Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Leu-enkephalin
go back to main search page
Accession:CHEBI:89656 term browser browse the term
Definition:A pentapeptide comprising L-tyrosine, glycine, glycine, L-phenylalanine and L-leucine residues joined in sequence by peptide linkages. It is an endogenous opioid peptide produced in vertebrate species, including rodents, primates and humans that results from decomposition of proenkephalin or dynorphin and exhibits antinociceptive properties.
Synonyms:exact_synonym: L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine
 related_synonym: (2S)-2-[(2S)-2-(2-{2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]acetamido}acetamido)-3-phenylpropanamido]-4-methylpentanoic acid;   Formula=C28H37N5O7;   H-Tyr-Gly-Gly-Phe-Leu-OH;   InChI=1S/C28H37N5O7/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40)/t21-,22-,23-/m0/s1;   InChIKey=URLZCHNOLZSCCA-VABKMULXSA-N;   L-ENK;   L-Tyr-Gly-Gly-L-Phe-L-Leu;   Leu-ENK;   LeuENK;   Leucine enkephalin;   N-(N-(N-(N-L-tyrosylglycyl)glycyl)-L-phenylalanyl)-L-leucine;   SMILES=CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC1=CC=C(O)C=C1)C(O)=O;   Tyr-Gly-Gly-Phe-Leu;   Tyr-Gly-Gly-Phe-Leu-OH;   Y-G-G-F-L;   YGGFL;   [5-Leucine]Enkephalin;   [Leu 5]enkephalin;   enkephalin L;   leucyl-enkephalin
 alt_id: CHEBI:80263
 xref: CAS:58822-25-6;   Chemspider:406229;   FooDB:FDB022389;   HMDB:HMDB0001045;   KEGG:C16041
 xref_mesh: MESH:D004743
 xref: PMID:16802191;   PMID:20161518;   PMID:20669325;   PMID:22323423;   PMID:23661424;   PMID:23912034;   PMID:24480726;   PMID:2583565;   PMID:26723675;   PMID:26763532;   PMID:28233882;   PMID:28382489;   PMID:29351722;   PMID:29648788;   PMID:29793486;   PMID:29981318;   PMID:30014064;   PMID:30234204;   PMID:31843219;   PMID:32556047;   PMID:32961052;   PMID:33389463;   PMID:33573373;   PMID:33663067;   PMID:4069309;   PMID:9450624;   Reaxys:3582445;   Wikipedia:Leu-enkephalin
 cyclic_relationship: is_tautomer_of CHEBI:190689


show annotations for term's descendants           Sort by:
Leu-enkephalin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dpp3 dipeptidylpeptidase 3 increases cleavage
multiple interactions		 ISO DPP3 protein results in increased cleavage of Enkephalin, Leucine
spinorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]; tynorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]		 CTD PMID:10873616 NCBI chr 1:202,204,683...202,228,501
Ensembl chr 1:202,204,693...202,228,541 		JBrowse link
G Oprd1 opioid receptor, delta 1 increases activity ISO Enkephalin, Leucine results in increased activity of OPRD1 protein CTD PMID:26476280 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprm1 opioid receptor, mu 1 increases activity ISO Enkephalin, Leucine results in increased activity of OPRM1 protein CTD PMID:26476280 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        molecular messenger 18659
          neurotransmitter 11681
            Leu-enkephalin 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    main group molecular entity 19811
                      s-block molecular entity 19647
                        hydrogen molecular entity 19628
                          hydrides 19139
                            organic hydride 18687
                              organic fundamental parent 18687
                                hydrocarbon 18438
                                  cyclic hydrocarbon 17231
                                    monocyclic hydrocarbon 6164
                                      annulene 5817
                                        aromatic annulene 5817
                                          benzene 5817
                                            alkylbenzene 3538
                                              methylbenzene 3392
                                                toluene 3264
                                                  benzyl group 2674
                                                    phenylalanine 2674
                                                      L-phenylalanine 2398
                                                        Leu-enkephalin 3
paths to the root