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Gene: Slc12a5 (solute carrier family 12, member 5) Mus musculus
Symbol: Slc12a5
Name: solute carrier family 12, member 5
Description: Exhibits potassium:chloride symporter activity. Involved in several processes, including growth; learning; and thermosensory behavior. Localizes to the dendritic shaft; neuronal cell body; and plasma membrane. Used to study epilepsy. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 34 and idiopathic generalized epilepsy 14. Is expressed in several structures, including central nervous system and retina. Orthologous to human SLC12A5 (solute carrier family 12 member 5); INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; 5-aza-2'-deoxycytidine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: electroneutral potassium-chloride cotransporter 2; K-Cl cotransporter 2; KCC2; KCC2a variant 1; KCC2a-S25 variant 1; KCC2b variant 2; mKCC2; mKIAA1176; neuronal K-Cl cotransporter; solute carrier family 12 member 5
Homo sapiens (human) : SLC12A5 (solute carrier family 12 member 5)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Slc12a5 (solute carrier family 12 member 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc12a5 (solute carrier family 12 member 5)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC12A5 (solute carrier family 12 member 5)
Canis lupus familiaris (dog) : SLC12A5 (solute carrier family 12 member 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc12a5 (solute carrier family 12 member 5)
Sus scrofa (pig) : SLC12A5 (solute carrier family 12 member 5)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm382164,960,846 - 164,999,731 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372164,793,488 - 164,825,231 (+)NCBIGRCm37mm9NCBIm37
MGSCv362164,659,524 - 164,690,936 (+)NCBImm8
Celera2170,905,292 - 170,937,000 (+)NCBICelera
Cytogenetic Map2 H3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Slc12a5
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731045
Created: 2003-12-10
Species: Mus musculus
Last Modified: 2019-10-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.