Xrn2 (5'-3' exoribonuclease 2) - Rat Genome Database

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Gene: Xrn2 (5'-3' exoribonuclease 2) Mus musculus
Analyze
Symbol: Xrn2
Name: 5'-3' exoribonuclease 2
RGD ID: 1320992
MGI Page MGI
Description: Predicted to enable RNA exonuclease activity, producing 5'-phosphomonoesters; identical protein binding activity; and nucleic acid binding activity. Involved in RNA metabolic process and spermatogenesis. Predicted to be located in aggresome; nucleolus; and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in adenoid cystic carcinoma and lung cancer. Orthologous to human XRN2 (5'-3' exoribonuclease 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: protein Dhm1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392146,854,672 - 146,919,922 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2146,854,916 - 146,919,920 (+)EnsemblGRCm39 Ensembl
GRCm382147,012,755 - 147,078,000 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2147,012,996 - 147,078,000 (+)EnsemblGRCm38mm10GRCm38
MGSCv372146,838,796 - 146,903,736 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362146,704,563 - 146,766,521 (+)NCBIMGSCv36mm8
Celera2148,268,335 - 148,333,354 (+)NCBICelera
Cytogenetic Map2G2NCBI
cM Map272.63NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
aggresome  (IEA,ISO)
nucleolus  (ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IBA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. CpG island methylation profiling in human salivary gland adenoid cystic carcinoma. Bell A, etal., Cancer. 2011 Jul 1;117(13):2898-909. doi: 10.1002/cncr.25818. Epub 2011 Jan 11.
2. Pre-mRNA 3'-end processing complex assembly and function. Chan S, etal., Wiley Interdiscip Rev RNA. 2011 May-Jun;2(3):321-35. doi: 10.1002/wrna.54. Epub 2010 Oct 18.
3. Gene expression signatures of primary and metastatic uterine leiomyosarcoma. Davidson B, etal., Hum Pathol. 2014 Apr;45(4):691-700. doi: 10.1016/j.humpath.2013.11.003. Epub 2013 Nov 13.
4. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
5. Pilocarpine-induced seizures trigger differential regulation of microRNA-stability related genes in rat hippocampal neurons. Kinjo ER, etal., Sci Rep. 2016 Feb 12;6:20969. doi: 10.1038/srep20969.
6. Genetic variants cis-regulating Xrn2 expression contribute to the risk of spontaneous lung tumor. Lu Y, etal., Oncogene. 2010 Feb 18;29(7):1041-9. doi: 10.1038/onc.2009.396. Epub 2009 Nov 16.
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. The roles of SSU processome components and surveillance factors in the initial processing of human ribosomal RNA. Sloan KE, etal., RNA. 2014 Apr;20(4):540-50. doi: 10.1261/rna.043471.113. Epub 2014 Feb 18.
Additional References at PubMed
PMID:7671812   PMID:7885830   PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:15489334  
PMID:16141072   PMID:16141073   PMID:16919269   PMID:17967808   PMID:18799693   PMID:20368287   PMID:21036871   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22057269   PMID:22767893  
PMID:24457600   PMID:26336360   PMID:27331609   PMID:28378742   PMID:29459677   PMID:30196744   PMID:32325033   PMID:32560809   PMID:36495875   PMID:37697435  


Genomics

Comparative Map Data
Xrn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392146,854,672 - 146,919,922 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2146,854,916 - 146,919,920 (+)EnsemblGRCm39 Ensembl
GRCm382147,012,755 - 147,078,000 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2147,012,996 - 147,078,000 (+)EnsemblGRCm38mm10GRCm38
MGSCv372146,838,796 - 146,903,736 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362146,704,563 - 146,766,521 (+)NCBIMGSCv36mm8
Celera2148,268,335 - 148,333,354 (+)NCBICelera
Cytogenetic Map2G2NCBI
cM Map272.63NCBI
XRN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382021,303,331 - 21,389,825 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2021,303,331 - 21,389,825 (+)EnsemblGRCh38hg38GRCh38
GRCh372021,283,969 - 21,370,463 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362021,231,942 - 21,318,463 (+)NCBINCBI36Build 36hg18NCBI36
Build 342021,231,941 - 21,318,463NCBI
Celera2021,360,521 - 21,444,351 (+)NCBICelera
Cytogenetic Map20p11.22NCBI
HuRef2021,248,976 - 21,332,731 (+)NCBIHuRef
CHM1_12021,284,715 - 21,370,457 (+)NCBICHM1_1
T2T-CHM13v2.02021,362,698 - 21,446,483 (+)NCBIT2T-CHM13v2.0
Xrn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83154,888,558 - 154,962,519 (+)NCBIGRCr8
mRatBN7.23134,436,916 - 134,509,308 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3134,437,109 - 134,509,306 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3138,350,638 - 138,422,835 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03146,934,742 - 147,006,929 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03144,637,900 - 144,710,092 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03141,224,858 - 141,298,272 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3141,225,290 - 141,298,265 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03147,641,256 - 147,716,287 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43135,651,059 - 135,724,442 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13135,541,370 - 135,629,673 (+)NCBI
Celera3133,299,770 - 133,372,470 (+)NCBICelera
Cytogenetic Map3q41NCBI
Xrn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541529,107,034 - 29,175,538 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541529,107,060 - 29,175,374 (+)NCBIChiLan1.0ChiLan1.0
XRN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22122,192,379 - 22,278,708 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12022,188,948 - 22,275,544 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02021,260,871 - 21,347,430 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12021,222,138 - 21,308,561 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2021,222,138 - 21,308,561 (+)Ensemblpanpan1.1panPan2
XRN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1242,042,521 - 2,128,942 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl242,042,888 - 2,128,867 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha242,070,749 - 2,157,181 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0242,449,943 - 2,536,442 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl242,449,949 - 2,536,432 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1242,046,962 - 2,133,487 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0242,150,331 - 2,236,452 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0242,427,267 - 2,513,473 (-)NCBIUU_Cfam_GSD_1.0
Xrn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640150,649,492 - 150,724,750 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366204,069,934 - 4,145,745 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366204,069,956 - 4,145,212 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
XRN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1729,107,667 - 29,193,479 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11729,107,641 - 29,193,500 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21733,060,057 - 33,145,974 (+)NCBISscrofa10.2Sscrofa10.2susScr3
XRN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1250,287,718 - 50,373,869 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl250,288,073 - 50,373,883 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660785,086,667 - 5,173,118 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Xrn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474121,691,199 - 21,767,790 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474121,691,099 - 21,768,267 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:314
Count of miRNA genes:246
Interacting mature miRNAs:280
Transcripts:ENSMUST00000028921, ENSMUST00000136136, ENSMUST00000137358, ENSMUST00000147057
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301907Rends_mrenal disease susceptibility (mouse)Not determined2135699221169699361Mouse
11038696Ltpr2f_mLeishmania tropica response 2f (mouse)2115212857149212994Mouse
1301783Bhr1_mbronchial hyperresponsiveness 1 (mouse)Not determined2142593476178442452Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
11039521Ltpr2g_mLeishmania tropica response 2g (mouse)2115212857149212994Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118589253160611165Mouse
1558939Gnf1_mgrowth and fatness 1 (mouse)Not determined2143773445169117924Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118589253160611165Mouse
11353826Bdln10_mbody length 10 (mouse)2140441482174441482Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144515861180896594Mouse
1300806Aod4_mautoimmune ovarian dysgenesis 4 (mouse)Not determined2145228719179228841Mouse
4141033Wg2d_mweight gain in high growth mice 2d (mouse)Not determined143773445160303008Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294230345154241920Mouse
1301066Otx2m2_morthodenticle homolog 2 (Drosophila) modifier 2 (mouse)Not determined2123231973148700377Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118589253160611165Mouse
1301961Bts1_mbladder tumor susceptibility 1 (mouse)Not determined2132024159166024330Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118589253160611165Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284013198148522175Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124441920168241920Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2110916118154354667Mouse
10054066Bwq9_mbody weight QTL 9 (mouse)Not determined2135699221169699361Mouse
1302143Bwq5_mbody weight (mouse)Not determined2127664019161664118Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284013198148667470Mouse
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2123937311157937424Mouse
10043956Gnf5_mgrowth and fatness 5 (mouse)Not determined2135699221169699361Mouse
1302013Tbbmd3_mtotal body bone mineral density 3 (mouse)Not determined2145196949179197085Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
12880427V25Dq3_mvitamin D inactive form serum level QTL 3 (mouse)2129341920163341920Mouse
13504830Bacsq1_mbaculum shape QTL 1 (mouse)2145716184161016184Mouse
12801456Intmrm1_mintima/media ratio modifier 1 (mouse)2142428347176428450Mouse
1301031Bdln3_mbody length 3 (mouse)Not determined2127664019161664118Mouse
1558881Ses7_msalmonella enteritidis susceptibility 7 (mouse)Not determined2116306330150306474Mouse
12801461Intim1_mintima modifier 1 (mouse)2142428347176428450Mouse
11049566Lmr28e_mleishmaniasis resistance 28e (mouse)2133144911167145058Mouse
11049567Lmr28f_mleishmaniasis resistance 28f (mouse)2133144911167145058Mouse
1357484Bsbob_mBSB obesity (mouse)Not determined2143773445165665019Mouse
4141703Chlq13_mcirculating hormone level QTL 13 (mouse)Not determined2135699221169699361Mouse
11341717Rvfs1_mRift Valley fever susceptibility 1 (mouse)2135432544173449616Mouse
1301865Hdlq19_mHDL QTL 19 (mouse)Not determined2145518775179518926Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102630345159941920Mouse
1301295Prdt1_mprion disease incubation time 1 (mouse)Not determined2116077623150077741Mouse
1300846Pbwg11_mpostnatal body weight growth 11 (mouse)Not determined2138966600172966729Mouse
1301294Hrtfm5_mheart failure modifier 5 (mouse)Not determined2122883015156883131Mouse

Markers in Region
RH125855  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382147,045,833 - 147,046,082UniSTSGRCm38
MGSCv372146,871,569 - 146,871,818UniSTSGRCm37
Celera2148,301,229 - 148,301,478UniSTS
Cytogenetic Map2H1UniSTS
Whitehead/MRC_RH21739.07UniSTS
UniSTS:234548  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382147,077,701 - 147,077,884UniSTSGRCm38
MGSCv372146,903,437 - 146,903,620UniSTSGRCm37
Celera2148,333,055 - 148,333,238UniSTS
Cytogenetic Map2H1UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001356402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001356403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011239519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030250983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK004800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK031247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL928876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC052395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC052823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC054743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D38517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000028921   ⟹   ENSMUSP00000028921
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2146,854,916 - 146,919,920 (+)Ensembl
GRCm38.p6 Ensembl2147,012,996 - 147,078,000 (+)Ensembl
Ensembl Acc Id: ENSMUST00000136136
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2146,884,466 - 146,889,742 (+)Ensembl
GRCm38.p6 Ensembl2147,042,546 - 147,047,822 (+)Ensembl
Ensembl Acc Id: ENSMUST00000137358
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2146,903,360 - 146,910,820 (+)Ensembl
GRCm38.p6 Ensembl2147,061,440 - 147,068,900 (+)Ensembl
Ensembl Acc Id: ENSMUST00000147057
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2146,871,472 - 146,880,207 (+)Ensembl
GRCm38.p6 Ensembl2147,029,552 - 147,038,287 (+)Ensembl
RefSeq Acc Id: NM_001356402   ⟹   NP_001343331
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392146,854,919 - 146,919,920 (+)NCBI
GRCm382147,012,999 - 147,078,000 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001356403   ⟹   NP_001343332
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392146,854,919 - 146,919,920 (+)NCBI
GRCm382147,012,999 - 147,078,000 (+)NCBI
Sequence:
RefSeq Acc Id: NM_011917   ⟹   NP_036047
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392146,854,919 - 146,919,920 (+)NCBI
GRCm382147,012,999 - 147,078,000 (+)NCBI
MGSCv372146,838,796 - 146,903,736 (+)RGD
Celera2148,268,335 - 148,333,354 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011239519   ⟹   XP_011237821
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392146,854,672 - 146,901,930 (+)NCBI
GRCm382147,012,755 - 147,060,010 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030250983   ⟹   XP_030106843
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392146,866,428 - 146,919,922 (+)NCBI
GRCm382147,029,338 - 147,077,994 (+)NCBI
Sequence:
RefSeq Acc Id: NP_036047   ⟸   NM_011917
- Peptide Label: isoform 1
- UniProtKB: Q61489 (UniProtKB/Swiss-Prot),   Q3UZT9 (UniProtKB/Swiss-Prot),   Q3TKF2 (UniProtKB/Swiss-Prot),   Q3TI26 (UniProtKB/Swiss-Prot),   Q99KS7 (UniProtKB/Swiss-Prot),   Q9DBR1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011237821   ⟸   XM_011239519
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001343332   ⟸   NM_001356403
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001343331   ⟸   NM_001356402
- Peptide Label: isoform 2
RefSeq Acc Id: XP_030106843   ⟸   XM_030250983
- Peptide Label: isoform X2
Ensembl Acc Id: ENSMUSP00000028921   ⟸   ENSMUST00000028921

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9DBR1-F1-model_v2 AlphaFold Q9DBR1 1-951 view protein structure

Promoters
RGD ID:6833089
Promoter ID:MM_KWN:32106
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000037296,   UC008MSP.1,   UC008MSQ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362146,837,806 - 146,838,987 (+)MPROMDB
RGD ID:6833092
Promoter ID:MM_KWN:32108
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2
Transcripts:OTTMUST00000037298
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362146,867,726 - 146,868,226 (+)MPROMDB
RGD ID:6879030
Promoter ID:EPDNEW_M2966
Type:initiation region
Name:Xrn2_1
Description:Mus musculus 5'-3' exoribonuclease 2 , transcript variant 3,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M2967  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382147,013,035 - 147,013,095EPDNEW
RGD ID:6879032
Promoter ID:EPDNEW_M2967
Type:single initiation site
Name:Xrn2_2
Description:Mus musculus 5'-3' exoribonuclease 2 , transcript variant 3,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M2966  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382147,014,763 - 147,014,823EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:894687 AgrOrtholog
Ensembl Genes ENSMUSG00000027433 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000028921 ENTREZGENE
  ENSMUST00000028921.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.1050 UniProtKB/Swiss-Prot
  3.40.50.12390 UniProtKB/Swiss-Prot
InterPro 5_3_exoribonuclease UniProtKB/Swiss-Prot
  Put_53exo UniProtKB/Swiss-Prot
  Xrn1_helical UniProtKB/Swiss-Prot
  Xrn2/3/4 UniProtKB/Swiss-Prot
KEGG Report mmu:24128 UniProtKB/Swiss-Prot
MGD MGI:894687 ENTREZGENE
NCBI Gene 24128 ENTREZGENE
PANTHER 5'-3' EXORIBONUCLEASE 2 UniProtKB/Swiss-Prot
  PTHR12341 UniProtKB/Swiss-Prot
Pfam XRN_M UniProtKB/Swiss-Prot
  XRN_N UniProtKB/Swiss-Prot
PhenoGen Xrn2 PhenoGen
PIRSF Exonuclease_Xrn2 UniProtKB/Swiss-Prot
UniProt Q3TI26 ENTREZGENE
  Q3TKF2 ENTREZGENE
  Q3UZT9 ENTREZGENE
  Q61489 ENTREZGENE
  Q99KS7 ENTREZGENE
  Q9DBR1 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q3TI26 UniProtKB/Swiss-Prot
  Q3TKF2 UniProtKB/Swiss-Prot
  Q3UZT9 UniProtKB/Swiss-Prot
  Q61489 UniProtKB/Swiss-Prot
  Q99KS7 UniProtKB/Swiss-Prot