Polg (polymerase (DNA directed), gamma) - Rat Genome Database

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Gene: Polg (polymerase (DNA directed), gamma) Mus musculus
Analyze
Symbol: Polg
Name: polymerase (DNA directed), gamma
RGD ID: 732180
MGI Page MGI
Description: Enables exonuclease activity. Involved in mitochondrial DNA replication. Acts upstream of or within determination of adult lifespan. Located in mitochondrial inner membrane. Is expressed in several structures, including early conceptus; secondary oocyte; and telencephalon. Used to study bipolar disorder; mood disorder; and myelodysplastic syndrome. Human ortholog(s) of this gene implicated in several diseases, including mitochondrial DNA depletion syndrome (multiple); mitochondrial myopathy (multiple); neurodegenerative disease (multiple); ovarian disease (multiple); and sensory ataxic neuropathy, dysarthria, and ophthalmoparesis. Orthologous to human POLG (DNA polymerase gamma, catalytic subunit).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3'-5' exodeoxyribonuclease; 5'-deoxyribose-phosphate lyase; AA409516; DNA polymerase gamma subunit 1 (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha); DNA polymerase subunit gamma-1; mitochondrial DNA polymerase catalytic subunit; mitochondrial DNA polymerase gamma; mitochondrial DNA polymerase-gamma; mitochondrial polymerase gamma; P; Pol gamma; polG-alpha; PolgA; polymerase, gamma
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39779,095,979 - 79,117,659 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl779,095,979 - 79,116,110 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38779,446,231 - 79,467,911 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl779,446,231 - 79,466,362 (-)Ensemblmm10GRCm38
MGSCv37786,594,269 - 86,611,159 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36779,322,896 - 79,339,786 (-)NCBIMGSCv36mm8
Celera776,851,749 - 76,868,637 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.04NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Alpers-Huttenlocher syndrome  (IAGP,ISO)
asphyxiating thoracic dystrophy 3  (ISO)
Ataxia  (ISO)
autistic disorder  (ISO)
autosomal dominant intellectual developmental disorder  (ISO)
autosomal dominant progressive external ophthalmoplegia 1  (ISO)
autosomal recessive progressive external ophthalmoplegia 1  (ISO)
benign neonatal seizures  (ISO)
bipolar disorder  (IAGP)
Bloom syndrome  (ISO)
Camptocormia  (ISO)
cardiomyopathy  (ISO)
cerebellar ataxia  (ISO)
Charcot-Marie-Tooth disease axonal type 2U  (ISO)
Chemical and Drug Induced Liver Injury  (IAGP,ISO)
Childhood Myocerebrohepatopathy Spectrum  (ISO)
chronic progressive external ophthalmoplegia  (ISO)
colorectal cancer  (ISO)
D-2-hydroxyglutaric aciduria 2  (ISO)
Developmental Disabilities  (ISO)
epilepsy  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Failure to Thrive  (ISO)
Fanconi anemia  (ISO)
Fanconi anemia complementation group I  (ISO)
genetic disease  (ISO)
hepatocellular carcinoma  (IAGP)
hereditary spastic paraplegia  (ISO)
hypertrophic cardiomyopathy  (ISO)
intellectual disability  (ISO)
Lennox-Gastaut syndrome  (ISO)
male infertility  (ISO)
MELAS syndrome  (ISO)
microcephaly  (ISO)
mitochondrial DNA depletion syndrome  (ISO)
mitochondrial DNA depletion syndrome 1  (ISO)
mitochondrial DNA depletion syndrome 4B  (ISO)
mitochondrial DNA depletion syndrome 7  (ISO)
mitochondrial DNA depletion syndrome 8A  (ISO)
Mitochondrial DNA Depletion Syndrome, MNGIE Type  (ISO)
mitochondrial encephalomyopathy  (ISO)
mitochondrial metabolism disease  (ISO)
mood disorder  (IAGP,IMP)
multiple sclerosis  (ISO)
myelodysplastic syndrome  (IAGP)
Nervous System Malformations  (ISO)
Parkinson's disease  (ISO)
Parkinson's disease 20  (ISO)
Parkinsonism  (ISO)
polyneuropathy  (ISO)
Premature Aging  (IMP)
premature menopause  (ISO)
Presbycusis  (IMP)
Primary Ovarian Failure  (ISO)
primary ovarian insufficiency  (ISO)
primary progressive multiple sclerosis  (ISO)
Progressive External Ophthalmoplegia with Mitochondrial DNA Deletions, Autosomal Recessive  (ISO)
progressive myoclonus epilepsy 5  (ISO)
sensory ataxic neuropathy, dysarthria, and ophthalmoparesis  (ISO)
Spinocerebellar Ataxia with Epilepsy  (ISO)
Spinocerebellar Ataxias  (ISO)
status epilepticus  (ISO)
vascular dementia  (ISO)
visual epilepsy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
5-fluorouracil  (ISO)
acetamide  (ISO)
acetohydrazide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
amphotericin B  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
aspartame  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[ghi]perylene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
calcium dihydroxide  (EXP)
carbamazepine  (ISO)
carbon monoxide  (EXP)
carbon nanotube  (EXP)
chloramphenicol  (ISO)
clofibric acid  (ISO)
crocidolite asbestos  (EXP)
diazinon  (ISO)
diclofenac  (ISO)
dimethylarsinic acid  (EXP)
doxorubicin  (ISO)
favipiravir  (ISO)
finasteride  (ISO)
fipronil  (ISO)
flutamide  (ISO)
folic acid  (EXP)
furan  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
hydrazine  (EXP)
indole-3-methanol  (ISO)
ketamine  (ISO)
leflunomide  (ISO)
monosodium L-glutamate  (EXP)
N-nitrosodiethylamine  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenethyl caffeate  (ISO)
pirinixic acid  (EXP)
rac-lactic acid  (EXP)
rotenone  (EXP,ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
superoxide  (EXP)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
triphenyl phosphate  (ISO)
triptonide  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bone marrow cell physiology  (IAGP)
abnormal coat/hair pigmentation  (IAGP)
abnormal crypts of Lieberkuhn morphology  (IAGP)
abnormal erythroid lineage cell morphology  (IAGP)
abnormal GABAergic neuron morphology  (IAGP)
abnormal gait  (IAGP)
abnormal lymphopoiesis  (IAGP)
abnormal mitochondrial ATP synthesis coupled electron transport  (IAGP)
abnormal mitochondrial physiology  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal nucleotide metabolism  (IAGP)
abnormal oxidative phosphorylation  (IAGP)
abnormal thymus involution  (IAGP)
alopecia  (IAGP)
azoospermia  (IAGP)
brain inflammation  (IAGP)
cochlear ganglion degeneration  (IAGP)
cochlear hair cell degeneration  (IAGP)
cochlear outer hair cell degeneration  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating interferon-beta level  (IAGP)
decreased circulating interferon-gamma level  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased embryo size  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased hemoglobin content  (IAGP)
decreased hepatocyte mitochondrial DNA content  (IAGP)
decreased immature B cell number  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased mature B cell number  (IAGP)
decreased neuron mitochondrial DNA content  (IAGP)
decreased pre-B cell number  (IAGP)
decreased pro-B cell number  (IAGP)
decreased skeletal muscle mass  (IAGP)
decreased subcutaneous adipose tissue amount  (IAGP)
decreased thymocyte number  (IAGP)
decreased total body fat amount  (IAGP)
dilated heart left ventricle  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between somite formation and embryo turning, complete penetrance  (IAGP)
hepatic necrosis  (IAGP)
hypochromic macrocytic anemia  (IAGP)
impaired coordination  (IAGP)
increased apoptosis  (IAGP)
increased B cell derived lymphoma incidence  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating lactate level  (IAGP)
increased erythroblast number  (IAGP)
increased heart weight  (IAGP)
increased incidence of induced tumors  (IAGP)
increased mean corpuscular volume  (IAGP)
increased mitochondrial size  (IAGP)
increased necroptotic process  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
increased susceptibility to age-related hearing loss  (IAGP)
increased susceptibility to Flaviviridae infection  (IAGP)
kyphosis  (IAGP)
liver inflammation  (IAGP)
macrocytic anemia  (IAGP)
macrocytosis  (IAGP)
oligozoospermia  (IAGP)
osteoporosis  (IAGP)
oxidative stress  (IAGP)
premature aging  (IAGP)
premature death  (IAGP)
premature hair loss  (IAGP)
reduced female fertility  (IAGP)
reduced male fertility  (IAGP)
seminiferous tubule degeneration  (IAGP)
small testis  (IAGP)
stria vascularis degeneration  (IAGP)
testicular atrophy  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Mono-allelic POLG expression resulting from nonsense-mediated decay and alternative splicing in a patient with Alpers syndrome. Chan SS, etal., DNA Repair (Amst). 2005 Dec 8;4(12):1381-9. Epub 2005 Sep 21.
2. Effects of mitochondrial mutations on hearing and cochlear pathology with age. Crawley BK and Keithley EM, Hear Res. 2011 Oct;280(1-2):201-8. doi: 10.1016/j.heares.2011.05.015. Epub 2011 Jun 1.
3. Early-onset familial parkinsonism due to POLG mutations. Davidzon G, etal., Ann Neurol. 2006 May;59(5):859-62.
4. Novel polymerase gamma (POLG1) gene mutation in the linker domain associated with parkinsonism. Dolhun R, etal., BMC Neurol. 2013 Jul 18;13:92. doi: 10.1186/1471-2377-13-92.
5. POLG1 variations presenting as multiple sclerosis. Echaniz-Laguna A, etal., Arch Neurol. 2010 Sep;67(9):1140-3. doi: 10.1001/archneurol.2010.219.
6. POLG1 mutations cause a syndromic epilepsy with occipital lobe predilection. Engelsen BA, etal., Brain. 2008 Mar;131(Pt 3):818-28. doi: 10.1093/brain/awn007. Epub 2008 Jan 30.
7. Infantile hepatocerebral syndromes associated with mutations in the mitochondrial DNA polymerase-gammaA. Ferrari G, etal., Brain. 2005 Apr;128(Pt 4):723-31. Epub 2005 Feb 2.
8. Clinical and genetic heterogeneity in progressive external ophthalmoplegia due to mutations in polymerase gamma. Filosto M, etal., Arch Neurol. 2003 Sep;60(9):1279-84.
9. Sensory ataxic neuropathy with dysarthria/dysphagia and ophthalmoplegia (SANDO). Two case reports. Gati I, etal., Acta Myol. 2011 Dec;30(3):188-90.
10. Association of novel POLG mutations and multiple mitochondrial DNA deletions with variable clinical phenotypes in a Spanish population. Gonzalez-Vioque E, etal., Arch Neurol. 2006 Jan;63(1):107-11.
11. Mutation of the linker region of the polymerase gamma-1 (POLG1) gene associated with progressive external ophthalmoplegia and Parkinsonism. Hudson G, etal., Arch Neurol. 2007 Apr;64(4):553-7.
12. Variants p.Q1236H and p.E1143G in mitochondrial DNA polymerase gamma POLG1 are not associated with increased risk for valproate-induced hepatotoxicity or pancreatic toxicity: A retrospective cohort study of patients with epilepsy. Hynynen J, etal., Epilepsia. 2018 Nov;59(11):2125-2136. doi: 10.1111/epi.14568. Epub 2018 Sep 26.
13. Acute liver failure after valproate exposure in patients with POLG1 mutations and the prognosis after liver transplantation. Hynynen J, etal., Liver Transpl. 2014 Nov;20(11):1402-12. doi: 10.1002/lt.23965. Epub 2014 Oct 3.
14. Mitochondrial DNA damage and impaired base excision repair during epileptogenesis. Jarrett SG, etal., Neurobiol Dis. 2008 Apr;30(1):130-8. Epub 2008 Jan 5.
15. Mice with neuron-specific accumulation of mitochondrial DNA mutations show mood disorder-like phenotypes. Kasahara T, etal., Mol Psychiatry. 2006 Jun;11(6):577-93, 523.
16. POLG1 mutations associated with progressive encephalopathy in childhood. Kollberg G, etal., J Neuropathol Exp Neurol. 2006 Aug;65(8):758-68.
17. A novel POLG gene mutation in 4 children with Alpers-like hepatocerebral syndromes. Kurt B, etal., Arch Neurol. 2010 Feb;67(2):239-44. doi: 10.1001/archneurol.2009.332.
18. Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase gamma. Lewis W, etal., Lab Invest. 2007 Apr;87(4):326-35. Epub 2006 Feb 19.
19. Polymorphisms in POLG were associated with the prognosis and mtDNA content in hepatocellular carcinoma patients. Long X, etal., Bull Cancer. 2017 Jun;104(6):500-507. doi: 10.1016/j.bulcan.2017.02.005. Epub 2017 Apr 28.
20. Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study. Luoma P, etal., Lancet. 2004 Sep 4-10;364(9437):875-82.
21. MGDs mouse GO annotations MGD data from the GO Consortium
22. MGD IEA MGD IEA
23. Sensory ataxic neuropathy with ophthalmoparesis caused by POLG mutations. Milone M, etal., Neuromuscul Disord. 2008 Aug;18(8):626-32. doi: 10.1016/j.nmd.2008.05.009. Epub 2008 Jun 27.
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. Dominant inheritance of premature ovarian failure associated with mutant mitochondrial DNA polymerase gamma. Pagnamenta AT, etal., Hum Reprod. 2006 Oct;21(10):2467-73. Epub 2006 Apr 4.
26. Mouse MP Annotation Import Pipeline RGD automated import pipeline
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. POLG, but not PEO1, is a frequent cause of cerebellar ataxia in Central Europe. Schicks J, etal., Mov Disord. 2010 Nov 15;25(15):2678-82. doi: 10.1002/mds.23286.
30. Phenotypic and genotypic variability in Alpers syndrome. Sofou K, etal., Eur J Paediatr Neurol. 2012 Jul;16(4):379-89. doi: 10.1016/j.ejpn.2011.12.006. Epub 2012 Jan 10.
31. Damaged mitochondrial DNA replication system and the development of diabetic retinopathy. Tewari S, etal., Antioxid Redox Signal. 2012 Aug 1;17(3):492-504. doi: 10.1089/ars.2011.4333. Epub 2012 Feb 17.
32. Mitochondria DNA replication and DNA methylation in the metabolic memory associated with continued progression of diabetic retinopathy. Tewari S, etal., Invest Ophthalmol Vis Sci. 2012 Jul 24;53(8):4881-8. doi: 10.1167/iovs.12-9732.
33. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Trifunovic A, etal., Nature. 2004 May 27;429(6990):417-23.
34. Novel POLG mutations in progressive external ophthalmoplegia mimicking mitochondrial neurogastrointestinal encephalomyopathy. Van Goethem G, etal., Eur J Hum Genet. 2003 Jul;11(7):547-9.
35. Mutation of POLG is associated with progressive external ophthalmoplegia characterized by mtDNA deletions. Van Goethem G, etal., Nat Genet 2001 Jul;28(3):211-2.
36. Recessive POLG mutations presenting with sensory and ataxic neuropathy in compound heterozygote patients with progressive external ophthalmoplegia. Van Goethem G, etal., Neuromuscul Disord. 2003 Feb;13(2):133-42.
37. Autosomal recessive mitochondrial ataxic syndrome due to mitochondrial polymerase gamma mutations. Winterthun S, etal., Neurology. 2005 Apr 12;64(7):1204-8.
Additional References at PubMed
PMID:8889548   PMID:9465903   PMID:10349636   PMID:10922068   PMID:11031098   PMID:11042159   PMID:11058962   PMID:11076861   PMID:11217851   PMID:11544199   PMID:12466851   PMID:12477932  
PMID:12865426   PMID:14651853   PMID:15177179   PMID:15782199   PMID:15888483   PMID:15895466   PMID:16020738   PMID:16141072   PMID:16141073   PMID:16172387   PMID:16327803   PMID:16332961  
PMID:16870370   PMID:17122057   PMID:17334366   PMID:17363114   PMID:17662273   PMID:18232733   PMID:18311139   PMID:18365022   PMID:18614015   PMID:18799693   PMID:19171187   PMID:19656491  
PMID:19734452   PMID:20403324   PMID:20628647   PMID:21041631   PMID:21109200   PMID:21311045   PMID:21332926   PMID:21368052   PMID:21368114   PMID:21455489   PMID:21555558   PMID:21873635  
PMID:21909133   PMID:22125488   PMID:22225879   PMID:22345551   PMID:22357654   PMID:22820179   PMID:22941637   PMID:22962610   PMID:22988144   PMID:23042113   PMID:23090476   PMID:23090637  
PMID:23197651   PMID:23418460   PMID:23850316   PMID:23935986   PMID:23965628   PMID:24722488   PMID:24915468   PMID:24945157   PMID:24985350   PMID:25106705   PMID:25378300   PMID:25411424  
PMID:25511702   PMID:25575636   PMID:26027936   PMID:26095671   PMID:26124126   PMID:26142281   PMID:26182419   PMID:26212336   PMID:26253742   PMID:26294258   PMID:26464968   PMID:26686024  
PMID:26757797   PMID:26876175   PMID:27626666   PMID:27869650   PMID:27986797   PMID:28158260   PMID:28699890   PMID:28768180   PMID:29109127   PMID:29601571   PMID:29660116   PMID:29875308  
PMID:29950568   PMID:30040856   PMID:30135585   PMID:30217445   PMID:30240410   PMID:30737259   PMID:30990467   PMID:31344454   PMID:31358769   PMID:31621839   PMID:31693894   PMID:31992827  
PMID:32098917   PMID:32107436   PMID:32119683   PMID:32325033   PMID:32669663   PMID:32744417   PMID:33193604   PMID:33315859   PMID:33358867   PMID:33626245   PMID:33956154   PMID:34143518  
PMID:34975341   PMID:36280265   PMID:37020546   PMID:38228611   PMID:38397399   PMID:38432635   PMID:38570685   PMID:39277581   PMID:39742470   PMID:40393978  


Genomics

Comparative Map Data
Polg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39779,095,979 - 79,117,659 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl779,095,979 - 79,116,110 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38779,446,231 - 79,467,911 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl779,446,231 - 79,466,362 (-)Ensemblmm10GRCm38
MGSCv37786,594,269 - 86,611,159 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36779,322,896 - 79,339,786 (-)NCBIMGSCv36mm8
Celera776,851,749 - 76,868,637 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.04NCBI
POLG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381589,316,320 - 89,334,824 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1589,305,198 - 89,334,861 (-)Ensemblhg38GRCh38
GRCh371589,859,551 - 89,878,055 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361587,660,554 - 87,679,030 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341587,660,552 - 87,679,030NCBI
Celera1566,260,895 - 66,279,201 (-)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1565,971,419 - 65,989,730 (-)NCBIHuRef
CHM1_11589,700,576 - 89,719,066 (-)NCBICHM1_1
T2T-CHM13v2.01587,071,147 - 87,089,647 (-)NCBIT2T-CHM13v2.0
Polg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81142,792,119 - 142,808,933 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1142,792,119 - 142,808,838 (-)EnsemblGRCr8
mRatBN7.21133,382,764 - 133,399,578 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1133,382,766 - 133,398,567 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1141,292,744 - 141,307,834 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01148,462,157 - 148,477,247 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01141,379,870 - 141,394,960 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01141,172,117 - 141,188,893 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1141,172,531 - 141,188,031 (-)Ensemblrn6Rnor6.0
Rnor_5.01142,133,892 - 142,150,597 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41135,197,075 - 135,212,178 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1125,446,563 - 125,461,666 (-)NCBICelera
RGSC_v3.11135,275,417 - 135,290,521 (-)NCBI
Cytogenetic Map1q31NCBI
Polg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541615,773,473 - 15,788,651 (+)Ensembl
ChiLan1.0NW_00495541615,773,005 - 15,788,736 (+)NCBIChiLan1.0ChiLan1.0
POLG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21678,864,098 - 78,883,228 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11582,568,484 - 82,587,617 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01568,008,214 - 68,028,241 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11587,214,451 - 87,234,739 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1587,214,451 - 87,234,739 (-)EnsemblpanPan2panpan1.1
POLG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1352,357,062 - 52,373,768 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl352,357,068 - 52,421,544 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha354,991,836 - 55,008,948 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0352,774,064 - 52,791,169 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl352,774,083 - 52,790,068 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1352,296,790 - 52,313,882 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0352,507,050 - 52,523,743 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0352,846,762 - 52,863,883 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Polg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640131,138,186 - 131,155,546 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648315,179,342 - 15,195,258 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648315,178,947 - 15,196,277 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POLG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl754,889,157 - 54,906,844 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1754,889,150 - 54,907,167 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2759,864,727 - 59,882,439 (-)NCBISscrofa10.2Sscrofa10.2susScr3
POLG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1297,864,319 - 7,881,577 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl297,863,277 - 7,882,068 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605938,932,949 - 38,951,612 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Polg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476816,491,555 - 16,509,900 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476816,493,123 - 16,509,747 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Polg
1098 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:3382
Count of miRNA genes:846
Interacting mature miRNAs:1153
Transcripts:ENSMUST00000073889, ENSMUST00000125562, ENSMUST00000127082, ENSMUST00000127734, ENSMUST00000132048, ENSMUST00000139290, ENSMUST00000139597, ENSMUST00000139668, ENSMUST00000139795, ENSMUST00000142915, ENSMUST00000143672, ENSMUST00000145154, ENSMUST00000149444, ENSMUST00000154403
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)774849748122199223Mouse
25314305Vmm6_mvariable multisystem mineralization 6, eye (mouse)761849748102749207Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
26884381Bzwq2_mbi-zygomatic width QTL 2, 5 week (mouse)76524974896949207Mouse
1301784Ses2_msalmonella enteritidis susceptibility 2 (mouse)Not determined767290094101290240Mouse
1301663Skull9_mskull morphology 9 (mouse)Not determined75732612191326352Mouse
14746989Manh62_mmandible shape 62 (mouse)775742528109742528Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse
1301383Aem2_manti-erythrocyte autoantibody modifier 2 (mouse)Not determined76413542498135653Mouse
1301514Rigs1_mradiation induced gastroschisis 1 (mouse)Not determined73628001592394346Mouse
27095937Ulnl7_mulna length 7, 10 week (mouse)76644974898349207Mouse
11565101Tsve1_mvariable short tail (Tsv) enhancer 1 (mouse)75588950887142720Mouse
1300620Pgia21_mproteoglycan induced arthritis 21 (mouse)Not determined767290094101290240Mouse
13208555Lgth10_mbody length 10 (mouse)751649748125599172Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)761749748121399223Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
10054064Bwq11_mbody weight QTL 11 (mouse)Not determined75112495485125093Mouse
1357752Tabw_mtally ho asscoiated body weight (mouse)Not determined74919327883193390Mouse
10053685Eae43_mexperimental allergic encephalomyelitis susceptibility 43 (mouse)Not determined75112495485125093Mouse
1301566Adip3_madiposity 3 (mouse)Not determined775394215109394346Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301155Bpq7_mblood pressure QTL 7 (mouse)Not determined770143137104143379Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
4142212Png1_mPostnatal growth 1 (mouse)Not determined7432612192394346Mouse
1300654Bomd1_mbone mineral density 1 (mouse)Not determined768365595102365702Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765249748126499172Mouse
27226715Metcl3_mmetatarsal-calcaneal length 3, 5 week (mouse)767849748119499223Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)767849748124199223Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)754819589116822815Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
1301465Egrm3_mearly growth rate (mouse)Not determined75732612191326352Mouse
1300952Hcs1_mhepatocarcinogenesis susceptibility 1 (mouse)Not determined75732612191326352Mouse
4142319Powg_mpost-ovarectomy weight gain (mouse)Not determined7285710592582163Mouse
1301826Pgia3_mproteoglycan induced arthritis 3 (mouse)Not determined767290094101290240Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
4141805Sle19_msystematic lupus erythematosus susceptibility 19 (mouse)Not determined3003248581135653Mouse
26884418Bzwq7_mbi-zygomatic width QTL 7, 10 week (mouse)767849748105449207Mouse
10043973Obq29_mobesity QTL 29 (mouse)Not determined772263372106263372Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
12880417V125Dq5_mvitamin D active form serum level QTL 5 (mouse)74524974879249748Mouse
12880418V125Dq6_mvitamin D active form serum level QTL 6 (mouse)75214974886149748Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)774849748122199223Mouse
11532741Tbrs5_mtuberculosis resistance 5 (mouse)74915922783235415Mouse
1302141Fcsa6_mfemoral cross-sectional area 6 (mouse)Not determined74838446182384607Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)761749748123699223Mouse
12801463Rta1_mretinal aging 1 (mouse)76716802789089989Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)767849748124999172Mouse
11553865Stmm1c_mskin tumor modifier of MSM 1c (mouse)76578898699788986Mouse
11553866Stmm1d_mskin tumor modifier of MSM 1d (mouse)76578898699788986Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773049748125699172Mouse
25314303Vmm4_mvariable multisystem mineralization 4, kidney (mouse)73729942587049208Mouse
11553869Stmm2b_mskin tumor modifier of MSM 2a (mouse)773725965107725965Mouse
27095907Scvln4_msacral vertebrae length 2, 5 week (mouse)769949748120499223Mouse

Markers in Region
Polg  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38779,456,778 - 79,458,325UniSTSGRCm38
MGSCv37786,601,664 - 86,603,211UniSTSGRCm37
Celera776,859,144 - 76,860,691UniSTS
Cytogenetic Map7EUniSTS
cM Map7 UniSTS
RH125851  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38779,449,583 - 79,449,832UniSTSGRCm38
MGSCv37786,594,469 - 86,594,718UniSTSGRCm37
Celera776,851,949 - 76,852,198UniSTS
Cytogenetic Map7D3UniSTS
Cytogenetic Map7EUniSTS
Whitehead/MRC_RH7778.28UniSTS
UniSTS:235697  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38779,463,920 - 79,464,160UniSTSGRCm38
MGSCv37786,608,806 - 86,609,046UniSTSGRCm37
Celera776,866,284 - 76,866,524UniSTS
Cytogenetic Map7EUniSTS
MARC_7859-7860:996688105:3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38779,449,991 - 79,450,632UniSTSGRCm38
MGSCv37786,594,877 - 86,595,518UniSTSGRCm37
Celera776,852,357 - 76,852,998UniSTS
Cytogenetic Map7EUniSTS
Cytogenetic Map7D3UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001360095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001360096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_153404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006540708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006540711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030242221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036152790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003946418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004934043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB121698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC110909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF019123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF019127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF019128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF019131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF019133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH009621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK132852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK139369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC053024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC080291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ182989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U53584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000073889   ⟹   ENSMUSP00000073551
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl779,095,979 - 79,116,110 (-)Ensembl
GRCm38.p6 Ensembl779,446,231 - 79,466,362 (-)Ensembl
Ensembl Acc Id: ENSMUST00000125562   ⟹   ENSMUSP00000143813
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl779,114,643 - 79,115,818 (-)Ensembl
GRCm38.p6 Ensembl779,464,895 - 79,466,070 (-)Ensembl
Ensembl Acc Id: ENSMUST00000127082
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl779,099,130 - 79,115,935 (-)Ensembl
GRCm38.p6 Ensembl779,449,382 - 79,466,187 (-)Ensembl
Ensembl Acc Id: ENSMUST00000127734
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl779,104,279 - 79,105,142 (-)Ensembl
GRCm38.p6 Ensembl779,454,531 - 79,455,394 (-)Ensembl
Ensembl Acc Id: ENSMUST00000132048   ⟹   ENSMUSP00000143933
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl779,099,325 - 79,115,946 (-)Ensembl
GRCm38.p6 Ensembl779,449,577 - 79,466,198 (-)Ensembl
Ensembl Acc Id: ENSMUST00000139290   ⟹   ENSMUSP00000144035
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl779,099,130 - 79,100,365 (-)Ensembl
GRCm38.p6 Ensembl779,449,382 - 79,450,617 (-)Ensembl
Ensembl Acc Id: ENSMUST00000139597
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl779,103,694 - 79,105,813 (-)Ensembl
GRCm38.p6 Ensembl779,453,946 - 79,456,065 (-)Ensembl
Ensembl Acc Id: ENSMUST00000139668   ⟹   ENSMUSP00000114414
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl779,105,234 - 79,109,189 (-)Ensembl
GRCm38.p6 Ensembl779,455,486 - 79,459,441 (-)Ensembl
Ensembl Acc Id: ENSMUST00000139795
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl779,101,678 - 79,104,088 (-)Ensembl
GRCm38.p6 Ensembl779,451,930 - 79,454,340 (-)Ensembl
Ensembl Acc Id: ENSMUST00000142915
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl779,109,270 - 79,111,552 (-)Ensembl
GRCm38.p6 Ensembl779,459,522 - 79,461,804 (-)Ensembl
Ensembl Acc Id: ENSMUST00000143672   ⟹   ENSMUSP00000122286
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl779,105,818 - 79,109,544 (-)Ensembl
GRCm38.p6 Ensembl779,456,070 - 79,459,796 (-)Ensembl
Ensembl Acc Id: ENSMUST00000145154
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl779,099,914 - 79,101,828 (-)Ensembl
GRCm38.p6 Ensembl779,450,166 - 79,452,080 (-)Ensembl
Ensembl Acc Id: ENSMUST00000149444   ⟹   ENSMUSP00000119616
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl779,099,311 - 79,115,928 (-)Ensembl
GRCm38.p6 Ensembl779,449,563 - 79,466,180 (-)Ensembl
Ensembl Acc Id: ENSMUST00000154403
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl779,099,130 - 79,104,828 (-)Ensembl
GRCm38.p6 Ensembl779,449,382 - 79,455,080 (-)Ensembl
Ensembl Acc Id: ENSMUST00000201030   ⟹   ENSMUSP00000143923
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl779,101,348 - 79,103,534 (-)Ensembl
GRCm38.p6 Ensembl779,451,600 - 79,453,786 (-)Ensembl
Ensembl Acc Id: ENSMUST00000201557
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl779,113,664 - 79,115,942 (-)Ensembl
GRCm38.p6 Ensembl779,463,916 - 79,466,194 (-)Ensembl
Ensembl Acc Id: ENSMUST00000201662   ⟹   ENSMUSP00000144510
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl779,099,129 - 79,101,382 (-)Ensembl
GRCm38.p6 Ensembl779,449,381 - 79,451,634 (-)Ensembl
Ensembl Acc Id: ENSMUST00000201907   ⟹   ENSMUSP00000144084
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl779,101,335 - 79,101,670 (-)Ensembl
GRCm38.p6 Ensembl779,451,587 - 79,451,922 (-)Ensembl
RefSeq Acc Id: NM_001360095   ⟹   NP_001347024
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39779,095,979 - 79,116,021 (-)NCBI
GRCm38779,446,231 - 79,466,273 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001360096   ⟹   NP_001347025
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39779,095,979 - 79,113,628 (-)NCBI
GRCm38779,446,231 - 79,463,880 (-)NCBI
Sequence:
RefSeq Acc Id: NM_017462   ⟹   NP_059490
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39779,095,979 - 79,116,021 (-)NCBI
GRCm38779,446,231 - 79,466,273 (-)NCBI
MGSCv37786,594,269 - 86,611,159 (-)RGD
Celera776,851,749 - 76,868,637 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_153404
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39779,095,979 - 79,113,628 (-)NCBI
GRCm38779,446,231 - 79,463,880 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006540708   ⟹   XP_006540771
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39779,098,658 - 79,117,659 (-)NCBI
GRCm38779,449,382 - 79,467,911 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006540711   ⟹   XP_006540774
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39779,106,654 - 79,116,061 (-)NCBI
GRCm38779,456,906 - 79,466,313 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030242221   ⟹   XP_030098081
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39779,098,658 - 79,117,659 (-)NCBI
GRCm38779,449,382 - 79,467,911 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036152790   ⟹   XP_036008683
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39779,098,658 - 79,114,348 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003946418
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39779,098,658 - 79,116,061 (-)NCBI
GRCm38779,449,563 - 79,466,313 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004934043
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39779,098,658 - 79,116,061 (-)NCBI
Sequence:
RefSeq Acc Id: NP_059490   ⟸   NM_017462
- Peptide Label: isoform 1
- UniProtKB: Q3UZX3 (UniProtKB/TrEMBL),   Q75WC0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006540771   ⟸   XM_006540708
- Peptide Label: isoform X1
- UniProtKB: Q3UZX3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006540774   ⟸   XM_006540711
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: NP_001347024   ⟸   NM_001360095
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001347025   ⟸   NM_001360096
- Peptide Label: isoform 3
RefSeq Acc Id: XP_030098081   ⟸   XM_030242221
- Peptide Label: isoform X2
Ensembl Acc Id: ENSMUSP00000143813   ⟸   ENSMUST00000125562
Ensembl Acc Id: ENSMUSP00000114414   ⟸   ENSMUST00000139668
Ensembl Acc Id: ENSMUSP00000144035   ⟸   ENSMUST00000139290
Ensembl Acc Id: ENSMUSP00000122286   ⟸   ENSMUST00000143672
Ensembl Acc Id: ENSMUSP00000073551   ⟸   ENSMUST00000073889
Ensembl Acc Id: ENSMUSP00000143933   ⟸   ENSMUST00000132048
Ensembl Acc Id: ENSMUSP00000119616   ⟸   ENSMUST00000149444
Ensembl Acc Id: ENSMUSP00000143923   ⟸   ENSMUST00000201030
Ensembl Acc Id: ENSMUSP00000144084   ⟸   ENSMUST00000201907
Ensembl Acc Id: ENSMUSP00000144510   ⟸   ENSMUST00000201662
RefSeq Acc Id: XP_036008683   ⟸   XM_036152790
- Peptide Label: isoform X2
Protein Domains
DNA mitochondrial polymerase exonuclease   DNA-directed DNA polymerase family A palm

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P54099-F1-model_v2 AlphaFold P54099 1-1218 view protein structure

Promoters
RGD ID:8664503
Promoter ID:EPDNEW_M10283
Type:single initiation site
Name:Polg_2
Description:Mus musculus polymerase , gamma , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M10284  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38779,451,037 - 79,451,097EPDNEW
RGD ID:8664505
Promoter ID:EPDNEW_M10284
Type:initiation region
Name:Polg_1
Description:Mus musculus polymerase , gamma , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M10283  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38779,466,198 - 79,466,258EPDNEW
RGD ID:6841825
Promoter ID:MM_KWN:51230
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain,   Lung
Transcripts:UC009HYK.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36786,596,471 - 86,596,971 (-)MPROMDB
RGD ID:6841795
Promoter ID:MM_KWN:51232
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Kidney,   Liver
Transcripts:OTTMUST00000072163,   OTTMUST00000072170,   OTTMUST00000072171
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36786,599,299 - 86,599,799 (-)MPROMDB
RGD ID:6841791
Promoter ID:MM_KWN:51233
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain
Transcripts:OTTMUST00000072169
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36786,601,206 - 86,601,706 (-)MPROMDB
RGD ID:6841790
Promoter ID:MM_KWN:51234
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000072166,   OTTMUST00000072167,   OTTMUST00000072168
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36786,605,361 - 86,605,861 (-)MPROMDB
RGD ID:6841789
Promoter ID:MM_KWN:51235
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   Brain
Transcripts:OTTMUST00000072165
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36786,606,146 - 86,606,646 (-)MPROMDB
RGD ID:6841189
Promoter ID:MM_KWN:51236
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   Spleen
Transcripts:AK139984_GM10616,   ENSMUST00000036427,   OTTMUST00000072160,   OTTMUST00000072161,   OTTMUST00000072162,   OTTMUST00000072164
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36786,610,341 - 86,611,382 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1196389 AgrOrtholog
Ensembl Genes ENSMUSG00000039176 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000073889 ENTREZGENE
  ENSMUST00000127082 ENTREZGENE
Gene3D-CATH 1.20.5.3960 UniProtKB/Swiss-Prot
  3.30.420.390 UniProtKB/Swiss-Prot
  3.30.70.370 UniProtKB/Swiss-Prot
  5' to 3' exonuclease, C-terminal subdomain UniProtKB/Swiss-Prot
InterPro DNA-dir_DNA_pol_A_CS UniProtKB/Swiss-Prot
  DNA-dir_DNA_pol_A_mt UniProtKB/Swiss-Prot
  DNA-dir_DNA_pol_A_palm_dom UniProtKB/Swiss-Prot
  DNA/RNA_pol_sf UniProtKB/Swiss-Prot
  DNApol_Exo UniProtKB/Swiss-Prot
  POLG_palm_dom UniProtKB/Swiss-Prot
  RNaseH-like_sf UniProtKB/Swiss-Prot
MGD MGI:1196389 ENTREZGENE
NCBI Gene 18975 ENTREZGENE
PANTHER DNA POLYMERASE SUBUNIT GAMMA-1 UniProtKB/Swiss-Prot
  PTHR10267 UniProtKB/Swiss-Prot
Pfam DNApol_Exo UniProtKB/Swiss-Prot
PhenoGen Polg PhenoGen
PIRSF DNA_pol_mt UniProtKB/Swiss-Prot
PRINTS DNAPOLG UniProtKB/Swiss-Prot
PROSITE DNA_POLYMERASE_A UniProtKB/Swiss-Prot
SMART POLAc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53098 UniProtKB/Swiss-Prot
  SSF56672 UniProtKB/Swiss-Prot
UniProt A0A0J9YTR4_MOUSE UniProtKB/TrEMBL
  A0A0J9YTZ6_MOUSE UniProtKB/TrEMBL
  A0A0J9YU03_MOUSE UniProtKB/TrEMBL
  A0A0J9YU70_MOUSE UniProtKB/TrEMBL
  A0A0J9YUA1_MOUSE UniProtKB/TrEMBL
  A0A0J9YV64_MOUSE UniProtKB/TrEMBL
  D6RIP1_MOUSE UniProtKB/TrEMBL
  DPOG1_MOUSE UniProtKB/Swiss-Prot
  F6YLN2_MOUSE UniProtKB/TrEMBL
  F7BP45_MOUSE UniProtKB/TrEMBL
  P54099 ENTREZGENE
  Q05BB8_MOUSE UniProtKB/TrEMBL
  Q3UG70_MOUSE UniProtKB/TrEMBL
  Q3UZX3 ENTREZGENE, UniProtKB/TrEMBL
  Q75WC0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q9JI28 UniProtKB/Swiss-Prot