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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions increases phosphorylation |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxyestradiol results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [4-hydroxyestradiol results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:15050414 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Alpg |
alkaline phosphatase, germ cell |
increases activity |
ISO |
4-hydroxyestradiol results in increased activity of ALPG protein |
CTD |
PMID:15993745 |
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NCBI chr 9:87,748,721...87,761,500
Ensembl chr 9:87,753,648...87,757,836
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G |
Ar |
androgen receptor |
affects binding |
EXP |
4-hydroxyestradiol binds to AR protein |
CTD |
PMID:14565775 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Ccnd1 |
cyclin D1 |
increases expression multiple interactions |
ISO |
4-hydroxyestradiol results in increased expression of CCND1 mRNA; 4-hydroxyestradiol results in increased expression of CCND1 protein alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of CCND1 mRNA]; alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of CCND1 protein] |
CTD |
PMID:23685341 PMID:31364906 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Cdh1 |
cadherin 1 |
multiple interactions decreases expression |
ISO |
alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in decreased expression of CDH1 mRNA]; alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in decreased expression of CDH1 protein] 4-hydroxyestradiol results in decreased expression of CDH1 mRNA; 4-hydroxyestradiol results in decreased expression of CDH1 protein |
CTD |
PMID:31364906 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Comt |
catechol-O-methyltransferase |
affects metabolic processing increases methylation multiple interactions |
ISO |
COMT protein affects the metabolism of 4-hydroxyestradiol COMT protein results in increased methylation of 4-hydroxyestradiol daidzein inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol]; Estradiol inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol]; Genistein inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol] |
CTD |
PMID:15377160 PMID:18192686 |
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NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
4-hydroxyestradiol promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] |
CTD |
PMID:12093619 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
affects chemical synthesis multiple interactions increases chemical synthesis |
ISO |
CYP1B1 protein affects the chemical synthesis of 4-hydroxyestradiol [CYP1B1 protein results in increased oxidation of Estradiol] which results in increased chemical synthesis of 4-hydroxyestradiol; CYP1B1 protein affects the metabolism of [4-hydroxyestradiol co-treated with Glutathione]; Resveratrol inhibits the reaction [CYP1B1 protein affects the chemical synthesis of 4-hydroxyestradiol] CYP1B1 gene polymorphism results in increased chemical synthesis of 4-hydroxyestradiol |
CTD |
PMID:14679015 PMID:15142886 PMID:18187806 PMID:32781018 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Esr1 |
estrogen receptor 1 |
affects binding multiple interactions increases expression |
ISO |
4-hydroxyestradiol binds to ESR1 protein 4-hydroxyestradiol inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; [4-hydroxyestradiol results in increased activity of ESR1 protein] promotes the reaction [ESR1 protein binds to TFF1 promoter] 4-hydroxyestradiol results in increased expression of ESR1 protein |
CTD |
PMID:9048584 PMID:15993745 PMID:20540524 PMID:23685341 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Esr2 |
estrogen receptor 2 |
affects binding multiple interactions decreases expression |
ISO EXP |
4-hydroxyestradiol binds to ESR2 protein 4-hydroxyestradiol inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein] 4-hydroxyestradiol results in decreased expression of ESR2 protein 4-OH-estradiol binds to Esr2 protein |
CTD RGD |
PMID:9048584 PMID:15993745 PMID:23685341 PMID:9048584 |
RGD:8694130 |
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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G |
Foxo1 |
forkhead box O1 |
decreases expression |
ISO |
4-hydroxyestradiol results in decreased expression of FOXO1 protein |
CTD |
PMID:23685341 |
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NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions increases expression |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxyestradiol results in increased expression of HIF1A protein]; Sirolimus inhibits the reaction [4-hydroxyestradiol results in increased expression of HIF1A protein]; wortmannin inhibits the reaction [4-hydroxyestradiol results in increased expression of HIF1A protein] |
CTD |
PMID:15050414 |
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Igf1r |
insulin-like growth factor 1 receptor |
increases expression |
ISO |
4-hydroxyestradiol results in increased expression of IGF1R protein |
CTD |
PMID:23685341 |
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NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
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G |
Igfbp1 |
insulin-like growth factor binding protein 1 |
increases expression multiple interactions |
ISO |
4-hydroxyestradiol results in increased expression of IGFBP1 mRNA 4-hydroxyestradiol promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of IGFBP1 mRNA] |
CTD |
PMID:32781018 |
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NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
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G |
Lep |
leptin |
increases abundance |
ISO |
LEP protein results in increased abundance of 4-hydroxyestradiol |
CTD |
PMID:24631339 |
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NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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G |
Ltf |
lactotransferrin |
increases expression |
ISO |
4-hydroxyestradiol results in increased expression of LTF mRNA |
CTD |
PMID:9371753 PMID:9607801 |
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NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
4-hydroxyestradiol results in increased phosphorylation of and results in increased activity of MAPK1 protein; U 0126 inhibits the reaction [4-hydroxyestradiol results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:15901486 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
4-hydroxyestradiol results in increased phosphorylation of and results in increased activity of MAPK3 protein; U 0126 inhibits the reaction [4-hydroxyestradiol results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:15901486 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions increases expression |
ISO |
alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of MMP2 mRNA]; alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of MMP2 protein] 4-hydroxyestradiol results in increased expression of MMP2 mRNA; 4-hydroxyestradiol results in increased expression of MMP2 protein |
CTD |
PMID:31364906 |
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NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions increases expression |
ISO |
alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of MMP9 mRNA]; alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of MMP9 protein] 4-hydroxyestradiol results in increased expression of MMP9 mRNA; 4-hydroxyestradiol results in increased expression of MMP9 protein |
CTD |
PMID:31364906 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mt-atp6 |
mitochondrially encoded ATP synthase membrane subunit 6 |
increases expression |
ISO |
4-hydroxyestradiol results in increased expression of ATP6 mRNA |
CTD |
PMID:9886577 |
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NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599
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G |
Mt-co3 |
mitochondrially encoded cytochrome c oxidase III |
increases expression |
ISO |
4-hydroxyestradiol results in increased expression of COX3 mRNA |
CTD |
PMID:9886577 |
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NCBI chr MT:8,599...9,382 NCBI chr MT:8,599...9,382 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
increases expression multiple interactions |
ISO |
4-hydroxyestradiol results in increased expression of MYC mRNA; 4-hydroxyestradiol results in increased expression of MYC protein alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of MYC mRNA]; alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of MYC protein] |
CTD |
PMID:23685341 PMID:31364906 |
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
4-hydroxyestradiol results in increased activity of [NFKB1 protein binds to RELA protein] |
CTD |
PMID:15901486 |
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NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Pgr |
progesterone receptor |
increases expression |
ISO |
4-hydroxyestradiol results in increased expression of PGR mRNA |
CTD |
PMID:9607801 |
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NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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G |
Prl |
prolactin |
increases expression multiple interactions |
ISO |
4-hydroxyestradiol results in increased expression of PRL mRNA 4-hydroxyestradiol promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of PRL mRNA] |
CTD |
PMID:32781018 |
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NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA; Acetylcysteine inhibits the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA]; Acetylcysteine inhibits the reaction [Estradiol promotes the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA]]; BAY 11-7085 inhibits the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA]; BAY 11-7085 inhibits the reaction [Estradiol promotes the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA]]; Estradiol promotes the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA] |
CTD |
PMID:18480072 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
4-hydroxyestradiol results in increased activity of [NFKB1 protein binds to RELA protein] |
CTD |
PMID:15901486 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Shbg |
sex hormone binding globulin |
increases expression |
ISO |
4-hydroxyestradiol results in increased expression of SHBG mRNA; 4-hydroxyestradiol results in increased expression of SHBG protein |
CTD |
PMID:21793624 |
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NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
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G |
Sphk1 |
sphingosine kinase 1 |
increases expression |
ISO |
4-hydroxyestradiol results in increased expression of SPHK1 mRNA |
CTD |
PMID:29654831 |
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NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
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G |
Tff1 |
trefoil factor 1 |
multiple interactions |
ISO |
[4-hydroxyestradiol results in increased activity of ESR1 protein] promotes the reaction [ESR1 protein binds to TFF1 promoter] |
CTD |
PMID:20540524 |
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NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions increases expression |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxyestradiol results in increased expression of VEGFA protein]; Sirolimus inhibits the reaction [4-hydroxyestradiol results in increased expression of VEGFA protein]; wortmannin inhibits the reaction [4-hydroxyestradiol results in increased expression of VEGFA protein] |
CTD |
PMID:15050414 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Vim |
vimentin |
multiple interactions increases expression |
ISO |
alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of VIM mRNA]; alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of VIM protein] 4-hydroxyestradiol results in increased expression of VIM mRNA; 4-hydroxyestradiol results in increased expression of VIM protein |
CTD |
PMID:31364906 |
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NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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