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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Leu-enkephalin
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Accession:CHEBI:89656 term browser browse the term
Definition:A pentapeptide comprising L-tyrosine, glycine, glycine, L-phenylalanine and L-leucine residues joined in sequence by peptide linkages. It is an endogenous opioid peptide produced in vertebrate species, including rodents, primates and humans that results from decomposition of proenkephalin or dynorphin and exhibits antinociceptive properties.
Synonyms:exact_synonym: L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine
 related_synonym: (2S)-2-[(2S)-2-(2-{2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]acetamido}acetamido)-3-phenylpropanamido]-4-methylpentanoic acid;   Formula=C28H37N5O7;   H-Tyr-Gly-Gly-Phe-Leu-OH;   InChI=1S/C28H37N5O7/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40)/t21-,22-,23-/m0/s1;   InChIKey=URLZCHNOLZSCCA-VABKMULXSA-N;   L-ENK;   L-Tyr-Gly-Gly-L-Phe-L-Leu;   Leu-ENK;   LeuENK;   Leucine enkephalin;   N-(N-(N-(N-L-tyrosylglycyl)glycyl)-L-phenylalanyl)-L-leucine;   SMILES=CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC1=CC=C(O)C=C1)C(O)=O;   Tyr-Gly-Gly-Phe-Leu;   Tyr-Gly-Gly-Phe-Leu-OH;   Y-G-G-F-L;   YGGFL;   [5-Leucine]Enkephalin;   [Leu 5]enkephalin;   enkephalin L;   leucyl-enkephalin
 alt_id: CHEBI:80263
 xref: CAS:58822-25-6;   Chemspider:406229;   FooDB:FDB022389;   HMDB:HMDB0001045;   KEGG:C16041
 xref_mesh: MESH:D004743
 xref: PMID:16802191;   PMID:20161518;   PMID:20669325;   PMID:22323423;   PMID:23661424;   PMID:23912034;   PMID:24480726;   PMID:2583565;   PMID:26723675;   PMID:26763532;   PMID:28233882;   PMID:28382489;   PMID:29351722;   PMID:29648788;   PMID:29793486;   PMID:29981318;   PMID:30014064;   PMID:30234204;   PMID:31843219;   PMID:32556047;   PMID:32961052;   PMID:33389463;   PMID:33573373;   PMID:33663067;   PMID:4069309;   PMID:9450624;   Reaxys:3582445;   Wikipedia:Leu-enkephalin
 cyclic_relationship: is_tautomer_of CHEBI:190689


show annotations for term's descendants           Sort by:
Leu-enkephalin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dpp3 dipeptidylpeptidase 3 increases cleavage
multiple interactions		 ISO DPP3 protein results in increased cleavage of Enkephalin, Leucine
spinorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]; tynorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]		 CTD PMID:10873616 NCBI chr 1:202,204,683...202,228,501
Ensembl chr 1:202,204,693...202,228,541 		JBrowse link
G Oprd1 opioid receptor, delta 1 increases activity ISO Enkephalin, Leucine results in increased activity of OPRD1 protein CTD PMID:26476280 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprm1 opioid receptor, mu 1 increases activity ISO Enkephalin, Leucine results in increased activity of OPRM1 protein CTD PMID:26476280 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19900
    role 19875
      biological role 19873
        molecular messenger 18660
          neurotransmitter 11525
            Leu-enkephalin 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19900
    subatomic particle 19898
      composite particle 19898
        hadron 19898
          baryon 19898
            nucleon 19898
              atomic nucleus 19898
                atom 19898
                  main group element atom 19845
                    main group molecular entity 19845
                      s-block molecular entity 19678
                        hydrogen molecular entity 19667
                          hydrides 19146
                            organic hydride 18704
                              organic fundamental parent 18704
                                hydrocarbon 18428
                                  cyclic hydrocarbon 17242
                                    monocyclic hydrocarbon 6109
                                      annulene 5759
                                        aromatic annulene 5759
                                          benzene 5759
                                            alkylbenzene 3459
                                              methylbenzene 3320
                                                toluene 3188
                                                  benzyl group 2596
                                                    phenylalanine 2596
                                                      L-phenylalanine 2329
                                                        Leu-enkephalin 3
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