Kcnc4 (potassium voltage gated channel, Shaw-related subfamily, member 4) - Rat Genome Database

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Gene: Kcnc4 (potassium voltage gated channel, Shaw-related subfamily, member 4) Mus musculus
Analyze
Symbol: Kcnc4
Name: potassium voltage gated channel, Shaw-related subfamily, member 4
RGD ID: 1616662
MGI Page MGI
Description: Predicted to have delayed rectifier potassium channel activity; voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential; and voltage-gated ion channel activity involved in regulation of presynaptic membrane potential. Involved in regulation of neurotransmitter secretion. Localizes to axon terminus and neuromuscular junction. Predicted to colocalize with synaptic vesicle. Is expressed in nervous system and olfactory epithelium. Orthologous to human KCNC4 (potassium voltage-gated channel subfamily C member 4); INTERACTS WITH 1,2-dimethylhydrazine; 3,4-methylenedioxymethamphetamine; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI850292; Kcr2-; Kcr2-4; KSHIIIC; Kv3.; Kv3.4; potassium voltage-gated channel subfamily C member 4; voltage-gated potassium channel subunit Kv3.4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393107,345,614 - 107,367,617 (-)NCBIGRCm39mm39
GRCm39 Ensembl3107,345,619 - 107,366,868 (-)Ensembl
GRCm383107,438,298 - 107,460,287 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3107,438,303 - 107,459,552 (-)EnsemblGRCm38mm10GRCm38
MGSCv373107,241,221 - 107,261,816 (-)NCBIGRCm37mm9NCBIm37
MGSCv363107,566,359 - 107,586,954 (-)NCBImm8
Celera3109,770,042 - 109,791,022 (-)NCBICelera
Cytogenetic Map3F2.3NCBI
cM Map346.83NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

References

Additional References at PubMed
PMID:1740329   PMID:7905852   PMID:8034307   PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11245975   PMID:12466851   PMID:12477932   PMID:15489334  
PMID:15610163   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16985003   PMID:20692344   PMID:21267068   PMID:21282332   PMID:21677750   PMID:21873635   PMID:25798587   PMID:28228266  
PMID:28390823   PMID:28904001  


Genomics

Comparative Map Data
Kcnc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393107,345,614 - 107,367,617 (-)NCBIGRCm39mm39
GRCm39 Ensembl3107,345,619 - 107,366,868 (-)Ensembl
GRCm383107,438,298 - 107,460,287 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3107,438,303 - 107,459,552 (-)EnsemblGRCm38mm10GRCm38
MGSCv373107,241,221 - 107,261,816 (-)NCBIGRCm37mm9NCBIm37
MGSCv363107,566,359 - 107,586,954 (-)NCBImm8
Celera3109,770,042 - 109,791,022 (-)NCBICelera
Cytogenetic Map3F2.3NCBI
cM Map346.83NCBI
KCNC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1110,211,343 - 110,283,100 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1110,210,314 - 110,283,100 (+)EnsemblGRCh38hg38GRCh38
GRCh381110,210,314 - 110,282,649 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371110,752,936 - 110,776,666 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361110,555,588 - 110,578,189 (+)NCBINCBI36hg18NCBI36
Build 341110,466,018 - 110,478,710NCBI
Celera1109,000,516 - 109,023,855 (+)NCBI
Cytogenetic Map1p13.3NCBI
HuRef1108,625,031 - 108,648,390 (+)NCBIHuRef
CHM1_11110,868,669 - 110,892,012 (+)NCBICHM1_1
Kcnc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22195,063,967 - 195,099,233 (-)NCBI
Rnor_6.0 Ensembl2210,220,908 - 210,241,455 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02210,220,908 - 210,241,447 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02229,694,932 - 229,732,890 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2187,727,839 - 187,748,108 (-)NCBICelera
Cytogenetic Map2q34NCBI
Kcnc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543513,728,708 - 13,750,660 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543513,728,272 - 13,750,420 (+)NCBIChiLan1.0ChiLan1.0
KCNC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11127,457,895 - 127,480,954 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1127,458,968 - 127,480,182 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01112,860,887 - 112,884,687 (+)NCBIMhudiblu_PPA_v0panPan3
KCNC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1641,743,214 - 41,764,572 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl641,738,653 - 41,764,578 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha644,496,309 - 44,541,283 (-)NCBI
ROS_Cfam_1.0642,051,239 - 42,096,226 (-)NCBI
UNSW_CanFamBas_1.0641,742,375 - 41,787,313 (-)NCBI
UU_Cfam_GSD_1.0642,177,396 - 42,222,420 (-)NCBI
Kcnc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505818,424,809 - 18,446,759 (-)NCBI
SpeTri2.0NW_0049367041,667,387 - 1,689,337 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4109,885,116 - 109,908,476 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14109,885,116 - 109,908,518 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24120,280,838 - 120,310,013 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNC4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12023,241,279 - 23,328,175 (-)NCBI
ChlSab1.1 Ensembl2023,304,679 - 23,327,382 (-)Ensembl
Vero_WHO_p1.0NW_02366603835,131,024 - 35,168,004 (+)NCBI
Kcnc4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247725,967,042 - 6,004,647 (+)NCBI

Position Markers
AI850292  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383107,438,624 - 107,438,718UniSTSGRCm38
MGSCv373107,241,542 - 107,241,636UniSTSGRCm37
Celera3109,770,363 - 109,770,457UniSTS
Cytogenetic Map3F2.3UniSTS
Whitehead/MRC_RH31173.6UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33200000142700000Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316000000109800000Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316450000130370000Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328900000119100000Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330013439147599053Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337120713143647422Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)341000000116000000Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352300000137500000Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)368000000128600000Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375555995109556242Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379641414113641521Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381177336115177481Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382239727116239868Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383556675117556821Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383556675117556821Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383556675117556821Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383556675117556821Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383556675117556821Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383556675117556821Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383556675117556821Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383975596117975728Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384981602118981751Mouse
14746984Manh54_mmandible shape 54 (mouse)385381836119381836Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387301597125522587Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387320699121320699Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389232660137747247Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390469620124469756Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390470701124470701Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391092789125101432Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392344217126344334Mouse
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396700000148100000Mouse
10043955Wt10q4_mbody weight, 10 weeks, QTL 4 (mouse)Not determined398830392132830548Mouse
11533920Mvb3_mmodifier of vibrator 3 (mouse)398841635132841734Mouse
12792984Modn1_mmodifier of Dstn neovascularization 1 (mouse)398841635132841734Mouse
1302114Tbs1_mtuberculosis severity 1 (mouse)Not determined399130456133130601Mouse
1300752Ap6q_malcohol preference 6 QTL (mouse)Not determined3100465596147339967Mouse
26884419Bzwq6_mbi-zygomatic width QTL 6, 10 week (mouse)3100700000137500000Mouse
27226733Tibmd6_mtibia midshaft diameter 6, 16 week (mouse)3101400000150100000Mouse
1301805Mors2_mmodifier of obesity related sterility 2 (mouse)Not determined3103689010137689134Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:625
Count of miRNA genes:377
Interacting mature miRNAs:448
Transcripts:ENSMUST00000009617
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000009617   ⟹   ENSMUSP00000009617
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl3107,438,303 - 107,459,552 (-)Ensembl
RefSeq Acc Id: ENSMUST00000238670   ⟹   ENSMUSP00000158751
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl3107,443,307 - 107,459,552 (-)Ensembl
RefSeq Acc Id: NM_001356447   ⟹   NP_001343376
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393107,345,617 - 107,366,214 (-)NCBI
GRCm383107,438,301 - 107,458,898 (-)NCBI
Sequence:
RefSeq Acc Id: NM_145922   ⟹   NP_666034
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393107,345,617 - 107,366,214 (-)NCBI
GRCm383107,438,301 - 107,458,898 (-)NCBI
MGSCv373107,241,221 - 107,261,816 (-)RGD
Celera3109,770,042 - 109,791,022 (-)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006502475   ⟹   XP_006502538
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393107,345,614 - 107,367,617 (-)NCBI
GRCm383107,438,298 - 107,460,287 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_666034   ⟸   NM_145922
- Peptide Label: isoform 2
- UniProtKB: Q8R1C0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006502538   ⟸   XM_006502475
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001343376   ⟸   NM_001356447
- Peptide Label: isoform 1
RefSeq Acc Id: ENSMUSP00000009617   ⟸   ENSMUST00000009617
RefSeq Acc Id: ENSMUSP00000158751   ⟸   ENSMUST00000238670
Protein Domains
BTB   Ion_trans

Promoters
RGD ID:6833992
Promoter ID:MM_KWN:35714
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:NM_145922
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363107,261,606 - 107,262,106 (-)MPROMDB
RGD ID:6882010
Promoter ID:EPDNEW_M4456
Type:initiation region
Name:Kcnc4_1
Description:Mus musculus potassium voltage gated channel, Shaw-related subfamily,member 4 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383107,458,910 - 107,458,970EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96670 AgrOrtholog
Ensembl Genes ENSMUSG00000027895 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000009617 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000158751 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000009617 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000238670 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv3.4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv3_ID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T1-type_BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VG_K_chnl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:99738 UniProtKB/Swiss-Prot
MGD MGI:96670 ENTREZGENE
NCBI Gene 99738 ENTREZGENE
PANTHER PTHR11537 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BTB_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Potassium_chann UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnc4 PhenoGen
PRINTS KV34CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KVCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SHAWCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A571BG98_MOUSE UniProtKB/TrEMBL
  KCNC4_MOUSE UniProtKB/Swiss-Prot
  Q3TZ61_MOUSE UniProtKB/TrEMBL
  Q8R1C0 ENTREZGENE