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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:telmisartan
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Accession:CHEBI:9434 term browser browse the term
Definition:A member of the class of benzimidazoles used widely in the treatment of hypertension.
Synonyms:exact_synonym: 4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl][1,1'-biphenyl]-2-carboxylic acid
 related_synonym: 4'-((4-methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl)methyl)-2-biphenylcarboxylic acid;   4'-[(1,4'-dimethyl-2'propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid;   4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl]biphenyl-2-carboxylic acid;   BIBR 277;   Formula=C33H30N4O2;   InChI=1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39);   InChIKey=RMMXLENWKUUMAY-UHFFFAOYSA-N;   Micardis;   SMILES=CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O)-c1nc2ccccc2n1C
 xref: CAS:144701-48-4;   DrugBank:DB00966;   Drug_Central:2583;   HMDB:HMDB0015101;   KEGG:C07710;   KEGG:D00627;   LINCS:LSM-3657
 xref_mesh: MESH:C084178
 xref: PMID:11558835;   PMID:15498586;   PMID:18008027;   PMID:18360028;   PMID:24048485;   Patent:EP502314;   Reaxys:6624054;   Wikipedia:Telmisartan


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telmisartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 decreases activity
multiple interactions		 ISO telmisartan results in decreased activity of ABCB11 protein
telmisartan inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]		 CTD PMID:20829430 PMID:23956101 PMID:24014644 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 multiple interactions
increases expression		 ISO PPARG mutant form inhibits the reaction [telmisartan results in increased expression of ABCG1 mRNA] CTD PMID:22124178 NCBI chr17:31,276,668...31,336,958
Ensembl chr17:31,276,649...31,336,962 		JBrowse link
G Ace angiotensin I converting enzyme decreases expression
multiple interactions		 ISO Telmisartan results in decreased expression of ACE mRNA; Telmisartan results in decreased expression of ACE protein
Telmisartan inhibits the reaction [Pregabalin results in increased expression of ACE protein]		 CTD PMID:19171132 PMID:25973029 PMID:29909460 PMID:31629013 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790 		JBrowse link
G Ace2 angiotensin converting enzyme 2 multiple interactions
increases expression
decreases expression
decreases expression 		EXP
ISO		 telmisartan inhibits the reaction [Streptozocin results in decreased expression of ACE2 protein]
Telmisartan results in increased expression of ACE2 mRNA; Telmisartan results in increased expression of ACE2 protein
Telmisartan results in decreased expression of ACE2 mRNA; Telmisartan results in decreased expression of ACE2 protein
Telmisartan inhibits the reaction [Pregabalin results in decreased expression of ACE2 protein]
telmisartan decreases expression of mRNA in mandible of rats with periodontal disease		 CTD
RGD		 PMID:21381899 PMID:25973029 PMID:28656296 PMID:29909460 PMID:31629013 More... RGD:329956421 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416 		JBrowse link
G Ache acetylcholinesterase multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [telmisartan inhibits the reaction [Streptozocin results in increased activity of ACHE protein]]; telmisartan inhibits the reaction [Streptozocin results in increased activity of ACHE protein] CTD PMID:23060470 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728 		JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant decreases activity ISO telmisartan decreases enzyme activity of Trap, Acp5 in serum of rats with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 9:22,038,023...22,047,042
Ensembl chr 9:22,038,023...22,047,007 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression EXP
ISO		 telmisartan results in increased expression of ADIPOQ mRNA
telmisartan results in increased expression of ADIPOQ protein		 CTD PMID:19730415 PMID:20555330 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Agt angiotensinogen multiple interactions
decreases expression		 EXP
ISO		 telmisartan inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results in increased expression of SERPINE1 mRNA]; telmisartan inhibits the reaction [AGT protein results in increased expression of IL6 protein]
Telmisartan inhibits the reaction [AGT protein results in decreased expression of PLAU mRNA]; Telmisartan inhibits the reaction [AGT protein results in decreased expression of SYP protein]; Telmisartan inhibits the reaction [AGT protein results in increased expression of AGTR1A mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of CACNA1G mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of CACNA1H mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of CRH protein]; Telmisartan inhibits the reaction [AGT protein results in increased expression of FN1 mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of FN1 protein]; Telmisartan inhibits the reaction [AGT protein results in increased expression of FOS protein]; Telmisartan inhibits the reaction [AGT protein results in increased expression of IL1B protein]; Telmisartan inhibits the reaction [AGT protein results in increased expression of IL6 protein]; Telmisartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; Telmisartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Telmisartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Telmisartan inhibits the reaction [AGT protein results in increased ubiquitination of SYP protein]; Telmisartan inhibits the reaction [arsenite results in increased expression of AGT protein]; Telmisartan inhibits the reaction [Diatrizoate results in increased expression of AGT protein]; Telmisartan inhibits the reaction [Iohexol results in increased expression of AGT protein]; Telmisartan inhibits the reaction [Pregabalin results in decreased expression of AGT protein]
telmisartan results in decreased expression of AGT mRNA; telmisartan results in decreased expression of AGT protein		 CTD PMID:9533614 PMID:17620961 PMID:18487452 PMID:19171132 PMID:19289654 More... NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions
decreases expression
affects binding
increases expression
decreases expression 		EXP
ISO		 telmisartan inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results in increased expression of SERPINE1 mRNA]; telmisartan inhibits the reaction [Streptozocin results in increased expression of AGTR1A protein]
telmisartan results in decreased expression of AGTR1A mRNA
telmisartan binds to and results in decreased activity of AGTR1 protein
telmisartan binds to AGTR1 protein
Telmisartan binds to and results in decreased activity of AGTR1 protein; Telmisartan inhibits the reaction [AGT protein results in increased expression of AGTR1A mRNA]; Telmisartan inhibits the reaction [Daunorubicin results in increased expression of AGTR1A protein]; Telmisartan inhibits the reaction [Pregabalin results in increased expression of AGTR1 protein]
telmisartan results in increased expression of AGTR1 mRNA
telmisartan decreases expression of mRNA in mandible of rats with periodontal disease		 CTD
RGD		 PMID:8220885 PMID:9533614 PMID:9728324 PMID:17620961 PMID:19171132 More... RGD:329956421 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b multiple interactions EXP telmisartan inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results in increased expression of SERPINE1 mRNA] CTD PMID:17620961 NCBI chr 3:20,368,637...20,421,341
Ensembl chr 3:20,368,637...20,421,341 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 increases expression ISO telmisartan increases expression of mRNA in mandible of rats with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr  X:21,350,863...21,355,072
Ensembl chr  X:21,350,783...21,355,403 		JBrowse link
G Ahr aryl-hydrocarbon receptor increases activity ISO Telmisartan results in increased activity of AHR protein CTD PMID:28728110 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
G Alb albumin affects expression
multiple interactions		 ISO
EXP		 telmisartan affects the expression of ALB protein modified form
Telmisartan affects the reaction [LEPR protein affects the abundance of ALB protein]		 CTD PMID:16671338 PMID:34464088 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Alpl alkaline phosphatase, liver/bone/kidney increases activity
multiple interactions		 ISO telmisartan increases enzyme activity of Alpl in serum of rats with periodontal disease
Telmisartan inhibits the reaction [Methotrexate results in increased expression of and results in increased secretion of ALPL protein]		 CTD
RGD		 PMID:27269004 PMID:33364953 RGD:329956421 NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695 		JBrowse link
G Ang2 angiogenin, ribonuclease A family, member 2 multiple interactions ISO telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of ANG2 protein] CTD PMID:23750309 NCBI chr14:51,432,781...51,436,400
Ensembl chr14:51,432,781...51,436,605 		JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX mRNA] CTD PMID:24831514 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 mRNA] CTD PMID:24831514 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bdnf brain derived neurotrophic factor multiple interactions EXP telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BDNF mRNA]; telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BDNF protein] CTD PMID:23747572 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Cacna1g calcium channel, voltage-dependent, T type, alpha 1G subunit multiple interactions
decreases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Telmisartan results in decreased expression of CACNA1G mRNA]; SB 203580 inhibits the reaction [Telmisartan results in decreased expression of CACNA1G mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of CACNA1G mRNA]
telmisartan results in decreased expression of CACNA1G mRNA		 CTD PMID:19292980 NCBI chr11:94,299,217...94,365,226
Ensembl chr11:94,299,217...94,365,024 		JBrowse link
G Cacna1h calcium channel, voltage-dependent, T type, alpha 1H subunit multiple interactions
decreases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [telmisartan results in decreased expression of CACNA1H mRNA]; SB 203580 inhibits the reaction [telmisartan results in decreased expression of CACNA1H mRNA]; telmisartan inhibits the reaction [AGT protein results in increased expression of CACNA1H mRNA] CTD PMID:19292980 NCBI chr17:25,593,259...25,655,308
Ensembl chr17:25,593,259...25,652,759 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression		 ISO
EXP		 telmisartan inhibits the reaction [Pyruvaldehyde results in increased cleavage of CASP3 protein]
telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of CASP3 protein]; telmisartan inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]
Telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of CASP3 protein]; Telmisartan inhibits the reaction [Diatrizoate results in increased activity of CASP3 protein]; Telmisartan inhibits the reaction [Iohexol results in increased activity of CASP3 protein]; Telmisartan inhibits the reaction [Methotrexate results in increased expression of CASP3 protein]; Telmisartan inhibits the reaction [sodium arsenite results in increased expression of CASP3]; Telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of and results in increased activity of CASP3 protein]; Telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CASP3 mRNA]
Telmisartan results in decreased expression of CASP3 protein		 CTD PMID:18565324 PMID:19452295 PMID:21620867 PMID:21819444 PMID:22750630 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Cat catalase multiple interactions ISO Telmisartan inhibits the reaction [arsenite results in decreased activity of CAT protein]; Telmisartan inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; Telmisartan inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein] CTD PMID:23750309 PMID:26929000 PMID:34339004 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression		 ISO telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]
telmisartan results in decreased expression of CCL2 protein		 CTD PMID:17922026 PMID:22124178 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases response to substance ISO telmisartan results in decreased susceptibility to CCL5 protein CTD PMID:18158351 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 decreases expression ISO telmisartan results in decreased expression of CCR2 mRNA CTD PMID:17922026 NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594 		JBrowse link
G Cd36 CD36 molecule increases expression
multiple interactions		 ISO telmisartan results in increased expression of CD36 mRNA
PPARG mutant form inhibits the reaction [telmisartan results in increased expression of CD36 mRNA]; T 0070907 inhibits the reaction [telmisartan results in increased expression of CD36 mRNA]		 CTD PMID:22124178 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO telmisartan inhibits the reaction [TNF protein promotes the reaction [CEBPB protein binds to IL6 promoter]] CTD PMID:19289654 NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338 		JBrowse link
G Crh corticotropin releasing hormone multiple interactions ISO Telmisartan inhibits the reaction [AGT protein results in increased expression of CRH protein] CTD PMID:33872574 NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560 		JBrowse link
G Crp C-reactive protein, pentraxin-related decreases expression ISO telmisartan results in decreased expression of CRP protein CTD PMID:20555330 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Ctsk cathepsin K decreases expression ISO telmisartan decreases expression of mRNA in mandible of rats with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 3:95,406,521...95,416,698
Ensembl chr 3:95,406,567...95,416,673 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions
decreases response to substance		 ISO PPARG protein promotes the reaction [telmisartan inhibits the reaction [CXCL12 protein affects the localization of ICAM3 protein]]; telmisartan inhibits the reaction [CXCL12 protein affects the localization of ICAM3 protein]
telmisartan results in decreased susceptibility to CXCL12 protein		 CTD PMID:18158351 NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 decreases expression ISO telmisartan metabolite results in decreased expression of CXCL8 mRNA CTD PMID:26528891 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression ISO telmisartan decreases expression of protein in mandible of SHR rats with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459 		JBrowse link
G Cyba cytochrome b-245, alpha polypeptide decreases expression
multiple interactions		 EXP
ISO		 telmisartan results in decreased expression of CYBA mRNA; telmisartan results in decreased expression of CYBA protein
telmisartan inhibits the reaction [Daunorubicin results in increased expression of CYBA protein]		 CTD PMID:16141465 PMID:19171132 PMID:21054405 NCBI chr 8:123,151,510...123,159,679
Ensembl chr 8:123,151,515...123,159,669 		JBrowse link
G Cybb cytochrome b-245, beta polypeptide multiple interactions
decreases expression		 EXP
ISO		 telmisartan inhibits the reaction [Streptozocin results in increased expression of CYBB protein]
telmisartan results in decreased expression of CYBB mRNA
Telmisartan inhibits the reaction [Glucose results in increased expression of CYBB mRNA]; Telmisartan inhibits the reaction [Glucose results in increased expression of CYBB protein]
Telmisartan inhibits the reaction [arsenite results in increased expression of CYBB mRNA]		 CTD PMID:19171132 PMID:21381899 PMID:34339004 PMID:34464088 NCBI chr  X:9,301,493...9,354,005
Ensembl chr  X:9,301,491...9,354,010 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CYCS mRNA] CTD PMID:24831514 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Cyp2j9 cytochrome P450, family 2, subfamily j, polypeptide 9 decreases activity ISO Telmisartan results in decreased activity of CYP2J2 protein CTD PMID:30965050 NCBI chr 4:96,456,661...96,480,748
Ensembl chr 4:96,456,666...96,479,815 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 decreases expression ISO telmisartan results in decreased expression of DDIT3 protein CTD PMID:19102871 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Edn1 endothelin 1 multiple interactions ISO telmisartan inhibits the reaction [Daunorubicin results in increased expression of EDN1 protein] CTD PMID:20888384 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466 		JBrowse link
G Ednra endothelin receptor type A multiple interactions ISO telmisartan inhibits the reaction [Daunorubicin results in increased expression of EDNRA protein] CTD PMID:20888384 NCBI chr 8:78,389,658...78,451,081
Ensembl chr 8:78,389,660...78,451,093 		JBrowse link
G Ednrb endothelin receptor type B multiple interactions ISO telmisartan promotes the reaction [Daunorubicin results in increased expression of EDNRB protein] CTD PMID:20888384 NCBI chr14:104,052,055...104,081,764
Ensembl chr14:104,052,061...104,081,838 		JBrowse link
G Fasl Fas ligand multiple interactions EXP
ISO		 telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of FASL protein]
telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of FASLG protein]		 CTD PMID:21620867 PMID:21819444 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO telmisartan inhibits the reaction [AGT protein results in increased expression of FN1 mRNA]; telmisartan inhibits the reaction [AGT protein results in increased expression of FN1 protein] CTD PMID:19706694 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359 		JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions ISO Telmisartan inhibits the reaction [AGT protein results in increased expression of FOS protein] CTD PMID:33872574 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Gdnf glial cell line derived neurotrophic factor multiple interactions EXP telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GDNF mRNA]; telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GDNF protein] CTD PMID:23747572 NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions
decreases expression		 EXP
ISO		 telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GFAP protein]
Telmisartan results in decreased expression of GFAP protein		 CTD PMID:23747572 PMID:29909460 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions ISO telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of GGT1 protein] CTD PMID:23750309 NCBI chr10:75,396,910...75,422,027
Ensembl chr10:75,397,438...75,422,034 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO Telmisartan inhibits the reaction [Dibutyl Phthalate results in increased expression of GJA1 protein] CTD PMID:37356649 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1, soluble multiple interactions ISO Telmisartan inhibits the reaction [Methotrexate results in increased expression of and results in increased secretion of GOT1 protein] CTD PMID:27269004 NCBI chr19:43,488,191...43,514,743
Ensembl chr19:43,488,191...43,513,044 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO Telmisartan inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; Telmisartan inhibits the reaction [Methotrexate results in increased expression of and results in increased secretion of GPT protein] CTD PMID:26929000 PMID:27269004 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Gsr glutathione reductase decreases activity
multiple interactions		 ISO Telmisartan results in decreased activity of GSR protein
Telmisartan inhibits the reaction [arsenite results in decreased activity of GSR protein]		 CTD PMID:34339004 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Hgf hepatocyte growth factor increases expression EXP telmisartan results in increased expression of HGF mRNA CTD PMID:21479465 NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150 		JBrowse link
G Hspa5 heat shock protein 5 decreases expression ISO telmisartan results in decreased expression of HSPA5 protein CTD PMID:19102871 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Ibsp integrin binding sialoprotein increases expression ISO telmisartan increases expression of mRNA in mandible of WKY rats with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 5:104,447,153...104,459,338
Ensembl chr 5:104,447,037...104,459,335 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO
EXP		 telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]
telmisartan inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]
telmisartan inhibits the reaction [Daunorubicin results in increased expression of ICAM1 protein]		 CTD PMID:17724226 PMID:20888384 PMID:22124178 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
decreases expression 		ISO telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL10 protein]
Telmisartan results in increased expression of IL10 protein
telmisartan decreases expression of protein in mandible of WKY rats with periodontal disease		 CTD
RGD		 PMID:24831514 PMID:29909460 PMID:33364953 RGD:329956421 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression 		ISO telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
Telmisartan inhibits the reaction [AGT protein results in increased expression of IL1B protein]; Telmisartan inhibits the reaction [arsenite results in increased expression of IL1B protein]
telmisartan decreases expression of protein in mandible of SHR rats with periodontal disease		 CTD
RGD		 PMID:22124178 PMID:33872574 PMID:34339004 PMID:33364953 RGD:329956421 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression		 ISO
EXP		 telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
telmisartan inhibits the reaction [AGT protein results in increased expression of IL6 protein]; telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 protein]
2-chloro-5-nitrobenzanilide inhibits the reaction [Telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; Telmisartan inhibits the reaction [AGT protein results in increased expression of IL6 protein]; Telmisartan inhibits the reaction [arsenite results in increased expression of IL6 protein]; Telmisartan inhibits the reaction [TNF protein promotes the reaction [CEBPB protein binds to IL6 promoter]]; Telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; Telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 protein]
telmisartan results in decreased expression of IL6 mRNA
Telmisartan results in decreased expression of IL6 protein		 CTD PMID:19289654 PMID:21479465 PMID:22124178 PMID:29909460 PMID:34339004 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Ins1 insulin I increases expression ISO Telmisartan results in increased expression of INS1 protein CTD PMID:19171132 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Ins2 insulin II decreases expression ISO telmisartan results in decreased expression of INS protein CTD PMID:15892894 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO [Atorvastatin co-treated with Telmisartan] results in decreased expression of IRAK1 mRNA CTD PMID:20524934 NCBI chr  X:73,057,520...73,067,527
Ensembl chr  X:73,057,520...73,067,524 		JBrowse link
G Kcnn4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 decreases expression ISO telmisartan decreases expression of KCNN4 mRNA and protein in CD4-positive alpha-beta T cell RGD PMID:26502942 RGD:329955577 NCBI chr 7:24,069,750...24,084,635
Ensembl chr 7:24,069,688...24,086,115 		JBrowse link
G Lepr leptin receptor multiple interactions EXP Telmisartan affects the reaction [LEPR protein affects the abundance of ALB protein]; Telmisartan affects the reaction [LEPR protein affects the expression of OCLN mRNA] CTD PMID:34464088 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549 		JBrowse link
G Lipe lipase, hormone sensitive multiple interactions
increases expression		 EXP PPARD promotes the reaction [telmisartan results in increased expression of LIPE protein] CTD PMID:20176998 NCBI chr 7:25,078,952...25,097,911
Ensembl chr 7:25,078,952...25,098,135 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO telmisartan inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
Telmisartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]		 CTD PMID:22124178 PMID:33872574 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 multiple interactions
decreases phosphorylation		 ISO telmisartan inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK14 protein]
telmisartan results in decreased phosphorylation of MAPK14 protein		 CTD PMID:19292980 PMID:22124178 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO telmisartan inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
Telmisartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]		 CTD PMID:22124178 PMID:33872574 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapkapk2 MAP kinase-activated protein kinase 2 multiple interactions EXP telmisartan inhibits the reaction [Streptozocin results in increased expression of MAPKAPK2 protein modified form] CTD PMID:21381899 NCBI chr 1:130,981,437...131,025,580
Ensembl chr 1:130,981,437...131,025,563 		JBrowse link
G Mas1 MAS1 oncogene multiple interactions
increases expression		 EXP
ISO		 telmisartan inhibits the reaction [Streptozocin results in decreased expression of MAS1 protein]
Telmisartan results in increased expression of MAS1 protein
Telmisartan inhibits the reaction [Pregabalin results in decreased expression of MAS1 protein]		 CTD PMID:21381899 PMID:28656296 PMID:31629013 NCBI chr17:13,056,981...13,087,037
Ensembl chr17:13,059,966...13,087,030 		JBrowse link
G Mir146 microRNA 146 multiple interactions ISO [Atorvastatin co-treated with Telmisartan] results in decreased expression of MIR146A
telmisartan inhibits the reaction [ischemia-reperfusion injury increases expression of Mir146a miRNA in kidney]		 CTD
RGD		 PMID:20524934 PMID:27760486 RGD:155882556 NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288 		JBrowse link
G Mir146b microRNA 146b multiple interactions ISO [Atorvastatin co-treated with Telmisartan] results in decreased expression of MIR146B CTD PMID:20524934 NCBI chr19:46,331,201...46,331,309
Ensembl chr19:46,331,201...46,331,309 		JBrowse link
G Mir320 microRNA 320 multiple interactions ISO telmisartan inhibits the reaction [ischemia-reperfusion injury increases expression of Mir320a miRNA in kidney] RGD PMID:27760486 RGD:155882556 NCBI chr14:70,680,950...70,681,031
Ensembl chr14:70,680,950...70,681,031 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
decreases expression 		ISO telmisartan results in decreased expression of MMP2 protein
telmisartan decreases expression of mRNA in mandible of WKY rats with periodontal disease		 CTD
RGD		 PMID:21054405 PMID:33364953 RGD:329956421 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO telmisartan decreases expression of mRNA in mandible of SHR rats with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP
ISO		 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [telmisartan inhibits the reaction [Streptozocin results in increased activity of MPO protein]]; telmisartan inhibits the reaction [Streptozocin results in increased activity of MPO protein]
telmisartan inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein]; telmisartan inhibits the reaction [sodium arsenite results in increased activity of MPO protein]; telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]		 CTD PMID:23060470 PMID:24831514 PMID:26439596 PMID:26929000 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Mylk myosin, light polypeptide kinase multiple interactions ISO MYLK protein inhibits the reaction [Telmisartan inhibits the reaction [Glucose results in decreased expression of OCLN mRNA]]; Telmisartan inhibits the reaction [Glucose results in increased expression of MYLK mRNA]; Telmisartan inhibits the reaction [Glucose results in increased expression of MYLK protein] CTD PMID:34464088 NCBI chr16:34,565,569...34,822,806
Ensembl chr16:34,565,580...34,822,790 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions
decreases expression		 EXP
ISO		 telmisartan inhibits the reaction [Streptozocin results in increased expression of NCF1 protein]
telmisartan results in decreased expression of NCF1 mRNA; telmisartan results in decreased expression of NCF1 protein
telmisartan inhibits the reaction [Daunorubicin results in increased expression of NCF1 protein]		 CTD PMID:16141465 PMID:19171132 PMID:21054405 PMID:21381899 NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions
decreases expression		 EXP
ISO		 telmisartan inhibits the reaction [Streptozocin results in increased expression of NCF2 protein]
telmisartan results in decreased expression of NCF2 mRNA; telmisartan results in decreased expression of NCF2 protein
telmisartan inhibits the reaction [Daunorubicin results in increased expression of NCF2 protein]		 CTD PMID:16141465 PMID:21054405 PMID:21381899 NCBI chr 1:152,675,904...152,712,743
Ensembl chr 1:152,675,945...152,712,742 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions EXP telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of NFKB1 protein] CTD PMID:21620867 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO PPARG mutant form inhibits the reaction [telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of NFKBIA mRNA]]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of NFKBIA mRNA] CTD PMID:22124178 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP
ISO		 telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of NOS2 protein]; telmisartan inhibits the reaction [sodium arsenite results in increased expression of NOS2 protein]
Telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of NOS2 protein]; Telmisartan inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; Telmisartan inhibits the reaction [Methotrexate results in increased expression of NOS2 protein]; Telmisartan inhibits the reaction [sodium arsenite results in increased expression of NOS2]; Telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]		 CTD PMID:21620867 PMID:21819444 PMID:22750630 PMID:24831514 PMID:26439596 More... NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell multiple interactions
increases expression
increases phosphorylation		 EXP 2-chloro-5-nitrobenzanilide inhibits the reaction [Telmisartan results in increased expression of NOS3 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Telmisartan results in increased phosphorylation of NOS3 protein]
telmisartan results in increased expression of NOS3 protein
telmisartan results in increased phosphorylation of NOS3 protein		 CTD PMID:21156825 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO telmisartan inhibits the reaction [Daunorubicin results in increased expression of NOX4 protein] CTD PMID:21054405 NCBI chr 7:86,893,638...87,047,918
Ensembl chr 7:86,895,304...87,047,918 		JBrowse link
G Nppb natriuretic peptide type B affects expression
decreases expression
multiple interactions		 ISO telmisartan affects the expression of NPPB protein
telmisartan results in decreased expression of NPPB protein
Telmisartan inhibits the reaction [Pregabalin results in increased expression of NPPB protein]		 CTD PMID:16671338 PMID:18712048 PMID:31629013 NCBI chr 4:148,070,264...148,071,662
Ensembl chr 4:148,070,245...148,071,662 		JBrowse link
G Ocln occludin multiple interactions EXP
ISO		 Telmisartan affects the reaction [LEPR protein affects the expression of OCLN mRNA]
MYLK protein inhibits the reaction [Telmisartan inhibits the reaction [Glucose results in decreased expression of OCLN mRNA]]; Telmisartan inhibits the reaction [Glucose results in decreased expression of OCLN mRNA]; Telmisartan inhibits the reaction [Glucose results in decreased expression of OCLN protein]		 CTD PMID:34464088 NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226 		JBrowse link
G Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 multiple interactions ISO telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of OLR1 mRNA]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of OLR1 protein] CTD PMID:22124178 NCBI chr 6:129,456,113...129,484,312
Ensembl chr 6:129,462,207...129,484,128 		JBrowse link
G Plau plasminogen activator, urokinase multiple interactions ISO telmisartan inhibits the reaction [AGT protein results in decreased expression of PLAU mRNA] CTD PMID:19706694 NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453 		JBrowse link
G Ppard peroxisome proliferator activator receptor delta multiple interactions
increases expression		 EXP
ISO		 PPARD promotes the reaction [Telmisartan results in increased expression of LIPE protein]; PPARD promotes the reaction [Telmisartan results in increased expression of UCP1 protein]; PPARD promotes the reaction [Telmisartan results in increased expression of UCP2 protein]; PPARD promotes the reaction [Telmisartan results in increased expression of UCP3 protein]
telmisartan results in increased expression of PPARD protein		 CTD PMID:20176998 NCBI chr17:28,451,715...28,520,446
Ensembl chr17:28,451,674...28,520,448 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions
increases activity
increases expression		 ISO
EXP		 PPARG mutant form inhibits the reaction [telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of NFKBIA mRNA]]; PPARG mutant form inhibits the reaction [telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; PPARG mutant form inhibits the reaction [telmisartan results in increased expression of ABCG1 mRNA]; PPARG mutant form inhibits the reaction [telmisartan results in increased expression of CD36 mRNA]; PPARG protein promotes the reaction [telmisartan inhibits the reaction [CXCL12 protein affects the localization of ICAM3 protein]]
Telmisartan results in increased activity of PPARG protein
telmisartan inhibits the reaction [Streptozocin results in decreased expression of PPARG protein]
telmisartan results in increased expression of PPARG protein
telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of PPARG mRNA]; telmisartan promotes the reaction [Daunorubicin results in increased expression of PPARG protein]		 CTD PMID:18158351 PMID:20176998 PMID:20888384 PMID:21381899 PMID:22124178 More... NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions EXP telmisartan inhibits the reaction [Streptozocin results in decreased expression of PPARGC1A protein] CTD PMID:21381899 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068 		JBrowse link
G Prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit multiple interactions ISO Telmisartan inhibits the reaction [Dibutyl Phthalate results in increased expression of PRKAA2 protein] CTD PMID:37356649 NCBI chr 4:104,886,846...104,967,095
Ensembl chr 4:104,887,071...104,967,087 		JBrowse link
G Prkaca protein kinase, cAMP dependent, catalytic, alpha multiple interactions ISO Telmisartan inhibits the reaction [Pregabalin results in decreased expression of PRKACA protein] CTD PMID:31629013 NCBI chr 8:84,699,607...84,723,073
Ensembl chr 8:84,699,622...84,723,072 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases activity		 ISO
EXP		 telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
[Telmisartan co-treated with Aspirin] inhibits the reaction [Streptozocin results in increased expression of PTGS2 protein]; Telmisartan inhibits the reaction [arsenite results in increased activity of PTGS2 protein]; Telmisartan inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; Telmisartan inhibits the reaction [Daunorubicin results in increased expression of PTGS2 protein]; Telmisartan inhibits the reaction [Methotrexate results in increased expression of PTGS2 protein]; Telmisartan inhibits the reaction [sodium arsenite results in increased expression of PTGS2]; Telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]
telmisartan inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]
Telmisartan results in increased activity of PTGS2 protein		 CTD PMID:20223228 PMID:20888384 PMID:22124178 PMID:22750630 PMID:24831514 More... NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Pth1r parathyroid hormone 1 receptor multiple interactions ISO telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of PTH1R protein] CTD PMID:23750309 NCBI chr 9:110,551,132...110,576,213
Ensembl chr 9:110,551,153...110,576,213 		JBrowse link
G Pthlh parathyroid hormone-like peptide multiple interactions ISO telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of PTHLH protein] CTD PMID:23750309 NCBI chr 6:147,153,607...147,165,511
Ensembl chr 6:147,153,599...147,165,681 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO [telmisartan co-treated with Aspirin] inhibits the reaction [Streptozocin results in increased expression of RELA protein]; telmisartan inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein]; telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RELA mRNA]; telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RELA protein]
telmisartan inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]		 CTD PMID:20223228 PMID:22124178 PMID:24831514 PMID:26929000 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Ren1 renin 1 structural increases expression ISO telmisartan results in increased expression of REN mRNA; telmisartan results in increased expression of REN protein CTD PMID:9533614 NCBI chr 1:133,278,412...133,288,058
Ensembl chr 1:133,278,248...133,288,063 		JBrowse link
G Runx2 runt related transcription factor 2 increases expression ISO telmisartan increases expression of mRNA in mandible of rats with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr17:44,806,873...45,125,518
Ensembl chr17:44,806,874...45,125,684 		JBrowse link
G Scn5a sodium channel, voltage-gated, type V, alpha increases activity ISO telmisartan results in increased activity of SCN5A protein CTD PMID:29306026 NCBI chr 9:119,312,470...119,408,096
Ensembl chr 9:119,312,474...119,408,082 		JBrowse link
G Sema3b sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B multiple interactions ISO telmisartan inhibits the reaction [Calcitriol results in increased expression of SEMA3B protein]; telmisartan inhibits the reaction [Progesterone results in increased expression of SEMA3B protein] CTD PMID:21933904 NCBI chr 9:107,474,868...107,486,440
Ensembl chr 9:107,474,873...107,486,428 		JBrowse link
G Sema3f sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F multiple interactions ISO telmisartan inhibits the reaction [Calcitriol results in increased expression of SEMA3F protein]; telmisartan inhibits the reaction [Progesterone results in increased expression of SEMA3F protein] CTD PMID:21933904 NCBI chr 9:107,558,698...107,587,674
Ensembl chr 9:107,558,699...107,587,674 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 multiple interactions EXP
ISO		 Telmisartan inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results in increased expression of SERPINE1 mRNA]; Telmisartan inhibits the reaction [Hydrogen Peroxide results in increased expression of SERPINE1 mRNA]
telmisartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]		 CTD PMID:17620961 PMID:19706694 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 multiple interactions EXP telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC18A2 protein] CTD PMID:23747572 NCBI chr19:59,249,310...59,284,444
Ensembl chr19:59,249,328...59,284,444 		JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO telmisartan inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375 		JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 multiple interactions EXP telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC6A3 mRNA]; telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC6A3 protein] CTD PMID:23747572 NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791 		JBrowse link
G Snca synuclein, alpha multiple interactions EXP telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA mRNA]; telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA protein] CTD PMID:23747572 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839 		JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions ISO Telmisartan inhibits the reaction [Methotrexate results in decreased expression of and results in decreased activity of SOD1 protein] CTD PMID:27269004 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Spmip11 sperm microtubule inner protein 11 multiple interactions ISO Telmisartan inhibits the reaction [Daunorubicin results in decreased expression of NPHS1 protein] CTD PMID:20888384 NCBI chr15:98,468,885...98,487,469
Ensembl chr15:98,468,885...98,487,461 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO telmisartan increases expression of mRNA in mandible of WKY rats with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916 		JBrowse link
G Syp synaptophysin multiple interactions EXP
ISO		 telmisartan inhibits the reaction [Streptozocin results in decreased expression of SYP protein]
telmisartan inhibits the reaction [AGT protein results in decreased expression of SYP protein]; telmisartan inhibits the reaction [AGT protein results in increased ubiquitination of SYP protein]		 CTD PMID:18487452 NCBI chr  X:7,504,819...7,519,495
Ensembl chr  X:7,504,710...7,519,495 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression		 EXP
ISO		 telmisartan inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]
telmisartan inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA]; telmisartan inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; telmisartan inhibits the reaction [Daunorubicin results in increased expression of TGFB1 protein]
telmisartan results in decreased expression of TGFB1 mRNA		 CTD PMID:19171132 PMID:19706694 PMID:20888384 PMID:21381899 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]; telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein] CTD PMID:23747572 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions
affects localization
decreases expression		 ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan affects the localization of TJP1 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan results in decreased expression of TJP1 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan results in decreased expression of TJP1 protein]; wortmannin inhibits the reaction [telmisartan affects the localization of TJP1 protein]; wortmannin inhibits the reaction [telmisartan results in decreased expression of TJP1 mRNA]; wortmannin inhibits the reaction [telmisartan results in decreased expression of TJP1 protein]
telmisartan results in decreased expression of TJP1 mRNA; telmisartan results in decreased expression of TJP1 protein		 CTD PMID:19252288 NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO [Atorvastatin co-treated with Telmisartan] results in decreased expression of TLR4 mRNA; [Atorvastatin co-treated with Telmisartan] results in decreased expression of TLR4 protein CTD PMID:20524934 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
decreases expression 		ISO
EXP		 PPARG mutant form inhibits the reaction [telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; T 0070907 inhibits the reaction [telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; T 0070907 inhibits the reaction [telmisartan inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
2-chloro-5-nitrobenzanilide inhibits the reaction [Telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; [Telmisartan co-treated with Aspirin] inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Telmisartan inhibits the reaction [arsenite results in increased expression of TNF protein]; Telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of TNF]; Telmisartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Telmisartan inhibits the reaction [sodium arsenite results in increased expression of TNF]; Telmisartan inhibits the reaction [TNF protein promotes the reaction [CEBPB protein binds to IL6 promoter]]; Telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; Telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 protein]; Telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of TNF protein]; telmisartan inhibits the reaction [sodium arsenite results in increased expression of TNF protein]; telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 protein]
Telmisartan results in decreased expression of TNF protein
telmisartan decreases expression of protein in mandible of SHR rats with periodontal disease		 CTD
RGD		 PMID:19289654 PMID:20223228 PMID:21620867 PMID:21819444 PMID:22124178 More... RGD:329956421 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) increases expression ISO telmisartan increases expression of mRNA in mandible of WKY rats with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr15:54,114,014...54,141,700
Ensembl chr15:54,114,015...54,141,880 		JBrowse link
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 decreases expression ISO telmisartan decreases expression of mRNA in mandible of SHR rats with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483 		JBrowse link
G Traf6 TNF receptor-associated factor 6 multiple interactions ISO [Atorvastatin co-treated with Telmisartan] results in decreased expression of TRAF6 mRNA CTD PMID:20524934 NCBI chr 2:101,508,765...101,532,013
Ensembl chr 2:101,508,774...101,532,014 		JBrowse link
G Ucp1 uncoupling protein 1 (mitochondrial, proton carrier) multiple interactions
increases expression		 EXP PPARD promotes the reaction [telmisartan results in increased expression of UCP1 protein] CTD PMID:20176998 NCBI chr 8:84,016,977...84,025,085
Ensembl chr 8:84,016,981...84,025,081 		JBrowse link
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) multiple interactions
increases expression		 EXP PPARD promotes the reaction [telmisartan results in increased expression of UCP2 protein] CTD PMID:20176998 NCBI chr 7:100,142,565...100,148,832
Ensembl chr 7:100,142,544...100,151,227 		JBrowse link
G Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) multiple interactions
increases expression		 EXP PPARD promotes the reaction [telmisartan results in increased expression of UCP3 protein] CTD PMID:20176998 NCBI chr 7:100,122,198...100,135,639
Ensembl chr 7:100,122,197...100,135,639 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO telmisartan inhibits the reaction [Daunorubicin results in increased expression of VCAM1 protein] CTD PMID:20888384 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression		 EXP
ISO		 telmisartan inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]
telmisartan results in decreased expression of VEGFA mRNA
telmisartan inhibits the reaction [sodium arsenite results in increased expression of VEGFA]		 CTD PMID:17724226 PMID:19171132 PMID:26439596 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Vtn vitronectin decreases expression ISO telmisartan decreases expression of mRNA in mandible of SHR rats with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr11:78,389,946...78,393,151
Ensembl chr11:78,389,917...78,393,150 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22307
    role 22292
      biological role 22291
        xenobiotic 19734
          telmisartan 124
Path 2
Term Annotations click to browse term
  CHEBI ontology 22307
    subatomic particle 22302
      composite particle 22302
        hadron 22302
          baryon 22302
            nucleon 22302
              atomic nucleus 22302
                atom 22302
                  main group element atom 22182
                    p-block element atom 22182
                      carbon group element atom 21984
                        carbon atom 21924
                          organic molecular entity 21924
                            heteroorganic entity 21565
                              organochalcogen compound 21051
                                organooxygen compound 20899
                                  carbon oxoacid 19649
                                    carboxylic acid 19645
                                      aromatic carboxylic acid 12937
                                        benzoic acids 12915
                                          carboxybiphenyl 126
                                            telmisartan 124
paths to the root