Prox1 (prospero homeobox 1) - Rat Genome Database

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Gene: Prox1 (prospero homeobox 1) Mus musculus
Analyze
Symbol: Prox1
Name: prospero homeobox 1
RGD ID: 1315764
MGI Page MGI
Description: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; circulatory system development; and positive regulation of cell differentiation. Acts upstream of or within several processes, including animal organ development; epithelial cell differentiation; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; eye; and urinary system. Used to study dilated cardiomyopathy and obesity. Orthologous to human PROX1 (prospero homeobox 1); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A230003G05Rik; homeobox prospero-like protein PROX1; prospero homeobox protein 1; prospero-related homeobox 1; PROX-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391189,850,232 - 189,903,024 (-)NCBIGRCm39mm39
GRCm39 Ensembl1189,850,232 - 189,902,911 (-)Ensembl
GRCm381190,118,035 - 190,170,827 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1190,118,035 - 190,170,714 (-)EnsemblGRCm38mm10GRCm38
MGSCv371191,945,654 - 191,994,559 (-)NCBIGRCm37mm9NCBIm37
MGSCv361191,822,563 - 191,871,468 (-)NCBImm8
Celera1197,032,975 - 197,082,606 (-)NCBICelera
Cytogenetic Map1H6NCBI
cM Map195.85NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acinar cell differentiation  (IMP)
aorta smooth muscle tissue morphogenesis  (IMP)
atrial cardiac muscle tissue morphogenesis  (IMP)
brain development  (ISO)
branching involved in pancreas morphogenesis  (IMP)
cell fate determination  (IMP)
cerebellar granule cell differentiation  (IMP)
circadian rhythm  (IEP)
dentate gyrus development  (IMP)
embryonic retina morphogenesis in camera-type eye  (IEP,ISO)
endocardium formation  (IMP)
endothelial cell differentiation  (IMP)
hepatocyte cell migration  (IMP)
hepatocyte differentiation  (IEP,ISO)
hepatocyte proliferation  (IMP)
inner ear development  (IMP)
kidney development  (ISO)
lens development in camera-type eye  (ISO)
lens fiber cell morphogenesis  (IMP)
lens morphogenesis in camera-type eye  (IMP)
lens placode formation involved in camera-type eye formation  (IEP)
liver development  (ISO)
lung development  (ISO)
lymph vessel development  (IMP)
lymphangiogenesis  (ISO)
lymphatic endothelial cell differentiation  (IMP,ISO)
lymphatic endothelial cell fate commitment  (ISO)
negative regulation of bile acid biosynthetic process  (ISO)
negative regulation of cell population proliferation  (IMP,ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of transcription by RNA polymerase II  (IDA,ISO)
negative regulation of transcription, DNA-templated  (IDA,ISO)
negative regulation of viral genome replication  (ISO)
neuronal stem cell population maintenance  (IMP)
pancreas development  (ISO)
positive regulation of cell cycle  (IMP)
positive regulation of cell cycle checkpoint  (IMP)
positive regulation of cell population proliferation  (IMP,ISO)
positive regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of forebrain neuron differentiation  (IMP)
positive regulation of heart growth  (IMP)
positive regulation of neural precursor cell proliferation  (IMP)
positive regulation of sarcomere organization  (IMP)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
regulation of circadian rhythm  (ISO)
regulation of gene expression  (IMP,ISO)
regulation of transcription by RNA polymerase II  (IBA)
regulation of transcription, DNA-templated  (IEA)
response to nutrient levels  (ISO)
rhythmic process  (IEA)
skeletal muscle thin filament assembly  (IMP)
venous blood vessel morphogenesis  (IMP)
ventricular cardiac muscle tissue morphogenesis  (IMP)
ventricular cardiac myofibril assembly  (IMP)
ventricular septum morphogenesis  (IMP)

Cellular Component
cytoplasm  (IDA,ISO)
cytosol  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,IDA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal atrial thrombosis  (IAGP)
abnormal cardiac thrombosis  (IAGP)
abnormal dentate gyrus morphology  (IAGP)
abnormal endocrine pancreas morphology  (IAGP)
abnormal eye development  (IAGP)
abnormal heart morphology  (IAGP)
abnormal hippocampus CA4 region morphology  (IAGP)
abnormal hippocampus granule cell morphology  (IAGP)
abnormal interventricular septum morphology  (IAGP)
abnormal interventricular septum muscular part morphology  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal lens development  (IAGP)
abnormal lens morphology  (IAGP)
abnormal liver development  (IAGP)
abnormal lymph circulation  (IAGP)
abnormal lymph organ development  (IAGP)
abnormal lymphatic vessel morphology  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal retina morphology  (IAGP)
abnormal skeletal muscle morphology  (IAGP)
abnormal suckling behavior  (IAGP)
abnormal ventricular thrombosis  (IAGP)
absent lymphatic vessels  (IAGP)
absent retinal horizontal cells  (IAGP)
chylothorax  (IAGP)
cyanosis  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased hepatocyte proliferation  (IAGP)
decreased lymphatic vessel endothelial cell number  (IAGP)
decreased survivor rate  (IAGP)
dilated cardiomyopathy  (IAGP)
dilated heart  (IAGP)
edema  (IAGP)
enlarged heart  (IAGP)
hepatic steatosis  (IAGP)
hypoactivity  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating glucagon level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating leptin level  (IAGP)
increased fat cell size  (IAGP)
increased inflammatory response  (IAGP)
increased liver triglyceride level  (IAGP)
increased macrophage cell number  (IAGP)
increased pancreatic acinar cell number  (IAGP)
increased susceptibility to age related obesity  (IAGP)
increased total body fat amount  (IAGP)
increased total fat pad weight  (IAGP)
increased total retina thickness  (IAGP)
interventricular septum membranous part aneurysm  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
respiratory distress  (IAGP)
small liver  (IAGP)
small pancreas  (IAGP)
thick tricuspid valve cusps  (IAGP)
thin myocardium  (IAGP)
References

Additional References at PubMed
PMID:2137249   PMID:7760812   PMID:7821514   PMID:7908825   PMID:8951061   PMID:8995756   PMID:9703987   PMID:9876174   PMID:10080188   PMID:10349636   PMID:10499794   PMID:10603348  
PMID:10631168   PMID:10639171   PMID:10652278   PMID:10677506   PMID:10888866   PMID:11042159   PMID:11069887   PMID:11076861   PMID:11217851   PMID:11493524   PMID:11825874   PMID:11850194  
PMID:11927535   PMID:11983855   PMID:12072567   PMID:12351178   PMID:12426373   PMID:12477932   PMID:12522250   PMID:12692551   PMID:12816048   PMID:12834871   PMID:12853470   PMID:14634646  
PMID:14715945   PMID:14736742   PMID:14736744   PMID:15084498   PMID:15147765   PMID:15163631   PMID:15232737   PMID:15261829   PMID:15322537   PMID:15342729   PMID:15363391   PMID:15381696  
PMID:15465483   PMID:15489334   PMID:15509764   PMID:15580619   PMID:15604100   PMID:15618518   PMID:15739227   PMID:15782199   PMID:15858069   PMID:15882861   PMID:15917450   PMID:15976303  
PMID:16102745   PMID:16122728   PMID:16141072   PMID:16141073   PMID:16170315   PMID:16199865   PMID:16291864   PMID:16446698   PMID:16470382   PMID:16502417   PMID:16538679   PMID:16539717  
PMID:16602821   PMID:16678147   PMID:16818446   PMID:16919269   PMID:17066077   PMID:17075007   PMID:17092954   PMID:17107998   PMID:17117437   PMID:17117441   PMID:17123502   PMID:17287396  
PMID:17299096   PMID:17368742   PMID:17395646   PMID:17410548   PMID:17468181   PMID:17480014   PMID:17493607   PMID:17540175   PMID:17554007   PMID:17576138   PMID:17604700   PMID:17609113  
PMID:17644613   PMID:17823936   PMID:17908929   PMID:17916349   PMID:17936262   PMID:17969168   PMID:18094027   PMID:18094249   PMID:18097475   PMID:18213584   PMID:18287559   PMID:18291358  
PMID:18302773   PMID:18304521   PMID:18367606   PMID:18385072   PMID:18411305   PMID:18424556   PMID:18430230   PMID:18448566   PMID:18455124   PMID:18455718   PMID:18465790   PMID:18502050  
PMID:18514180   PMID:18521945   PMID:18570254   PMID:18579678   PMID:18579736   PMID:18580962   PMID:18588871   PMID:18620078   PMID:18635606   PMID:18652815   PMID:18652817   PMID:18694563  
PMID:18757513   PMID:18778700   PMID:18786638   PMID:18815287   PMID:18816838   PMID:18836739   PMID:18924607   PMID:18931657   PMID:18940586   PMID:18985738   PMID:19007884   PMID:19011097  
PMID:19020026   PMID:19020049   PMID:19022256   PMID:19023449   PMID:19030180   PMID:19033471   PMID:19056883   PMID:19060331   PMID:19088125   PMID:19091769   PMID:19097184   PMID:19103804  
PMID:19233265   PMID:19334279   PMID:19386638   PMID:19398761   PMID:19409883   PMID:19416500   PMID:19515696   PMID:19556507   PMID:19570848   PMID:19619645   PMID:19623612   PMID:19666824  
PMID:19681134   PMID:19686679   PMID:19692620   PMID:19705443   PMID:19743445   PMID:19748502   PMID:19766716   PMID:19825936   PMID:19890917   PMID:19901262   PMID:19906871   PMID:19938109  
PMID:19944164   PMID:20027181   PMID:20027618   PMID:20059953   PMID:20105280   PMID:20110424   PMID:20111592   PMID:20144606   PMID:20152827   PMID:20181838   PMID:20186345   PMID:20194433  
PMID:20215346   PMID:20223757   PMID:20230750   PMID:20237275   PMID:20308569   PMID:20360386   PMID:20364082   PMID:20382171   PMID:20407033   PMID:20427652   PMID:20436479   PMID:20453716  
PMID:20463215   PMID:20512592   PMID:20558617   PMID:20584329   PMID:20610746   PMID:20621054   PMID:20661473   PMID:20713964   PMID:20808958   PMID:20843830   PMID:20932899   PMID:20932939  
PMID:20949055   PMID:20978081   PMID:21040746   PMID:21087508   PMID:21118511   PMID:21146598   PMID:21166921   PMID:21172016   PMID:21181199   PMID:21192082   PMID:21203589   PMID:21233129  
PMID:21267068   PMID:21280160   PMID:21300049   PMID:21375603   PMID:21420948   PMID:21436036   PMID:21436445   PMID:21451052   PMID:21452232   PMID:21472479   PMID:21472480   PMID:21504908  
PMID:21515254   PMID:21536023   PMID:21558380   PMID:21562282   PMID:21601656   PMID:21632926   PMID:21677750   PMID:21705651   PMID:21731503   PMID:21743007   PMID:21778431   PMID:21795542  
PMID:21807945   PMID:21857657   PMID:21873635   PMID:21932312   PMID:21985497   PMID:21991391   PMID:22012621   PMID:22096492   PMID:22157817   PMID:22159122   PMID:22171010   PMID:22173065  
PMID:22174793   PMID:22178591   PMID:22230615   PMID:22232212   PMID:22235033   PMID:22235191   PMID:22240097   PMID:22241837   PMID:22252499   PMID:22258620   PMID:22275127   PMID:22292060  
PMID:22306086   PMID:22354871   PMID:22354878   PMID:22374700   PMID:22378868   PMID:22411557   PMID:22412967   PMID:22491411   PMID:22503753   PMID:22508481   PMID:22526732   PMID:22538088  
PMID:22573682   PMID:22613570   PMID:22622036   PMID:22647876   PMID:22723300   PMID:22753134   PMID:22791897   PMID:22827438   PMID:22855803   PMID:22859612   PMID:22902294   PMID:22923088  
PMID:22975310   PMID:22988430   PMID:23042739   PMID:23056351   PMID:23136392   PMID:23192966   PMID:23223288   PMID:23226461   PMID:23299940   PMID:23341894   PMID:23345230   PMID:23393595  
PMID:23426374   PMID:23426945   PMID:23447624   PMID:23482492   PMID:23483698   PMID:23554936   PMID:23589895   PMID:23595735   PMID:23614009   PMID:23615281   PMID:23652001   PMID:23653198  
PMID:23723244   PMID:23741013   PMID:23761906   PMID:23776487   PMID:23813480   PMID:23828756   PMID:23840823   PMID:23850867   PMID:23863479   PMID:23926259   PMID:23946445   PMID:23946447  
PMID:24019067   PMID:24023676   PMID:24038357   PMID:24038449   PMID:24101523   PMID:24125957   PMID:24133138   PMID:24140542   PMID:24146773   PMID:24155945   PMID:24161570   PMID:24269955  
PMID:24274029   PMID:24292710   PMID:24307298   PMID:24324671   PMID:24361262   PMID:24381169   PMID:24384391   PMID:24391519   PMID:24430181   PMID:24449835   PMID:24463367   PMID:24465223  
PMID:24493818   PMID:24496615   PMID:24503550   PMID:24523456   PMID:24523460   PMID:24530424   PMID:24567373   PMID:24659232   PMID:24690185   PMID:24700724   PMID:24733830   PMID:24764452  
PMID:24767998   PMID:24767999   PMID:24771490   PMID:24827370   PMID:24858485   PMID:24917500   PMID:24938781   PMID:24948604   PMID:24952961   PMID:25057208   PMID:25061877   PMID:25176043  
PMID:25176150   PMID:25182747   PMID:25202984   PMID:25203207   PMID:25228773   PMID:25242330   PMID:25271254   PMID:25271623   PMID:25274728   PMID:25299669   PMID:25302779   PMID:25314967  
PMID:25336627   PMID:25347445   PMID:25378163   PMID:25382630   PMID:25411503   PMID:25411508   PMID:25482882   PMID:25501893   PMID:25529452   PMID:25532873   PMID:25576926   PMID:25737499  
PMID:25745057   PMID:25772358   PMID:25794677   PMID:25814692   PMID:25879659   PMID:25904789   PMID:25915623   PMID:25926459   PMID:25992544   PMID:25993027   PMID:25999820   PMID:26027726  
PMID:26079578   PMID:26138486   PMID:26209882   PMID:26214525   PMID:26319580   PMID:26377473   PMID:26446156   PMID:26457609   PMID:26520399   PMID:26529256   PMID:26542011   PMID:26549461  
PMID:26620267   PMID:26631740   PMID:26657765   PMID:26701169   PMID:26709696   PMID:26764128   PMID:26818521   PMID:26859490   PMID:26953188   PMID:26973883   PMID:26992918   PMID:26999610  
PMID:27010197   PMID:27034423   PMID:27068685   PMID:27105579   PMID:27140400   PMID:27159393   PMID:27214551   PMID:27233452   PMID:27246713   PMID:27313318   PMID:27348588   PMID:27385012  
PMID:27476001   PMID:27518902   PMID:27571008   PMID:27596755   PMID:27597886   PMID:27623309   PMID:27631609   PMID:27633988   PMID:27633990   PMID:27701636   PMID:27731315   PMID:27770010  
PMID:27789626   PMID:27824296   PMID:27880905   PMID:27899284   PMID:27918583   PMID:28024299   PMID:28026853   PMID:28031177   PMID:28049845   PMID:28082864   PMID:28090691   PMID:28118374  
PMID:28129664   PMID:28179430   PMID:28179432   PMID:28218627   PMID:28414797   PMID:28467822   PMID:28506990   PMID:28530642   PMID:28552523   PMID:28560839   PMID:28579317   PMID:28646551  
PMID:28671696   PMID:28686870   PMID:28701711   PMID:28705793   PMID:28763805   PMID:28823936   PMID:28900118   PMID:28916805   PMID:28920924   PMID:28974734   PMID:29025924   PMID:29035278  
PMID:29106382   PMID:29107558   PMID:29229772   PMID:29237738   PMID:29311744   PMID:29358640   PMID:29360039   PMID:29361560   PMID:29371594   PMID:29420689   PMID:29507213   PMID:29513653  
PMID:29569811   PMID:29633855   PMID:29749639   PMID:29768210   PMID:29773646   PMID:29853539   PMID:29877568   PMID:29931031   PMID:29934628   PMID:30006544   PMID:30042182   PMID:30046111  
PMID:30059908   PMID:30084950   PMID:30093671   PMID:30102256   PMID:30115739   PMID:30127719   PMID:30133047   PMID:30154153   PMID:30224810   PMID:30332639   PMID:30352686   PMID:30354217  
PMID:30355615   PMID:30410537   PMID:30429248   PMID:30482854   PMID:30504829   PMID:30582452   PMID:30591517   PMID:30770379   PMID:30787001   PMID:30796881   PMID:30873428   PMID:30886418  
PMID:30894622   PMID:30929925   PMID:31070778   PMID:31083674   PMID:31112709   PMID:31130354   PMID:31276493   PMID:31323030   PMID:31415243   PMID:31461654   PMID:31570121   PMID:31582413  
PMID:31672914   PMID:31702554   PMID:31710307   PMID:31806049   PMID:31808745   PMID:31843520   PMID:31913277   PMID:31980640   PMID:32043969   PMID:32059772   PMID:32112176   PMID:32169553  
PMID:32188632   PMID:32325033   PMID:32366272   PMID:32386572   PMID:32510325   PMID:32515838   PMID:32525258   PMID:32541002   PMID:32594240   PMID:32673288   PMID:32675279   PMID:32840212  
PMID:32857951   PMID:32951265   PMID:32986815   PMID:32994318   PMID:33060128   PMID:33084572   PMID:33087478   PMID:33130914   PMID:33203851   PMID:33298956   PMID:33299187   PMID:33431871  
PMID:33462113   PMID:33605987   PMID:33692421   PMID:33743353  


Genomics

Comparative Map Data
Prox1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391189,850,232 - 189,903,024 (-)NCBIGRCm39mm39
GRCm39 Ensembl1189,850,232 - 189,902,911 (-)Ensembl
GRCm381190,118,035 - 190,170,827 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1190,118,035 - 190,170,714 (-)EnsemblGRCm38mm10GRCm38
MGSCv371191,945,654 - 191,994,559 (-)NCBIGRCm37mm9NCBIm37
MGSCv361191,822,563 - 191,871,468 (-)NCBImm8
Celera1197,032,975 - 197,082,606 (-)NCBICelera
Cytogenetic Map1H6NCBI
cM Map195.85NCBI
PROX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1213,983,181 - 214,041,510 (+)EnsemblGRCh38hg38GRCh38
GRCh381213,983,239 - 214,041,510 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371214,161,316 - 214,214,853 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361212,228,483 - 212,276,389 (+)NCBINCBI36hg18NCBI36
Build 341210,550,254 - 210,598,155NCBI
Celera1187,384,890 - 187,432,754 (+)NCBI
Cytogenetic Map1q32.3NCBI
HuRef1184,835,849 - 184,890,058 (+)NCBIHuRef
CHM1_11215,433,762 - 215,487,303 (+)NCBICHM1_1
Prox1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.213101,669,184 - 101,719,804 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl13108,382,399 - 108,443,294 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.013108,382,536 - 108,444,107 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.013113,004,568 - 113,064,606 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413106,421,541 - 106,471,350 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.113106,611,772 - 106,660,015 (-)NCBI
Celera13101,149,597 - 101,200,064 (-)NCBICelera
Cytogenetic Map13q27NCBI
Prox1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554063,719,972 - 3,770,555 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554063,715,140 - 3,770,019 (-)NCBIChiLan1.0ChiLan1.0
PROX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11194,412,980 - 194,466,170 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1194,412,980 - 194,460,763 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01189,556,124 - 189,609,297 (+)NCBIMhudiblu_PPA_v0panPan3
PROX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1711,996,282 - 12,047,693 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl711,996,703 - 12,044,036 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha711,570,534 - 11,623,681 (+)NCBI
ROS_Cfam_1.0711,705,650 - 11,758,863 (+)NCBI
UMICH_Zoey_3.1711,629,931 - 11,683,010 (+)NCBI
UNSW_CanFamBas_1.0711,734,165 - 11,787,370 (+)NCBI
UU_Cfam_GSD_1.0711,858,013 - 11,911,782 (+)NCBI
Prox1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934462,175,888 - 62,230,044 (-)NCBI
SpeTri2.0NW_0049366284,185,712 - 4,240,680 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PROX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9129,532,164 - 129,580,979 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19129,527,704 - 129,583,693 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29142,424,393 - 142,480,770 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PROX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12515,533,546 - 15,592,834 (-)NCBI
ChlSab1.1 Ensembl2515,538,964 - 15,587,059 (-)Ensembl
Vero_WHO_p1.0NW_02366605516,013,948 - 16,067,368 (-)NCBI
Prox1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477119,188,543 - 19,238,621 (+)NCBI

Position Markers
Prox1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371191,946,805 - 191,947,237UniSTSGRCm37
Celera1197,034,126 - 197,034,558UniSTS
Cytogenetic Map1H6UniSTS
cM Map1106.3UniSTS
cM Map1106.3UniSTS
Prox1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1H6UniSTS
cM Map1106.3UniSTS
Prox1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381190,122,926 - 190,123,358UniSTSGRCm38
MGSCv371191,946,805 - 191,947,237UniSTSGRCm37
Celera1197,034,126 - 197,034,558UniSTS
Cytogenetic Map1H6UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301652Cpfd2_mcerebellum pattern fissures (mouse)Not determined1172571254195471971Mouse
1300948Fglu2_mfasting glucose 2 (mouse)Not determined1157628733191628870Mouse
1301565Mnotch_mmodifier of Notch (mouse)Not determined1157628733191628870Mouse
1301596Elnt_mescape latencies during navigation task (mouse)Not determined1162317638194429220Mouse
1301602Bslm4_mbasal locomotor activity 4 (mouse)Not determined1157628733191628870Mouse
1559024Zit1_mzinc induced tolerance 1 (mouse)Not determined1167730317195471971Mouse
1302158Fembrs5_mfemur breaking strength 5 (mouse)Not determined1167730317195471971Mouse
1558802Skmw6_mskeletal muscle weight 6 (mouse)Not determined1168222387195471971Mouse
1302023Orch4_mautoimmune orchitis resistance 4 (mouse)Not determined1175529010195471971Mouse
1301431Pcho1_mplasma cholesterol 1 (mouse)Not determined1159435007193435127Mouse
1300842Sle9_msystematic lupus erythematosus susceptibility 9 (mouse)Not determined1158641251192641372Mouse
1300888Berr1_mberghei resistance locus 1 (mouse)Not determined1164315658190802075Mouse
1357620Aaj1_manxiety in A/J 1 (mouse)Not determined1181004752192168463Mouse
1357692Axtq1_manxiety QTL 1 (mouse)Not determined1181004752192168463Mouse
4141483Femwf7_mfemur work to failure 7 (mouse)Not determined167730317195471971Mouse
1300727Mptp1_mMPTP sensitivity 1 (mouse)Not determined1171804480192998742Mouse
1300732Melm2_mmelanoma modifier 2 (mouse)Not determined1157628733191628870Mouse
1300745Gvhd1_mgraft-versus-host disease 1 (mouse)Not determined1157628733191628870Mouse
1357732Tbbmd1_mtotal body bone mineral density 1 (mouse)Not determined1172250913195471971Mouse
4141245Cq2_mcholesterol QTL 2 (mouse)Not determined1157628733191628870Mouse
1301339Hdlq15_mHDL QTL 15 (mouse)Not determined1166092111195471971Mouse
1301202Yaa4_mY-linked autoimmune acceleration 4 (mouse)Not determined1158641251192641372Mouse
1301216Cbm1_mcerebellum weight 1 (mouse)Not determined1157628733191628870Mouse
1301251Scc3_mcolon tumor susceptibility 3 (mouse)Not determined1168481626195471971Mouse
1301132Mors1_mmodifier of obesity related sterility 1 (mouse)Not determined1170647303195471971Mouse
1300823Ath9_matherosclerosis 9 (mouse)Not determined1160285202194285317Mouse
1301632Bw8q1_mbody weight at 8 weeks QTL 1 (mouse)Not determined1161373696195373830Mouse
10043863Swrl5_mSWR lupus locus 5 (mouse)Not determined1172571254195471971Mouse
10402498Lmr20_mleishmaniasis resistance 20 (mouse)Not determined1158641251192641372Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1104005680191493284Mouse
12792983Liq1_mlimb inflammation QTL 1 (mouse)1167758517191493284Mouse
11049575Lmr8b_mleishmaniasis resistance 8b (mouse)1172571254195471971Mouse
12880426V25Dq2_mvitamin D inactive form serum level QTL 2 (mouse)1172800000195471971Mouse
11059558Lmr20c_mleishmaniasis resistance 20c (mouse)1158641251192641372Mouse
11532690Sluc37_msusceptibility to lung cancer 37 (mouse)1175641251194429220Mouse
12880429V25Dq1_mvitamin D inactive form serum level QTL 1 (mouse)1172900000195471971Mouse
11059557Lmr20a_mleishmaniasis resistance 20a (mouse)1158641251192641372Mouse
12790987Tgl5_mtriglyceride 5 (mouse)1160269591194269591Mouse
11059556Lmr20b_mleishmaniasis resistance 20b (mouse)1158641251192641372Mouse
12790988Phdlc5_mplasma HDL cholesterol 5 (mouse)9160269591194269591Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2514
Count of miRNA genes:767
Interacting mature miRNAs:1035
Transcripts:ENSMUST00000010319, ENSMUST00000175916, ENSMUST00000177288
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001360827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006497125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006497126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006497127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC026911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC126032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF061576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK038396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK045963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK047685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK050086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000010319   ⟹   ENSMUSP00000010319
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1190,122,453 - 190,169,399 (-)Ensembl
RefSeq Acc Id: ENSMUST00000175916   ⟹   ENSMUSP00000135703
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1190,118,035 - 190,170,714 (-)Ensembl
RefSeq Acc Id: ENSMUST00000177288   ⟹   ENSMUSP00000135066
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1190,123,010 - 190,170,680 (-)Ensembl
RefSeq Acc Id: NM_001360827   ⟹   NP_001347756
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391189,850,232 - 189,901,712 (-)NCBI
GRCm381190,118,035 - 190,169,515 (-)NCBI
Sequence:
RefSeq Acc Id: NM_008937   ⟹   NP_032963
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391189,850,232 - 189,903,024 (-)NCBI
GRCm381190,118,035 - 190,170,827 (-)NCBI
MGSCv371191,945,654 - 191,994,559 (-)RGD
Celera1197,032,975 - 197,082,606 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006497125   ⟹   XP_006497188
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391189,850,232 - 189,901,715 (-)NCBI
GRCm381190,118,035 - 190,169,603 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006497126   ⟹   XP_006497189
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391189,850,232 - 189,902,433 (-)NCBI
GRCm381190,118,035 - 190,170,231 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006497127   ⟹   XP_006497190
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391189,850,232 - 189,903,017 (-)NCBI
GRCm381190,118,035 - 190,170,819 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036162790   ⟹   XP_036018683
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391189,850,232 - 189,903,016 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_032963   ⟸   NM_008937
- UniProtKB: P48437 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006497190   ⟸   XM_006497127
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006497189   ⟸   XM_006497126
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006497188   ⟸   XM_006497125
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001347756   ⟸   NM_001360827
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000135066   ⟸   ENSMUST00000177288
RefSeq Acc Id: ENSMUSP00000010319   ⟸   ENSMUST00000010319
RefSeq Acc Id: ENSMUSP00000135703   ⟸   ENSMUST00000175916
RefSeq Acc Id: XP_036018683   ⟸   XM_036162790
- Peptide Label: isoform X2
Protein Domains
Prospero   Prospero-type homeo

Promoters
RGD ID:6876082
Promoter ID:EPDNEW_M1489
Type:initiation region
Name:Prox1_1
Description:Mus musculus prospero homeobox 1 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381190,170,681 - 190,170,741EPDNEW
RGD ID:6817312
Promoter ID:MM_KWN:3278
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:UC007EBA.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361191,943,086 - 191,945,587 (-)MPROMDB
RGD ID:6818286
Promoter ID:MM_KWN:3279
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:UC007EBC.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361191,992,686 - 191,993,186 (-)MPROMDB
RGD ID:6818285
Promoter ID:MM_KWN:3280
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Liver
Transcripts:ENSMUST00000010319,   NM_008937
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361191,994,201 - 191,994,701 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97772 AgrOrtholog
Ensembl Genes ENSMUSG00000010175 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000010319 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000135066 UniProtKB/Swiss-Prot
  ENSMUSP00000135703 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000010319 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000175916 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000177288 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.500 UniProtKB/Swiss-Prot
InterPro Homeo_prospero_dom UniProtKB/Swiss-Prot
  Homeo_prospero_dom_sf UniProtKB/Swiss-Prot
  Homeobox-like_sf UniProtKB/Swiss-Prot
  Prospero_homeodomain UniProtKB/Swiss-Prot
  Prox1 UniProtKB/Swiss-Prot
KEGG Report mmu:19130 UniProtKB/Swiss-Prot
MGD MGI:97772 ENTREZGENE
NCBI Gene 19130 ENTREZGENE
PANTHER PTHR12198 UniProtKB/Swiss-Prot
  PTHR12198:SF6 UniProtKB/Swiss-Prot
Pfam HPD UniProtKB/Swiss-Prot
PhenoGen Prox1 PhenoGen
PROSITE HOMEO_PROSPERO UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot
UniProt P48437 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O88478 UniProtKB/Swiss-Prot
  Q3UPV1 UniProtKB/Swiss-Prot
  Q543D8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-26 Prox1  prospero homeobox 1    prospero-related homeobox 1  Symbol and/or name change 5135510 APPROVED