Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   


The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

go back to main search page
Accession:CHEBI:89656 term browser browse the term
Definition:A pentapeptide comprising L-tyrosine, glycine, glycine, L-phenylalanine and L-leucine residues joined in sequence by peptide linkages. It is an endogenous opioid peptide produced in vertebrate species, including rodents, primates and humans that results from decomposition of proenkephalin or dynorphin and exhibits antinociceptive properties.
Synonyms:exact_synonym: L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine
 related_synonym: (2S)-2-[(2S)-2-(2-{2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]acetamido}acetamido)-3-phenylpropanamido]-4-methylpentanoic acid;   Formula=C28H37N5O7;   H-Tyr-Gly-Gly-Phe-Leu-OH;   InChI=1S/C28H37N5O7/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40)/t21-,22-,23-/m0/s1;   InChIKey=URLZCHNOLZSCCA-VABKMULXSA-N;   L-ENK;   L-Tyr-Gly-Gly-L-Phe-L-Leu;   Leu-ENK;   LeuENK;   Leucine enkephalin;   N-(N-(N-(N-L-tyrosylglycyl)glycyl)-L-phenylalanyl)-L-leucine;   SMILES=CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC1=CC=C(O)C=C1)C(O)=O;   Tyr-Gly-Gly-Phe-Leu;   Tyr-Gly-Gly-Phe-Leu-OH;   Y-G-G-F-L;   YGGFL;   [5-Leucine]Enkephalin;   [Leu 5]enkephalin;   enkephalin L;   leucyl-enkephalin
 alt_id: CHEBI:80263
 xref: CAS:58822-25-6;   Chemspider:406229;   FooDB:FDB022389;   HMDB:HMDB0001045;   KEGG:C16041
 xref_mesh: MESH:D004743
 xref: PMID:16802191;   PMID:20161518;   PMID:20669325;   PMID:22323423;   PMID:23661424;   PMID:23912034;   PMID:24480726;   PMID:2583565;   PMID:26723675;   PMID:26763532;   PMID:28233882;   PMID:28382489;   PMID:29351722;   PMID:29648788;   PMID:29793486;   PMID:29981318;   PMID:30014064;   PMID:30234204;   PMID:31843219;   PMID:32556047;   PMID:32961052;   PMID:33389463;   PMID:33573373;   PMID:33663067;   PMID:4069309;   PMID:9450624;   Reaxys:3582445;   Wikipedia:Leu-enkephalin

show annotations for term's descendants           Sort by:
Leu-enkephalin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dpp3 dipeptidylpeptidase 3 increases cleavage
multiple interactions
ISO DPP3 protein results in increased cleavage of Enkephalin, Leucine
spinorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]; tynorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]
CTD PMID:10873616 NCBI chr 1:202,204,683...202,228,501
Ensembl chr 1:202,204,693...202,228,541
JBrowse link
G Oprd1 opioid receptor, delta 1 increases activity ISO Enkephalin, Leucine results in increased activity of OPRD1 protein CTD PMID:26476280 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprm1 opioid receptor, mu 1 increases activity ISO Enkephalin, Leucine results in increased activity of OPRM1 protein CTD PMID:26476280 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        molecular messenger 18301
          neurotransmitter 10943
            Leu-enkephalin 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    main group molecular entity 19698
                      s-block molecular entity 19479
                        hydrogen molecular entity 19471
                          hydrides 18834
                            organic hydride 18348
                              organic fundamental parent 18348
                                hydrocarbon 18059
                                  cyclic hydrocarbon 17069
                                    monocyclic hydrocarbon 5845
                                      annulene 5672
                                        aromatic annulene 5672
                                          benzene 5672
                                            alkylbenzene 3388
                                              methylbenzene 3254
                                                toluene 3119
                                                  benzyl group 2533
                                                    phenylalanine 2533
                                                      L-phenylalanine 2277
                                                        Leu-enkephalin 3
paths to the root