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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: nuclear factor, erythroid 2-like 2
Acc ID: CHEBI:87602
Term: 4-hydroxyestrone
Definition: A 4-hydroxy steroid that is estrone substituted by a hydroxy group at position 4.
Chemical ID: MESH:C026418
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2decreases expressionISORGD:7344316480464CTD4-hydroxyestrone results in decreased expression of NFE2L2 mRNAPMID:25231996
Nfe2l2decreases response to substanceISORGD:7344316480464CTDNFE2L2 protein results in decreased susceptibility to 4-hydroxyestronePMID:25231996
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