|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions increases phosphorylation |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxyestradiol results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [4-hydroxyestradiol results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:15050414 |
|
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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G |
Alpg |
alkaline phosphatase, germ cell |
increases activity |
ISO |
4-hydroxyestradiol results in increased activity of ALPG protein |
CTD |
PMID:15993745 |
|
NCBI chr 9:94,164,667...94,184,972
Ensembl chr 9:94,178,221...94,181,010
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G |
Ar |
androgen receptor |
affects binding |
EXP |
4-hydroxyestradiol binds to AR protein |
CTD |
PMID:14565775 |
|
NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
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G |
Ccnd1 |
cyclin D1 |
increases expression |
ISO |
4-hydroxyestradiol results in increased expression of CCND1 protein |
CTD |
PMID:23685341 |
|
NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
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G |
Comt |
catechol-O-methyltransferase |
affects metabolic processing increases methylation multiple interactions |
ISO |
COMT protein affects the metabolism of 4-hydroxyestradiol COMT protein results in increased methylation of 4-hydroxyestradiol daidzein inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol]; Estradiol inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol]; Genistein inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol] |
CTD |
PMID:15377160 PMID:18192686 |
|
NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
4-hydroxyestradiol promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] |
CTD |
PMID:12093619 |
|
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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|
G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
affects chemical synthesis increases chemical synthesis multiple interactions |
ISO |
CYP1B1 protein affects the chemical synthesis of 4-hydroxyestradiol CYP1B1 gene polymorphism results in increased chemical synthesis of 4-hydroxyestradiol CYP1B1 protein affects the metabolism of [4-hydroxyestradiol co-treated with Glutathione]; resveratrol inhibits the reaction [CYP1B1 protein affects the chemical synthesis of 4-hydroxyestradiol] |
CTD |
PMID:14679015 PMID:15142886 PMID:18187806 |
|
NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
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G |
Esr1 |
estrogen receptor 1 |
affects binding increases expression multiple interactions |
ISO |
4-hydroxyestradiol binds to ESR1 protein 4-hydroxyestradiol results in increased expression of ESR1 protein 4-hydroxyestradiol inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; [4-hydroxyestradiol results in increased activity of ESR1 protein] promotes the reaction [ESR1 protein binds to TFF1 promoter] |
CTD |
PMID:9048584 PMID:15993745 PMID:20540524 PMID:23685341 |
|
NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
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|
G |
Esr2 |
estrogen receptor 2 |
affects binding decreases expression multiple interactions |
ISO EXP |
4-hydroxyestradiol binds to ESR2 protein 4-hydroxyestradiol results in decreased expression of ESR2 protein 4-hydroxyestradiol inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein] |
CTD |
PMID:9048584 PMID:15993745 PMID:23685341 |
|
NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
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G |
Foxo1 |
forkhead box O1 |
decreases expression |
ISO |
4-hydroxyestradiol results in decreased expression of FOXO1 protein |
CTD |
PMID:23685341 |
|
NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions increases expression |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxyestradiol results in increased expression of HIF1A protein]; Sirolimus inhibits the reaction [4-hydroxyestradiol results in increased expression of HIF1A protein]; wortmannin inhibits the reaction [4-hydroxyestradiol results in increased expression of HIF1A protein] |
CTD |
PMID:15050414 |
|
NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
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G |
Igf1r |
insulin-like growth factor 1 receptor |
increases expression |
ISO |
4-hydroxyestradiol results in increased expression of IGF1R protein |
CTD |
PMID:23685341 |
|
NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
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G |
Lep |
leptin |
increases abundance |
ISO |
LEP protein results in increased abundance of 4-hydroxyestradiol |
CTD |
PMID:24631339 |
|
NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
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G |
Ltf |
lactotransferrin |
increases expression |
ISO |
4-hydroxyestradiol results in increased expression of LTF mRNA |
CTD |
PMID:9371753 PMID:9607801 |
|
NCBI chr 8:119,290,416...119,313,261
Ensembl chr 8:119,290,416...119,313,261
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
4-hydroxyestradiol results in increased phosphorylation of and results in increased activity of MAPK1 protein; U 0126 inhibits the reaction [4-hydroxyestradiol results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:15901486 |
|
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
4-hydroxyestradiol results in increased phosphorylation of and results in increased activity of MAPK3 protein; U 0126 inhibits the reaction [4-hydroxyestradiol results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:15901486 |
|
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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|
G |
Mt-atp6 |
mitochondrially encoded ATP synthase membrane subunit 6 |
increases expression |
ISO |
4-hydroxyestradiol results in increased expression of ATP6 mRNA |
CTD |
PMID:9886577 |
|
NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599
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G |
Mt-co3 |
mitochondrially encoded cytochrome c oxidase III |
increases expression |
ISO |
4-hydroxyestradiol results in increased expression of COX3 mRNA |
CTD |
PMID:9886577 |
|
NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382
|
|
G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
increases expression |
ISO |
4-hydroxyestradiol results in increased expression of MYC protein |
CTD |
PMID:23685341 |
|
NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
4-hydroxyestradiol results in increased activity of [NFKB1 protein binds to RELA protein] |
CTD |
PMID:15901486 |
|
NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
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G |
Pgr |
progesterone receptor |
increases expression |
ISO |
4-hydroxyestradiol results in increased expression of PGR mRNA |
CTD |
PMID:9607801 |
|
NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA; Acetylcysteine inhibits the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA]; Acetylcysteine inhibits the reaction [Estradiol promotes the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA]]; BAY 11-7085 inhibits the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA]; BAY 11-7085 inhibits the reaction [Estradiol promotes the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA]]; Estradiol promotes the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA] |
CTD |
PMID:18480072 |
|
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
4-hydroxyestradiol results in increased activity of [NFKB1 protein binds to RELA protein] |
CTD |
PMID:15901486 |
|
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Shbg |
sex hormone binding globulin |
increases expression |
ISO |
4-hydroxyestradiol results in increased expression of SHBG mRNA; 4-hydroxyestradiol results in increased expression of SHBG protein |
CTD |
PMID:21793624 |
|
NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
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G |
Sphk1 |
sphingosine kinase 1 |
increases expression |
ISO |
4-hydroxyestradiol results in increased expression of SPHK1 mRNA |
CTD |
PMID:29654831 |
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NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
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G |
Tff1 |
trefoil factor 1 |
multiple interactions |
ISO |
[4-hydroxyestradiol results in increased activity of ESR1 protein] promotes the reaction [ESR1 protein binds to TFF1 promoter] |
CTD |
PMID:20540524 |
|
NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions increases expression |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxyestradiol results in increased expression of VEGFA protein]; Sirolimus inhibits the reaction [4-hydroxyestradiol results in increased expression of VEGFA protein]; wortmannin inhibits the reaction [4-hydroxyestradiol results in increased expression of VEGFA protein] |
CTD |
PMID:15050414 |
|
NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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G |
Nfe2l2 |
nuclear factor, erythroid 2-like 2 |
decreases expression decreases response to substance |
ISO |
4-hydroxyestrone results in decreased expression of NFE2L2 mRNA NFE2L2 protein results in decreased susceptibility to 4-hydroxyestrone |
CTD |
PMID:25231996 |
|
NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases glucuronidation |
ISO |
UGT1A1 protein results in increased glucuronidation of 4-hydroxyestrone |
CTD |
PMID:15117964 |
|
NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
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G |
Ugt1a2 |
UDP glucuronosyltransferase 1 family, polypeptide A2 |
increases glucuronidation |
ISO |
UGT1A3 protein results in increased glucuronidation of 4-hydroxyestrone |
CTD |
PMID:15117964 |
|
NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
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G |
Ugt1a8 |
UDP glucuronosyltransferase family 1 member A8 |
increases glucuronidation |
ISO |
UGT1A8 protein results in increased glucuronidation of 4-hydroxyestrone |
CTD |
PMID:15117964 |
|
NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
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G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
increases glucuronidation |
ISO |
UGT1A9 protein results in increased glucuronidation of 4-hydroxyestrone |
CTD |
PMID:15117964 |
|
NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
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G |
Ugt2b7 |
UDP glucuronosyltransferase family 2 member B7 |
increases glucuronidation |
ISO |
UGT2B7 protein alternative form results in increased glucuronidation of 4-hydroxyestrone; UGT2B7 protein results in increased glucuronidation of 4-hydroxyestrone |
CTD |
PMID:8423545 PMID:8517101 |
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NCBI chr14:22,597,103...22,619,968
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
withaferin A inhibits the reaction [[ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]] |
CTD |
PMID:20438634 |
|
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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G |
Adam17 |
ADAM metallopeptidase domain 17 |
multiple interactions |
ISO |
withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of ADAM17 protein]; withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]] |
CTD |
PMID:24632454 |
|
NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
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G |
Atf4 |
activating transcription factor 4 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [withaferin A results in increased expression of ATF4 protein] |
CTD |
PMID:21266191 |
|
NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
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G |
Bad |
BCL2-associated agonist of cell death |
multiple interactions |
ISO |
withaferin A results in decreased expression of and results in decreased phosphorylation of BAD protein |
CTD |
PMID:20438634 |
|
NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
withaferin A results in decreased expression of BCL2 protein |
CTD |
PMID:20438634 PMID:21256832 PMID:21964475 |
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NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Bcl2a1 |
BCL2-related protein A1 |
multiple interactions |
ISO |
withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2A1 mRNA] |
CTD |
PMID:20438634 |
|
NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
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G |
Bcl2l11 |
BCL2 like 11 |
decreases expression |
ISO |
withaferin A results in decreased expression of BCL2L11 protein |
CTD |
PMID:20438634 |
|
NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA] |
CTD |
PMID:20438634 |
|
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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G |
Ccnd1 |
cyclin D1 |
multiple interactions |
ISO |
withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCND1 mRNA] |
CTD |
PMID:20438634 |
|
NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
affects binding multiple interactions increases expression |
ISO |
withaferin A binds to CDKN1A protein withaferin A results in increased expression of and affects the localization of CDKN1A protein withaferin A results in increased expression of CDKN1A mRNA |
CTD |
PMID:22973447 |
|
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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G |
Cdkn2aip |
CDKN2A interacting protein |
decreases expression |
ISO |
withaferin A results in decreased expression of CDKN2AIP protein |
CTD |
PMID:22973447 |
|
NCBI chr16:47,664,864...47,670,935
Ensembl chr16:47,665,816...47,669,093
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
affects response to substance multiple interactions increases expression |
ISO |
DDIT3 mRNA affects the susceptibility to withaferin A Acetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT3 protein] |
CTD |
PMID:21266191 |
|
NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
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G |
Ddit4 |
DNA-damage-inducible transcript 4 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT4 protein] |
CTD |
PMID:21266191 |
|
NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
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G |
Dnmt1 |
DNA methyltransferase 1 |
decreases expression |
ISO |
withaferin A results in decreased expression of DNMT1 mRNA; withaferin A results in decreased expression of DNMT1 protein |
CTD |
PMID:23593078 |
|
NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
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G |
Dnmt3a |
DNA methyltransferase 3 alpha |
decreases expression |
ISO |
withaferin A results in decreased expression of DNMT3A mRNA |
CTD |
PMID:23593078 |
|
NCBI chr 6:28,205,375...28,346,052
Ensembl chr 6:28,235,695...28,340,577
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G |
Dnmt3b |
DNA methyltransferase 3 beta |
decreases expression |
ISO |
withaferin A results in decreased expression of DNMT3B mRNA |
CTD |
PMID:23593078 |
|
NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786
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G |
Eif2a |
eukaryotic translation initiation factor 2A |
increases phosphorylation |
ISO |
withaferin A results in increased phosphorylation of EIF2A protein |
CTD |
PMID:21266191 |
|
NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
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G |
Ezr |
ezrin |
multiple interactions |
ISO |
[6,7-epoxy-5,17-dihydroxy-1-oxowitha-2,24-dienolide co-treated with withaferin A] results in decreased expression of EZR protein |
CTD |
PMID:25236891 |
|
NCBI chr 1:47,287,872...47,331,412
Ensembl chr 1:47,287,874...47,331,412
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G |
Hdac1 |
histone deacetylase 1 |
decreases expression |
ISO |
withaferin A results in decreased expression of HDAC1 protein |
CTD |
PMID:23593078 |
|
NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
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G |
Hnrnpk |
heterogeneous nuclear ribonucleoprotein K |
multiple interactions |
ISO |
[6,7-epoxy-5,17-dihydroxy-1-oxowitha-2,24-dienolide co-treated with withaferin A] results in decreased expression of HNRNPK protein; withaferin A binds to and results in decreased activity of HNRNPK protein |
CTD |
PMID:25236891 |
|
NCBI chr17:6,664,730...6,676,753
Ensembl chr17:6,665,659...6,676,654
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G |
Hspa9 |
heat shock protein family A (Hsp70) member 9 |
affects binding multiple interactions |
ISO |
withaferin A binds to HSPA9 protein [6,7-epoxy-5,17-dihydroxy-1-oxowitha-2,24-dienolide co-treated with withaferin A] results in decreased expression of HSPA9 protein; [withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]] which affects the localization of and results in increased activity of TP53 protein; withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein] |
CTD |
PMID:22973447 PMID:25236891 |
|
NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]] |
CTD |
PMID:24632454 |
|
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL6 protein] |
CTD |
PMID:20438634 |
|
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; [6,7-epoxy-5,17-dihydroxy-1-oxowitha-2,24-dienolide co-treated with withaferin A] results in decreased expression of MAPK1 protein; Acetylcysteine inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:24019090 PMID:24632454 PMID:25236891 |
|
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases phosphorylation |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; [6,7-epoxy-5,17-dihydroxy-1-oxowitha-2,24-dienolide co-treated with withaferin A] results in decreased expression of MAPK3 protein; Acetylcysteine inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:24019090 PMID:24632454 PMID:25236891 |
|
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
increases phosphorylation |
ISO |
withaferin A results in increased phosphorylation of MAPK8 protein |
CTD |
PMID:21964475 |
|
NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
multiple interactions increases expression |
ISO |
MCL1 mutant form promotes the reaction [withaferin A results in increased cleavage of PARP1 protein] withaferin A results in increased expression of MCL1 protein |
CTD |
PMID:24019090 |
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NCBI chr 2:197,786,212...197,788,992
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G |
Mecp2 |
methyl CpG binding protein 2 |
decreases expression |
ISO |
withaferin A results in decreased expression of MECP2 protein |
CTD |
PMID:23593078 |
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NCBI chr X:156,650,389...156,713,813
Ensembl chr X:156,655,960...156,705,233
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions |
ISO |
[6,7-epoxy-5,17-dihydroxy-1-oxowitha-2,24-dienolide co-treated with withaferin A] results in decreased expression of MMP2 protein |
CTD |
PMID:25236891 |
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NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
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G |
Nfe2l2 |
nuclear factor, erythroid 2-like 2 |
affects binding |
ISO |
withaferin A binds to NFE2L2 protein |
CTD |
PMID:22973447 |
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NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein] |
CTD |
PMID:20438634 |
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NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases cleavage |
ISO |
Dithiothreitol inhibits the reaction [withaferin A results in increased cleavage of PARP1 protein]; MCL1 mutant form promotes the reaction [withaferin A results in increased cleavage of PARP1 protein] |
CTD |
PMID:20438634 PMID:24019090 |
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NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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G |
Procr |
protein C receptor |
multiple interactions |
ISO |
withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]] |
CTD |
PMID:24632454 |
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NCBI chr 3:151,285,321...151,289,581
Ensembl chr 3:151,285,249...151,289,595
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
withaferin A inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; withaferin A inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] |
CTD |
PMID:21396905 |
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NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein] |
CTD |
PMID:20438634 |
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NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
ISO |
SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:24019090 |
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NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
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G |
Stat1 |
signal transducer and activator of transcription 1 |
multiple interactions |
ISO |
withaferin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased localization of and results in increased activity of STAT1 protein] |
CTD |
PMID:21396905 |
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NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
withaferin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of STAT3 protein] |
CTD |
PMID:21396905 |
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NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
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G |
Tnf |
tumor necrosis factor |
multiple interactions decreases activity |
ISO |
withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]] withaferin A results in decreased activity of TNF protein |
CTD |
PMID:20438634 PMID:24632454 |
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NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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G |
Tnfaip3 |
TNF alpha induced protein 3 |
multiple interactions |
ISO |
withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA] |
CTD |
PMID:20438634 |
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NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
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G |
Tp53 |
tumor protein p53 |
increases expression affects binding multiple interactions |
ISO |
withaferin A results in increased expression of TP53 mRNA withaferin A binds to TP53 protein [withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]] which affects the localization of and results in increased activity of TP53 protein; withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein] |
CTD |
PMID:22973447 |
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NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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G |
Tuba1a |
tubulin, alpha 1A |
decreases expression |
ISO |
withaferin A results in decreased expression of TUBA1A mRNA |
CTD |
PMID:24297176 |
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NCBI chr 7:140,637,287...140,640,953
Ensembl chr 7:140,637,287...140,640,953
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G |
Tubb5 |
tubulin, beta 5 class I |
decreases expression |
ISO |
withaferin A results in decreased expression of TUBB mRNA |
CTD |
PMID:24297176 |
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NCBI chr20:3,422,448...3,426,420
Ensembl chr20:3,422,461...3,426,371
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions decreases expression |
ISO |
[6,7-epoxy-5,17-dihydroxy-1-oxowitha-2,24-dienolide co-treated with withaferin A] results in decreased secretion of VEGFA protein; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA] withaferin A results in decreased expression of VEGFA protein |
CTD |
PMID:20438634 PMID:25236891 |
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NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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G |
Xbp1 |
X-box binding protein 1 |
increases expression increases splicing |
ISO |
withaferin A results in increased expression of XBP1 protein withaferin A results in increased splicing of XBP1 mRNA |
CTD |
PMID:21266191 |
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NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
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