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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:status epilepticus
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Accession:DOID:1824 term browser browse the term
Definition:A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)
Synonyms:exact_synonym: Complex Partial Status Epilepticus;   Electrographic Status Epilepticus;   Generalized Convulsive Status Epilepticus;   Generalized Status Epilepticus;   Grand Mal Status Epilepticus;   Non Convulsive Status Epilepticus;   Petit Mal Status;   Simple Partial Status Epilepticus;   absence status;   grand mal status;   subclinical status epilepticus
 primary_id: MESH:D013226
 xref: EFO:0008526;   GARD:10191;   NCI:C85079
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
status epilepticus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase ISO RGD PMID:9344635 RGD:1598522 NCBI chr16:8,331,293...8,439,432
Ensembl chr16:8,331,293...8,439,432 		JBrowse link
G Abcb1a ATP-binding cassette, sub-family B member 1A EXP CTD Direct Evidence: marker/mechanism CTD PMID:14706787 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B ISO
EXP		 mRNA:increased expression:dentate gyrus, posterior parahippocampal gyrus (rat)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:14706787 PMID:15380564 RGD:1358367 NCBI chr 5:8,848,147...8,916,314
Ensembl chr 5:8,848,147...8,916,315 		JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16504477 PMID:16504477 RGD:1598613 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
G Abcc8 ATP-binding cassette, sub-family C member 8 ISO mRNA:decreased expression:hippocampus RGD PMID:22050960 RGD:5686281 NCBI chr 7:45,753,952...45,829,441
Ensembl chr 7:45,753,947...45,829,457 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) ISO protein:increased expression:brain, astrocyte RGD PMID:16190927 RGD:2315587 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Acan aggrecan ISO RGD PMID:22934955 RGD:11570543 NCBI chr 7:78,702,974...78,764,847
Ensembl chr 7:78,703,231...78,764,847 		JBrowse link
G Adam10 a disintegrin and metallopeptidase domain 10 ISO mRNA:increased expression:dentate gyrus RGD PMID:15950787 RGD:1559151 NCBI chr 9:70,586,133...70,687,511
Ensembl chr 9:70,586,279...70,687,511 		JBrowse link
G Adam9 ADAM metallopeptidase domain 9 ISO mRNA:increased expression:dentate gyrus RGD PMID:15950787 RGD:1559151 NCBI chr 8:25,439,627...25,507,138
Ensembl chr 8:25,439,627...25,506,943 		JBrowse link
G Aif1 allograft inflammatory factor 1 ISO protein:increased expression:dentate gyrus, brain subventricular zone (rat) RGD PMID:17178407 RGD:2313036 NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044 		JBrowse link
G Alad aminolevulinate, delta-, dehydratase ISO protein:decreased activity:hippocampus, frontal cortex (rat) RGD PMID:20026167 RGD:4144137 NCBI chr 4:62,422,762...62,438,300
Ensembl chr 4:62,427,406...62,438,155 		JBrowse link
G Ank3 ankyrin 3, epithelial ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19306853 PMID:19306853 RGD:6767290 NCBI chr10:69,234,608...69,863,266
Ensembl chr10:69,234,603...69,863,268 		JBrowse link
G Apex1 apurinic/apyrimidinic endonuclease 1 ISO protein:increased expression:brain RGD PMID:11852039 RGD:1599366 NCBI chr14:51,162,406...51,164,645
Ensembl chr14:51,162,425...51,164,596 		JBrowse link
G Apod apolipoprotein D ISO mRNA:increased expression:hippocampus RGD PMID:10372566 RGD:2311203 NCBI chr16:31,115,010...31,133,626
Ensembl chr16:31,115,010...31,133,626 		JBrowse link
G Aqp1 aquaporin 1 ISO RGD PMID:19619613 RGD:2316077 NCBI chr 6:55,313,284...55,325,540
Ensembl chr 6:55,313,417...55,325,540 		JBrowse link
G Aqp4 aquaporin 4 severity ISO
IMP
IEP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:20886625 PMID:20886625 PMID:22361023 PMID:22361023 RGD:5148023, RGD:8695999, RGD:8695999 NCBI chr18:15,522,451...15,544,039
Ensembl chr18:15,522,553...15,544,039 		JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 ISO RGD PMID:11564418 RGD:2314147 NCBI chr10:87,326,681...87,329,522
Ensembl chr10:87,326,681...87,329,522 		JBrowse link
G Atm ataxia telangiectasia mutated ISO RGD PMID:11852039 RGD:1599366 NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040 		JBrowse link
G Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15288437 NCBI chr 5:122,591,576...122,640,288
Ensembl chr 5:122,591,576...122,640,288 		JBrowse link
G Bax BCL2-associated X protein treatment ISO RGD PMID:22849356 RGD:10054246 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 treatment ISO protein:decreased expression:hippocampus RGD PMID:18076646 PMID:22842798 RGD:2293065, RGD:11522734 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 ISO mRNA:increased expression:dentate gyrus (rat) RGD PMID:24051278 RGD:11352818 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Bdnf brain derived neurotrophic factor ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:8635431 PMID:8821376 PMID:19366663 PMID:19686240 RGD:4891125, RGD:5684912 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Becn1 beclin 1, autophagy related ISO mRNA:protein:increased expression
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:19138675 PMID:19138675 RGD:6483096 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112 		JBrowse link
G Casp1 caspase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18571097 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290 		JBrowse link
G Casp2 caspase 2 disease_progression ISO RGD PMID:17627033 RGD:4107076 NCBI chr 6:42,241,942...42,259,442
Ensembl chr 6:42,241,919...42,259,442 		JBrowse link
G Casp3 caspase 3 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16679645 PMID:18571097 PMID:20214503 RGD:10054104 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp6 caspase 6 ISO protein:increased expression, increased activity:hippocampus RGD PMID:15749343 RGD:2301314 NCBI chr 3:129,695,064...129,707,761
Ensembl chr 3:129,695,074...129,707,752 		JBrowse link
G Casp8 caspase 8 ISO protein:increased activity:hippocampus
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:18571097 PMID:15036620 RGD:2311439 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Cat catalase ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:15245787 PMID:15752349 PMID:17383094 PMID:18096215 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19490431 PMID:20034406 PMID:17950261 RGD:2307057 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19490431 PMID:22248156 RGD:8552226 NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 ISO mRNA, protein:increased expression:brain RGD PMID:21731074 RGD:5683875 NCBI chr11:83,553,410...83,555,509
Ensembl chr11:83,553,410...83,555,509 		JBrowse link
G Ccnd1 cyclin D1 treatment ISO RGD PMID:24051278 RGD:11352818 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Ccr10 C-C motif chemokine receptor 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17181556 NCBI chr11:101,063,824...101,066,269
Ensembl chr11:101,063,823...101,066,269 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19490431 PMID:20034406 NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594 		JBrowse link
G Ccr3 C-C motif chemokine receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19490431 NCBI chr 9:123,817,799...123,831,729
Ensembl chr 9:123,822,009...123,831,726 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 ISO RGD PMID:22248156 RGD:8552226 NCBI chr 9:123,921,557...123,934,153
Ensembl chr 9:123,921,580...123,947,736 		JBrowse link
G Ccr7 C-C motif chemokine receptor 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17181556 NCBI chr11:99,035,025...99,045,903
Ensembl chr11:99,035,022...99,045,903 		JBrowse link
G Ccr8 C-C motif chemokine receptor 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17181556 NCBI chr 9:119,921,199...119,923,972
Ensembl chr 9:119,921,180...119,923,972 		JBrowse link
G Ccr9 C-C motif chemokine receptor 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17181556 NCBI chr 9:123,596,276...123,612,522
Ensembl chr 9:123,507,504...123,613,395 		JBrowse link
G Cd40 CD40 antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:18455351 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868 		JBrowse link
G Cdh2 cadherin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12125071 NCBI chr18:16,721,934...16,942,303
Ensembl chr18:16,721,934...16,942,303 		JBrowse link
G Cfl1 cofilin 1, non-muscle treatment ISO RGD PMID:27642592 RGD:11568691 NCBI chr19:5,540,483...5,544,059
Ensembl chr19:5,540,483...5,545,229 		JBrowse link
G Ckmt1 creatine kinase, mitochondrial 1, ubiquitous ISO RGD PMID:20979657 RGD:11565113 NCBI chr 2:121,188,257...121,194,218
Ensembl chr 2:121,188,195...121,194,218 		JBrowse link
G Cnr1 cannabinoid receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19368833 PMID:19368833 RGD:2314675 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831 		JBrowse link
G Crh corticotropin releasing hormone ISO CTD Direct Evidence: marker/mechanism CTD PMID:7756609 NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560 		JBrowse link
G Crp C-reactive protein, pentraxin-related ISO protein:increased expression:plasma: RGD PMID:23398413 RGD:9586015 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 treatment ISO RGD PMID:21481949 RGD:9491789 NCBI chr 8:95,498,808...95,509,055
Ensembl chr 8:95,498,637...95,509,055 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 treatment ISO RGD PMID:21481949 RGD:9491789 NCBI chr 9:119,877,749...119,897,362
Ensembl chr 9:119,877,749...119,898,945 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 ISO protein:increased expression:brain, neuron, endothelial cell RGD PMID:21535896 RGD:5134992 NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 ISO protein:increased expression:brain RGD PMID:19054393 RGD:2306568 NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 ISO Protein:increased expression:brain RGD PMID:16780839 RGD:1599696 NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306 		JBrowse link
G Dab1 disabled 1 ISO protein:increased expression:dentate gyrus (rat) RGD PMID:17314278 RGD:2317783 NCBI chr 4:103,476,425...104,602,041
Ensembl chr 4:103,476,556...104,602,041 		JBrowse link
G Dmd dystrophin, muscular dystrophy ISO protein:decreased expression:piriform cortex
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:20886625 PMID:20886625 RGD:5148023 NCBI chr  X:81,858,244...84,248,656
Ensembl chr  X:81,992,476...84,249,747 		JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 treatment ISO RGD PMID:22761705 RGD:10045560 NCBI chr14:67,040,313...67,148,490
Ensembl chr14:67,040,313...67,148,410 		JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16492139 NCBI chr17:79,157,933...79,190,001
Ensembl chr17:79,159,993...79,190,002 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16492139 NCBI chr 6:70,821,468...70,882,225
Ensembl chr 6:70,821,499...70,882,229 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:15003282 NCBI chr12:78,908,846...78,933,784
Ensembl chr12:78,908,593...78,933,784 		JBrowse link
G Elavl4 ELAV like RNA binding protein 4 ISO mRNA:increased expression:hippocampus: RGD PMID:17577668 RGD:9685310 NCBI chr 4:110,060,934...110,209,127
Ensembl chr 4:110,060,919...110,209,106 		JBrowse link
G Epo erythropoietin ISO CTD Direct Evidence: therapeutic CTD PMID:16679645 PMID:17166730 NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504 		JBrowse link
G Fos FBJ osteosarcoma oncogene ISO CTD Direct Evidence: marker/mechanism CTD PMID:7984056 PMID:16696126 PMID:18587450 PMID:18988310 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Foxo3 forkhead box O3 IEP protein:decreased expression:hippocampus,mitochondrion: RGD PMID:23278239 RGD:10402198 NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751 		JBrowse link
G Gap43 growth associated protein 43 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10366005 NCBI chr16:42,068,915...42,161,014
Ensembl chr16:42,068,805...42,161,014 		JBrowse link
G Gdnf glial cell line derived neurotrophic factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:7854063 PMID:12914250 NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056 		JBrowse link
G Ghsr growth hormone secretagogue receptor ISO mRNA:decreased expression:hippocampus: RGD PMID:23129314 RGD:12907502 NCBI chr 3:27,425,500...27,433,384
Ensembl chr 3:27,425,500...27,432,159 		JBrowse link
G Gjb6 gap junction protein, beta 6 ISO mRNA:increased expression:brain RGD PMID:12359154 RGD:632751 NCBI chr14:57,360,760...57,370,764
Ensembl chr14:57,360,760...57,371,068 		JBrowse link
G Glp1r glucagon-like peptide 1 receptor IMP RGD PMID:12925848 RGD:1598440 NCBI chr17:31,120,841...31,155,484
Ensembl chr17:31,120,791...31,159,765 		JBrowse link
G Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) ISO protein:decreased expression:hippocampus (rat) RGD PMID:19914343 PMID:25457025 RGD:4107719, RGD:13792697 NCBI chr11:56,902,342...57,221,070
Ensembl chr11:56,902,213...57,221,070 		JBrowse link
G Gria2 glutamate receptor, ionotropic, AMPA2 (alpha 2) ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19222700 PMID:25457025 RGD:13792697 NCBI chr 3:80,588,757...80,711,534
Ensembl chr 3:80,588,757...80,710,142 		JBrowse link
G Grik1 glutamate receptor, ionotropic, kainate 1 ISO RGD PMID:12724156 RGD:1642496 NCBI chr16:87,692,789...88,087,751
Ensembl chr16:87,692,788...88,087,153 		JBrowse link
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) ISO RGD PMID:25457025 RGD:13792697 NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199 		JBrowse link
G Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) ISO RGD PMID:25457025 RGD:13792697 NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424 		JBrowse link
G Grm1 glutamate receptor, metabotropic 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15058486 PMID:17446080 NCBI chr10:10,561,803...10,958,126
Ensembl chr10:10,561,803...10,958,100 		JBrowse link
G Grm5 glutamate receptor, metabotropic 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17634364 PMID:18774262 NCBI chr 7:87,233,212...87,784,271
Ensembl chr 7:87,233,376...87,784,115 		JBrowse link
G Grm8 glutamate receptor, metabotropic 8 IDA RGD PMID:17430409 RGD:6771183 NCBI chr 6:27,275,120...28,135,094
Ensembl chr 6:27,275,118...28,135,177 		JBrowse link
G Grn granulin ISO mRNA, protein:increased expression:brain RGD PMID:23887054 RGD:10401660 NCBI chr11:102,321,333...102,327,635
Ensembl chr11:102,321,141...102,327,874 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta treatment ISO RGD PMID:22761705 RGD:10045560 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G H2ax H2A.X variant histone ISO protein:increased phosphorylation:brain RGD PMID:21613478 RGD:8693708 NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374 		JBrowse link
G Hcn1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 ISO RGD PMID:21976514 RGD:9686365 NCBI chr13:117,738,856...118,117,564
Ensembl chr13:117,738,856...118,123,954 		JBrowse link
G Hmox1 heme oxygenase 1 ISO protein:increased expression:cerebral cortex (rat)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:20971094 PMID:20971094 RGD:4145131 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hrh3 histamine receptor H3 ISO mRNA:increased expression:brain RGD PMID:16137576 RGD:1626426 NCBI chr 2:179,741,258...179,746,264
Ensembl chr 2:179,741,258...179,746,281 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 ISO mRNA:increased expression:hippocampus RGD PMID:22050960 RGD:5686281 NCBI chr 1:192,903,917...192,946,345
Ensembl chr 1:192,903,942...192,946,383 		JBrowse link
G Hspa1a heat shock protein 1A ISO protein:increased expression:cerebral spinal fluid: RGD PMID:22509781 RGD:7257648 NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132 		JBrowse link
G Hspb1 heat shock protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20971094 NCBI chr 5:135,916,773...135,918,417
Ensembl chr 5:135,916,773...135,918,417 		JBrowse link
G Htra2 HtrA serine peptidase 2 ISO protein:increased expression:hippocampus CA1, neuron, cytoplasm (rat) RGD PMID:21132459 RGD:5688370 NCBI chr 6:83,028,247...83,031,552
Ensembl chr 6:83,028,247...83,032,254 		JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial ISO protein:increased acetylation:hippocampus RGD PMID:29778462 RGD:14985255 NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140 		JBrowse link
G Il18 interleukin 18 ISO RGD PMID:20674684 RGD:4889491 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il1b interleukin 1 beta ISO mRNA:increased expression:hippocampus (rat) RGD PMID:14678765 PMID:22960129 RGD:1626682, RGD:7204701 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO CTD Direct Evidence: therapeutic CTD PMID:19010416 NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506 		JBrowse link
G Il6st interleukin 6 signal transducer ISO mRNA:increased expression:hippocampus (rat) RGD PMID:14614900 RGD:1627571 NCBI chr13:112,600,604...112,643,394
Ensembl chr13:112,600,604...112,646,620 		JBrowse link
G Jun jun proto-oncogene ISO CTD Direct Evidence: marker/mechanism CTD PMID:7984056 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Junb jun B proto-oncogene ISO CTD Direct Evidence: marker/mechanism CTD PMID:7984056 NCBI chr 8:85,703,538...85,705,377
Ensembl chr 8:85,701,113...85,705,347 		JBrowse link
G Jund jun D proto-oncogene ISO CTD Direct Evidence: marker/mechanism CTD PMID:7984056 NCBI chr 8:71,150,389...71,153,265
Ensembl chr 8:71,151,599...71,153,265 		JBrowse link
G Kcnc4 potassium voltage gated channel, Shaw-related subfamily, member 4 ISO mRNA:decreased expression:subiculum, perirhinal cortex, entorhinal cortex (rat) RGD PMID:17942314 PMID:20971086 RGD:9686050, RGD:10411905 NCBI chr 3:107,345,614...107,367,617
Ensembl chr 3:107,345,619...107,366,868 		JBrowse link
G Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 ISO mRNA:increased expression:hippocampus RGD PMID:22050960 RGD:5686281 NCBI chr 7:45,746,545...45,750,215
Ensembl chr 7:45,743,377...45,750,188 		JBrowse link
G Kcnk3 potassium channel, subfamily K, member 3 ISO protein:decreased expression:hippocampus, astrocyte RGD PMID:18671295 RGD:2316522 NCBI chr 5:30,745,514...30,782,614
Ensembl chr 5:30,745,514...30,782,615 		JBrowse link
G Kcnk5 potassium channel, subfamily K, member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19220408 NCBI chr14:20,190,125...20,231,850
Ensembl chr14:20,190,125...20,231,877 		JBrowse link
G Kcnma1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18695509 NCBI chr14:23,342,356...24,055,173
Ensembl chr14:23,339,499...24,064,559 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19272430 NCBI chr  X:37,488,524...37,545,337
Ensembl chr  X:37,490,234...37,545,331 		JBrowse link
G Mef2c myocyte enhancer factor 2C ISO mRNA:increased expression:dentate gyrus
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:18949272 PMID:18949272 RGD:5131610 NCBI chr13:83,652,136...83,815,197
Ensembl chr13:83,652,153...83,815,199 		JBrowse link
G Mfn1 mitofusin 1 ISO mRNA:decreased expression:hippocampus (rat) RGD PMID:27045873 RGD:12436727 NCBI chr 3:32,583,594...32,633,384
Ensembl chr 3:32,583,614...32,633,388 		JBrowse link
G Mir21a microRNA 21a ameliorates ISO RNA:increased expression: hippocampus RGD PMID:22019057 PMID:29751355 RGD:41404707, RGD:41404714 NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO mRNA:increased expression:hippocampus, astrocyte, dendrite RGD PMID:17928157 RGD:8547922 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO protein:increased serine phosphorylation:hippocampus RGD PMID:23211629 PMID:23724051 RGD:7175521, RGD:10041026 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Ngf nerve growth factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:8635431 PMID:8821376 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Nlgn1 neuroligin 1 ISO RGD PMID:22539981 RGD:9831126 NCBI chr 3:25,475,972...26,387,504
Ensembl chr 3:25,480,379...26,386,609 		JBrowse link
G Nlgn2 neuroligin 2 ISO RGD PMID:22539981 RGD:9831126 NCBI chr11:69,713,949...69,728,610
Ensembl chr11:69,713,948...69,728,610 		JBrowse link
G Nos1 nitric oxide synthase 1, neuronal ISO CTD Direct Evidence: marker/mechanism CTD PMID:20149694 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible ISO CTD Direct Evidence: marker/mechanism CTD PMID:20149694 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Npy neuropeptide Y ISO RGD PMID:19270346 RGD:10448969 NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 treatment ISO RGD PMID:28386312 RGD:13439740 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 ISO mRNA:decreased expression:hippocampus RGD PMID:22050960 RGD:5686281 NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474 		JBrowse link
G Nt5e 5' nucleotidase, ecto ISO protein:increased activity:cerebral cortex, synaptosome (rat) RGD PMID:16274951 RGD:5134344 NCBI chr 9:88,209,662...88,254,142
Ensembl chr 9:88,209,250...88,254,145 		JBrowse link
G Ntf3 neurotrophin 3 ISO CTD Direct Evidence: marker/mechanism
RNA:decreased expression: hippocampus		 CTD
RGD		 PMID:8635431 PMID:22019057 RGD:41404707 NCBI chr 6:126,078,375...126,143,703
Ensembl chr 6:126,078,375...126,143,873 		JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8635431 PMID:8821376 NCBI chr13:58,954,363...59,281,782
Ensembl chr13:58,954,383...59,281,784 		JBrowse link
G Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8635431 NCBI chr 7:77,825,711...78,228,865
Ensembl chr 7:77,825,707...78,387,760 		JBrowse link
G Ogg1 8-oxoguanine DNA-glycosylase 1 ISO RGD PMID:18295498 RGD:2317139 NCBI chr 6:113,303,959...113,311,149
Ensembl chr 6:113,303,933...113,312,029 		JBrowse link
G Olig2 oligodendrocyte transcription factor 2 ISO mRNA, protein:decreased expression:white matter of cerebral lobe RGD PMID:31415741 RGD:40902837 NCBI chr16:91,016,745...91,025,567
Ensembl chr16:91,022,345...91,025,565 		JBrowse link
G Osbpl2 oxysterol binding protein-like 2 treatment ISO RGD PMID:33132826 RGD:41404657 NCBI chr 2:179,758,059...179,804,475
Ensembl chr 2:179,761,099...179,804,473 		JBrowse link
G Pcp4 Purkinje cell protein 4 ISO mRNA,protein:increased expression:brain: RGD PMID:20505763 RGD:9850150 NCBI chr16:96,268,806...96,326,993
Ensembl chr16:96,268,806...96,326,993 		JBrowse link
G Pgf placental growth factor ISO protein:increased expression:cerebral cortex, hippocampus RGD PMID:22079325 RGD:6483774 NCBI chr12:85,213,413...85,224,087
Ensembl chr12:85,213,409...85,224,564 		JBrowse link
G Plat plasminogen activator, tissue ISO RGD PMID:17040480 RGD:6484215 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860 		JBrowse link
G Plau plasminogen activator, urokinase IMP
ISO		 mRNA, protein:increased expression:hippocampus (rat) RGD PMID:20026272 PMID:17040480 PMID:19527776 RGD:6483805, RGD:6484215, RGD:6483810 NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453 		JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO mRNA:increased expression:hippocampus RGD PMID:19527776 RGD:6483810 NCBI chr 7:24,161,857...24,175,393
Ensembl chr 7:24,161,909...24,175,393 		JBrowse link
G Pnpo pyridoxine 5'-phosphate oxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19356691 NCBI chr11:96,828,642...96,834,845
Ensembl chr11:96,828,651...96,834,812 		JBrowse link
G Polg polymerase (DNA directed), gamma ISO RGD PMID:18295498 RGD:2317139 NCBI chr 7:79,095,979...79,117,659
Ensembl chr 7:79,095,979...79,116,110 		JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory inhibitor subunit 1B ISO protein:increased phosphorylation:brain RGD PMID:25219249 RGD:13515071 NCBI chr11:98,239,232...98,248,622
Ensembl chr11:98,239,230...98,248,622 		JBrowse link
G Prkcb protein kinase C, beta ISO protein:increased expression:hippocampus RGD PMID:15058486 RGD:1625525 NCBI chr 7:121,888,327...122,233,625
Ensembl chr 7:121,887,974...122,233,625 		JBrowse link
G Prox1 prospero homeobox 1 ISO protein:increased expression:dentate gyrus hilus RGD PMID:17042797 RGD:5133273 NCBI chr 1:189,850,232...189,903,024
Ensembl chr 1:189,850,232...189,902,911 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:18988310 PMID:20643531 RGD:5135057 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Ptk2b PTK2 protein tyrosine kinase 2 beta ISO protein:increased phosphorylation:hippocampus, postsynaptic density
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:16600505 PMID:16600505 RGD:1581409 NCBI chr14:66,390,706...66,518,549
Ensembl chr14:66,390,706...66,518,501 		JBrowse link
G Ptprz1 protein tyrosine phosphatase receptor type Z, polypeptide 1 ISO RGD PMID:10582521 RGD:9589822 NCBI chr 6:22,875,302...23,052,915
Ensembl chr 6:22,875,501...23,052,915 		JBrowse link
G Qdpr quinoid dihydropteridine reductase ISO protein:increased expression:hippocampus (rat) RGD PMID:17366478 RGD:5128581 NCBI chr 5:45,591,374...45,607,571
Ensembl chr 5:45,591,363...45,607,578 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) ISO protein:increased expression:nucleus, hippocampus RGD PMID:17727632 RGD:2298852 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Reln reelin ISO protein:decreased expression:dentate gyrus (rat) RGD PMID:17314278 RGD:2317783 NCBI chr 5:22,089,452...22,549,703
Ensembl chr 5:22,089,452...22,549,700 		JBrowse link
G Ret ret proto-oncogene ISO CTD Direct Evidence: marker/mechanism CTD PMID:12914250 NCBI chr 6:118,128,709...118,174,705
Ensembl chr 6:118,128,706...118,174,679 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 ISO RGD PMID:19126440 RGD:13524534 NCBI chr 1:169,569,046...169,575,211
Ensembl chr 1:169,569,046...169,575,211 		JBrowse link
G Scn8a sodium channel, voltage-gated, type VIII, alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:19306853 NCBI chr15:100,766,600...100,943,819
Ensembl chr15:100,767,739...100,943,819 		JBrowse link
G Slc12a5 solute carrier family 12, member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20600929 NCBI chr 2:164,802,766...164,841,651
Ensembl chr 2:164,802,722...164,841,651 		JBrowse link
G Slc18a3 solute carrier family 18 (vesicular monoamine), member 3 IMP RGD PMID:18394802 RGD:5686685 NCBI chr14:32,184,394...32,186,807
Ensembl chr14:32,184,395...32,186,807 		JBrowse link
G Slc6a8 solute carrier family 6 (neurotransmitter transporter, creatine), member 8 ISO RGD PMID:20979657 RGD:11565113 NCBI chr  X:72,716,739...72,726,108
Ensembl chr  X:72,716,756...72,726,108 		JBrowse link
G Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 ISO protein:decreased expression:brain
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:20888801 PMID:15461673 RGD:2316980 NCBI chr17:81,680,534...82,045,816
Ensembl chr17:81,680,534...82,045,806 		JBrowse link
G Slc8a2 solute carrier family 8 (sodium/calcium exchanger), member 2 ISO RGD PMID:15461673 RGD:2316980 NCBI chr 7:15,861,540...15,894,988
Ensembl chr 7:15,863,751...15,894,988 		JBrowse link
G Slc8a3 solute carrier family 8 (sodium/calcium exchanger), member 3 ISO protein:decreased expression:brain
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:20888801 PMID:15461673 RGD:2316980 NCBI chr12:81,244,686...81,380,506
Ensembl chr12:81,244,689...81,379,954 		JBrowse link
G Snta1 syntrophin, acidic 1 ISO protein:decreased expression:piriform cortex
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:20886625 PMID:20886625 RGD:5148023 NCBI chr 2:154,218,234...154,250,004
Ensembl chr 2:154,218,233...154,250,019 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 ISO mRNA:increased expression:hippocampus RGD PMID:14614901 RGD:1625688 NCBI chr11:117,856,905...117,860,192
Ensembl chr11:117,856,905...117,860,873 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial ISO mRNA, protein:increased expression:hippocampus RGD PMID:25333348 RGD:11035304 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Src Rous sarcoma oncogene ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16600505 PMID:16600505 RGD:1581409 NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782 		JBrowse link
G Sstr1 somatostatin receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18951627 NCBI chr12:58,258,524...58,262,822
Ensembl chr12:58,258,558...58,260,673 		JBrowse link
G Sstr2 somatostatin receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18951627 NCBI chr11:113,510,153...113,516,854
Ensembl chr11:113,510,168...113,516,854 		JBrowse link
G Sstr3 somatostatin receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18951627 NCBI chr15:78,421,214...78,433,565
Ensembl chr15:78,421,208...78,428,885 		JBrowse link
G Sstr4 somatostatin receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:18951627 PMID:18951627 RGD:2324996 NCBI chr 2:148,237,297...148,238,684
Ensembl chr 2:148,237,264...148,238,687 		JBrowse link
G Sstr5 somatostatin receptor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18951627 NCBI chr17:25,708,849...25,716,262
Ensembl chr17:25,708,847...25,733,577 		JBrowse link
G Tfam transcription factor A, mitochondrial ISO RGD PMID:21854834 RGD:6767574 NCBI chr10:71,061,298...71,074,157
Ensembl chr10:71,061,294...71,074,110 		JBrowse link
G Tnf tumor necrosis factor ISO protein:increased expression:brain
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:18455351 PMID:20649973 RGD:4143383 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism CTD PMID:17533168 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Xrn2 5'-3' exoribonuclease 2 ISO mRNA:increased expression:hippocampus (rat) RGD PMID:26869208 RGD:11041797 NCBI chr 2:146,854,672...146,919,922
Ensembl chr 2:146,854,916...146,919,920 		JBrowse link
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  disease 16106
    disease of anatomical entity 15662
      nervous system disease 13530
        central nervous system disease 12116
          brain disease 11376
            epilepsy 2816
              status epilepticus 158
                Epilepsia Partialis Continua 0
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