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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:89656 term browser browse the term
Definition:A pentapeptide comprising L-tyrosine, glycine, glycine, L-phenylalanine and L-leucine residues joined in sequence by peptide linkages. It is an endogenous opioid peptide produced in vertebrate species, including rodents, primates and humans that results from decomposition of proenkephalin or dynorphin and exhibits antinociceptive properties.
Synonyms:exact_synonym: L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine
 related_synonym: (2S)-2-[(2S)-2-(2-{2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]acetamido}acetamido)-3-phenylpropanamido]-4-methylpentanoic acid;   Formula=C28H37N5O7;   H-Tyr-Gly-Gly-Phe-Leu-OH;   InChI=1S/C28H37N5O7/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40)/t21-,22-,23-/m0/s1;   InChIKey=URLZCHNOLZSCCA-VABKMULXSA-N;   L-ENK;   L-Tyr-Gly-Gly-L-Phe-L-Leu;   Leu-ENK;   LeuENK;   Leucine enkephalin;   N-(N-(N-(N-L-tyrosylglycyl)glycyl)-L-phenylalanyl)-L-leucine;   SMILES=CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC1=CC=C(O)C=C1)C(O)=O;   Tyr-Gly-Gly-Phe-Leu;   Tyr-Gly-Gly-Phe-Leu-OH;   Y-G-G-F-L;   YGGFL;   [5-Leucine]Enkephalin;   [Leu 5]enkephalin;   enkephalin L;   leucyl-enkephalin
 alt_id: CHEBI:80263
 xref: CAS:58822-25-6;   Chemspider:406229;   FooDB:FDB022389;   HMDB:HMDB0001045;   KEGG:C16041
 xref_mesh: MESH:D004743
 xref: PMID:16802191;   PMID:20161518;   PMID:20669325;   PMID:22323423;   PMID:23661424;   PMID:23912034;   PMID:24480726;   PMID:2583565;   PMID:26723675;   PMID:26763532;   PMID:28233882;   PMID:28382489;   PMID:29351722;   PMID:29648788;   PMID:29793486;   PMID:29981318;   PMID:30014064;   PMID:30234204;   PMID:31843219;   PMID:32556047;   PMID:32961052;   PMID:33389463;   PMID:33573373;   PMID:33663067;   PMID:4069309;   PMID:9450624;   Reaxys:3582445;   Wikipedia:Leu-enkephalin

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Leu-enkephalin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dpp3 dipeptidylpeptidase 3 increases cleavage
multiple interactions
ISO DPP3 protein results in increased cleavage of Enkephalin, Leucine
spinorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]; tynorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]
CTD PMID:10873616 NCBI chr 1:220,166,124...220,189,762
Ensembl chr 1:220,166,127...220,188,541
JBrowse link
G Oprd1 opioid receptor, delta 1 increases activity ISO Enkephalin, Leucine results in increased activity of OPRD1 protein CTD PMID:26476280 NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063
JBrowse link
G Oprm1 opioid receptor, mu 1 increases activity ISO Enkephalin, Leucine results in increased activity of OPRM1 protein CTD PMID:26476280 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19773
    role 19723
      biological role 19723
        molecular messenger 18303
          neurotransmitter 10804
            Leu-enkephalin 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    main group molecular entity 19665
                      s-block molecular entity 19430
                        hydrogen molecular entity 19424
                          hydrides 18758
                            organic hydride 18356
                              organic fundamental parent 18356
                                hydrocarbon 18076
                                  cyclic hydrocarbon 17091
                                    monocyclic hydrocarbon 5813
                                      annulene 5639
                                        aromatic annulene 5639
                                          benzene 5639
                                            alkylbenzene 3361
                                              methylbenzene 3225
                                                toluene 3089
                                                  benzyl group 2500
                                                    phenylalanine 2500
                                                      L-phenylalanine 2247
                                                        Leu-enkephalin 3
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