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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:62845
Term: 4-hydroxy-17beta-estradiol
Definition: A 4-hydroxy steroid that consists of 17beta-estradiol having an additional hydroxy group at position 4.
Chemical ID: MESH:C014036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfaincreases expressionISOVEGFA (Homo sapiens)6480464CTD4-hydroxyestradiol results in increased expression of VEGFA proteinPMID:15050414
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxyestradiol results in increased expression of VEGFA protein]; Sirolimus inhibits the reaction [4-hydroxyestradiol results in increased expression of VEGFA protein]; wortmannin inhibits the reaction [4-hydroxyestradiol results in increased expression of VEGFA protein]PMID:15050414
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