Sstr1 (somatostatin receptor 1) - Rat Genome Database

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Gene: Sstr1 (somatostatin receptor 1) Mus musculus
Analyze
Symbol: Sstr1
Name: somatostatin receptor 1
RGD ID: 737192
MGI Page MGI
Description: Enables somatostatin receptor activity. Acts upstream of or within cellular response to leukemia inhibitory factor; glutamate receptor signaling pathway; and neuropeptide signaling pathway. Located in plasma membrane. Is expressed in several structures, including brain; eye; genitourinary system; gut; and respiratory system. Orthologous to human SSTR1 (somatostatin receptor 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Sms; Smst; Smstr-1; Smstr1; somatostatin receptor type 1; SRIF-2; ss; SS-1-R; SS1-R; SS1R; sst1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391258,258,524 - 58,262,822 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1258,258,558 - 58,260,673 (+)EnsemblGRCm39 Ensembl
GRCm381258,211,421 - 58,216,037 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1258,211,772 - 58,214,444 (+)EnsemblGRCm38mm10GRCm38
MGSCv371259,312,791 - 59,317,023 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361259,129,816 - 59,132,456 (+)NCBIMGSCv36mm8
Celera1259,362,952 - 59,367,171 (+)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1225.61NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. An intracellular multi-effector complex mediates somatostatin receptor 1 activation of phospho-tyrosine phosphatase eta. Arena S, etal., Mol Endocrinol. 2007 Jan;21(1):229-46. Epub 2006 Oct 4.
2. Pituitary and hypothalamic somatostatin receptor subtype messenger ribonucleic acid expression in the food-deprived and diabetic rat. Bruno JF, etal., Endocrinology. 1994 Nov;135(5):1787-92.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1346068   PMID:7929134   PMID:9166719   PMID:9226367   PMID:10349636   PMID:10622746   PMID:10996426   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11337941   PMID:11585698  
PMID:11897118   PMID:11988224   PMID:12145348   PMID:12759718   PMID:14614951   PMID:14750962   PMID:15093692   PMID:15464758   PMID:15548214   PMID:16141072   PMID:16141073   PMID:16406265  
PMID:16602821   PMID:16987237   PMID:17010429   PMID:17425570   PMID:17652715   PMID:17950729   PMID:18206294   PMID:18624922   PMID:18845633   PMID:18951956   PMID:19324858   PMID:19811607  
PMID:20439489   PMID:20589901   PMID:21267068   PMID:21564422   PMID:21873635   PMID:21912697   PMID:22311350   PMID:22581439   PMID:22723691   PMID:22986312   PMID:24952961   PMID:25149275  
PMID:25268135   PMID:25784603   PMID:31381945   PMID:33795231  


Genomics

Comparative Map Data
Sstr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391258,258,524 - 58,262,822 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1258,258,558 - 58,260,673 (+)EnsemblGRCm39 Ensembl
GRCm381258,211,421 - 58,216,037 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1258,211,772 - 58,214,444 (+)EnsemblGRCm38mm10GRCm38
MGSCv371259,312,791 - 59,317,023 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361259,129,816 - 59,132,456 (+)NCBIMGSCv36mm8
Celera1259,362,952 - 59,367,171 (+)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1225.61NCBI
SSTR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381438,207,904 - 38,213,067 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1438,207,904 - 38,213,067 (+)EnsemblGRCh38hg38GRCh38
GRCh371438,677,109 - 38,682,272 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361437,746,955 - 37,752,019 (+)NCBINCBI36Build 36hg18NCBI36
Build 341437,746,954 - 37,752,019NCBI
Celera1418,541,740 - 18,546,804 (+)NCBICelera
Cytogenetic Map14q21.1NCBI
HuRef1418,792,180 - 18,797,244 (+)NCBIHuRef
CHM1_11438,674,961 - 38,680,025 (+)NCBICHM1_1
T2T-CHM13v2.01432,396,603 - 32,401,766 (+)NCBIT2T-CHM13v2.0
Sstr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8681,567,237 - 81,571,759 (+)NCBIGRCr8
mRatBN7.2675,832,292 - 75,836,806 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl675,832,530 - 75,836,802 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx676,235,331 - 76,239,631 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0676,534,673 - 76,538,973 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0675,962,144 - 75,966,444 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0679,252,914 - 79,258,611 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl679,254,339 - 79,258,611 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0688,783,414 - 88,787,997 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4678,803,393 - 78,806,978 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1678,806,518 - 78,810,104 (+)NCBI
Celera674,603,631 - 74,607,903 (+)NCBICelera
RH 3.4 Map6546.4RGD
Cytogenetic Map6q23NCBI
Sstr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540922,889,800 - 22,894,480 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540922,889,800 - 22,894,480 (-)NCBIChiLan1.0ChiLan1.0
SSTR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21539,532,858 - 39,536,701 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11438,749,551 - 38,753,211 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01418,968,969 - 18,973,560 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11437,327,348 - 37,332,961 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1437,329,309 - 37,330,484 (+)Ensemblpanpan1.1panPan2
SSTR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1816,571,069 - 16,575,730 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha816,377,472 - 16,378,647 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0816,688,125 - 16,691,797 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl816,688,172 - 16,689,347 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1816,381,728 - 16,382,903 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0816,439,948 - 16,441,123 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0816,740,560 - 16,741,735 (+)NCBIUU_Cfam_GSD_1.0
Sstr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864048,558,403 - 48,563,242 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649412,065,473 - 12,066,648 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649412,065,388 - 12,067,759 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SSTR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl761,890,563 - 61,894,978 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1761,890,560 - 61,900,567 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2766,593,626 - 66,599,948 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SSTR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12415,000,190 - 15,006,757 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2415,003,116 - 15,004,291 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660534,033,896 - 4,039,724 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sstr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248137,539,304 - 7,540,479 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248137,538,104 - 7,543,836 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sstr1
158 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:332
Count of miRNA genes:255
Interacting mature miRNAs:281
Transcripts:ENSMUST00000044299, ENSMUST00000110671
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142234Tmc1m3_mTmc1 modifier 3 (mouse)Not determined12541844077031203Mouse
27226753Femd7_mfemur midshaft diameter 7, 10 week (mouse)12955000084146774Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121166000197176774Mouse
1558978Cplaq10_mcircadian period of locomotor activity 10 (mouse)Not determined121534102679040364Mouse
1301574Lmblgq5_mlimb length QTL 5 (mouse)Not determined121759644780956883Mouse
1301989Hdlq18_mHDL QTL 18 (mouse)Not determined122916068563160884Mouse
1300636Gct2_mgranulosa cell tumorigenesis 2 (mouse)Not determined122916068563160884Mouse
4141843Moen3_mmodifier of engrailed QTL 3 (mouse)Not determined122980158463801733Mouse
14747008Mancz10_mmandible centroid size 10 (mouse)122986352263863522Mouse
10402492Dipa8_mdrug induced psychomotor activation 8 (mouse)Not determined123493387268934019Mouse
1300818Bbaa10_mB.burgdorferi-associated arthritis 10 (mouse)Not determined123509100465511019Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
1357479Splwt1_mspleen weight 1 (mouse)Not determined124169317590887526Mouse
1357757Lnopy2_mlens opacity 2 (mouse)Not determined125284662686846796Mouse
1357749Vtbt13_mvertebral trabecular bone trait 13 (mouse)Not determined125313200287132145Mouse
12832727Ahrq1_mairway hyperresponsiveness QTL 1 (mouse)125469591082665939Mouse
13504832Bacszq2_mbaculum size QTL 2 (mouse)125694579875345787Mouse

Markers in Region
Sstr1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381258,213,415 - 58,213,505UniSTSGRCm38
MGSCv371259,314,402 - 59,314,492UniSTSGRCm37
Celera1259,364,564 - 59,364,654UniSTS
Cytogenetic Map12C1UniSTS
cM Map1223.0UniSTS
D1Mit334  
Mouse AssemblyChrPosition (strand)SourceJBrowse
cM Map149.7UniSTS
Whitehead Genetic149.2UniSTS
Whitehead/MRC_RH11185.23UniSTS
Whitehead_YAC1 UniSTS
D1Mit45  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38193,013,187 - 93,013,355UniSTSGRCm38
MGSCv37194,909,764 - 94,909,932UniSTSGRCm37
Celera195,962,253 - 95,962,429UniSTS
cM Map158.5UniSTS
Whitehead Genetic157.9UniSTS
Whitehead/MRC_RH11314.48UniSTS
D1Mit49  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38187,202,974 - 87,203,100UniSTSGRCm38
MGSCv37189,099,549 - 89,099,675UniSTSGRCm37
Celera190,176,044 - 90,176,162UniSTS
cM Map154.5UniSTS
Whitehead Genetic152.5UniSTS
Whitehead/MRC_RH11262.1UniSTS
Smstr1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381258,213,424 - 58,213,559UniSTSGRCm38
MGSCv371259,314,411 - 59,314,546UniSTSGRCm37
Celera1259,364,573 - 59,364,708UniSTS
Cytogenetic Map12C1UniSTS
cM Map1223.0UniSTS
Smstr1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381258,213,540 - 58,213,657UniSTSGRCm38
MGSCv371259,314,527 - 59,314,644UniSTSGRCm37
Celera1259,364,689 - 59,364,806UniSTS
Cytogenetic Map12C1UniSTS
cM Map1223.0UniSTS
Smstr1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12C1UniSTS
cM Map1223.0UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000044299   ⟹   ENSMUSP00000037045
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1258,258,590 - 58,261,230 (+)Ensembl
GRCm38.p6 Ensembl1258,211,804 - 58,214,444 (+)Ensembl
RefSeq Acc Id: ENSMUST00000110671   ⟹   ENSMUSP00000106299
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1258,258,558 - 58,260,673 (+)Ensembl
GRCm38.p6 Ensembl1258,211,772 - 58,213,887 (+)Ensembl
RefSeq Acc Id: NM_001411890   ⟹   NP_001398819
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391258,258,524 - 58,262,822 (+)NCBI
RefSeq Acc Id: NM_009216   ⟹   NP_033242
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391258,258,590 - 58,262,822 (+)NCBI
GRCm381258,211,804 - 58,216,036 (+)NCBI
MGSCv371259,312,791 - 59,317,023 (+)RGD
Celera1259,362,952 - 59,367,171 (+)RGD
cM Map12 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_033242   ⟸   NM_009216
- UniProtKB: P30873 (UniProtKB/Swiss-Prot),   Q543T0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000106299   ⟸   ENSMUST00000110671
RefSeq Acc Id: ENSMUSP00000037045   ⟸   ENSMUST00000044299
RefSeq Acc Id: NP_001398819   ⟸   NM_001411890
- UniProtKB: P30873 (UniProtKB/Swiss-Prot),   Q543T0 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30873-F1-model_v2 AlphaFold P30873 1-391 view protein structure

Promoters
RGD ID:8678332
Promoter ID:EPDNEW_M17197
Type:initiation region
Name:Sstr1_1
Description:Mus musculus somatostatin receptor 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381258,211,738 - 58,211,798EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98327 AgrOrtholog
Ensembl Genes ENSMUSG00000035431 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000044299.3 UniProtKB/Swiss-Prot
  ENSMUST00000110671 ENTREZGENE
  ENSMUST00000110671.3 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatstn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatstn_rcpt_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20605 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:98327 ENTREZGENE
NCBI Gene 20605 ENTREZGENE
PANTHER NEUROPEPTIDES RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOMATOSTATIN RECEPTOR TYPE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sstr1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOMATOSTATNR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOMATOSTTN1R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P30873 ENTREZGENE
  Q543T0 ENTREZGENE, UniProtKB/TrEMBL
  SSR1_MOUSE UniProtKB/Swiss-Prot