Htra2 (HtrA serine peptidase 2) - Rat Genome Database
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Gene: Htra2 (HtrA serine peptidase 2) Mus musculus
Analyze
Symbol: Htra2
Name: HtrA serine peptidase 2
RGD ID: 1318944
MGI Page MGI
Description: Is expressed in several structures, including gut; nervous system; reproductive system; thymus; and trachea. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 8; Parkinson's disease; and motor neuron disease. Orthologous to human HTRA2 (HtrA serine peptidase 2); PARTICIPATES IN intrinsic apoptotic pathway; Parkinson's disease pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; amiodarone.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI481710; high temperature requirement protein A2; Htr; mnd; mnd2; motor neuron degeneration 2; O; Omi; omi stress-regulated endoprotease; Pr; protease, serine, 25; Prss25; serine protease 25; serine protease HTRA2, mitochondrial; serine protease OMI; serine proteinase OMI
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,028,247 - 83,031,552 (-)NCBIGRCm39mm39
GRCm39 Ensembl683,028,247 - 83,032,254 (-)Ensembl
GRCm38683,051,266 - 83,054,571 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,051,266 - 83,055,273 (-)EnsemblGRCm38mm10GRCm38
MGSCv37683,001,260 - 83,004,565 (-)NCBIGRCm37mm9NCBIm37
MGSCv36683,016,940 - 83,020,229 (-)NCBImm8
Celera685,033,853 - 85,037,160 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-deoxy-D-glucose  (ISO)
3-phenylprop-2-enal  (ISO)
acrolein  (ISO)
alpha-pinene  (ISO)
alvocidib  (ISO)
amiodarone  (EXP)
antirheumatic drug  (ISO)
apocynin  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (ISO)
crocidolite asbestos  (EXP)
cyclosporin A  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dinophysistoxin 1  (ISO)
doxorubicin  (ISO)
ethanol  (EXP,ISO)
flutamide  (ISO)
folic acid  (EXP)
gentamycin  (ISO)
hydrogen peroxide  (ISO)
isoprenaline  (EXP)
LGK974  (ISO)
lonidamine  (ISO)
methotrexate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
okadaic acid  (ISO)
oxidopamine  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctanoic acid  (ISO)
phlorizin  (EXP)
potassium chromate  (ISO)
quartz  (ISO)
quercetin  (ISO)
resveratrol  (EXP)
rotenone  (ISO)
S-nitrosoglutathione  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
Soman  (ISO)
testosterone  (ISO)
theophylline  (ISO)
toluene  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal action potential  (IAGP)
abnormal astrocyte morphology  (IAGP)
abnormal basal ganglion morphology  (IAGP)
abnormal behavior  (IAGP)
abnormal bone marrow cell morphology/development  (IAGP)
abnormal brain morphology  (IAGP)
abnormal cerebellar granule cell morphology  (IAGP)
abnormal gait  (IAGP)
abnormal immune system morphology  (IAGP)
abnormal interleukin level  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal mitochondrial crista morphology  (IAGP)
abnormal mitochondrial inner membrane morphology  (IAGP)
abnormal mitochondrial morphology  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal respiratory electron transport chain  (IAGP)
abnormal spinal cord morphology  (IAGP)
abnormal stationary movement  (IAGP)
abnormal thymus morphology  (IAGP)
abnormal tumor necrosis factor level  (IAGP)
akinesia  (IAGP)
ataxia  (IAGP)
bradykinesia  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased brain size  (IAGP)
decreased brain weight  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased grip strength  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased pre-B cell number  (IAGP)
decreased pro-B cell number  (IAGP)
decreased single-positive T cell number  (IAGP)
decreased total body fat amount  (IAGP)
dilated mitochondria  (IAGP)
dystonia  (IAGP)
dystrophic muscle  (IAGP)
gliosis  (IAGP)
hunched posture  (IAGP)
hypoactivity  (IAGP)
impaired balance  (IAGP)
impaired coordination  (IAGP)
increased apoptosis  (IAGP)
increased brain apoptosis  (IAGP)
increased stereotypic behavior  (IAGP)
increased susceptibility to neuronal excitotoxicity  (IAGP)
lethargy  (IAGP)
limb grasping  (IAGP)
loss of basal ganglia neurons  (IAGP)
motor neuron degeneration  (IAGP)
muscle spasm  (IAGP)
muscle weakness  (IAGP)
muscular atrophy  (IAGP)
neurodegeneration  (IAGP)
no spontaneous movement  (IAGP)
paralysis  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
seizures  (IAGP)
small heart  (IAGP)
small spleen  (IAGP)
small thymus  (IAGP)
sparse hair  (IAGP)
spleen atrophy  (IAGP)
thymus atrophy  (IAGP)
tremors  (IAGP)
References

References - curated
1. Althaus J, etal., Neurochem Int. 2007 Jan;50(1):172-80. Epub 2006 Sep 15.
2. Bogaerts V, etal., Hum Mutat. 2008 Jun;29(6):832-40.
3. Hayashi T, etal., Int J Urol. 2006 Feb;13(2):157-64.
4. Hu XY, etal., APMIS. 2006 Dec;114(12):893-8.
5. Hu Y, etal., Int Immunopharmacol. 2013 May;16(1):108-13. doi: 10.1016/j.intimp.2013.03.019. Epub 2013 Apr 2.
6. Hua B, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2010 Aug;12(8):658-61.
7. Inagaki R, etal., Eur J Neurosci. 2008 Jul;28(1):30-40.
8. Jones JM, etal., Nature. 2003 Oct 16;425(6959):721-7. Epub 2003 Oct 8.
9. Kang S, etal., Cell Death Differ. 2013 Feb;20(2):259-69. doi: 10.1038/cdd.2012.117. Epub 2012 Sep 14.
10. Lee SH, etal., APMIS. 2003 May;111(5):586-90.
11. Lin CH, etal., Hum Genet. 2011 Dec;130(6):817-27. Epub 2011 Jun 24.
12. Liu HR, etal., Circulation. 2005 Jan 4;111(1):90-6. Epub 2004 Dec 20.
13. Martins LM, etal., Mol Cell Biol. 2004 Nov;24(22):9848-62.
14. MGD data from the GO Consortium
15. MGD IEA
16. Narkiewicz J, etal., Clin Biochem. 2008 May;41(7-8):561-9. Epub 2008 Jan 16.
17. Narkiewicz J, etal., Oncol Rep. 2009 Jun;21(6):1529-37.
18. OMIM Disease Annotation Pipeline
19. Pipeline to import KEGG annotations from KEGG into RGD
20. Rami A, etal., Neurochem Res. 2010 Dec;35(12):2199-207. Epub 2010 Dec 4.
21. RGD automated import pipeline
22. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. RGD automated import pipeline for gene-chemical interactions
24. Saito A, etal., Brain Res Mol Brain Res. 2004 Aug 23;127(1-2):89-95.
25. Simon-Sanchez J and Singleton AB, Hum Mol Genet. 2008 Jul 1;17(13):1988-93. Epub 2008 Mar 25.
26. Strauss KM, etal., Hum Mol Genet. 2005 Aug 1;14(15):2099-111. Epub 2005 Jun 16.
27. Su D, etal., Anat Rec (Hoboken). 2009 Jun;292(6):854-61. doi: 10.1002/ar.20910.
28. Wang CY, etal., Brain Res. 2011 Apr 18;1385:293-7. Epub 2011 Feb 19.
29. Westerlund M, etal., FASEB J. 2011 Apr;25(4):1345-52. Epub 2010 Dec 16.
Additional References at PubMed
PMID:7774940   PMID:7987303   PMID:8188273   PMID:8325640   PMID:8889548   PMID:9070275   PMID:9073523   PMID:9806835   PMID:9927484   PMID:10051670   PMID:10349636   PMID:10922068  
PMID:10971580   PMID:11007969   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11287196   PMID:11602612   PMID:11604410   PMID:11803371   PMID:12009762   PMID:12466851   PMID:12477932  
PMID:12815069   PMID:14610273   PMID:14651853   PMID:15044455   PMID:15574596   PMID:15782199   PMID:16081829   PMID:16141072   PMID:16141073   PMID:16461771   PMID:17684015   PMID:17707776  
PMID:18259191   PMID:18288109   PMID:18479146   PMID:18614015   PMID:18772386   PMID:18799693   PMID:19023330   PMID:19435805   PMID:19443712   PMID:19631192   PMID:20064504   PMID:20123086  
PMID:20219823   PMID:20368287   PMID:20467442   PMID:20614026   PMID:20705111   PMID:20926611   PMID:20971077   PMID:21701498   PMID:22057932   PMID:22535253   PMID:22739987   PMID:22912494  
PMID:23479728   PMID:23542127   PMID:23921894   PMID:24090154   PMID:24194600   PMID:24606398   PMID:24662565   PMID:24709290   PMID:25056906   PMID:25094062   PMID:25118933   PMID:25531304  
PMID:26238290   PMID:26299953   PMID:26340347   PMID:26604148   PMID:27626380   PMID:27924873   PMID:27998213   PMID:28008946   PMID:29855523   PMID:31543347   PMID:31547195   PMID:31627188  
PMID:32048867   PMID:32210343   PMID:32325033   PMID:33229071  


Genomics

Comparative Map Data
Htra2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,028,247 - 83,031,552 (-)NCBIGRCm39mm39
GRCm39 Ensembl683,028,247 - 83,032,254 (-)Ensembl
GRCm38683,051,266 - 83,054,571 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,051,266 - 83,055,273 (-)EnsemblGRCm38mm10GRCm38
MGSCv37683,001,260 - 83,004,565 (-)NCBIGRCm37mm9NCBIm37
MGSCv36683,016,940 - 83,020,229 (-)NCBImm8
Celera685,033,853 - 85,037,160 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
HTRA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl274,529,725 - 74,533,332 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl274,529,377 - 74,533,348 (+)EnsemblGRCh38hg38GRCh38
GRCh38274,529,405 - 74,533,556 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37274,756,532 - 74,760,683 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36274,610,040 - 74,614,191 (+)NCBINCBI36hg18NCBI36
Build 34274,668,186 - 74,672,098NCBI
Celera274,587,640 - 74,591,791 (+)NCBI
Cytogenetic Map2p13.1NCBI
HuRef274,492,793 - 74,496,944 (+)NCBIHuRef
CHM1_1274,685,928 - 74,690,079 (+)NCBICHM1_1
Htra2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24115,556,914 - 115,560,202 (-)NCBI
Rnor_6.0 Ensembl4113,883,670 - 113,886,994 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04113,883,671 - 113,886,833 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04178,568,771 - 178,571,933 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,262,206 - 117,265,368 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14117,506,685 - 117,509,829 (-)NCBI
Celera4104,551,592 - 104,554,754 (-)NCBICelera
Cytogenetic Map4q34NCBI
Htra2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542411,255,756 - 11,259,170 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542411,255,756 - 11,259,170 (-)NCBIChiLan1.0ChiLan1.0
HTRA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A76,102,240 - 76,106,169 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A76,102,240 - 76,106,152 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A74,596,020 - 74,599,790 (+)NCBIMhudiblu_PPA_v0panPan3
HTRA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1748,610,408 - 48,613,399 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11748,610,408 - 48,613,399 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Htra2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936556741,718 - 746,016 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HTRA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl368,516,500 - 68,519,886 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1368,516,666 - 68,520,025 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2371,688,452 - 71,690,709 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HTRA2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11432,745,436 - 32,749,176 (-)NCBI
ChlSab1.1 Ensembl1432,743,708 - 32,748,577 (-)Ensembl
Htra2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474928,980,375 - 28,983,719 (-)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64531405987426034Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65117915085179300Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7132262186275719Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67710000090000000Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1497
Count of miRNA genes:467
Interacting mature miRNAs:541
Transcripts:ENSMUST00000089645, ENSMUST00000113962, ENSMUST00000113963, ENSMUST00000122955, ENSMUST00000132099, ENSMUST00000134606, ENSMUST00000144058, ENSMUST00000150217, ENSMUST00000154829
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC104324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC134899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF164513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF175324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK176936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC033276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC049880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM899329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000089645   ⟹   ENSMUSP00000087073
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,051,266 - 83,054,571 (-)Ensembl
RefSeq Acc Id: ENSMUST00000113962   ⟹   ENSMUSP00000109595
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,051,266 - 83,054,442 (-)Ensembl
RefSeq Acc Id: ENSMUST00000113963   ⟹   ENSMUSP00000109596
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,051,266 - 83,054,571 (-)Ensembl
RefSeq Acc Id: ENSMUST00000122955   ⟹   ENSMUSP00000138153
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,051,280 - 83,054,571 (-)Ensembl
RefSeq Acc Id: ENSMUST00000132099   ⟹   ENSMUSP00000138148
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,051,387 - 83,053,686 (-)Ensembl
RefSeq Acc Id: ENSMUST00000134606   ⟹   ENSMUSP00000115547
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,051,477 - 83,053,837 (-)Ensembl
RefSeq Acc Id: ENSMUST00000144058
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,051,486 - 83,053,837 (-)Ensembl
RefSeq Acc Id: ENSMUST00000150217   ⟹   ENSMUSP00000118234
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,051,749 - 83,054,037 (-)Ensembl
RefSeq Acc Id: ENSMUST00000154829
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,051,284 - 83,055,273 (-)Ensembl
RefSeq Acc Id: ENSMUST00000203339
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,053,147 - 83,053,885 (-)Ensembl
RefSeq Acc Id: ENSMUST00000204281
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,053,038 - 83,055,165 (-)Ensembl
RefSeq Acc Id: NM_019752   ⟹   NP_062726
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39683,028,247 - 83,031,552 (-)NCBI
GRCm38683,051,266 - 83,054,571 (-)ENTREZGENE
MGSCv37683,001,260 - 83,004,565 (-)RGD
Celera685,033,853 - 85,037,160 (-)RGD
cM Map6 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_062726   ⟸   NM_019752
- UniProtKB: Q9JIY5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000118234   ⟸   ENSMUST00000150217
RefSeq Acc Id: ENSMUSP00000109595   ⟸   ENSMUST00000113962
RefSeq Acc Id: ENSMUSP00000109596   ⟸   ENSMUST00000113963
RefSeq Acc Id: ENSMUSP00000138148   ⟸   ENSMUST00000132099
RefSeq Acc Id: ENSMUSP00000087073   ⟸   ENSMUST00000089645
RefSeq Acc Id: ENSMUSP00000115547   ⟸   ENSMUST00000134606
RefSeq Acc Id: ENSMUSP00000138153   ⟸   ENSMUST00000122955
Protein Domains
PDZ

Promoters
RGD ID:6848001
Promoter ID:MM_ACW:41726
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:MEF_B4
Transcripts:HTRA2.LSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36683,001,221 - 83,001,721 (-)MPROMDB
RGD ID:6839470
Promoter ID:MM_KWN:46562
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Liver,   Lung,   MEF_B6,   Spleen
Transcripts:ENSMUST00000113962,   ENSMUST00000113963,   OTTMUST00000053814,   OTTMUST00000053816,   OTTMUST00000053818,   OTTMUST00000053821,   OTTMUST00000053822,   UC009CLV.1,   UC009CLW.1,   UC009CLX.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36683,003,381 - 83,005,842 (-)MPROMDB
RGD ID:6890114
Promoter ID:EPDNEW_M8507
Type:initiation region
Name:Htra2_2
Description:Mus musculus HtrA serine peptidase 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8508  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38683,053,768 - 83,053,828EPDNEW
RGD ID:6890116
Promoter ID:EPDNEW_M8508
Type:initiation region
Name:Htra2_1
Description:Mus musculus HtrA serine peptidase 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8507  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38683,054,390 - 83,054,450EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1928676 AgrOrtholog
Ensembl Genes ENSMUSG00000068329 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000087073 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000109595 UniProtKB/TrEMBL
  ENSMUSP00000109596 UniProtKB/TrEMBL
  ENSMUSP00000115547 UniProtKB/TrEMBL
  ENSMUSP00000118234 UniProtKB/TrEMBL
  ENSMUSP00000138148 UniProtKB/TrEMBL
  ENSMUSP00000138153 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000089645 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000113962 UniProtKB/TrEMBL
  ENSMUST00000113963 UniProtKB/TrEMBL
  ENSMUST00000122955 UniProtKB/TrEMBL
  ENSMUST00000132099 UniProtKB/TrEMBL
  ENSMUST00000134606 UniProtKB/TrEMBL
  ENSMUST00000150217 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.10.10 UniProtKB/TrEMBL
InterPro PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:64704 UniProtKB/Swiss-Prot
MGD MGI:1928676 ENTREZGENE
NCBI Gene 64704 ENTREZGENE
Pfam PDZ_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Htra2 PhenoGen
PRINTS PROTEASES2C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3YX27_MOUSE UniProtKB/TrEMBL
  D3YX28_MOUSE UniProtKB/TrEMBL
  F6TCV0_MOUSE UniProtKB/TrEMBL
  F6XUR8_MOUSE UniProtKB/TrEMBL
  HTRA2_MOUSE UniProtKB/Swiss-Prot
  Q3TXN0_MOUSE UniProtKB/TrEMBL
  Q3UJR3_MOUSE UniProtKB/TrEMBL
  Q80V84_MOUSE UniProtKB/TrEMBL
  Q9JIY5 ENTREZGENE
  S4R1A8_MOUSE UniProtKB/TrEMBL
  S4R1B3_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q9R108 UniProtKB/Swiss-Prot