4-hydroxy steroid - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	4-hydroxy steroid	go back to main search page
Accession:	CHEBI:62846	browse the term
Definition:	Any steroid bearing a 4-hydroxy substituent.
Synonyms:	related_synonym:	4-hydroxy steroids

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Rat (108) Mouse (110) Human (115) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (108)

4-hydroxy-17beta-estradiol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions
increases phosphorylation

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxyestradiol results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [4-hydroxyestradiol results in increased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

alkaline phosphatase, germ cell

increases activity

4-hydroxyestradiol results in increased activity of ALPG protein

NCBI chr 9:87,748,721...87,761,500
Ensembl chr 9:87,753,648...87,757,836

G

androgen receptor

affects binding

4-hydroxyestradiol binds to AR protein

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

cyclin D1

increases expression
multiple interactions

4-hydroxyestradiol results in increased expression of CCND1 mRNA; 4-hydroxyestradiol results in increased expression of CCND1 protein
alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of CCND1 mRNA]; alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of CCND1 protein]

PMID:23685341 PMID:31364906

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cadherin 1

multiple interactions
decreases expression

alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in decreased expression of CDH1 mRNA]; alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in decreased expression of CDH1 protein]
4-hydroxyestradiol results in decreased expression of CDH1 mRNA; 4-hydroxyestradiol results in decreased expression of CDH1 protein

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

catechol-O-methyltransferase

affects metabolic processing
multiple interactions
increases methylation

COMT protein affects the metabolism of 4-hydroxyestradiol
daidzein inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol]; Estradiol inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol]; Genistein inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol]

PMID:15377160 PMID:18192686

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

4-hydroxyestradiol promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily b, polypeptide 1

affects chemical synthesis
increases chemical synthesis
multiple interactions

CYP1B1 protein affects the chemical synthesis of 4-hydroxyestradiol
CYP1B1 gene polymorphism results in increased chemical synthesis of 4-hydroxyestradiol
[CYP1B1 protein results in increased oxidation of Estradiol] which results in increased chemical synthesis of 4-hydroxyestradiol; CYP1B1 protein affects the metabolism of [4-hydroxyestradiol co-treated with Glutathione]; Resveratrol inhibits the reaction [CYP1B1 protein affects the chemical synthesis of 4-hydroxyestradiol]

PMID:14679015 PMID:15142886 PMID:18187806 PMID:32781018

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

estrogen receptor 1

affects binding
increases expression
multiple interactions

4-hydroxyestradiol binds to ESR1 protein
4-hydroxyestradiol results in increased expression of ESR1 protein
4-hydroxyestradiol inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; [4-hydroxyestradiol results in increased activity of ESR1 protein] promotes the reaction [ESR1 protein binds to TFF1 promoter]

PMID:9048584 PMID:15993745 PMID:20540524 PMID:23685341

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

affects binding
decreases expression
multiple interactions

4-hydroxyestradiol binds to ESR2 protein
4-OH-estradiol binds to Esr2 protein
4-hydroxyestradiol results in decreased expression of ESR2 protein
4-hydroxyestradiol inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]

CTD
RGD

PMID:9048584 PMID:15993745 PMID:23685341 PMID:9048584

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

forkhead box O1

decreases expression

4-hydroxyestradiol results in decreased expression of FOXO1 protein

NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
increases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxyestradiol results in increased expression of HIF1A protein]; Sirolimus inhibits the reaction [4-hydroxyestradiol results in increased expression of HIF1A protein]; wortmannin inhibits the reaction [4-hydroxyestradiol results in increased expression of HIF1A protein]

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

insulin-like growth factor 1 receptor

increases expression

4-hydroxyestradiol results in increased expression of IGF1R protein

NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777

G

insulin-like growth factor binding protein 1

increases expression
multiple interactions

4-hydroxyestradiol results in increased expression of IGFBP1 mRNA
4-hydroxyestradiol promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of IGFBP1 mRNA]

NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482

G

leptin

increases abundance

LEP protein results in increased abundance of 4-hydroxyestradiol

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

lactotransferrin

increases expression

4-hydroxyestradiol results in increased expression of LTF mRNA

PMID:9371753 PMID:9607801

NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795

G

mitogen activated protein kinase 1

multiple interactions

4-hydroxyestradiol results in increased phosphorylation of and results in increased activity of MAPK1 protein; U 0126 inhibits the reaction [4-hydroxyestradiol results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

4-hydroxyestradiol results in increased phosphorylation of and results in increased activity of MAPK3 protein; U 0126 inhibits the reaction [4-hydroxyestradiol results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

matrix metallopeptidase 2

multiple interactions
increases expression

alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of MMP2 mRNA]; alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of MMP2 protein]
4-hydroxyestradiol results in increased expression of MMP2 mRNA; 4-hydroxyestradiol results in increased expression of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions
increases expression

alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of MMP9 mRNA]; alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of MMP9 protein]
4-hydroxyestradiol results in increased expression of MMP9 mRNA; 4-hydroxyestradiol results in increased expression of MMP9 protein

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

mitochondrially encoded ATP synthase membrane subunit 6

increases expression

4-hydroxyestradiol results in increased expression of ATP6 mRNA

NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599

G

mitochondrially encoded cytochrome c oxidase III

increases expression

4-hydroxyestradiol results in increased expression of COX3 mRNA

NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382

G

MYC proto-oncogene, bHLH transcription factor

increases expression
multiple interactions

4-hydroxyestradiol results in increased expression of MYC mRNA; 4-hydroxyestradiol results in increased expression of MYC protein
alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of MYC mRNA]; alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of MYC protein]

PMID:23685341 PMID:31364906

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

nuclear factor kappa B subunit 1

multiple interactions

4-hydroxyestradiol results in increased activity of [NFKB1 protein binds to RELA protein]

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

progesterone receptor

increases expression

4-hydroxyestradiol results in increased expression of PGR mRNA

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

prolactin

increases expression
multiple interactions

4-hydroxyestradiol results in increased expression of PRL mRNA
4-hydroxyestradiol promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of PRL mRNA]

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA; Acetylcysteine inhibits the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA]; Acetylcysteine inhibits the reaction [Estradiol promotes the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA]]; BAY 11-7085 inhibits the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA]; BAY 11-7085 inhibits the reaction [Estradiol promotes the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA]]; Estradiol promotes the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

4-hydroxyestradiol results in increased activity of [NFKB1 protein binds to RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

sex hormone binding globulin

increases expression

4-hydroxyestradiol results in increased expression of SHBG mRNA; 4-hydroxyestradiol results in increased expression of SHBG protein

NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057

G

sphingosine kinase 1

increases expression

4-hydroxyestradiol results in increased expression of SPHK1 mRNA

NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240

G

trefoil factor 1

multiple interactions

[4-hydroxyestradiol results in increased activity of ESR1 protein] promotes the reaction [ESR1 protein binds to TFF1 promoter]

NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597

G

vascular endothelial growth factor A

multiple interactions
increases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxyestradiol results in increased expression of VEGFA protein]; Sirolimus inhibits the reaction [4-hydroxyestradiol results in increased expression of VEGFA protein]; wortmannin inhibits the reaction [4-hydroxyestradiol results in increased expression of VEGFA protein]

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vimentin

multiple interactions
increases expression

alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of VIM mRNA]; alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of VIM protein]
4-hydroxyestradiol results in increased expression of VIM mRNA; 4-hydroxyestradiol results in increased expression of VIM protein

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

4-hydroxyestrone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

NFE2 like bZIP transcription factor 2

decreases expression
decreases response to substance

4-hydroxyestrone results in decreased expression of NFE2L2 mRNA
NFE2L2 protein results in decreased susceptibility to 4-hydroxyestrone

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

UGT1A1 protein results in increased glucuronidation of 4-hydroxyestrone

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases glucuronidation

UGT1A3 protein results in increased glucuronidation of 4-hydroxyestrone

NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of 4-hydroxyestrone

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 2 member B7

increases glucuronidation

UGT2B7 protein alternative form results in increased glucuronidation of 4-hydroxyestrone; UGT2B7 protein results in increased glucuronidation of 4-hydroxyestrone

PMID:8423545 PMID:8517101

NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604

withaferin A

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

withaferin A inhibits the reaction [[ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

acetyl-CoA carboxylase alpha

multiple interactions

withaferin A promotes the reaction [Ethanol results in decreased expression of ACACA mRNA]

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

ADAM metallopeptidase domain 17

multiple interactions

withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of ADAM17 protein]; withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]

NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639

G

AKT serine/threonine kinase 1

multiple interactions

withaferin A inhibits the reaction [Cholesterol, Dietary results in decreased expression of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

arachidonate 15-lipoxygenase

multiple interactions

withaferin A inhibits the reaction [Cholesterol, Dietary results in increased activity of ALOX15 protein]

NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874

G

activating transcription factor 4

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [withaferin A results in increased expression of ATF4 protein]

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

BCL2-associated agonist of cell death

multiple interactions

withaferin A results in decreased expression of and results in decreased phosphorylation of BAD protein

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2 associated X, apoptosis regulator

multiple interactions

withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

withaferin A results in decreased expression of BCL2 protein
withaferin A inhibits the reaction [Cholesterol, Dietary results in decreased expression of BCL2 protein]

PMID:20438634 PMID:21256832 PMID:21964475 PMID:35734936

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL2-related protein A1

multiple interactions

withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2A1 mRNA]

NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998

G

Bcl2-like 11

decreases expression
multiple interactions

withaferin A results in decreased expression of BCL2L11 protein
withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of BCL2L11 protein]

PMID:20438634 PMID:35734936

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

caspase 3

multiple interactions

withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of CASP3 protein]
withaferin A inhibits the reaction [Elements, Radioactive results in increased activity of CASP3 protein]

PMID:35734936 PMID:36716864

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

multiple interactions

withaferin A inhibits the reaction [Cholesterol, Dietary results in decreased expression of CASP9 protein]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions
increases expression

withaferin A inhibits the reaction [Cholesterol, Dietary results in decreased activity of CAT protein]
withaferin A results in increased expression of CAT protein

PMID:35734936 PMID:36716864

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

multiple interactions

withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cyclin D1

multiple interactions

withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCND1 mRNA]

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin-dependent kinase inhibitor 1A

affects binding
multiple interactions
increases expression

withaferin A binds to CDKN1A protein
withaferin A results in increased expression of and affects the localization of CDKN1A protein
withaferin A results in increased expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

CDKN2A interacting protein

decreases expression

withaferin A results in decreased expression of CDKN2AIP protein

NCBI chr16:44,536,147...44,546,216
Ensembl chr16:44,536,234...44,540,033

G

claudin 1

decreases response to substance
decreases expression

CLDN1 protein results in decreased susceptibility to withaferin A
withaferin A results in decreased expression of CLDN1 mRNA; withaferin A results in decreased expression of CLDN1 protein

NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724

G

ceruloplasmin

multiple interactions

withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of CP protein]

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

carnitine palmitoyltransferase 1c

multiple interactions

withaferin A inhibits the reaction [Ethanol results in decreased expression of CPT1C mRNA]

NCBI chr 1:95,442,814...95,457,347
Ensembl chr 1:95,442,817...95,457,342

G

C-reactive protein

multiple interactions

withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of CRP protein]

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

DNA-damage inducible transcript 3

affects response to substance
multiple interactions
increases expression

DDIT3 mRNA affects the susceptibility to withaferin A
Acetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT3 protein]

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DNA-damage-inducible transcript 4

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT4 protein]

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

G

DNA methyltransferase 1

decreases expression

withaferin A results in decreased expression of DNMT1 mRNA; withaferin A results in decreased expression of DNMT1 protein

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

DNA methyltransferase 3 alpha

decreases expression

withaferin A results in decreased expression of DNMT3A mRNA

NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687

G

DNA methyltransferase 3 beta

decreases expression

withaferin A results in decreased expression of DNMT3B mRNA

NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124

G

EGF like repeats and discoidin domains 3

decreases expression

withaferin A results in decreased expression of EDIL3 mRNA

NCBI chr 2:19,890,396...20,405,028
Ensembl chr 2:19,890,373...20,405,008

G

enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

multiple interactions

withaferin A promotes the reaction [Ethanol results in decreased expression of EHHADH mRNA]

NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188

G

eukaryotic translation initiation factor 2A

increases phosphorylation

withaferin A results in increased phosphorylation of EIF2A protein

NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068

G

ezrin

multiple interactions

[withanone co-treated with withaferin A] results in decreased expression of EZR protein

NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505

G

Fas cell surface death receptor

multiple interactions

withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of FAS protein]

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

fatty acid synthase

multiple interactions

withaferin A inhibits the reaction [Ethanol results in increased expression of FASN mRNA]

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

FOS like 1, AP-1 transcription factor subunit

increases expression

withaferin A results in increased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

glucose-6-phosphatase catalytic subunit 1

decreases expression

withaferin A results in decreased expression of G6PC1 protein

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions

withaferin A inhibits the reaction [Ethanol results in increased expression of GCLC mRNA]

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamic--pyruvic transaminase

multiple interactions

withaferin A inhibits the reaction [Ethanol results in increased expression of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione-disulfide reductase

multiple interactions

withaferin A binds to and affects the localization of GSR protein

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

histone deacetylase 1

decreases expression

withaferin A results in decreased expression of HDAC1 protein

NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111

G

heme oxygenase 1

increases expression

withaferin A results in increased expression of HMOX1 protein

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heterogeneous nuclear ribonucleoprotein K

multiple interactions

[withanone co-treated with withaferin A] results in decreased expression of HNRNPK protein; withaferin A binds to and results in decreased activity of HNRNPK protein

NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997

G

heat shock transcription factor 1

increases activity

withaferin A results in increased activity of HSF1 protein

NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011

G

heat shock protein family A (Hsp70) member 9

affects binding
multiple interactions

withaferin A binds to HSPA9 protein
[withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]] which affects the localization of and results in increased activity of TP53 protein; [withanone co-treated with withaferin A] results in decreased expression of HSPA9 protein; withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]

PMID:22973447 PMID:25236891

NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292

G

interleukin 1 beta

multiple interactions

withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]

PMID:24632454 PMID:37467946

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL6 protein]
withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of IL6 protein]

PMID:20438634 PMID:35734936

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

keratin 13

decreases expression

withaferin A results in decreased expression of KRT13 mRNA

NCBI chr10:85,051,887...85,056,099
Ensembl chr10:85,051,889...85,056,084

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; [withanone co-treated with withaferin A] results in decreased expression of MAPK1 protein; Acetylcysteine inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]

PMID:24019090 PMID:24632454 PMID:25236891 PMID:36716864

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; [withanone co-treated with withaferin A] results in decreased expression of MAPK3 protein; Acetylcysteine inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]

PMID:24019090 PMID:24632454 PMID:25236891 PMID:36716864

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

increases phosphorylation

withaferin A results in increased phosphorylation of MAPK8 protein

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

MCL1 apoptosis regulator, BCL2 family member

multiple interactions
increases expression

MCL1 mutant form promotes the reaction [withaferin A results in increased cleavage of PARP1 protein]
withaferin A results in increased expression of MCL1 protein

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

methyl CpG binding protein 2

decreases expression

withaferin A results in decreased expression of MECP2 protein

NCBI chr X:151,781,177...151,844,687
Ensembl chr X:151,789,930...151,844,689

G

matrix metallopeptidase 2

multiple interactions

[withanone co-treated with withaferin A] results in decreased expression of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

myeloperoxidase

multiple interactions

withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

NFE2 like bZIP transcription factor 2

affects binding
increases phosphorylation

withaferin A binds to NFE2L2 protein
withaferin A results in increased phosphorylation of NFE2L2 protein

PMID:22973447 PMID:36716864

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

multiple interactions

withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide synthase 2

multiple interactions

withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

withaferin A inhibits the reaction [Ethanol results in increased expression of NQO1 mRNA]

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

5' nucleotidase, ecto

increases expression

withaferin A results in increased expression of NT5E mRNA

NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

Dithiothreitol inhibits the reaction [withaferin A results in increased cleavage of PARP1 protein]; MCL1 mutant form promotes the reaction [withaferin A results in increased cleavage of PARP1 protein]

PMID:20438634 PMID:24019090

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

peroxiredoxin 2

increases expression

withaferin A results in increased expression of PRDX2 protein

NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194

G

protein C receptor

multiple interactions

withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]

NCBI chr 3:144,254,596...144,258,863
Ensembl chr 3:144,254,380...144,258,903

G

prostaglandin-endoperoxide synthase 2

multiple interactions

withaferin A inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; withaferin A inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

serpin family A member 6

decreases expression

withaferin A results in decreased expression of SERPINA6 protein

NCBI chr 6:122,780,040...122,790,274
Ensembl chr 6:122,780,043...122,790,349

G

solute carrier organic anion transporter family, member 4a1

increases expression

withaferin A results in increased expression of SLCO4A1 mRNA

NCBI chr 3:167,559,177...167,578,307
Ensembl chr 3:167,559,316...167,578,305

G

superoxide dismutase 2

multiple interactions
increases expression

SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]
withaferin A results in increased expression of SOD2 protein

PMID:24019090 PMID:36716864

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

sterol regulatory element binding transcription factor 1

multiple interactions

withaferin A inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

sterol regulatory element binding transcription factor 2

multiple interactions

withaferin A inhibits the reaction [Ethanol results in increased expression of SREBF2 mRNA]

NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848

G

signal transducer and activator of transcription 1

multiple interactions

withaferin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased localization of and results in increased activity of STAT1 protein]

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 3

multiple interactions

withaferin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of STAT3 protein]

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

tyrosine aminotransferase

decreases expression

withaferin A results in decreased expression of TAT protein

NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031

G

thiol methyltransferase 1A

decreases expression

withaferin A results in decreased expression of TMT1A mRNA

NCBI chr 7:131,452,099...131,460,154
Ensembl chr 7:131,451,641...131,460,154

G

tumor necrosis factor

multiple interactions
decreases activity

withaferin A inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]
withaferin A results in decreased activity of TNF protein
withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of TNF protein]

PMID:20438634 PMID:24632454 PMID:35734936 PMID:37467946

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 3

multiple interactions

withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA]

NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282

G

tumor protein p53

increases expression
multiple interactions
affects binding

withaferin A results in increased expression of TP53 mRNA
[withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]] which affects the localization of and results in increased activity of TP53 protein; withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]
withaferin A binds to TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tubulin, alpha 1A

decreases expression

withaferin A results in decreased expression of TUBA1A mRNA

NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186

G

tubulin, beta 5 class I

decreases expression

withaferin A results in decreased expression of TUBB mRNA

NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940

G

vascular endothelial growth factor A

multiple interactions
decreases expression

[withanone co-treated with withaferin A] results in decreased secretion of VEGFA protein; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]
withaferin A results in decreased expression of VEGFA protein

PMID:20438634 PMID:25236891

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

X-box binding protein 1

increases expression
increases splicing

withaferin A results in increased expression of XBP1 protein
withaferin A results in increased splicing of XBP1 mRNA

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19838
chemical entity	19836
molecular entity	19836
polyatomic entity	19793
heteroatomic molecular entity	19748
hydroxides	19312
organic hydroxy compound	18943
hydroxy steroid	14453
4-hydroxy steroid	108
(25R)-3beta,4beta-dihydroxycholest-5-en-26-al	0
(25R)-3beta,4beta-dihydroxycholest-5-en-26-oic acid	0
(25R)-4beta,26-dihydroxycholesterol	0
(9xi,14xi,25S)-cholestane-3beta,4beta,6alpha,7alpha,8,15alpha,16beta,26-octol +	0
(9xi,14xi,25S)-cholestane-3beta,4beta,6beta,7alpha,8,15alpha,16beta,26-octol	0
17alpha-hydroxywithaferin A	0
17alpha-hydroxywithanolide D	0
17alpha-sitoindoside IX	0
2,3-dihydro-3beta-O-sulfate withaferin A	0
2,3-dihydro-3beta-methoxy withaferin A	0
2,3-dihydrowithaferin A	0
20-hydroxytubocapsanolide A	0
23-hydroxytubocapsanolide A	0
3alpha,6alpha-epoxy-4beta,5beta,27-trihydroxy-1-oxowitha-24-enolide	0
4-hydroxy-17beta-estradiol +	33
4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronide)	0
4-hydroxyestrone +	5
4-hydroxyestrone 3-O-(beta-D-glucuronide)	0
4beta,24S-dihydroxycholesterol	0
4beta,7alpha-dihydroxycholesterol	0
sitoindoside IX	0
tubocapsanolide A +	0
tubocapsanolide F	0
viscosalactone B	0
withaferin A +	79
withalongolide A	0
withalongolide B	0
withalongolide C	0
withalongolide D	0
withalongolide E	0
withalongolide G	0
withalongolide H	0
withanolide D +	0
Path 2
Term	Annotations
CHEBI ontology	19838
subatomic particle	19836
composite particle	19836
hadron	19836
baryon	19836
nucleon	19836
atomic nucleus	19836
atom	19836
main group element atom	19782
p-block element atom	19782
carbon group element atom	19722
carbon atom	19719
organic molecular entity	19719
organic molecule	19670
organic cyclic compound	19481
organic polycyclic compound	17242
steroid	14704
hydroxy steroid	14453
4-hydroxy steroid	108
(25R)-3beta,4beta-dihydroxycholest-5-en-26-al	0
(25R)-3beta,4beta-dihydroxycholest-5-en-26-oic acid	0
(25R)-4beta,26-dihydroxycholesterol	0
(9xi,14xi,25S)-cholestane-3beta,4beta,6alpha,7alpha,8,15alpha,16beta,26-octol +	0
(9xi,14xi,25S)-cholestane-3beta,4beta,6beta,7alpha,8,15alpha,16beta,26-octol	0
17alpha-hydroxywithaferin A	0
17alpha-hydroxywithanolide D	0
17alpha-sitoindoside IX	0
2,3-dihydro-3beta-O-sulfate withaferin A	0
2,3-dihydro-3beta-methoxy withaferin A	0
2,3-dihydrowithaferin A	0
20-hydroxytubocapsanolide A	0
23-hydroxytubocapsanolide A	0
3alpha,6alpha-epoxy-4beta,5beta,27-trihydroxy-1-oxowitha-24-enolide	0
4-hydroxy-17beta-estradiol +	33
4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronide)	0
4-hydroxyestrone +	5
4-hydroxyestrone 3-O-(beta-D-glucuronide)	0
4beta,24S-dihydroxycholesterol	0
4beta,7alpha-dihydroxycholesterol	0
sitoindoside IX	0
tubocapsanolide A +	0
tubocapsanolide F	0
viscosalactone B	0
withaferin A +	79
withalongolide A	0
withalongolide B	0
withalongolide C	0
withalongolide D	0
withalongolide E	0
withalongolide G	0
withalongolide H	0
withanolide D +	0

paths to the root