Ccr2 (chemokine (C-C motif) receptor 2) - Rat Genome Database

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Gene: Ccr2 (chemokine (C-C motif) receptor 2) Mus musculus
Symbol: Ccr2
Name: chemokine (C-C motif) receptor 2
RGD ID: 1552061
Description: Enables C-C chemokine binding activity and C-C chemokine receptor activity. Involved in several processes, including positive regulation of cell migration; regulation of cytokine production; and regulation of leukocyte activation. Acts upstream of or within several processes, including cellular defense response; monocyte chemotaxis; and regulation of leukocyte migration. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Coronavirus infectious disease and age related macular degeneration. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; aggressive periodontitis; coronary artery disease (multiple); glucose metabolism disease (multiple); and uveitis (multiple). Orthologous to human CCR2 (C-C motif chemokine receptor 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-C chemokine receptor type 2; C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC RECEPTOR) (MCP-1 RECEPTOR); C-C CKR-2; CC-CKR-; Cc-ckr-2; CCR; CCR-2; Ccr2a; Ccr2b; chemoattractant protein-1 receptor; chemokine (C-C) receptor 2; CKR; Ckr2; Ckr2a; Ckr2b; Cmkbr; Cmkbr2; JE/FIC receptor; MCP-1 receptor; MIP-1 alphaR; mJe-r
RGD Orthologs
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm399123,901,954 - 123,913,594 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9123,901,987 - 123,913,594 (+)EnsemblGRCm39 Ensembl
GRCm389124,101,918 - 124,109,140 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9124,101,950 - 124,113,557 (+)EnsemblGRCm38mm10GRCm38
MGSCv379124,016,922 - 124,023,879 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369123,950,982 - 123,957,349 (+)NCBIMGSCv36mm8
Celera9124,890,502 - 124,897,441 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map975.05NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
age related macular degeneration  (IAGP)
aggressive periodontitis  (ISO)
Alcoholic Fatty Liver  (IEP)
allergic bronchopulmonary aspergillosis  (IMP)
allergic contact dermatitis  (IMP,ISO)
allergic disease  (ISO)
Alveolar Bone Loss  (IMP)
amyotrophic lateral sclerosis  (ISO)
Animal Toxoplasmosis  (IMP)
anxiety disorder  (IMP)
asthma  (IEP,ISO)
atopic dermatitis  (ISO)
bacterial pneumonia  (IMP)
Brain Hypoxia-Ischemia  (ISO)
Bronchial Hyperreactivity  (IMP)
bronchiolitis obliterans  (IEP)
Chemical and Drug Induced Liver Injury  (ISO)
Choroidal Neovascularization  (IMP)
Chronic Periodontitis  (ISO)
congestive heart failure  (ISO)
corneal neovascularization  (IMP)
coronary artery disease  (ISO)
Coronavirus infectious disease  (IAGP)
cutaneous leishmaniasis  (IEP)
demyelinating disease  (ISO)
dermatomyositis  (ISO)
Diabetic Nephropathies  (IMP,ISO)
dry eye syndrome  (IMP)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Uveitis  (IMP)
Experimental Autoimmune Uveoretinitis  (IEP)
fungal infectious disease  (ISO)
Geographic Atrophy  (ISO)
Hearing Loss, Noise-Induced  (IMP)
Herpes Simplex Encephalitis  (IMP)
Herpesviridae Infections  (IMP)
human immunodeficiency virus infectious disease  (ISO)
Hyperalgesia  (IMP,ISO)
ileitis  (IMP)
inclusion body myositis  (ISO)
intermediate uveitis  (ISO)
interstitial lung disease  (ISO)
Intervertebral Disc Disease  (ISO)
Intimal Hyperplasia  (IMP)
Kawasaki disease  (ISO)
Knee Osteoarthritis  (IMP)
Kuhnt-Junius degeneration  (ISO)
leishmaniasis  (IMP)
limited scleroderma  (IEP)
lipoatrophic diabetes mellitus  (IEP,IMP)
liver disease  (ISO)
Liver Reperfusion Injury  (IMP)
lung disease  (IMP,ISO)
macular degeneration  (ISO)
Mouth Neoplasms  (ISO)
myeloid sarcoma  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
non-alcoholic fatty liver disease  (ISO)
oral squamous cell carcinoma  (ISO)
Pain  (IEP,ISO)
Perennial Allergic Rhinitis  (ISO)
Peri-Implantitis  (ISO)
Periapical Diseases  (IMP)
periapical granuloma  (ISO)
periapical periodontitis  (ISO)
Periodontal Cyst  (ISO)
pleural tuberculosis  (ISO)
pneumonia  (IDA,IMP,ISO)
polymyositis  (ISO)
posterior uveitis  (ISO)
prediabetes syndrome  (ISO)
psoriasis  (ISO)
psoriatic arthritis  (ISO)
pulmonary fibrosis  (IMP,ISO)
pulmonary tuberculosis  (IMP)
retinal degeneration  (IMP)
retinitis  (IMP)
rhinitis  (ISO)
sarcoidosis  (ISO)
sciatic neuropathy  (IEP)
sialadenitis  (IDA)
Spinal Cord Injuries  (ISO)
status epilepticus  (ISO)
systemic scleroderma  (IMP)
Thoracic Injuries  (ISO)
Transplant Rejection  (IMP)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urticaria  (ISO)
vasculitis  (IMP)
visceral leishmaniasis  (IEP,IMP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-pilocarpine  (EXP,ISO)
(R)-mevalonic acid  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dinitrobenzenesulfonic acid  (EXP)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-butoxyethanol  (EXP)
3-chlorophenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
9-cis-retinoic acid  (ISO)
acetaldehyde  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
ammonium hexachloroplatinate  (ISO)
amphetamine  (ISO)
amphotericin B  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
asbestos  (ISO)
asperentin  (EXP)
barium sulfate  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
benzylpenicillin  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
buta-1,3-diene  (EXP)
carbon nanotube  (EXP)
celecoxib  (EXP)
ceric oxide  (ISO)
chenodeoxycholic acid  (ISO)
chloroprene  (EXP)
choline  (EXP)
cis-caffeic acid  (EXP)
cisplatin  (ISO)
cocaine  (EXP,ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP)
cyclosporin A  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (EXP)
dextran sulfate  (EXP)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
Didecyldimethylammonium  (EXP)
diethylstilbestrol  (EXP)
disulfiram  (ISO)
doxorubicin  (ISO)
erythromycin A  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
flumequine  (EXP)
folic acid  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
isoniazide  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP,ISO)
linuron  (EXP)
lipopolysaccharide  (ISO)
losartan  (ISO)
LY294002  (ISO)
mechlorethamine  (ISO)
MeIQx  (EXP)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
metformin  (EXP)
methamphetamine  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
mycophenolic acid  (EXP)
mycotoxin  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
nefazodone  (ISO)
neoechinulin A  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
olaparib  (EXP)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paricalcitol  (EXP)
PCB138  (ISO)
pentachlorophenol  (ISO)
perindopril  (EXP)
picrotoxin  (ISO)
piperidines  (ISO)
proanthocyanidin  (ISO)
protein kinase inhibitor  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
serpentine asbestos  (EXP)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP)
sodium chlorate  (ISO)
sodium fluoride  (ISO)
sterigmatocystin  (EXP)
streptozocin  (EXP)
sulforaphane  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (EXP)
telmisartan  (ISO)
tetrachloromethane  (EXP)
thiram  (ISO)
titanium dioxide  (EXP)
toluene 2,4-diisocyanate  (EXP)
topotecan  (ISO)
trans-caffeic acid  (EXP)
trichostatin A  (ISO)
tungsten  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)
zinc sulfate  (ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (TAS)
apoptotic cell clearance  (IC)
blood vessel remodeling  (IEA,ISO)
cellular defense response  (IMP)
cellular homeostasis  (IDA)
chemokine-mediated signaling pathway  (ISO)
chemotaxis  (IEA)
cytokine-mediated signaling pathway  (ISA,ISO)
G protein-coupled receptor signaling pathway  (ISO)
hemopoiesis  (IMP)
homeostasis of number of cells within a tissue  (IMP)
humoral immune response  (IMP)
immune response  (IBA,IMP)
inflammatory response  (IBA,IMP,ISO)
inflammatory response to antigenic stimulus  (ISO)
inflammatory response to wounding  (IMP)
intracellular calcium ion homeostasis  (ISO)
leukocyte adhesion to vascular endothelial cell  (IMP)
macrophage migration  (IMP)
monocyte chemotaxis  (IMP)
monocyte extravasation  (IMP)
negative regulation of angiogenesis  (IMP)
negative regulation of eosinophil degranulation  (IMP)
negative regulation of type 2 immune response  (IMP)
neutrophil clearance  (IMP)
positive regulation of alpha-beta T cell proliferation  (IMP)
positive regulation of astrocyte chemotaxis  (ISO)
positive regulation of CD8-positive, alpha-beta T cell extravasation  (IMP)
positive regulation of cold-induced thermogenesis  (IMP)
positive regulation of hematopoietic stem cell migration  (IMP)
positive regulation of immune complex clearance by monocytes and macrophages  (IMP)
positive regulation of inflammatory response  (IDA)
positive regulation of interleukin-2 production  (IMP)
positive regulation of leukocyte tethering or rolling  (IMP)
positive regulation of monocyte chemotaxis  (IMP,ISO)
positive regulation of monocyte extravasation  (IMP)
positive regulation of NMDA glutamate receptor activity  (ISO)
positive regulation of p38MAPK cascade  (ISO)
positive regulation of synaptic transmission, glutamatergic  (IMP)
positive regulation of T cell activation  (IMP)
positive regulation of T cell chemotaxis  (IDA)
positive regulation of T-helper 1 cell differentiation  (IC)
positive regulation of T-helper 1 type immune response  (IMP)
positive regulation of thymocyte migration  (IMP)
positive regulation of tumor necrosis factor production  (IMP,ISO)
positive regulation of type II interferon production  (IMP)
regulation of inflammatory response  (IMP)
regulation of macrophage migration  (IMP)
regulation of mononuclear cell migration  (IMP)
regulation of T cell cytokine production  (IMP)
regulation of T cell differentiation  (IMP)
regulation of T cell migration  (IMP)
regulation of vascular endothelial growth factor production  (IMP)
response to hyperoxia  (ISO)
response to hypoxia  (ISO)
sensory perception of pain  (IMP)
signal transduction  (IEA)
T-helper 17 cell chemotaxis  (IDA)
wound healing involved in inflammatory response  (NAS)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bone mineral density  (IAGP)
abnormal bone trabecula morphology  (IAGP)
abnormal Bruch membrane morphology  (IAGP)
abnormal cellular extravasation  (IAGP)
abnormal chemokine secretion  (IAGP)
abnormal cholesterol homeostasis  (IAGP)
abnormal choriocapillaris morphology  (IAGP)
abnormal conditioned taste aversion behavior  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal dendritic cell chemotaxis  (IAGP)
abnormal gait  (IEA)
abnormal glucose homeostasis  (IAGP)
abnormal immune serum protein physiology  (IAGP)
abnormal immune system organ morphology  (IAGP)
abnormal interferon level  (IAGP)
abnormal Langerhans cell physiology  (IAGP)
abnormal leukocyte adhesion  (IAGP)
abnormal leukocyte migration  (IAGP)
abnormal leukocyte physiology  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal lymphocyte cell number  (IAGP)
abnormal macrophage chemotaxis  (IAGP)
abnormal macrophage morphology  (IAGP)
abnormal microglial cell physiology  (IAGP)
abnormal monocyte morphology  (IAGP)
abnormal optic choroid morphology  (IAGP)
abnormal osteoclast cell number  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal osteoclast physiology  (IAGP)
abnormal podocyte morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal response to cardiac infarction  (IAGP)
abnormal retina pigment epithelium morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal tumor necrosis factor level  (IAGP)
abnormal urine protein level  (IAGP)
abnormal vascular wound healing  (IAGP)
abnormal wound healing  (IAGP)
albuminuria  (IAGP)
alcohol aversion  (IAGP)
alcohol preference  (IAGP)
amyloid beta deposits  (IAGP)
amyloidosis  (IAGP)
bronchiolitis  (IAGP)
choroidal neovascularization  (IAGP)
decreased acute inflammation  (IAGP)
decreased airway responsiveness  (IAGP)
decreased alcohol consumption  (IAGP)
decreased CD11b-high dendritic cell number  (IAGP)
decreased CD4-positive, alpha beta T cell number  (IAGP)
decreased circulating adiponectin level  (IAGP)
decreased circulating alanine transaminase level  (IAGP)
decreased circulating creatinine level  (IAGP)
decreased common myeloid progenitor cell number  (IAGP)
decreased inflammatory response  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-2 secretion  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased lymphocyte cell number  (IEA)
decreased macrophage cell number  (IAGP)
decreased monocyte cell number  (IAGP)
decreased neutrophil cell number  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased splenocyte proliferation  (IAGP)
decreased susceptibility to atherosclerosis  (IAGP)
decreased susceptibility to bone fracture  (IAGP)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
decreased susceptibility to induced colitis  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased susceptibility to kidney reperfusion injury  (IAGP)
decreased susceptibility to type I hypersensitivity reaction  (IAGP)
decreased T cell proliferation  (IAGP)
decreased tumor growth/size  (IAGP)
diarrhea  (IAGP)
enlarged heart  (IEA)
enlarged liver  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
expanded mesangial matrix  (IAGP)
glomerulonephritis  (IAGP)
glomerulosclerosis  (IAGP)
hepatic necrosis  (IAGP)
impaired leukocyte tethering or rolling  (IAGP)
impaired macrophage chemotaxis  (IAGP)
increased alcohol consumption  (IAGP)
increased B cell number  (IAGP)
increased CD11b-high dendritic cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating leptin level  (IAGP)
increased dendritic cell number  (IAGP)
increased eosinophil cell number  (IAGP)
increased fluid intake  (IAGP)
increased hepatocyte apoptosis  (IAGP)
increased IgG level  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to Coronaviridae infection  (IAGP)
increased susceptibility to Coronaviridae infection induced morbidity/mortality  (IAGP)
increased susceptibility to induced colitis  (IAGP)
increased trabecular bone thickness  (IAGP)
increased trabecular bone volume  (IAGP)
increased tumor necrosis factor secretion  (IAGP)
intracranial hemorrhage  (IAGP)
kidney inflammation  (IAGP)
lipofuscinosis  (IAGP)
liver hemorrhage  (IAGP)
liver inflammation  (IAGP)
multifocal hepatic necrosis  (IAGP)
premature death  (IAGP)
renal tubule atrophy  (IAGP)
retina degeneration  (IAGP)
retina deposits  (IAGP)
retina outer nuclear layer degeneration  (IAGP)
retina photoreceptor degeneration  (IAGP)
weight loss  (IAGP)

References - curated
# Reference Title Reference Citation
1. Polymorphisms of chemokine and chemokine receptor genes in idiopathic immune-mediated posterior segment uveitis. Ahad MA, etal., Mol Vis. 2007 Mar 23;13:388-96.
2. Inhibition of corneal neovascularization by genetic ablation of CCR2. Ambati BK, etal., Cornea. 2003 Jul;22(5):465-7.
3. Immunohistochemical detection of CCR2 and CX3CR1 in sepsis-induced lung injury. An JL, etal., Forensic Sci Int. 2009 Nov 20;192(1-3):e21-5. Epub 2009 Sep 4.
4. Chemokine receptors CCR2 and CX3CR1 regulate skin fibrosis in the mouse model of cytokine-induced systemic sclerosis. Arai M, etal., J Dermatol Sci. 2013 Mar;69(3):250-8. doi: 10.1016/j.jdermsci.2012.10.010. Epub 2012 Oct 24.
5. Increased presence of dendritic cells and dendritic cell chemokines in the sinus mucosa of chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis. Ayers CM, etal., Int Forum Allergy Rhinol. 2011 Jul-Aug;1(4):296-302. doi: 10.1002/alr.20046. Epub 2011 Apr 11.
6. Therapeutic effect of a topical CCR2 antagonist on induced alveolar bone loss in mice. Barros SP, etal., J Periodontal Res. 2011 Apr;46(2):246-51. doi: 10.1111/j.1600-0765.2010.01340.x. Epub 2011 Jan 18.
7. MCP-1 and CCR2 gene variants in oral squamous cell carcinoma. Bektas-Kayhan K, etal., Oral Dis. 2012 Jan;18(1):55-9. doi: 10.1111/j.1601-0825.2011.01843.x. Epub 2011 Aug 24.
8. Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome. Belperio JA, etal., J Clin Invest. 2001 Aug;108(4):547-56.
9. Delayed functional expression of neuronal chemokine receptors following focal nerve demyelination in the rat: a mechanism for the development of chronic sensitization of peripheral nociceptors. Bhangoo S, etal., Mol Pain. 2007 Dec 12;3:38.
10. Enhanced pulmonary allergic responses to Aspergillus in CCR2-/- mice. Blease K, etal., J Immunol. 2000 Sep 1;165(5):2603-11.
11. Impact of deficiency in CCR2 and CX3CR1 receptors on monocytes trafficking in herpes simplex virus encephalitis. Boivin N, etal., J Gen Virol. 2012 Jun;93(Pt 6):1294-304. doi: 10.1099/vir.0.041046-0. Epub 2012 Feb 29.
12. Polymorphisms in chemokine receptor genes and susceptibility to Kawasaki disease. Breunis WB, etal., Clin Exp Immunol. 2007 Oct;150(1):83-90. Epub 2007 Aug 2.
13. Possible contribution of chemokine receptor CCR2 and CCR5 polymorphisms in the pathogenesis of chronic spontaneous autoreactive urticaria. Brzoza Z, etal., Allergol Immunopathol (Madr). 2013 May 30. pii: S0301-0546(13)00103-1. doi: 10.1016/j.aller.2013.02.003.
14. Monocyte chemoattractant protein-1 mediates cockroach allergen-induced bronchial hyperreactivity in normal but not CCR2-/- mice: the role of mast cells. Campbell EM, etal., J Immunol. 1999 Aug 15;163(4):2160-7.
15. CCR2-64I gene polymorphism increase susceptibility to oral cancer. Chen MK, etal., Oral Oncol. 2011 Jul;47(7):577-82. doi: 10.1016/j.oraloncology.2011.04.008. Epub 2011 May 12.
16. Spontaneous Development of Autoimmune Uveitis Is CCR2 Dependent. Chen YF, etal., Am J Pathol. 2014 Jun;184(6):1695-705. doi: 10.1016/j.ajpath.2014.02.024. Epub 2014 Apr 13.
17. Inflammation drives dysbiosis and bacterial invasion in murine models of ileal Crohn's disease. Craven M, etal., PLoS One. 2012;7(7):e41594. doi: 10.1371/journal.pone.0041594. Epub 2012 Jul 25.
18. Development of experimental autoimmune uveitis: efficient recruitment of monocytes is independent of CCR2. Dagkalis A, etal., Invest Ophthalmol Vis Sci. 2009 Sep;50(9):4288-94. doi: 10.1167/iovs.09-3434. Epub 2009 Apr 8.
19. Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist-treated rats. Dansereau MA, etal., J Neurochem. 2008 Jul;106(2):757-69. Epub 2008 Apr 17.
20. Beta-chemokine receptor expression in idiopathic inflammatory myopathies. De Paepe B and De Bleecker JL, Muscle Nerve. 2005 May;31(5):621-7.
21. Comprehensive analysis of the candidate genes CCL2, CCR2, and TLR4 in age-related macular degeneration. Despriet DD, etal., Invest Ophthalmol Vis Sci. 2008 Jan;49(1):364-71. doi: 10.1167/iovs.07-0656.
22. MCP-1, CCR2 and CCR5 polymorphisms in Tunisian patients with atopic asthma. Dhaouadi T, etal., Iran J Allergy Asthma Immunol. 2013 Mar;12(1):29-36. doi: 012.01/ijaai.2936.
23. CCR2-dependent intraepithelial lymphocytes mediate inflammatory gut pathology during Toxoplasma gondii infection. Egan CE, etal., Mucosal Immunol. 2009 Nov;2(6):527-35. doi: 10.1038/mi.2009.105. Epub 2009 Sep 9.
24. Chemokine/chemokine receptor interactions in extramedullary leukaemia of the skin in childhood AML: differential roles for CCR2, CCR5, CXCR4 and CXCR7. Faaij CM, etal., Pediatr Blood Cancer. 2010 Aug;55(2):344-8. doi: 10.1002/pbc.22500.
25. [Expression of chemokine receptor CCR2 in cerebral tissue of newborn rat with experimental hypoxic-ischemic brain damage] Feng X and Yao YJ, Sichuan Da Xue Xue Bao Yi Xue Ban. 2007 Nov;38(6):942-4, 964.
26. Lack of association of CCR2-64I and CCR5-Delta 32 with type 1 diabetes and latent autoimmune diabetes in adults. Gambelunghe G, etal., Hum Immunol. 2003 Jun;64(6):629-32.
27. CCR2 deficiency results in increased osteolysis in experimental periapical lesions in mice. Garlet TP, etal., J Endod. 2010 Feb;36(2):244-50. doi: 10.1016/j.joen.2009.09.004. Epub 2009 Oct 23.
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PMID:27600773   PMID:27601660   PMID:27621476   PMID:27653687   PMID:27653688   PMID:27655900   PMID:27680685   PMID:27697834   PMID:27716507   PMID:27728804   PMID:27733491   PMID:27760760  
PMID:27777976   PMID:27798193   PMID:27799620   PMID:27820834   PMID:27829467   PMID:27831552   PMID:27868108   PMID:27872905   PMID:27881779   PMID:27888192   PMID:27907215   PMID:27914709  
PMID:27930721   PMID:27932444   PMID:27932459   PMID:27933701   PMID:27956622   PMID:27974221   PMID:27982014   PMID:27995603   PMID:28002729   PMID:28011675   PMID:28087538   PMID:28092668  
PMID:28120849   PMID:28125278   PMID:28148720   PMID:28168553   PMID:28202513   PMID:28235764   PMID:28257233   PMID:28290520   PMID:28329706   PMID:28383062   PMID:28383204   PMID:28384349  
PMID:28409543   PMID:28419151   PMID:28450294   PMID:28506464   PMID:28507030   PMID:28508873   PMID:28516946   PMID:28550204   PMID:28580944   PMID:28627412   PMID:28636955   PMID:28650342  
PMID:28650582   PMID:28663258   PMID:28683286   PMID:28691930   PMID:28694451   PMID:28698550   PMID:28716963   PMID:28729715   PMID:28736159   PMID:28758900   PMID:28763796   PMID:28778590  
PMID:28799208   PMID:28801233   PMID:28803730   PMID:28813661   PMID:28813662   PMID:28814744   PMID:28834747   PMID:28836302   PMID:28836308   PMID:28836736   PMID:28851810   PMID:28900008  
PMID:28912156   PMID:28935758   PMID:28951461   PMID:28963396   PMID:28978634   PMID:28983053   PMID:28990934   PMID:29016864   PMID:29045904   PMID:29052263   PMID:29084208   PMID:29106985  
PMID:29150241   PMID:29155051   PMID:29166591   PMID:29170400   PMID:29175959   PMID:29184215   PMID:29202448   PMID:29246952   PMID:29251628   PMID:29263104   PMID:29299998   PMID:29320561  
PMID:29339450   PMID:29339724   PMID:29363580   PMID:29378914   PMID:29420066   PMID:29422500   PMID:29446073   PMID:29463561   PMID:29469612   PMID:29474906   PMID:29540615   PMID:29563178  
PMID:29572892   PMID:29593265   PMID:29615957   PMID:29630857   PMID:29632086   PMID:29632244   PMID:29662169   PMID:29676784   PMID:29688375   PMID:29705291   PMID:29720578   PMID:29739958  
PMID:29750189   PMID:29771686   PMID:29798841   PMID:29861285   PMID:29872758   PMID:29879295   PMID:29903736   PMID:29930553   PMID:29946039   PMID:29993042   PMID:30026864   PMID:30097537  
PMID:30115997   PMID:30127427   PMID:30146391   PMID:30147688   PMID:30173915   PMID:30181265   PMID:30184491   PMID:30202015   PMID:30213824   PMID:30265749   PMID:30269986   PMID:30322871  
PMID:30323343   PMID:30382157   PMID:30392829   PMID:30413362   PMID:30433869   PMID:30442669   PMID:30470612   PMID:30484118   PMID:30498200   PMID:30510003   PMID:30552233   PMID:30553275  
PMID:30560927   PMID:30581430   PMID:30582448   PMID:30588668   PMID:30595478   PMID:30598527   PMID:30679343   PMID:30681731   PMID:30687013   PMID:30696630   PMID:30700910   PMID:30715407  
PMID:30745458   PMID:30784579   PMID:30799265   PMID:30833511   PMID:30842418   PMID:30846482   PMID:30890724   PMID:30905786   PMID:30909963   PMID:30971441   PMID:30978353   PMID:30988524  
PMID:31138703   PMID:31150565   PMID:31169521   PMID:31182817   PMID:31182869   PMID:31189971   PMID:31201094   PMID:31231364   PMID:31235930   PMID:31252033   PMID:31263278   PMID:31266773  
PMID:31289116   PMID:31306468   PMID:31315031   PMID:31320454   PMID:31324779   PMID:31332247   PMID:31358982   PMID:31424112   PMID:31427395   PMID:31439648   PMID:31481690   PMID:31498850  
PMID:31561945   PMID:31578820   PMID:31586035   PMID:31599921   PMID:31619539   PMID:31676674   PMID:31714898   PMID:31727842   PMID:31732166   PMID:31800964   PMID:31801071   PMID:31813573  
PMID:31825829   PMID:31843499   PMID:31873073   PMID:31879345   PMID:31904407   PMID:31923400   PMID:31928435   PMID:31931959   PMID:31937758   PMID:31959883   PMID:31967645   PMID:32066949  
PMID:32101732   PMID:32103173   PMID:32103760   PMID:32117251   PMID:32130903   PMID:32130954   PMID:32151226   PMID:32165624   PMID:32176388   PMID:32188932   PMID:32213564   PMID:32253243  
PMID:32259484   PMID:32269105   PMID:32276965   PMID:32284594   PMID:32298657   PMID:32349774   PMID:32391790   PMID:32392463   PMID:32421904   PMID:32439942   PMID:32457369   PMID:32459864  
PMID:32460031   PMID:32485165   PMID:32516589   PMID:32562599   PMID:32572481   PMID:32615332   PMID:32639068   PMID:32644975   PMID:32667673   PMID:32696994   PMID:32744730   PMID:32747818  
PMID:32780724   PMID:32783928   PMID:32820177   PMID:32873797   PMID:32879367   PMID:32895539   PMID:32896623   PMID:32901029   PMID:32923636   PMID:32937134   PMID:32959911   PMID:33020472  
PMID:33029008   PMID:33036616   PMID:33052233   PMID:33077946   PMID:33082253   PMID:33098174   PMID:33108405   PMID:33113353   PMID:33117383   PMID:33127853   PMID:33159073   PMID:33160071  
PMID:33187533   PMID:33207209   PMID:33228784   PMID:33293358   PMID:33378665   PMID:33378682   PMID:33413615   PMID:33440159   PMID:33443065   PMID:33495636   PMID:33519816   PMID:33536334  
PMID:33543002   PMID:33555074   PMID:33556903   PMID:33567267   PMID:33593983   PMID:33620118   PMID:33627402   PMID:33664739   PMID:33760886   PMID:33789113   PMID:33813049   PMID:33827672  
PMID:33879579   PMID:33887203   PMID:33951416   PMID:33952647   PMID:33968067   PMID:33971183   PMID:34003466   PMID:34007995   PMID:34270930   PMID:34290699   PMID:34298846   PMID:34311579  
PMID:34320366   PMID:34371259   PMID:34385589   PMID:34413303   PMID:34423781   PMID:34484228   PMID:34489438   PMID:34512626   PMID:34533228   PMID:34551293   PMID:34551300   PMID:34556874  
PMID:34560074   PMID:34582748   PMID:34593796   PMID:34613772   PMID:34671097   PMID:34687652   PMID:34749524   PMID:34831339   PMID:34874920   PMID:34910930   PMID:34911964   PMID:34925336  
PMID:34965421   PMID:34995099   PMID:35013585   PMID:35021063   PMID:35021097   PMID:35069539   PMID:35121993   PMID:35182483   PMID:35239515   PMID:35245124   PMID:35296858   PMID:35476440  
PMID:35508166   PMID:35699420   PMID:35705045   PMID:35795142   PMID:35820932   PMID:35909564   PMID:36075514   PMID:36250393   PMID:36256464   PMID:36275765   PMID:36361722   PMID:36591261  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm399123,901,954 - 123,913,594 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9123,901,987 - 123,913,594 (+)EnsemblGRCm39 Ensembl
GRCm389124,101,918 - 124,109,140 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9124,101,950 - 124,113,557 (+)EnsemblGRCm38mm10GRCm38
MGSCv379124,016,922 - 124,023,879 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369123,950,982 - 123,957,349 (+)NCBIMGSCv36mm8
Celera9124,890,502 - 124,897,441 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map975.05NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38346,354,111 - 46,360,940 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl346,353,864 - 46,360,940 (+)EnsemblGRCh38hg38GRCh38
GRCh37346,395,602 - 46,402,431 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,370,364 - 46,377,432 (+)NCBINCBI36Build 36hg18NCBI36
Celera346,332,557 - 46,339,734 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef346,438,874 - 46,446,051 (+)NCBIHuRef
CHM1_1346,345,233 - 46,352,410 (+)NCBICHM1_1
T2T-CHM13v2.0346,369,948 - 46,376,777 (+)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.28123,734,465 - 123,742,483 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8123,734,430 - 123,742,100 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8129,328,887 - 129,330,008 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.08127,528,007 - 127,529,128 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.08125,345,931 - 125,347,052 (+)NCBIRnor_WKY
RGSC_v3.48128,892,784 - 128,893,905 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18128,912,520 - 128,913,642 (+)NCBI
Celera8122,833,545 - 122,834,666 (+)NCBICelera
Cytogenetic Map8q32NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0NW_00495542025,641,184 - 25,664,413 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.1347,361,118 - 47,368,312 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,361,124 - 47,368,312 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0346,255,725 - 46,263,285 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12042,305,344 - 42,313,258 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2042,307,580 - 42,308,698 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2042,220,658 - 42,229,191 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02042,787,203 - 42,795,751 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2042,787,205 - 42,793,246 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12042,028,417 - 42,036,962 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02042,429,835 - 42,438,385 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02042,710,738 - 42,719,282 (-)NCBIUU_Cfam_GSD_1.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1329,285,012 - 29,376,343 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,368,735 - 29,374,564 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,532,565 - 32,538,394 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1227,795,192 - 7,801,242 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl227,798,646 - 7,799,728 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041159,351,063 - 159,358,108 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1748
Count of miRNA genes:498
Interacting mature miRNAs:566
Transcripts:ENSMUST00000055918, ENSMUST00000165984, ENSMUST00000168841, ENSMUST00000171719
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12910770Splic1_mspleen iron content 1 (mouse)991291078124359700Mouse
12910772Lvic6_mliver iron content 6 (mouse)991291078124359700Mouse
12910773Splic3_mspleen iron content 3 (mouse)991291078124359700Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991518283124359700Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991518283124359700Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991518283124359700Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991518283124359700Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991518283124359700Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991518283124359700Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991560372124359700Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991560372124359700Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991560372124359700Mouse
1301484Bwq6_mbody weight (mouse)Not determined993591658124359700Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993591658124359700Mouse
14746992Manh67_mmandible shape 67 (mouse)993865836124359700Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996746658124359700Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9100889929124359700Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9101829255124359700Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9101829255124359700Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103118511124359700Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103118511124359700Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103118511124359700Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389124,106,712 - 124,106,794UniSTSGRCm38
MGSCv379124,021,451 - 124,021,533UniSTSGRCm37
Celera9124,892,848 - 124,892,930UniSTS
Cytogenetic Map9FUniSTS
cM Map971.9UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389124,105,966 - 124,106,045UniSTSGRCm38
GRCm389124,124,574 - 124,124,653UniSTSGRCm38
MGSCv379124,020,705 - 124,020,784UniSTSGRCm37
MGSCv379124,039,313 - 124,039,392UniSTSGRCm37
Celera9124,893,597 - 124,893,676UniSTS
Celera9124,875,063 - 124,875,142UniSTS
Cytogenetic Map9FUniSTS
cM Map971.9UniSTS
cM Map972.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389124,106,786 - 124,106,915UniSTSGRCm38
MGSCv379124,021,525 - 124,021,654UniSTSGRCm37
Celera9124,892,727 - 124,892,856UniSTS
Cytogenetic Map9FUniSTS
cM Map972.0UniSTS



Nucleotide Sequences
RefSeq Transcripts NM_009915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006512428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011243063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011243064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC168021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK039755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK046579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U47035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U51717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U56819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000055918   ⟹   ENSMUSP00000049909
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9123,902,220 - 123,908,587 (+)Ensembl
GRCm38.p6 Ensembl9124,102,183 - 124,108,550 (+)Ensembl
RefSeq Acc Id: ENSMUST00000165984   ⟹   ENSMUSP00000128734
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9123,905,663 - 123,909,177 (+)Ensembl
GRCm38.p6 Ensembl9124,105,626 - 124,109,140 (+)Ensembl
RefSeq Acc Id: ENSMUST00000168841   ⟹   ENSMUSP00000132453
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9123,902,195 - 123,909,544 (+)Ensembl
GRCm38.p6 Ensembl9124,102,158 - 124,109,507 (+)Ensembl
RefSeq Acc Id: ENSMUST00000171719   ⟹   ENSMUSP00000130112
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9123,901,987 - 123,913,594 (+)Ensembl
GRCm38.p6 Ensembl9124,101,950 - 124,113,557 (+)Ensembl
RefSeq Acc Id: NM_009915   ⟹   NP_034045
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm399123,902,220 - 123,909,177 (+)NCBI
GRCm389124,102,183 - 124,109,140 (+)NCBI
MGSCv379124,016,922 - 124,023,879 (+)RGD
Celera9124,890,502 - 124,897,441 (-)RGD
RefSeq Acc Id: XM_006512428   ⟹   XP_006512491
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm399123,903,933 - 123,909,177 (+)NCBI
GRCm389124,103,888 - 124,109,140 (+)NCBI
RefSeq Acc Id: XM_011243063   ⟹   XP_011241365
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm399123,901,954 - 123,909,177 (+)NCBI
GRCm389124,101,918 - 124,109,140 (+)NCBI
RefSeq Acc Id: XM_011243064   ⟹   XP_011241366
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm399123,903,370 - 123,909,177 (+)NCBI
GRCm389124,103,328 - 124,109,140 (+)NCBI
RefSeq Acc Id: XM_036154585   ⟹   XP_036010478
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm399123,901,955 - 123,909,177 (+)NCBI
RefSeq Acc Id: XM_036154586   ⟹   XP_036010479
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm399123,901,954 - 123,909,177 (+)NCBI
RefSeq Acc Id: XM_036154587   ⟹   XP_036010480
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm399123,901,954 - 123,913,594 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_034045   ⟸   NM_009915
- UniProtKB: Q61172 (UniProtKB/Swiss-Prot),   P51683 (UniProtKB/Swiss-Prot),   Q3TRK1 (UniProtKB/TrEMBL),   Q543S8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006512491   ⟸   XM_006512428
- Peptide Label: isoform X1
- UniProtKB: Q61172 (UniProtKB/Swiss-Prot),   P51683 (UniProtKB/Swiss-Prot),   Q543S8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011241365   ⟸   XM_011243063
- Peptide Label: isoform X1
- UniProtKB: Q61172 (UniProtKB/Swiss-Prot),   P51683 (UniProtKB/Swiss-Prot),   Q543S8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011241366   ⟸   XM_011243064
- Peptide Label: isoform X1
- UniProtKB: Q61172 (UniProtKB/Swiss-Prot),   P51683 (UniProtKB/Swiss-Prot),   Q543S8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000130112   ⟸   ENSMUST00000171719
RefSeq Acc Id: ENSMUSP00000128734   ⟸   ENSMUST00000165984
RefSeq Acc Id: ENSMUSP00000132453   ⟸   ENSMUST00000168841
RefSeq Acc Id: ENSMUSP00000049909   ⟸   ENSMUST00000055918
RefSeq Acc Id: XP_036010480   ⟸   XM_036154587
- Peptide Label: isoform X1
- UniProtKB: Q61172 (UniProtKB/Swiss-Prot),   Q543S8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036010479   ⟸   XM_036154586
- Peptide Label: isoform X1
- UniProtKB: Q61172 (UniProtKB/Swiss-Prot),   Q543S8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036010478   ⟸   XM_036154585
- Peptide Label: isoform X1
- UniProtKB: Q61172 (UniProtKB/Swiss-Prot),   Q543S8 (UniProtKB/TrEMBL)
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51683-F1-model_v2 AlphaFold P51683 1-373 view protein structure

RGD ID:6848386
Promoter ID:MM_ACW:52573
SO ACC ID:SO:0000170
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour
Transcripts:CCR2.CSEP07,   CCR2.DSEP07
Mouse AssemblyChrPosition (strand)Source
MGSCv369124,018,009 - 124,018,509 (+)MPROMDB
RGD ID:8671368
Promoter ID:EPDNEW_M13715
Type:initiation region
Description:Mus musculus chemokine (C-C motif) receptor 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_M13716  
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm389124,102,152 - 124,102,212EPDNEW
RGD ID:8671370
Promoter ID:EPDNEW_M13716
Type:multiple initiation site
Description:Mus musculus chemokine (C-C motif) receptor 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_M13715  
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm389124,103,618 - 124,103,678EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:106185 AgrOrtholog
Ensembl Genes ENSMUSG00000049103 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000049909 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000128734 UniProtKB/Swiss-Prot
  ENSMUSP00000130112 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000132453 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000055918 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000165984 UniProtKB/Swiss-Prot
  ENSMUST00000168841 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000171719 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Chemokine_CCR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12772 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ccr2 PhenoGen
  CHEMOKINER2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Secondary Q61172 UniProtKB/Swiss-Prot