir results in increased expression of CYP2B6 protein
CTD
PMID:14977870 PMID:26626330
NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
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Cyp2c6v1
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1
increases expression
ISO
Ritonavir results in increased expression of CYP2C19 mRNA
CTD
PMID:11918509
NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
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Cyp2c79
cytochrome P450, family 2, subfamily c, polypeptide 79
decreases activity
ISO
Ritonavir results in decreased activity of CYP2C8 protein
CTD
PMID:15601807
NCBI chr 1:147,236,480...147,307,988
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
affects metabolic processing
ISO
CYP2D6 protein affects the metabolism of Ritonavir
CTD
PMID:15286053
NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
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Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
increases expression
EXP
Ritonavir results in increased expression of CYP3A23-3A1 mRNA
CTD
PMID:17719200
NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
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Cyp3a62
cytochrome P450, family 3, subfamily a, polypeptide 62
affects binding increases expression affects metabolic processing decreases activity
ISO
CYP3A4 protein binds to Ritonavir analog Ritonavir results in increased expression of CYP3A4 mRNA CYP3A4 protein affects the metabolism of Ritonavir Ritonavir results in decreased activity of CYP3A4 protein
CTD
PMID:15286053 PMID:15523003 PMID:15860655 PMID:16837568 PMID:26626330 PMID:27966929
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
decreases activity
ISO
Ritonavir results in decreased activity of CYP3A5 protein
CTD
PMID:15523003
NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
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Cyp4a3
cytochrome P450, family 4, subfamily a, polypeptide 3
decreases expression
EXP
Ritonavir results in decreased expression of CYP4A3 mRNA
CTD
PMID:17719200
NCBI chr 5:134,468,666...134,484,851
Ensembl chr 5:134,469,270...134,484,839
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Cyp4b1
cytochrome P450, family 4, subfamily b, polypeptide 1
affects expression decreases expression
EXP
Ritonavir affects the expression of CYP4B1 mRNA Ritonavir results in decreased expression of CYP4B1 mRNA
CTD
PMID:17719200
NCBI chr 5:134,508,728...134,526,103
Ensembl chr 5:134,508,730...134,526,089
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Cyp51
cytochrome P450, family 51
increases expression
EXP
Ritonavir results in increased expression of CYP51 mRNA
CTD
PMID:17719200
NCBI chr 4:27,175,564...27,194,018
Ensembl chr 4:27,175,243...27,194,018
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Cyp7a1
cytochrome P450 family 7 subfamily A member 1
decreases expression
ISO EXP
Ritonavir results in decreased expression of CYP7A1 mRNA
CTD
PMID:17719200 PMID:26626330
NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
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Cyp8b1
cytochrome P450 family 8 subfamily B member 1
decreases expression
ISO EXP
Ritonavir results in decreased expression of CYP8B1 Ritonavir results in decreased expression of CYP8B1 mRNA
CTD
PMID:17719200 PMID:26626330
NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388
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Dhcr7
7-dehydrocholesterol reductase
affects expression
EXP
Ritonavir affects the expression of DHCR7 mRNA
CTD
PMID:17719200
NCBI chr 1:217,018,916...217,034,890
Ensembl chr 1:217,018,916...217,034,904
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E2f1
E2F transcription factor 1
decreases expression
ISO
Ritonavir results in decreased expression of E2F1 mRNA; Ritonavir results in decreased expression of E2F1 protein
CTD
PMID:19386116
NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
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E2f2
E2F transcription factor 2
decreases expression
ISO
Ritonavir results in decreased expression of E2F2 mRNA
CTD
PMID:19386116
NCBI chr 5:154,516,611...154,540,228
Ensembl chr 5:154,522,119...154,540,265
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E2f3
E2F transcription factor 3
decreases expression
ISO
Ritonavir results in decreased expression of E2F3 mRNA
CTD
PMID:19386116
NCBI chr17:36,334,136...36,408,831
Ensembl chr17:36,334,147...36,408,831
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Ehhadh
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
affects expression
EXP
Ritonavir affects the expression of EHHADH mRNA
CTD
PMID:17719200
NCBI chr11:82,945,104...82,978,364
Ensembl chr11:82,945,104...82,978,364
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Esr1
estrogen receptor 1
decreases expression
ISO
Ritonavir results in decreased expression of ESR1 protein
CTD
PMID:16551874
NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
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Faslg
Fas ligand
decreases expression
ISO
Ritonavir results in decreased expression of FASLG protein
CTD
PMID:10551732
NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
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Fasn
fatty acid synthase
affects expression
EXP
Ritonavir affects the expression of FASN mRNA
CTD
PMID:17719200
NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
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Fgf19
fibroblast growth factor 19
increases expression
ISO
Ritonavir results in increased expression of FGF19 mRNA
CTD
PMID:26626330
NCBI chr 1:218,058,405...218,061,693
Ensembl chr 1:218,058,405...218,061,693
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
Ritonavir results in increased expression of FOS protein
CTD
PMID:15504750
NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
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Glb1
galactosidase, beta 1
multiple interactions increases activity
ISO
Acetylcysteine inhibits the reaction [Ritonavir results in increased activity of GLB1 protein]; FTI 277 inhibits the reaction [Ritonavir results in increased activity of GLB1 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Ritonavir results in increased activity of GLB1 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased activity of GLB1 protein]
CTD
PMID:20884875
NCBI chr 8:122,439,328...122,511,939
Ensembl chr 8:122,439,328...122,511,939
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Gpd1
glycerol-3-phosphate dehydrogenase 1
multiple interactions
ISO
Ritonavir promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of GPD1 protein]
CTD
PMID:11101056
NCBI chr 7:141,368,928...141,377,931
Ensembl chr 7:141,370,491...141,377,928
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Hmox1
heme oxygenase 1
multiple interactions increases expression
ISO
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Bilirubin inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; HMOX1 protein inhibits the reaction [Ritonavir results in increased expression of ICAM1 protein]; NFE2L2 protein mutant form inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]; Ritonavir promotes the reaction [Atazanavir Sulfate results in increased expression of HMOX1 mRNA]; Ritonavir promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]; Ritonavir promotes the reaction [Lopinavir results in increased expression of HMOX1 mRNA]; Rotenone inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; tricarbonyldichlororuthenium (II) dimer promotes the reaction [Ritonavir results in increased expression of HMOX1 protein] Ritonavir results in increased expression of HMOX1 mRNA; Ritonavir results in increased expression of HMOX1 protein
CTD
PMID:15504750 PMID:26968795
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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Hsp90aa1
heat shock protein 90 alpha family class A member 1
affects response to substance
ISO
HSP90AA1 protein affects the susceptibility to Ritonavir
CTD
PMID:16551874
NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775 Ensembl chr 6:135,107,271...135,112,775
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Hsph1
heat shock protein family H (Hsp110) member 1
increases expression
ISO
Ritonavir results in increased expression of HSPH1 protein
CTD
PMID:26626330
NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
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Icam1
intercellular adhesion molecule 1
increases expression multiple interactions
ISO
Ritonavir results in increased expression of ICAM1 protein HMOX1 protein inhibits the reaction [Ritonavir results in increased expression of ICAM1 protein]
CTD
PMID:26968795
NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
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Ifng
interferon gamma
multiple interactions
ISO
Ritonavir inhibits the reaction [IFNG protein results in increased secretion of TNF protein]
CTD
PMID:10551732
NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
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Il6
interleukin 6
multiple interactions increases expression increases secretion
ISO
diphenyleneiodonium inhibits the reaction [Ritonavir results in increased expression of IL6 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased secretion of IL6 protein]; Ritonavir inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] rosiglitazone inhibits the reaction [Ritonavir results in increased expression of IL6 mRNA] Ritonavir results in increased expression of IL6 mRNA; Ritonavir results in increased expression of IL6 protein
CTD
PMID:15388451 PMID:15865214 PMID:17668557 PMID:20884875
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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Il7
interleukin 7
decreases expression
ISO
Ritonavir results in decreased expression of IL7
CTD
PMID:26626330
NCBI chr 2:96,427,884...96,474,979
Ensembl chr 2:96,439,286...96,474,977
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
Ritonavir results in increased expression of JUN protein
CTD
PMID:15504750
NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
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Lep
leptin
multiple interactions decreases expression
ISO
diphenyleneiodonium inhibits the reaction [Ritonavir results in decreased expression of LEP protein]
CTD
PMID:17668557
NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
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Lif
LIF, interleukin 6 family cytokine
decreases expression
ISO
Ritonavir results in decreased expression of LIF
CTD
PMID:26626330
NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642
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Lmna
lamin A/C
increases expression increases farnesylation
ISO
Ritonavir results in increased expression of LMNA protein Ritonavir results in increased farnesylation of LMNA protein alternative form
CTD
PMID:18230615 PMID:20884875
NCBI chr 2:187,842,884...187,863,552
Ensembl chr 2:187,842,885...187,863,516
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Lpl
lipoprotein lipase
affects expression
ISO
Ritonavir affects the expression of LPL mRNA
CTD
PMID:11741158
NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
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Myc
MYC proto-oncogene, bHLH transcription factor
decreases expression
ISO
Ritonavir results in decreased expression of MYC mRNA
CTD
PMID:16174765
NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
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Nfe2l2
nuclear factor, erythroid 2-like 2
increases expression multiple interactions
ISO
Ritonavir results in increased expression of NFE2L2 protein NFE2L2 protein mutant form inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]
CTD
PMID:26968795
NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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Nfkb1
nuclear factor kappa B subunit 1
decreases activity
ISO
Ritonavir results in decreased activity of NFKB1 protein
CTD
PMID:16174765
NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
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Nfkbia
NFKB inhibitor alpha
decreases phosphorylation
ISO
Ritonavir results in decreased phosphorylation of NFKBIA protein
CTD
PMID:16174765
NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
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Nlrc5
NLR family, CARD domain containing 5
decreases expression
ISO
Ritonavir results in decreased expression of NLRC5
CTD
PMID:26626330
NCBI chr19:10,904,381...11,006,202
Ensembl chr19:10,905,542...10,976,396
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Nos3
nitric oxide synthase 3
multiple interactions decreases expression
ISO
Masoprocol inhibits the reaction [Ritonavir results in decreased expression of NOS3 mRNA]
CTD
PMID:22037733
NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
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Notch4
notch receptor 4
decreases expression multiple interactions
EXP
Ritonavir results in decreased expression of NOTCH4 protein [Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of NOTCH4 protein; Vitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of NOTCH4 protein]
CTD
PMID:20722969
NCBI chr20:4,329,794...4,353,868
Ensembl chr20:4,329,811...4,353,785
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
increases expression
ISO
Ritonavir results in increased expression of NR1H4 mRNA
CTD
PMID:26626330
NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions increases activity
ISO EXP
Ritonavir binds to and results in increased activity of NR1I2 protein Ritonavir results in increased activity of NR1I2 protein
CTD
PMID:14977870 PMID:15849716 PMID:27732639
NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
G
Parp1
poly (ADP-ribose) polymerase 1
increases cleavage
ISO
Ritonavir results in increased cleavage of PARP1 protein
CTD
PMID:19386116 PMID:21270666
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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Pon1
paraoxonase 1
decreases activity
EXP
Ritonavir results in decreased activity of PON1 protein
CTD
PMID:27378623
NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions increases expression
ISO
Ritonavir inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of PPARG protein] Ritonavir results in increased expression of PPARG mRNA
CTD
PMID:11101056 PMID:17879945
NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
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Prkca
protein kinase C, alpha
multiple interactions increases activity increases expression
ISO
Ritonavir binds to and affects the localization of PRKCA protein Ritonavir results in increased activity of PRKCA protein Ritonavir results in increased expression of PRKCA protein
CTD
PMID:22020176
NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
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Psma1
proteasome 20S subunit alpha 1
affects expression
EXP
Ritonavir affects the expression of PSMA1 mRNA
CTD
PMID:17719200
NCBI chr 1:183,733,567...183,744,586
Ensembl chr 1:183,733,567...183,744,586
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Psmb3
proteasome 20S subunit beta 3
affects expression
EXP
Ritonavir affects the expression of PSMB3 mRNA
CTD
PMID:17719200
NCBI chr10:85,646,646...85,653,729
Ensembl chr10:85,646,633...85,653,729
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Psmb5
proteasome 20S subunit beta 5
increases expression
EXP
Ritonavir results in increased expression of PSMB5 mRNA
CTD
PMID:20213465
NCBI chr15:33,259,039...33,263,634
Ensembl chr15:33,259,043...33,263,659
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Rb1
RB transcriptional corepressor 1
decreases phosphorylation increases expression
ISO
Ritonavir results in decreased phosphorylation of RB1 protein Ritonavir results in increased expression of RB1 mRNA
CTD
PMID:16551874 PMID:19386116 PMID:21270666
NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
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Rbl1
RB transcriptional corepressor like 1
increases expression
ISO
Ritonavir results in increased expression of RBL1 mRNA
CTD
PMID:19386116
NCBI chr 3:153,263,692...153,321,351
Ensembl chr 3:153,263,692...153,321,352
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Rbl2
RB transcriptional corepressor like 2
decreases expression
ISO
Ritonavir results in decreased expression of RBL2 mRNA
CTD
PMID:19386116
NCBI chr19:17,300,088...17,346,865
Ensembl chr19:17,300,089...17,346,808
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Rel
REL proto-oncogene, NF-kB subunit
decreases activity
ISO
Ritonavir results in decreased activity of REL protein
CTD
PMID:16174765
NCBI chr14:108,490,794...108,517,582
Ensembl chr14:108,491,069...108,509,892
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Rela
RELA proto-oncogene, NF-kB subunit
decreases activity
ISO
Ritonavir results in decreased activity of RELA protein
CTD
PMID:16174765
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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Scarb1
scavenger receptor class B, member 1
multiple interactions increases expression
ISO
Estradiol inhibits the reaction [Ritonavir results in increased expression of SCARB1 protein] Ritonavir results in increased expression of SCARB1 mRNA
CTD
PMID:17879945
NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
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Scp2
sterol carrier protein 2
decreases expression
ISO
Ritonavir results in decreased expression of SCP2
CTD
PMID:26626330
NCBI chr 5:127,647,934...127,735,703
Ensembl chr 5:127,620,274...127,735,739
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Slc10a1
solute carrier family 10 member 1
decreases expression
ISO
Ritonavir results in decreased expression of SLC10A1
CTD
PMID:26626330
NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
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Slc51a
solute carrier family 51 subunit alpha
decreases expression
ISO
Ritonavir results in decreased expression of SLC51A
CTD
PMID:26626330
NCBI chr11:71,533,078...71,547,476
Ensembl chr11:71,533,078...71,547,476
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Src
SRC proto-oncogene, non-receptor tyrosine kinase
decreases phosphorylation
ISO
Ritonavir results in decreased phosphorylation of SRC protein
CTD
PMID:21270666
NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
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Srebf1
sterol regulatory element binding transcription factor 1
multiple interactions
ISO
Ritonavir promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SREBF1 protein]
CTD
PMID:11101056
NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
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Stat3
signal transducer and activator of transcription 3
decreases phosphorylation
ISO
Ritonavir results in decreased phosphorylation of STAT3 protein
CTD
PMID:21270666
NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
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Tjp1
tight junction protein 1
decreases expression multiple interactions
EXP
Ritonavir results in decreased expression of TJP1 protein [Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of TJP1 protein; Vitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of TJP1 protein]
CTD
PMID:20722969
NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
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Tnf
tumor necrosis factor
decreases secretion multiple interactions increases expression
ISO
Ritonavir results in decreased secretion of TNF protein rosiglitazone inhibits the reaction [Ritonavir results in increased expression of TNF mRNA] Ritonavir inhibits the reaction [IFNG protein results in increased secretion of TNF protein]; Ritonavir inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] Ritonavir results in increased expression of TNF mRNA; Ritonavir results in increased expression of TNF protein
CTD
PMID:10551732 PMID:15388451 PMID:15865214
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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Tp53
tumor protein p53
multiple interactions increases expression
ISO
FTI 277 inhibits the reaction [Ritonavir results in increased expression of TP53 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Ritonavir results in increased expression of TP53 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased expression of TP53 protein]
CTD
PMID:19386116 PMID:20884875
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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Ugt1a1
UDP glucuronosyltransferase family 1 member A1
affects expression
ISO
Ritonavir affects the expression of UGT1A1 mRNA
CTD
PMID:15849716
NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
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Zmpste24
zinc metallopeptidase STE24
decreases activity
ISO
Ritonavir results in decreased activity of ZMPSTE24 protein
CTD
PMID:18230615
NCBI chr 5:139,982,404...140,015,541
Ensembl chr 5:139,983,680...140,015,541
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Abcc1
ATP binding cassette subfamily C member 1
multiple interactions
ISO
[selenomethylselenocysteine co-treated with irinotecan] results in decreased expression of ABCC1
CTD
PMID:15897249
NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
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Abcc4
ATP binding cassette subfamily C member 4
multiple interactions decreases expression
EXP
Isoflavones promotes the reaction [selenomethylselenocysteine results in decreased expression of ABCC4 mRNA]
CTD
PMID:19025659
NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
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Apaf1
apoptotic peptidase activating factor 1
increases expression
ISO
selenomethylselenocysteine metabolite results in increased expression of APAF1 mRNA
CTD
PMID:25321483
NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
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Ar
androgen receptor
decreases expression
ISO EXP
selenomethylselenocysteine results in decreased expression of AR protein selenomethylselenocysteine results in decreased expression of AR mRNA
CTD
PMID:16637076 PMID:19025659
NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
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Arntl
aryl hydrocarbon receptor nuclear translocator-like
decreases expression
EXP
selenomethylselenocysteine results in decreased expression of ARNTL mRNA
CTD
PMID:19122877
NCBI chr 1:178,039,002...178,137,469
Ensembl chr 1:178,039,063...178,137,465
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Bak1
BCL2-antagonist/killer 1
increases expression
ISO
selenomethylselenocysteine metabolite results in increased expression of BAK1 mRNA
CTD
PMID:25321483
NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
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Banp
Btg3 associated nuclear protein
increases expression
ISO
selenomethylselenocysteine results in increased expression of BANP mRNA
CTD
PMID:18514395
NCBI chr19:54,766,441...54,843,795
Ensembl chr19:54,766,589...54,840,569
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Bcl2
BCL2, apoptosis regulator
decreases expression multiple interactions
ISO EXP
selenomethylselenocysteine results in decreased expression of BCL2 mRNA selenomethylselenocysteine results in decreased expression of BCL2 protein [selenomethylselenocysteine results in decreased expression of BCL2 mRNA] which results in increased activity of TNFSF10 protein
CTD
PMID:11396176 PMID:19360359
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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Bcl2l1
Bcl2-like 1
decreases expression
ISO
selenomethylselenocysteine metabolite results in decreased expression of BCL2L1 mRNA
CTD
PMID:25321483
NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
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Bcl2l11
BCL2 like 11
increases expression
ISO
selenomethylselenocysteine metabolite results in increased expression of BCL2L11 mRNA
CTD
PMID:25321483
NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
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Bmf
Bcl2 modifying factor
multiple interactions increases expression
ISO
BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP3 protein modified form]; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP6 protein modified form]; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP9 protein modified form]; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of PARP1 protein modified form]; C646 compound inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]; HDAC8 inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]; selenomethylselenocysteine metabolite inhibits the reaction [HDAC8 protein binds to BMF promoter]; selenomethylselenocysteine metabolite inhibits the reaction [STAT3 protein binds to BMF promoter]; selenomethylselenocysteine metabolite promotes the reaction [EP300 protein binds to BMF promoter]; selenomethylselenocysteine metabolite promotes the reaction [SP3 protein binds to BMF promoter]; STAT3 protein inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA] selenomethylselenocysteine metabolite results in increased expression of BMF protein selenomethylselenocysteine metabolite results in increased expression of BMF mRNA; selenomethylselenocysteine metabolite results in increased expression of BMF protein
CTD
PMID:25321483
NCBI chr 3:110,303,515...110,324,125
Ensembl chr 3:110,306,067...110,324,084
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Casp3
caspase 3
increases activity increases expression multiple interactions
ISO
selenomethylselenocysteine results in increased activity of CASP3 protein selenomethylselenocysteine metabolite results in increased expression of CASP3 protein modified form BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP3 protein modified form]
CTD
PMID:15318939 PMID:25321483
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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Casp6
caspase 6
increases expression multiple interactions
ISO
selenomethylselenocysteine metabolite results in increased expression of CASP6 protein modified form BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP6 protein modified form]
CTD
PMID:25321483
NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967 Ensembl chr 2:235,341,365...235,353,967
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Casp8
caspase 8
increases expression
ISO
selenomethylselenocysteine metabolite results in increased expression of CASP8 protein modified form
CTD
PMID:25321483
NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
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Casp9
caspase 9
multiple interactions increases expression
ISO
BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP9 protein modified form]
CTD
PMID:25321483
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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Ccna2
cyclin A2
decreases expression
EXP
selenomethylselenocysteine results in decreased expression of CCNA2 protein
CTD
PMID:11396176
NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
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Ccnd1
cyclin D1
decreases expression multiple interactions
ISO EXP
selenomethylselenocysteine results in decreased expression of CCND1 protein selenomethylselenocysteine results in decreased expression of CCND1 mRNA; selenomethylselenocysteine results in decreased expression of CCND1 protein [selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of CCND1 protein
CTD
PMID:11396176 PMID:18855134 PMID:19276161
NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
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Cdk2
cyclin dependent kinase 2
multiple interactions
ISO
selenomethylselenocysteine results in decreased phosphorylation of and results in decreased activity of CDK2 protein
CTD
PMID:10656618
NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression multiple interactions
ISO
selenomethylselenocysteine metabolite results in increased expression of CDKN1A protein [Aminooxyacetic Acid results in decreased metabolism of selenomethylselenocysteine] which results in decreased expression of CDKN1A protein
CTD
PMID:25321483
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
increases expression
EXP
selenomethylselenocysteine results in increased expression of CDKN1B protein
CTD
PMID:11396176 PMID:19276161
NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
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Ces1d
carboxylesterase 1D
increases expression
ISO
selenomethylselenocysteine results in increased expression of CES1
CTD
PMID:15897249
NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
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Chmp1a
charged multivesicular body protein 1A
increases expression
ISO
selenomethylselenocysteine results in increased expression of CHMP1A mRNA
CTD
PMID:18514395
NCBI chr19:56,001,724...56,010,004
Ensembl chr19:56,001,724...56,010,004
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Col1a1
collagen type I alpha 1 chain
decreases expression
ISO
selenomethylselenocysteine results in decreased expression of COL1A1 mRNA; selenomethylselenocysteine results in decreased expression of COL1A1 protein
CTD
PMID:18514395
NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
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Col1a2
collagen type I alpha 2 chain
decreases expression
ISO
selenomethylselenocysteine results in decreased expression of COL1A2 mRNA; selenomethylselenocysteine results in decreased expression of COL1A2 protein
CTD
PMID:18514395
NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
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Col4a5
collagen type IV alpha 5 chain
increases expression
ISO
selenomethylselenocysteine results in increased expression of COL4A5 mRNA
CTD
PMID:18514395
NCBI chr X:112,769,595...112,983,720
Ensembl chr X:112,769,645...112,983,685
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Col6a1
collagen type VI alpha 1 chain
increases expression
ISO
selenomethylselenocysteine results in increased expression of COL6A1 mRNA
CTD
PMID:18514395
NCBI chr20:12,657,913...12,676,370
Ensembl chr20:12,658,065...12,675,561
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Col7a1
collagen type VII alpha 1 chain
decreases expression
ISO
selenomethylselenocysteine results in decreased expression of COL7A1 mRNA
CTD
PMID:18514395
NCBI chr 8:117,694,441...117,726,844
Ensembl chr 8:117,694,605...117,726,844
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Cry2
cryptochrome circadian regulator 2
increases expression
EXP
selenomethylselenocysteine results in increased expression of CRY2 mRNA
CTD
PMID:19122877
NCBI chr 3:81,314,151...81,344,143
Ensembl chr 3:81,314,149...81,344,110
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
multiple interactions
ISO
[selenomethylselenocysteine co-treated with irinotecan] results in increased expression of CYP3A5
CTD
PMID:15897249
NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
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Dbp
D-box binding PAR bZIP transcription factor
increases expression
EXP
selenomethylselenocysteine results in increased expression of DBP mRNA
CTD
PMID:19122877
NCBI chr 1:101,687,896...101,692,845
Ensembl chr 1:101,687,855...101,692,846
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Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
selenomethylselenocysteine results in increased expression of DDIT3 mRNA
CTD
PMID:10656618
NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
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Dhcr24
24-dehydrocholesterol reductase
decreases expression
EXP
selenomethylselenocysteine results in decreased expression of DHCR24 mRNA
CTD
PMID:19025659
NCBI chr 5:126,164,708...126,188,926
Ensembl chr 5:126,164,674...126,191,206
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Drg1
developmentally regulated GTP binding protein 1
multiple interactions
ISO
[selenomethylselenocysteine co-treated with irinotecan] results in decreased expression of DRG1
CTD
PMID:15897249
NCBI chr14:83,460,540...83,476,568
Ensembl chr14:83,460,540...83,476,568
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Ep300
E1A binding protein p300
multiple interactions
ISO
selenomethylselenocysteine metabolite promotes the reaction [EP300 protein binds to BMF promoter]
CTD
PMID:25321483
NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
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Esr1
estrogen receptor 1
decreases expression multiple interactions
ISO
selenomethylselenocysteine results in decreased expression of ESR1 protein [selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of ESR1 protein
CTD
PMID:18855134
NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
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Faslg
Fas ligand
multiple interactions
ISO
[selenomethylselenocysteine co-treated with irinotecan] results in increased expression of FASLG
CTD
PMID:15897249
NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
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Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
ISO
selenomethylselenocysteine results in increased expression of GADD45A mRNA
CTD
PMID:10656618
NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
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Gpx1
glutathione peroxidase 1
increases activity increases expression
ISO
selenomethylselenocysteine results in increased activity of GPX1 protein selenomethylselenocysteine results in increased expression of GPX1 mRNA; selenomethylselenocysteine results in increased expression of GPX1 protein
CTD
PMID:18514395 PMID:19033020
NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
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Gpx4
glutathione peroxidase 4
increases expression
ISO
selenomethylselenocysteine results in increased expression of GPX4 mRNA
CTD
PMID:18514395
NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
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Grik1
glutamate ionotropic receptor kainate type subunit 1
increases expression
ISO
selenomethylselenocysteine results in increased expression of GRIK1 mRNA
CTD
PMID:18514395
NCBI chr11:27,811,954...28,213,940
Ensembl chr11:27,811,957...27,971,359
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Grik3
glutamate ionotropic receptor kainate type subunit 3
increases expression
ISO
selenomethylselenocysteine results in increased expression of GRIK3 mRNA
CTD
PMID:18514395
NCBI chr 5:143,500,441...143,715,546
Ensembl chr 5:143,500,441...143,715,546
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Hdac8
histone deacetylase 8
multiple interactions
ISO
HDAC8 inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]; selenomethylselenocysteine metabolite inhibits the reaction [HDAC8 protein binds to BMF promoter]
CTD
PMID:25321483
NCBI chr X:72,163,777...72,370,058
Ensembl chr X:72,163,777...72,370,044
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Igf1r
insulin-like growth factor 1 receptor
increases expression
ISO
selenomethylselenocysteine results in increased expression of IGF1R mRNA
CTD
PMID:18514395
NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases phosphorylation
EXP
selenomethylselenocysteine results in increased phosphorylation of JUN protein
CTD
PMID:19276161
NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
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Klk1
kallikrein 1
decreases expression
ISO
selenomethylselenocysteine results in decreased expression of KLK3 protein
CTD
PMID:16637076
NCBI chr 1:100,131,562...100,135,556
Ensembl chr 1:100,059,967...100,203,329 Ensembl chr 1:100,059,967...100,203,329 Ensembl chr 1:100,059,967...100,203,329
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Mki67
marker of proliferation Ki-67
multiple interactions decreases expression
ISO
[selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of MKI67 protein selenomethylselenocysteine results in decreased expression of MKI67 protein
CTD
PMID:18855134
NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
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Msrb1
methionine sulfoxide reductase B1
increases expression
ISO
selenomethylselenocysteine results in increased expression of MSRB1 mRNA
CTD
PMID:18514395
NCBI chr10:14,105,750...14,111,463
Ensembl chr10:14,105,750...14,111,463
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Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO
selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein]
CTD
PMID:21213327
NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD
PMID:21213327
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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P4ha1
prolyl 4-hydroxylase subunit alpha 1
increases expression
ISO
selenomethylselenocysteine results in increased expression of P4HA1 mRNA
CTD
PMID:18514395
NCBI chr20:28,920,616...28,972,576
Ensembl chr20:28,920,616...28,971,966
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Parp1
poly (ADP-ribose) polymerase 1
multiple interactions increases expression
ISO
[Aminooxyacetic Acid results in decreased metabolism of selenomethylselenocysteine] which results in decreased expression of PARP1 protein modified form; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of PARP1 protein modified form]
CTD
PMID:25321483
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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Per2
period circadian regulator 2
increases expression
EXP
selenomethylselenocysteine results in increased expression of PER2 mRNA
CTD
PMID:19122877
NCBI chr 9:98,555,154...98,597,362
Ensembl chr 9:98,555,169...98,597,359
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Per3
period circadian regulator 3
increases expression
EXP
selenomethylselenocysteine results in increased expression of PER3 mRNA
CTD
PMID:19122877
NCBI chr 5:168,088,126...168,123,482
Ensembl chr 5:168,086,998...168,123,395
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Pgr
progesterone receptor
decreases expression multiple interactions
ISO
selenomethylselenocysteine results in decreased expression of PGR protein [selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of PGR protein
CTD
PMID:18855134
NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
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Ppp1r15a
protein phosphatase 1, regulatory subunit 15A
increases expression
ISO
selenomethylselenocysteine results in increased expression of PPP1R15A mRNA
CTD
PMID:10656618
NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
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Prkce
protein kinase C, epsilon
decreases expression
ISO
selenomethylselenocysteine results in decreased expression of PRKCE protein
CTD
PMID:10656618
NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396
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Prkcz
protein kinase C, zeta
decreases expression
ISO
selenomethylselenocysteine results in decreased expression of PRKCZ protein
CTD
PMID:10656618
NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421
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Rab3b
RAB3B, member RAS oncogene family
increases expression
ISO
selenomethylselenocysteine results in increased expression of RAB3B mRNA
CTD
PMID:18514395
NCBI chr 5:128,501,789...128,568,170
Ensembl chr 5:128,501,847...128,568,188
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Rab4a
RAB4A, member RAS oncogene family
increases expression
ISO
selenomethylselenocysteine results in increased expression of RAB4A mRNA
CTD
PMID:18514395
NCBI chr19:56,585,598...56,613,078
Ensembl chr19:56,585,767...56,613,075
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]
CTD
PMID:21213327
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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Scarb1
scavenger receptor class B, member 1
increases expression
ISO
selenomethylselenocysteine results in increased expression of SCARB1 mRNA
CTD
PMID:18514395
NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
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Selenof
selenoprotein F
increases expression
ISO
selenomethylselenocysteine results in increased expression of SELENOF mRNA
CTD
PMID:18514395
NCBI chr 2:250,600,823...250,633,903
Ensembl chr 2:250,600,823...250,633,897
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Selenop
selenoprotein P
increases expression
ISO
selenomethylselenocysteine results in increased expression of SELENOP mRNA
CTD
PMID:18514395
NCBI chr 2:53,105,912...53,116,198
Ensembl chr 2:53,109,684...53,114,858
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Selenow
selenoprotein W
increases expression
ISO
selenomethylselenocysteine results in increased expression of SELENOW mRNA
CTD
PMID:18514395
NCBI chr 1:77,530,692...77,535,765
Ensembl chr 1:77,533,148...77,535,681 Ensembl chr 1:77,533,148...77,535,681
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Slc3a1
solute carrier family 3 member 1
increases uptake
ISO
SLC3A1 protein results in increased uptake of selenomethylselenocysteine
CTD
PMID:18845132
NCBI chr 6:8,284,937...8,318,649
Ensembl chr 6:8,284,878...8,318,674
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Slc6a19
solute carrier family 6 member 19
increases uptake
ISO
SLC6A19 protein results in increased uptake of selenomethylselenocysteine
CTD
PMID:18845132
NCBI chr 1:32,199,869...32,218,628
Ensembl chr 1:32,199,810...32,220,045
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Snap23
synaptosome associated protein 23
decreases expression
ISO
selenomethylselenocysteine results in decreased expression of SNAP23 mRNA
CTD
PMID:18514395
NCBI chr 3:112,333,972...112,362,960
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Sort1
sortilin 1
increases expression
ISO
selenomethylselenocysteine results in increased expression of SORT1 mRNA
CTD
PMID:18514395
NCBI chr 2:211,078,092...211,156,312
Ensembl chr 2:211,078,334...211,156,312
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Sp3
Sp3 transcription factor
multiple interactions
ISO
selenomethylselenocysteine metabolite promotes the reaction [SP3 protein binds to BMF promoter]
CTD
PMID:25321483
NCBI chr 3:59,644,579...59,689,011
Ensembl chr 3:59,646,015...59,688,692
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Spp1
secreted phosphoprotein 1
decreases expression
ISO
selenomethylselenocysteine results in decreased expression of SPP1 protein
CTD
PMID:15318939
NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
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Srd5a1
steroid 5 alpha-reductase 1
multiple interactions
EXP
[selenomethylselenocysteine co-treated with Isoflavones] results in decreased activity of SRD5A1 protein
CTD
PMID:19025659
NCBI chr 1:36,320,504...36,354,694
Ensembl chr 1:36,320,461...36,354,756
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Stat3
signal transducer and activator of transcription 3
multiple interactions
ISO
selenomethylselenocysteine metabolite inhibits the reaction [STAT3 protein binds to BMF promoter]; STAT3 protein inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]
CTD
PMID:25321483
NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
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Tnfsf10
TNF superfamily member 10
multiple interactions
ISO
[selenomethylselenocysteine results in decreased expression of BCL2 mRNA] which results in increased activity of TNFSF10 protein
CTD
PMID:19360359
NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
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Trnau1ap
tRNA selenocysteine 1 associated protein 1
increases expression
ISO
selenomethylselenocysteine results in increased expression of TRNAU1AP mRNA
CTD
PMID:18514395
NCBI chr 5:150,463,797...150,506,803
Ensembl chr 5:150,492,587...150,506,871
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Xpa
XPA, DNA damage recognition and repair factor
multiple interactions
ISO
selenomethylselenocysteine inhibits the reaction [Zinc binds to XPA protein]
CTD
PMID:15265038
NCBI chr 5:61,749,767...61,793,641
Ensembl chr 5:61,749,767...61,792,928
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Klrc1
killer cell lectin like receptor C1
decreases expression
ISO
sofosbuvir co-treated with ledipasvir decreased expression of NCR1 protein in natural killer cells
RGD
PMID:31218578
RGD:40400920
NCBI chr 4:163,453,435...163,463,718
Ensembl chr 4:163,458,528...163,463,718
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Ncr1
natural cytotoxicity triggering receptor 1
affects expression
ISO
sofosbuvir co-treated with ledipasvir affects expression of NCR1 protein in natural killer cells
RGD
PMID:31218578
RGD:40400920
NCBI chr 1:73,178,917...73,226,504
Ensembl chr 1:73,179,013...73,226,777
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