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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-hydroxyestrone
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Accession:CHEBI:87602 term browser browse the term
Definition:A 4-hydroxy steroid that is estrone substituted by a hydroxy group at position 4.
Synonyms:exact_synonym: 3,4-dihydroxyestra-1,3,5(10)-trien-17-one
 related_synonym: 3,4-dihydroxy-estra-1,3,5(10)-trien-17-one;   Formula=C18H22O3;   InChI=1S/C18H22O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,19,21H,2-3,5,7-9H2,1H3/t11-,12-,14+,18+/m1/s1;   InChIKey=XQZVQQZZOVBNLU-QDTBLXIISA-N;   SMILES=C[C@]12CC[C@H]3[C@@H](CCc4c(O)c(O)ccc34)[C@@H]1CCC2=O;   estra-1,3,5(10)-triene-3,4-diol-17-one
 xref: CAS:3131-23-5;   HMDB:HMDB0005895
 xref_mesh: MESH:C026418
 xref: PMID:11054642;   PMID:12865317;   PMID:15525577;   PMID:19926488;   PMID:29713726;   PMID:4616428;   PMID:6540166;   PMID:7414657;   PMID:7956900;   Reaxys:2221832


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4-hydroxyestrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases expression
decreases response to substance
ISO 4-hydroxyestrone results in decreased expression of NFE2L2 mRNA
NFE2L2 protein results in decreased susceptibility to 4-hydroxyestrone
CTD PMID:25231996 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of 4-hydroxyestrone CTD PMID:15117964 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of 4-hydroxyestrone CTD PMID:15117964 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of 4-hydroxyestrone CTD PMID:15117964 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of 4-hydroxyestrone CTD PMID:15117964 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein alternative form results in increased glucuronidation of 4-hydroxyestrone; UGT2B7 protein results in increased glucuronidation of 4-hydroxyestrone CTD PMID:8423545 PMID:8517101 NCBI chr14:22,597,103...22,619,968 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      biological role 19716
        aetiopathogenetic role 18967
          carcinogenic agent 18336
            4-hydroxyestrone 6
              4-hydroxyestrone 3-O-(beta-D-glucuronide) 0
              4-hydroxyestrone 4-O-(beta-D-glucuronide) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic group 18599
                              organic divalent group 18590
                                organodiyl group 18590
                                  carbonyl group 18505
                                    carbonyl compound 18505
                                      ketone 16829
                                        oxo steroid 9722
                                          17-oxo steroid 259
                                            estrone 126
                                              4-hydroxyestrone 6
                                                4-hydroxyestrone 3-O-(beta-D-glucuronide) 0
                                                4-hydroxyestrone 4-O-(beta-D-glucuronide) 0
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