Ccr8 (chemokine (C-C motif) receptor 8) - Rat Genome Database
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Gene: Ccr8 (chemokine (C-C motif) receptor 8) Mus musculus
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Symbol: Ccr8
Name: chemokine (C-C motif) receptor 8
RGD ID: 1312593
MGI Page MGI
Description: Exhibits C-C chemokine receptor activity. Involved in chemotaxis. Predicted to localize to external side of plasma membrane. Is expressed in central nervous system; retina; and thymus primordium. Orthologous to human CCR8 (C-C motif chemokine receptor 8); INTERACTS WITH (+)-pilocarpine; 1,2-dichloroethane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C-C; C-C chemokine receptor type 8; C-C CKR-8; C-C motif chemokine receptor 8; CC-CKR-8; CCR-8; chemokine (C-C) receptor 8; CKR-8; Cmkbr; Cmkbr8; mCCR8; MGC123958; MGC123959
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,921,199 - 119,923,972 (+)NCBIGRCm39mm39
GRCm389120,092,133 - 120,094,906 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9120,092,114 - 120,094,906 (+)EnsemblGRCm38mm10GRCm38
MGSCv379120,001,251 - 120,004,024 (+)NCBIGRCm37mm9NCBIm37
MGSCv369119,940,831 - 119,943,604 (+)NCBImm8
Celera9120,561,813 - 120,564,500 (+)NCBICelera
Cytogenetic Map9F4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:9469461   PMID:9670926   PMID:11238588   PMID:12050188   PMID:12471141   PMID:12477932   PMID:12496446   PMID:12574386   PMID:14736884   PMID:15534368   PMID:15699124   PMID:16129397  
PMID:16239514   PMID:16384913   PMID:16517726   PMID:16602821   PMID:17023422   PMID:17082609   PMID:17321573   PMID:17404314   PMID:17641040   PMID:17850582   PMID:17947648   PMID:19062085  
PMID:21217759   PMID:21267068   PMID:21873635   PMID:22031018   PMID:22479563   PMID:22729248   PMID:23747724   PMID:23798714   PMID:23999500   PMID:24477914   PMID:24714157   PMID:25264308  
PMID:25344933   PMID:26750312   PMID:27160938   PMID:27760760   PMID:28533380   PMID:30024927   PMID:30170811   PMID:31121182   PMID:31270368   PMID:31537642   PMID:32111837  


Genomics

Comparative Map Data
Ccr8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,921,199 - 119,923,972 (+)NCBIGRCm39mm39
GRCm389120,092,133 - 120,094,906 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9120,092,114 - 120,094,906 (+)EnsemblGRCm38mm10GRCm38
MGSCv379120,001,251 - 120,004,024 (+)NCBIGRCm37mm9NCBIm37
MGSCv369119,940,831 - 119,943,604 (+)NCBImm8
Celera9120,561,813 - 120,564,500 (+)NCBICelera
Cytogenetic Map9F4NCBI
CCR8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl339,329,709 - 39,333,680 (+)EnsemblGRCh38hg38GRCh38
GRCh38339,329,709 - 39,333,680 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37339,371,197 - 39,375,171 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36339,346,219 - 39,351,077 (+)NCBINCBI36hg18NCBI36
Build 34339,346,218 - 39,351,077NCBI
Celera339,312,784 - 39,316,758 (+)NCBI
Cytogenetic Map3p22.1NCBI
HuRef339,414,545 - 39,418,520 (+)NCBIHuRef
CHM1_1339,322,282 - 39,326,257 (+)NCBICHM1_1
Ccr8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08128,779,552 - 128,782,531 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,781,395 - 128,782,456 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,980,462 - 127,983,445 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48125,075,457 - 125,076,518 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18125,095,193 - 125,096,255 (+)NCBI
Celera8118,970,968 - 118,973,947 (+)NCBICelera
Cytogenetic Map8q32NCBI
Ccr8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542724,644,479 - 24,691,132 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542724,646,358 - 24,690,580 (-)NCBIChiLan1.0ChiLan1.0
CCR8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1339,513,153 - 39,517,077 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0339,232,185 - 39,236,157 (+)NCBIMhudiblu_PPA_v0panPan3
CCR8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl239,018,060 - 9,018,589 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1239,013,242 - 9,019,513 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ccr8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647328,590,471 - 28,591,538 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCR8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1324,009,762 - 24,015,037 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11323,994,097 - 24,014,849 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21326,225,651 - 26,275,438 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCR8
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11583,215 - 87,282 (-)NCBI
ChlSab1.1 Ensembl1583,495 - 84,562 (-)Ensembl
Ccr8
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247311,634,460 - 1,635,629 (-)NCBI

Position Markers
UniSTS:489042  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389120,093,807 - 120,094,906UniSTSGRCm38
MGSCv379120,002,925 - 120,004,024UniSTSGRCm37
Celera9120,563,491 - 120,564,500UniSTS
Cytogenetic Map9F4UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:219
Count of miRNA genes:195
Interacting mature miRNAs:211
Transcripts:ENSMUST00000048777
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000048777   ⟹   ENSMUSP00000038473
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9120,092,114 - 120,094,906 (+)Ensembl
RefSeq Acc Id: NM_007720   ⟹   NP_031746
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,921,199 - 119,923,972 (+)NCBI
GRCm389120,092,133 - 120,094,906 (+)ENTREZGENE
MGSCv379120,001,251 - 120,004,024 (+)RGD
Celera9120,561,813 - 120,564,500 (+)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_031746   ⟸   NM_007720
- UniProtKB: P56484 (UniProtKB/Swiss-Prot),   Q3ZB17 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000038473   ⟸   ENSMUST00000048777
Protein Domains
G_PROTEIN_RECEP_F1_2

Promoters
RGD ID:8671218
Promoter ID:EPDNEW_M13640
Type:multiple initiation site
Name:Ccr8_1
Description:Mus musculus chemokine (C-C motif) receptor 8 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389120,092,114 - 120,092,174EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1201402 AgrOrtholog
Ensembl Genes ENSMUSG00000042262 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000038473 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000048777 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Chemokine_CCR8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12776 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1201402 ENTREZGENE
NCBI Gene 12776 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ccr8 PhenoGen
PRINTS CCCHEMOKINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CHEMOKINER8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CCR8_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3ZB17 ENTREZGENE, UniProtKB/TrEMBL