Ccr8 (C-C motif chemokine receptor 8) - Rat Genome Database

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Gene: Ccr8 (C-C motif chemokine receptor 8) Mus musculus
Analyze
Symbol: Ccr8
Name: C-C motif chemokine receptor 8 (Ensembl:chemokine (C-C motif) receptor 8)
RGD ID: 1312593
MGI Page MGI
Description: Enables C-C chemokine receptor activity. Acts upstream of or within chemotaxis. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Is expressed in central nervous system; retina; and thymus primordium. Orthologous to human CCR8 (C-C motif chemokine receptor 8).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-C; C-C chemokine receptor type 8; C-C CKR-8; CC-CKR-8; CCR-8; chemokine (C-C motif) receptor 8; chemokine (C-C) receptor 8; CKR-8; Cmkbr; Cmkbr8; mCCR8; MGC123958; MGC123959
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,921,199 - 119,923,972 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9119,921,180 - 119,923,972 (+)EnsemblGRCm39 Ensembl
GRCm389120,092,133 - 120,094,906 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9120,092,114 - 120,094,906 (+)EnsemblGRCm38mm10GRCm38
MGSCv379120,001,251 - 120,004,024 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369119,940,831 - 119,943,604 (+)NCBIMGSCv36mm8
Celera9120,561,813 - 120,564,500 (+)NCBICelera
Cytogenetic Map9F4NCBI
cM Map971.39NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. MGD IEA MGD IEA
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Elevated expression of TARC (CCL17) and MDC (CCL22) in models of cigarette smoke-induced pulmonary inflammation. Ritter M, etal., Biochem Biophys Res Commun. 2005 Aug 19;334(1):254-62.
Additional References at PubMed
PMID:9469461   PMID:9670926   PMID:11238588   PMID:12050188   PMID:12471141   PMID:12477932   PMID:12496446   PMID:12574386   PMID:14736884   PMID:15534368   PMID:15699124   PMID:16129397  
PMID:16239514   PMID:16384913   PMID:16517726   PMID:16602821   PMID:17023422   PMID:17082609   PMID:17321573   PMID:17404314   PMID:17641040   PMID:17850582   PMID:17947648   PMID:19062085  
PMID:21217759   PMID:21267068   PMID:21873635   PMID:22031018   PMID:22479563   PMID:22729248   PMID:23747724   PMID:23798714   PMID:23999500   PMID:24477914   PMID:24714157   PMID:25264308  
PMID:25344933   PMID:26750312   PMID:27160938   PMID:27760760   PMID:28533380   PMID:30024927   PMID:30170811   PMID:31121182   PMID:31270368   PMID:31537642   PMID:32111837   PMID:33613532  
PMID:33900818   PMID:34253059   PMID:34391459   PMID:34407391   PMID:35140181   PMID:37921466  


Genomics

Comparative Map Data
Ccr8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,921,199 - 119,923,972 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9119,921,180 - 119,923,972 (+)EnsemblGRCm39 Ensembl
GRCm389120,092,133 - 120,094,906 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9120,092,114 - 120,094,906 (+)EnsemblGRCm38mm10GRCm38
MGSCv379120,001,251 - 120,004,024 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369119,940,831 - 119,943,604 (+)NCBIMGSCv36mm8
Celera9120,561,813 - 120,564,500 (+)NCBICelera
Cytogenetic Map9F4NCBI
cM Map971.39NCBI
CCR8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38339,329,709 - 39,333,680 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl339,329,709 - 39,333,680 (+)EnsemblGRCh38hg38GRCh38
GRCh37339,371,200 - 39,375,171 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36339,346,219 - 39,351,077 (+)NCBINCBI36Build 36hg18NCBI36
Build 34339,346,218 - 39,351,077NCBI
Celera339,312,784 - 39,316,758 (+)NCBICelera
Cytogenetic Map3p22.1NCBI
HuRef339,414,545 - 39,418,520 (+)NCBIHuRef
CHM1_1339,322,282 - 39,326,257 (+)NCBICHM1_1
T2T-CHM13v2.0339,342,606 - 39,346,577 (+)NCBIT2T-CHM13v2.0
Ccr8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88128,703,966 - 128,705,926 (+)NCBIGRCr8
mRatBN7.28119,826,332 - 119,828,292 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8119,826,568 - 119,827,629 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.08128,779,552 - 128,782,531 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,781,395 - 128,782,456 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,980,462 - 127,983,445 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48125,075,457 - 125,076,518 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18125,095,193 - 125,096,255 (+)NCBI
Celera8118,970,968 - 118,973,947 (+)NCBICelera
Cytogenetic Map8q32NCBI
Ccr8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542724,644,479 - 24,691,132 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542724,646,358 - 24,690,580 (-)NCBIChiLan1.0ChiLan1.0
CCR8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2239,287,566 - 39,291,535 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1339,292,328 - 39,296,297 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0339,232,185 - 39,236,157 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1339,513,153 - 39,517,077 (+)NCBIpanpan1.1PanPan1.1panPan2
CCR8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1239,013,242 - 9,019,513 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl239,018,060 - 9,018,589 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha239,049,245 - 9,054,989 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0239,298,398 - 9,304,140 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl239,302,701 - 9,303,230 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1239,111,800 - 9,117,552 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0239,254,429 - 9,260,168 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0239,248,048 - 9,253,796 (+)NCBIUU_Cfam_GSD_1.0
Ccr8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118195,451,898 - 195,452,965 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647328,590,471 - 28,591,538 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647328,590,471 - 28,591,538 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCR8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1324,012,708 - 24,013,775 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11323,994,097 - 24,014,849 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21326,225,651 - 26,275,438 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCR8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11583,215 - 87,282 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1583,495 - 84,562 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660638,808,510 - 8,809,787 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccr8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247311,634,562 - 1,635,629 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247311,634,460 - 1,635,629 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ccr8
99 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:219
Count of miRNA genes:195
Interacting mature miRNAs:211
Transcripts:ENSMUST00000048777
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63239711120191934Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63239711120191934Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963239711120191934Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986107600120107729Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986121898120118690Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986625682120625682Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987677199121677199Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989162124123162124Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989289476123289595Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989440541123440541Mouse
12910770Splic1_mspleen iron content 1 (mouse)991291078124359700Mouse
12910772Lvic6_mliver iron content 6 (mouse)991291078124359700Mouse
12910773Splic3_mspleen iron content 3 (mouse)991291078124359700Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991518283124359700Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991518283124359700Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991518283124359700Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991518283124359700Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991518283124359700Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991518283124359700Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991560372124359700Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991560372124359700Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991560372124359700Mouse
1301484Bwq6_mbody weight (mouse)Not determined993591658124359700Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993591658124359700Mouse
14746992Manh67_mmandible shape 67 (mouse)993865836124359700Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996746658124359700Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9100889929124359700Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9101829255124359700Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9101829255124359700Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103118511124359700Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103118511124359700Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103118511124359700Mouse

Markers in Region
UniSTS:489042  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389120,093,807 - 120,094,906UniSTSGRCm38
MGSCv379120,002,925 - 120,004,024UniSTSGRCm37
Celera9120,563,491 - 120,564,500UniSTS
Cytogenetic Map9F4UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000048777   ⟹   ENSMUSP00000038473
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9119,921,180 - 119,923,972 (+)Ensembl
GRCm38.p6 Ensembl9120,092,114 - 120,094,906 (+)Ensembl
RefSeq Acc Id: NM_007720   ⟹   NP_031746
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399119,921,199 - 119,923,972 (+)NCBI
GRCm389120,092,133 - 120,094,906 (+)ENTREZGENE
MGSCv379120,001,251 - 120,004,024 (+)RGD
Celera9120,561,813 - 120,564,500 (+)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_031746   ⟸   NM_007720
- UniProtKB: P56484 (UniProtKB/Swiss-Prot),   Q3ZB17 (UniProtKB/TrEMBL),   Q27VK4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000038473   ⟸   ENSMUST00000048777
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P56484-F1-model_v2 AlphaFold P56484 1-353 view protein structure

Promoters
RGD ID:8671218
Promoter ID:EPDNEW_M13640
Type:multiple initiation site
Name:Ccr8_1
Description:Mus musculus chemokine (C-C motif) receptor 8 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389120,092,114 - 120,092,174EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1201402 AgrOrtholog
Ensembl Genes ENSMUSG00000042262 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000048777 ENTREZGENE
  ENSMUST00000048777.4 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Chemokine_CCR8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12776 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1201402 ENTREZGENE
NCBI Gene 12776 ENTREZGENE
PANTHER C-C CHEMOKINE RECEPTOR TYPE 8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CELL ADHESION MOLECULE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ccr8 PhenoGen
PRINTS CCCHEMOKINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CHEMOKINER8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CCR8_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q27VK4 ENTREZGENE, UniProtKB/TrEMBL
  Q3ZB17 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-07-04 Ccr8  C-C motif chemokine receptor 8  Ccr8  chemokine (C-C motif) receptor 8  Symbol and/or name change 5135510 APPROVED