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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-hydroxy steroid
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Accession:CHEBI:62846 term browser browse the term
Definition:Any steroid bearing a 4-hydroxy substituent.
Synonyms:related_synonym: 4-hydroxy steroids


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4-hydroxy-17beta-estradiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxyestradiol results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [4-hydroxyestradiol results in increased phosphorylation of AKT1 protein] CTD PMID:15050414 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alpg alkaline phosphatase, germ cell increases activity ISO 4-hydroxyestradiol results in increased activity of ALPG protein CTD PMID:15993745 NCBI chr 9:87,748,721...87,761,500
Ensembl chr 9:87,753,648...87,757,836 		JBrowse link
G Ar androgen receptor affects binding EXP 4-hydroxyestradiol binds to AR protein CTD PMID:14565775 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO 4-hydroxyestradiol results in increased expression of CCND1 protein CTD PMID:23685341 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Comt catechol-O-methyltransferase affects metabolic processing
multiple interactions
increases methylation		 ISO COMT protein affects the metabolism of 4-hydroxyestradiol
daidzein inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol]; Estradiol inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol]; Genistein inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol]		 CTD PMID:15377160 PMID:18192686 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO 4-hydroxyestradiol promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:12093619 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 affects chemical synthesis
increases chemical synthesis
multiple interactions		 ISO CYP1B1 protein affects the chemical synthesis of 4-hydroxyestradiol
CYP1B1 gene polymorphism results in increased chemical synthesis of 4-hydroxyestradiol
[CYP1B1 protein results in increased oxidation of Estradiol] which results in increased chemical synthesis of 4-hydroxyestradiol; CYP1B1 protein affects the metabolism of [4-hydroxyestradiol co-treated with Glutathione]; Resveratrol inhibits the reaction [CYP1B1 protein affects the chemical synthesis of 4-hydroxyestradiol]		 CTD PMID:14679015 PMID:15142886 PMID:18187806 PMID:32781018 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Esr1 estrogen receptor 1 affects binding
increases expression
multiple interactions		 ISO 4-hydroxyestradiol binds to ESR1 protein
4-hydroxyestradiol results in increased expression of ESR1 protein
4-hydroxyestradiol inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; [4-hydroxyestradiol results in increased activity of ESR1 protein] promotes the reaction [ESR1 protein binds to TFF1 promoter]		 CTD PMID:9048584 PMID:15993745 PMID:20540524 PMID:23685341 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 affects binding
decreases expression
multiple interactions		 ISO
EXP		 4-hydroxyestradiol binds to ESR2 protein
4-OH-estradiol binds to Esr2 protein
4-hydroxyestradiol results in decreased expression of ESR2 protein
4-hydroxyestradiol inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]		 CTD
RGD		 PMID:9048584 PMID:15993745 PMID:23685341 PMID:9048584 RGD:8694130 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Foxo1 forkhead box O1 decreases expression ISO 4-hydroxyestradiol results in decreased expression of FOXO1 protein CTD PMID:23685341 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxyestradiol results in increased expression of HIF1A protein]; Sirolimus inhibits the reaction [4-hydroxyestradiol results in increased expression of HIF1A protein]; wortmannin inhibits the reaction [4-hydroxyestradiol results in increased expression of HIF1A protein] CTD PMID:15050414 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor increases expression ISO 4-hydroxyestradiol results in increased expression of IGF1R protein CTD PMID:23685341 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression
multiple interactions		 ISO 4-hydroxyestradiol results in increased expression of IGFBP1 mRNA
4-hydroxyestradiol promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of IGFBP1 mRNA]		 CTD PMID:32781018 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482 		JBrowse link
G Lep leptin increases abundance ISO LEP protein results in increased abundance of 4-hydroxyestradiol CTD PMID:24631339 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Ltf lactotransferrin increases expression ISO 4-hydroxyestradiol results in increased expression of LTF mRNA CTD PMID:9371753 PMID:9607801 NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 4-hydroxyestradiol results in increased phosphorylation of and results in increased activity of MAPK1 protein; U 0126 inhibits the reaction [4-hydroxyestradiol results in increased phosphorylation of MAPK1 protein] CTD PMID:15901486 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 4-hydroxyestradiol results in increased phosphorylation of and results in increased activity of MAPK3 protein; U 0126 inhibits the reaction [4-hydroxyestradiol results in increased phosphorylation of MAPK3 protein] CTD PMID:15901486 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 increases expression ISO 4-hydroxyestradiol results in increased expression of ATP6 mRNA CTD PMID:9886577 NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599 		JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III increases expression ISO 4-hydroxyestradiol results in increased expression of COX3 mRNA CTD PMID:9886577 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO 4-hydroxyestradiol results in increased expression of MYC protein CTD PMID:23685341 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO 4-hydroxyestradiol results in increased activity of [NFKB1 protein binds to RELA protein] CTD PMID:15901486 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Pgr progesterone receptor increases expression ISO 4-hydroxyestradiol results in increased expression of PGR mRNA CTD PMID:9607801 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Prl prolactin increases expression
multiple interactions		 ISO 4-hydroxyestradiol results in increased expression of PRL mRNA
4-hydroxyestradiol promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of PRL mRNA]		 CTD PMID:32781018 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA; Acetylcysteine inhibits the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA]; Acetylcysteine inhibits the reaction [Estradiol promotes the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA]]; BAY 11-7085 inhibits the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA]; BAY 11-7085 inhibits the reaction [Estradiol promotes the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA]]; Estradiol promotes the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA] CTD PMID:18480072 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 4-hydroxyestradiol results in increased activity of [NFKB1 protein binds to RELA protein] CTD PMID:15901486 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Shbg sex hormone binding globulin increases expression ISO 4-hydroxyestradiol results in increased expression of SHBG mRNA; 4-hydroxyestradiol results in increased expression of SHBG protein CTD PMID:21793624 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
G Sphk1 sphingosine kinase 1 increases expression ISO 4-hydroxyestradiol results in increased expression of SPHK1 mRNA CTD PMID:29654831 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240 		JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO [4-hydroxyestradiol results in increased activity of ESR1 protein] promotes the reaction [ESR1 protein binds to TFF1 promoter] CTD PMID:20540524 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxyestradiol results in increased expression of VEGFA protein]; Sirolimus inhibits the reaction [4-hydroxyestradiol results in increased expression of VEGFA protein]; wortmannin inhibits the reaction [4-hydroxyestradiol results in increased expression of VEGFA protein] CTD PMID:15050414 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
4-hydroxyestrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression
decreases response to substance		 ISO 4-hydroxyestrone results in decreased expression of NFE2L2 mRNA
NFE2L2 protein results in decreased susceptibility to 4-hydroxyestrone		 CTD PMID:25231996 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of 4-hydroxyestrone CTD PMID:15117964 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of 4-hydroxyestrone CTD PMID:15117964 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of 4-hydroxyestrone CTD PMID:15117964 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein alternative form results in increased glucuronidation of 4-hydroxyestrone; UGT2B7 protein results in increased glucuronidation of 4-hydroxyestrone CTD PMID:8423545 PMID:8517101 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
withaferin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO withaferin A inhibits the reaction [[ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]] CTD PMID:20438634 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO withaferin A promotes the reaction [Ethanol results in decreased expression of ACACA mRNA] CTD PMID:34995708 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 multiple interactions ISO withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of ADAM17 protein]; withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]] CTD PMID:24632454 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [withaferin A results in increased expression of ATF4 protein] CTD PMID:21266191 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO withaferin A results in decreased expression of and results in decreased phosphorylation of BAD protein CTD PMID:20438634 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO withaferin A results in decreased expression of BCL2 protein CTD PMID:20438634 PMID:21256832 PMID:21964475 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions ISO withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2A1 mRNA] CTD PMID:20438634 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998 		JBrowse link
G Bcl2l11 Bcl2-like 11 decreases expression ISO withaferin A results in decreased expression of BCL2L11 protein CTD PMID:20438634 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA] CTD PMID:20438634 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCND1 mRNA] CTD PMID:20438634 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A affects binding
multiple interactions
increases expression		 ISO withaferin A binds to CDKN1A protein
withaferin A results in increased expression of and affects the localization of CDKN1A protein
withaferin A results in increased expression of CDKN1A mRNA		 CTD PMID:22973447 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn2aip CDKN2A interacting protein decreases expression ISO withaferin A results in decreased expression of CDKN2AIP protein CTD PMID:22973447 NCBI chr16:44,536,147...44,546,216
Ensembl chr16:44,536,234...44,540,033 		JBrowse link
G Cldn1 claudin 1 decreases response to substance
decreases expression		 ISO CLDN1 protein results in decreased susceptibility to withaferin A
withaferin A results in decreased expression of CLDN1 mRNA; withaferin A results in decreased expression of CLDN1 protein		 CTD PMID:33665778 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724 		JBrowse link
G Cpt1c carnitine palmitoyltransferase 1c multiple interactions ISO withaferin A inhibits the reaction [Ethanol results in decreased expression of CPT1C mRNA] CTD PMID:34995708 NCBI chr 1:95,442,814...95,457,347
Ensembl chr 1:95,442,817...95,457,342 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 affects response to substance
multiple interactions
increases expression		 ISO DDIT3 mRNA affects the susceptibility to withaferin A
Acetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT3 protein]		 CTD PMID:21266191 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT4 protein] CTD PMID:21266191 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105 		JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression ISO withaferin A results in decreased expression of DNMT1 mRNA; withaferin A results in decreased expression of DNMT1 protein CTD PMID:23593078 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha decreases expression ISO withaferin A results in decreased expression of DNMT3A mRNA CTD PMID:23593078 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta decreases expression ISO withaferin A results in decreased expression of DNMT3B mRNA CTD PMID:23593078 NCBI chr 3:142,130,592...142,169,124
Ensembl chr 3:142,130,592...142,169,124 		JBrowse link
G Edil3 EGF like repeats and discoidin domains 3 decreases expression ISO withaferin A results in decreased expression of EDIL3 mRNA CTD PMID:33665778 NCBI chr 2:19,890,396...20,405,028
Ensembl chr 2:19,890,373...20,405,008 		JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase multiple interactions ISO withaferin A promotes the reaction [Ethanol results in decreased expression of EHHADH mRNA] CTD PMID:34995708 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation ISO withaferin A results in increased phosphorylation of EIF2A protein CTD PMID:21266191 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068 		JBrowse link
G Ezr ezrin multiple interactions ISO [withanone co-treated with withaferin A] results in decreased expression of EZR protein CTD PMID:25236891 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO withaferin A inhibits the reaction [Ethanol results in increased expression of FASN mRNA] CTD PMID:34995708 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO withaferin A results in increased expression of FOSL1 mRNA CTD PMID:33665778 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO withaferin A inhibits the reaction [Ethanol results in increased expression of GCLC mRNA] CTD PMID:34995708 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO withaferin A inhibits the reaction [Ethanol results in increased expression of GPT protein] CTD PMID:34995708 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO withaferin A results in decreased expression of HDAC1 protein CTD PMID:23593078 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K multiple interactions ISO [withanone co-treated with withaferin A] results in decreased expression of HNRNPK protein; withaferin A binds to and results in decreased activity of HNRNPK protein CTD PMID:25236891 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO withaferin A results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 affects binding
multiple interactions		 ISO withaferin A binds to HSPA9 protein
[withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]] which affects the localization of and results in increased activity of TP53 protein; [withanone co-treated with withaferin A] results in decreased expression of HSPA9 protein; withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]		 CTD PMID:22973447 PMID:25236891 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]] CTD PMID:24632454 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL6 protein] CTD PMID:20438634 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Krt13 keratin 13 decreases expression ISO withaferin A results in decreased expression of KRT13 mRNA CTD PMID:33665778 NCBI chr10:85,052,122...85,056,032
Ensembl chr10:85,051,889...85,056,084 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; [withanone co-treated with withaferin A] results in decreased expression of MAPK1 protein; Acetylcysteine inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein] CTD PMID:24019090 PMID:24632454 PMID:25236891 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; [withanone co-treated with withaferin A] results in decreased expression of MAPK3 protein; Acetylcysteine inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein] CTD PMID:24019090 PMID:24632454 PMID:25236891 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO withaferin A results in increased phosphorylation of MAPK8 protein CTD PMID:21964475 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
increases expression		 ISO MCL1 mutant form promotes the reaction [withaferin A results in increased cleavage of PARP1 protein]
withaferin A results in increased expression of MCL1 protein		 CTD PMID:24019090 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mecp2 methyl CpG binding protein 2 decreases expression ISO withaferin A results in decreased expression of MECP2 protein CTD PMID:23593078 NCBI chr  X:151,781,177...151,844,687
Ensembl chr  X:151,789,930...151,844,689 		JBrowse link
G Mettl7a methyltransferase like 7A decreases expression ISO withaferin A results in decreased expression of METTL7A mRNA CTD PMID:33665778 NCBI chr 7:131,452,099...131,460,154
Ensembl chr 7:131,451,641...131,460,154 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO [withanone co-treated with withaferin A] results in decreased expression of MMP2 protein CTD PMID:25236891 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects binding ISO withaferin A binds to NFE2L2 protein CTD PMID:22973447 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein] CTD PMID:20438634 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO withaferin A inhibits the reaction [Ethanol results in increased expression of NQO1 mRNA] CTD PMID:34995708 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nt5e 5' nucleotidase, ecto increases expression ISO withaferin A results in increased expression of NT5E mRNA CTD PMID:33665778 NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO Dithiothreitol inhibits the reaction [withaferin A results in increased cleavage of PARP1 protein]; MCL1 mutant form promotes the reaction [withaferin A results in increased cleavage of PARP1 protein] CTD PMID:20438634 PMID:24019090 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Procr protein C receptor multiple interactions ISO withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]] CTD PMID:24632454 NCBI chr 3:144,254,596...144,258,863
Ensembl chr 3:144,254,380...144,258,903 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO withaferin A inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; withaferin A inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:21396905 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein] CTD PMID:20438634 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slco4a1 solute carrier organic anion transporter family, member 4a1 increases expression ISO withaferin A results in increased expression of SLCO4A1 mRNA CTD PMID:33665778 NCBI chr 3:167,559,177...167,578,307
Ensembl chr 3:167,559,316...167,578,305 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein] CTD PMID:24019090 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO withaferin A inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA] CTD PMID:34995708 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO withaferin A inhibits the reaction [Ethanol results in increased expression of SREBF2 mRNA] CTD PMID:34995708 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO withaferin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased localization of and results in increased activity of STAT1 protein] CTD PMID:21396905 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO withaferin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of STAT3 protein] CTD PMID:21396905 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases activity		 ISO withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]
withaferin A results in decreased activity of TNF protein		 CTD PMID:20438634 PMID:24632454 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 multiple interactions ISO withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA] CTD PMID:20438634 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
affects binding		 ISO withaferin A results in increased expression of TP53 mRNA
[withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]] which affects the localization of and results in increased activity of TP53 protein; withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]
withaferin A binds to TP53 protein		 CTD PMID:22973447 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tuba1a tubulin, alpha 1A decreases expression ISO withaferin A results in decreased expression of TUBA1A mRNA CTD PMID:24297176 NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186 		JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression ISO withaferin A results in decreased expression of TUBB mRNA CTD PMID:24297176 NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression		 ISO [withanone co-treated with withaferin A] results in decreased secretion of VEGFA protein; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]
withaferin A results in decreased expression of VEGFA protein		 CTD PMID:20438634 PMID:25236891 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Xbp1 X-box binding protein 1 increases expression
increases splicing		 ISO withaferin A results in increased expression of XBP1 protein
withaferin A results in increased splicing of XBP1 mRNA		 CTD PMID:21266191 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20072
    chemical entity 20071
      molecular entity 20071
        polyatomic entity 20001
          heteroatomic molecular entity 19937
            hydroxides 19452
              organic hydroxy compound 19003
                hydroxy steroid 14108
                  4-hydroxy steroid 89
                    (25R)-3beta,4beta-dihydroxycholest-5-en-26-al 0
                    (25R)-3beta,4beta-dihydroxycholest-5-en-26-oic acid 0
                    (25R)-4beta,26-dihydroxycholesterol 0
                    17alpha-hydroxywithanolide D 0
                    2,3-dihydro-3beta-O-sulfate withaferin A 0
                    2,3-dihydro-3beta-methoxy withaferin A 0
                    2,3-dihydrowithaferin A 0
                    20-hydroxytubocapsanolide A 0
                    23-hydroxytubocapsanolide A 0
                    3alpha,6alpha-epoxy-4beta,5beta,27-trihydroxy-1-oxowitha-24-enolide 0
                    4-hydroxy-17beta-estradiol + 29
                    4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronide) 0
                    4-hydroxyestrone + 5
                    4-hydroxyestrone 3-O-(beta-D-glucuronide) 0
                    4beta,24S-dihydroxycholesterol 0
                    4beta,7alpha-dihydroxycholesterol 0
                    sitoindoside IX 0
                    tubocapsanolide A + 0
                    tubocapsanolide F 0
                    viscosalactone B 0
                    withaferin A + 62
                    withalongolide A 0
                    withalongolide B 0
                    withalongolide C 0
                    withalongolide D 0
                    withalongolide E 0
                    withalongolide G 0
                    withalongolide H 0
                    withanolide D + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19974
                    p-block element atom 19974
                      carbon group element atom 19903
                        carbon atom 19896
                          organic molecular entity 19896
                            organic molecule 19844
                              organic cyclic compound 19605
                                organic polycyclic compound 17197
                                  steroid 14393
                                    hydroxy steroid 14108
                                      4-hydroxy steroid 89
                                        (25R)-3beta,4beta-dihydroxycholest-5-en-26-al 0
                                        (25R)-3beta,4beta-dihydroxycholest-5-en-26-oic acid 0
                                        (25R)-4beta,26-dihydroxycholesterol 0
                                        17alpha-hydroxywithanolide D 0
                                        2,3-dihydro-3beta-O-sulfate withaferin A 0
                                        2,3-dihydro-3beta-methoxy withaferin A 0
                                        2,3-dihydrowithaferin A 0
                                        20-hydroxytubocapsanolide A 0
                                        23-hydroxytubocapsanolide A 0
                                        3alpha,6alpha-epoxy-4beta,5beta,27-trihydroxy-1-oxowitha-24-enolide 0
                                        4-hydroxy-17beta-estradiol + 29
                                        4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronide) 0
                                        4-hydroxyestrone + 5
                                        4-hydroxyestrone 3-O-(beta-D-glucuronide) 0
                                        4beta,24S-dihydroxycholesterol 0
                                        4beta,7alpha-dihydroxycholesterol 0
                                        sitoindoside IX 0
                                        tubocapsanolide A + 0
                                        tubocapsanolide F 0
                                        viscosalactone B 0
                                        withaferin A + 62
                                        withalongolide A 0
                                        withalongolide B 0
                                        withalongolide C 0
                                        withalongolide D 0
                                        withalongolide E 0
                                        withalongolide G 0
                                        withalongolide H 0
                                        withanolide D + 0
paths to the root