Ncf2 (neutrophil cytosolic factor 2) - Rat Genome Database

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Gene: Ncf2 (neutrophil cytosolic factor 2) Mus musculus
Analyze
Symbol: Ncf2
Name: neutrophil cytosolic factor 2
RGD ID: 1319761
MGI Page MGI
Description: Enables small GTPase binding activity. Contributes to superoxide-generating NAD(P)H oxidase activity. Acts upstream of or within superoxide anion generation. Located in acrosomal vesicle. Is expressed in several structures, including hemolymphoid system; limb; and liver. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal recessive chronic granulomatous disease 2; and rheumatoid arthritis. Orthologous to human NCF2 (neutrophil cytosolic factor 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 67 kDa neutrophil oxidase factor; NADPH oxidase activator 2; NADPH oxidase subunit (67 kD); NADPH oxidase subunit (67kDa); Ncf-; Ncf-2; neutrophil cytosol factor 2; neutrophil NADPH oxidase factor 2; NO; NOXA2; p67-phox; p67p; p67phox
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Ncf2-rs  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391152,675,904 - 152,712,743 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1152,675,945 - 152,712,742 (+)EnsemblGRCm39 Ensembl
GRCm381152,800,153 - 152,836,990 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1152,800,194 - 152,836,991 (+)EnsemblGRCm38mm10GRCm38
MGSCv371154,655,020 - 154,684,120 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361154,570,108 - 154,599,208 (+)NCBIMGSCv36mm8
Celera1155,229,233 - 155,258,077 (+)NCBICelera
Cytogenetic Map1G3NCBI
cM Map165.05NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
8-Br-cAMP  (ISO)
acetamide  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
apocynin  (EXP,ISO)
arachidonic acid  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP,ISO)
azathioprine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
berberine  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
BQ 123  (EXP)
bromodichloromethane  (EXP)
cadmium dichloride  (ISO)
cannabidiol  (EXP)
carbamazepine  (ISO)
carbon nanotube  (EXP)
ceric oxide  (ISO)
cerium trichloride  (ISO)
CGP 52608  (ISO)
choline  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
clothianidin  (ISO)
cobalt dichloride  (EXP)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
D-glucose  (ISO)
daunorubicin  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
Diallyltetrasulfane  (ISO)
diarsenic trioxide  (EXP,ISO)
dichloromethane  (ISO)
diminazene diaceturate  (ISO)
dioxygen  (ISO)
dofetilide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
endosulfan  (ISO)
ethanol  (EXP)
ethylbenzene  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
gentamycin  (ISO)
glucose  (ISO)
hexadecanoic acid  (ISO)
hydrogen chloride  (EXP)
hydroquinone  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
kanamycin A  (EXP)
L-methionine  (EXP)
Lasiocarpine  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
medroxyprogesterone acetate  (ISO)
menadione  (EXP)
microcystin-LR  (EXP)
N-acetyl-L-cysteine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nebivolol  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
O-methyleugenol  (ISO)
o-xylene  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
potassium chromate  (ISO)
progesterone  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rottlerin  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
spironolactone  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
superoxide  (ISO)
tamoxifen  (ISO)
telmisartan  (EXP,ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
trichloroethene  (ISO)
triphenylstannane  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Flow-induced remodeling in resistance arteries from obese Zucker rats is associated with endothelial dysfunction. Bouvet C, etal., Hypertension. 2007 Jul;50(1):248-54. Epub 2007 May 21.
2. Elevated expression of p47phox and p67phox proteins in neutrophils from burned rats. Fazal N, etal., Shock. 1997 Oct;8(4):256-60.
3. Increased expression of NAD(P)H oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension. Feng D, etal., Cell Metab. 2012 Feb 8;15(2):201-8. doi: 10.1016/j.cmet.2012.01.003.
4. Genes for two autosomal recessive forms of chronic granulomatous disease assigned to 1q25 (NCF2) and 7q11.23 (NCF1). Francke U, etal., Am J Hum Genet. 1990 Sep;47(3):483-92.
5. Translocation of glomerular p47phox and p67phox by protein kinase C-beta activation is required for oxidative stress in diabetic nephropathy. Kitada M, etal., Diabetes. 2003 Oct;52(10):2603-14.
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity. Olsson LM, etal., Arthritis Res Ther. 2007;9(5):R98. doi: 10.1186/ar2299.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Activation of NADPH oxidase and extracellular superoxide production in seizure-induced hippocampal damage. Patel M, etal., J Neurochem. 2005 Jan;92(1):123-31.
10. Effect of chronic apocynin treatment on nitric oxide and reactive oxygen species production in borderline and spontaneous hypertension. Pechanova O, etal., Pharmacol Rep. 2009 Jan-Feb;61(1):116-22.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Activation of NADPH oxidase in Alzheimer's disease brains. Shimohama S, etal., Biochem Biophys Res Commun. 2000 Jun 24;273(1):5-9.
15. NAD(P)H oxidase, superoxide dismutase, catalase, glutathione peroxidase and nitric oxide synthase expression in subacute spinal cord injury. Vaziri ND, etal., Brain Res. 2004 Jan 2;995(1):76-83.
16. Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus. Wenzel P, etal., Atherosclerosis. 2008 May;198(1):65-76. Epub 2007 Dec 3.
Additional References at PubMed
PMID:6092933   PMID:8119734   PMID:9490028   PMID:10349636   PMID:10447107   PMID:10455184   PMID:10647999   PMID:11042159   PMID:11076861   PMID:11090627   PMID:11197687   PMID:11217851  
PMID:11489951   PMID:11818454   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15814684   PMID:15850784   PMID:16141072   PMID:16141073   PMID:16709856   PMID:17662968   PMID:18566430  
PMID:19283362   PMID:20454568   PMID:21267068   PMID:21551061   PMID:21677750   PMID:21873635   PMID:22075471   PMID:22221582   PMID:22787054   PMID:23401562   PMID:27689697   PMID:28378742  
PMID:28471497   PMID:29499563   PMID:30062795   PMID:30973865   PMID:31442911   PMID:32245826   PMID:32325033   PMID:32554809   PMID:34047696   PMID:35357446   PMID:36426951   PMID:38395995  


Genomics

Comparative Map Data
Ncf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391152,675,904 - 152,712,743 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1152,675,945 - 152,712,742 (+)EnsemblGRCm39 Ensembl
GRCm381152,800,153 - 152,836,990 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1152,800,194 - 152,836,991 (+)EnsemblGRCm38mm10GRCm38
MGSCv371154,655,020 - 154,684,120 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361154,570,108 - 154,599,208 (+)NCBIMGSCv36mm8
Celera1155,229,233 - 155,258,077 (+)NCBICelera
Cytogenetic Map1G3NCBI
cM Map165.05NCBI
NCF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381183,555,562 - 183,601,849 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1183,554,461 - 183,590,905 (-)EnsemblGRCh38hg38GRCh38
GRCh371183,524,697 - 183,560,049 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361181,791,320 - 181,826,339 (-)NCBINCBI36Build 36hg18NCBI36
Build 341180,256,354 - 180,291,668NCBI
Celera1156,635,747 - 156,671,088 (-)NCBICelera
Cytogenetic Map1q25.3NCBI
HuRef1154,760,563 - 154,795,907 (-)NCBIHuRef
CHM1_11184,947,718 - 184,983,070 (-)NCBICHM1_1
T2T-CHM13v2.01182,914,853 - 182,961,131 (-)NCBIT2T-CHM13v2.0
Ncf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81367,505,492 - 67,536,015 (+)NCBIGRCr8
mRatBN7.21364,955,622 - 64,986,144 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1364,955,503 - 64,986,277 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1367,557,295 - 67,587,614 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01368,844,234 - 68,874,605 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01366,095,157 - 66,125,664 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01370,226,441 - 70,259,019 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1370,226,647 - 70,257,576 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01375,197,561 - 75,229,600 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41367,806,516 - 67,834,105 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11367,797,870 - 67,848,218 (+)NCBI
Celera1364,862,007 - 64,890,467 (+)NCBICelera
Cytogenetic Map13q21NCBI
Ncf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540622,355,724 - 22,384,864 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540622,355,717 - 22,384,746 (-)NCBIChiLan1.0ChiLan1.0
NCF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2166,126,780 - 66,162,128 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1165,809,948 - 65,845,260 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01159,085,923 - 159,121,259 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11163,243,636 - 163,280,547 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1163,243,636 - 163,278,420 (-)Ensemblpanpan1.1panPan2
NCF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1716,914,629 - 16,946,370 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl716,904,031 - 16,945,372 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha716,500,692 - 16,530,126 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0716,646,647 - 16,676,710 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl716,643,324 - 16,676,880 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1716,555,169 - 16,584,783 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0716,664,590 - 16,693,979 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0716,795,528 - 16,824,986 (-)NCBIUU_Cfam_GSD_1.0
Ncf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934488,454,048 - 88,478,994 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364816,301,012 - 6,324,787 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364816,300,894 - 6,325,878 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NCF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9124,776,534 - 124,812,923 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19124,776,516 - 124,813,358 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29137,106,514 - 137,143,201 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NCF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12545,770,370 - 45,807,064 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2545,770,641 - 45,806,515 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605546,986,801 - 47,023,905 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ncf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462481410,107,357 - 10,134,711 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462481410,107,351 - 10,134,737 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ncf2
1233 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:261
Count of miRNA genes:213
Interacting mature miRNAs:237
Transcripts:ENSMUST00000027754
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
27095901Scvln8_msacral vertebrae length 2, 10 week (mouse)194127725172027567Mouse
27226779Tibl1_mtibia length 1, 5 week (mouse)195527725162027569Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse
1301149Lrnx12_mlearning-contextual 12 (mouse)Not determined1112008822168186402Mouse
1302098Eila1_methanol induced locomotor activity 1 (mouse)Not determined1112008822175468938Mouse
27095915Scvln13_msacral vertebrae length 2, 16 week (mouse)1117527730179827565Mouse
27226740Metcl13_mmetatarsal-calcaneal length 13, 16 week (mouse)1121727729153775746Mouse
27226743Metcl7_mmetatarsal-calcaneal length 7, 10 week (mouse)1121727729153875746Mouse
27226767Tibl10_mtibia length 10, 10 week (mouse)1121727729164827569Mouse
27226799Feml5_mfemur length 5, 5 week (mouse)1122027729164827569Mouse
12880408V125Dq3_mvitamin D active form serum level QTL 3 (mouse)1122927738156927738Mouse
27095935Ulnl5_mulna length 5, 10 week (mouse)1128727737181327565Mouse
1301608Emo3_memotionality 3 (mouse)Not determined1129130858163130993Mouse
1302128Ity3_mimmunity to S. typhimurium 3 (mouse)Not determined11131156308165139464Mouse
14746980Manh50_mmandible shape 50 (mouse)1134131564168131564Mouse
1301458Skts8_mskin tumor susceptibility 8 (mouse)Not determined1135794822169795012Mouse
1301408Lore8_mloss of righting induced by ethanol 8 (mouse)Not determined1135877901169878015Mouse
1357434Obsty1_mobesity 1 (mouse)Not determined1136209950170210094Mouse
4141160Cq1_mcholesterol QTL 1 (mouse)Not determined1139452188173452308Mouse
1301523Ccrs1_mcorpus callosum hemisphere surface size 1 (mouse)Not determined1139602037173602216Mouse
1300696Bpq2_mblood pressure QTL 2 (mouse)Not determined1139602037173602216Mouse
1357602Vtbt2_mvertebral trabecular bone trait 2 (mouse)Not determined1139602037173602216Mouse
1301710Bmd5_mbone mineral density 5 (mouse)Not determined1139602037173602216Mouse
11049576Lmr8a_mleishmaniasis resistance 8a (mouse)1139602037173602216Mouse
1301894Skull2_mskull morphology 2 (mouse)Not determined1139602037173602216Mouse
1302193Cpfd1_mcerebellum pattern fissures (mouse)Not determined1139602037173602216Mouse
1300740Tne1_mtotal number errors (mouse)Not determined1139602037173602216Mouse
4142014Wbcq5_mwhite blood cell quantitative locus 5 (mouse)Not determined1141095010175095156Mouse
1301467Pcir1_mperiosteal circumference 1 (mouse)Not determined1141233173175233272Mouse
1301191Stia1_mserum transfer induced arthritis 1 (mouse)Not determined1141233173175233272Mouse
11533913Rd6m1_mretinal degeneration 6 modifier 1 (mouse)1141233173175233272Mouse
4141233Femwf12_mfemur work to failure 12 (mouse)Not determined141233173175233272Mouse
1301151Hdlq14_mHDL QTL 14 (mouse)Not determined1142489543176489734Mouse
1558720Bpq8_mblood pressure QTL 8 (mouse)Not determined1143284665177284803Mouse
11537365Cnes4_mC. neoformans susceptibility locus 4 (mouse)1144449142178449142Mouse
1300571Opfa_mopen field activity (mouse)Not determined1144531347178531592Mouse
12790996Aath2_maortic arch atherosclerosis 2 (mouse)1145077630179077630Mouse
1300934Cfbw1_mcystic fibrosis body weight 1 (mouse)Not determined1145145207179145325Mouse
1301818Ap1q_malcohol preference 1 QTL (mouse)Not determined1146908199167586222Mouse
1301135Pas8_mpulmonary adenoma susceptibility 8 (mouse)Not determined1147125258158233272Mouse
1357567Nidd3k_mNidd3 on KK-A<y> (mouse)Not determined7147125258169038913Mouse
12910522Scgq2_mspontaneous crescentic glomerulonephritis QTL 2 (mouse)1147125258171632257Mouse
1301385Radpf2_mradiation pulmonary fibrosis 2 (mouse)Not determined1147125258182873798Mouse
4141149Hbnr4_mHeligmosomoides bakeri nematode resistance 4 (mouse)Not determined147125258188983224Mouse
12790984Pcho7_mplasma cholesterol 7 (mouse)1147219390181219390Mouse
12791001Aath6_maortic arch atherosclerosis 6 (mouse)1147219390181219390Mouse
1300777Chol10_mcholesterol 10 (mouse)Not determined9147875502181875616Mouse
10043899Hdlq99_mHDL QTL 99 (mouse)Not determined1147875502181875616Mouse
13452392Ity3a_mimmunity to S. typhimurium 3a (mouse)1149028612154228616Mouse
1357618Splq5_mspleen weight QTL 5 (mouse)Not determined1150193673188359312Mouse
1357493Lgaq3_mlate growth adjusted QTL 3 (mouse)Not determined1150193673188359312Mouse
1357485Lgq4_mlate growth QTL 4 (mouse)Not determined1150193673188359312Mouse
12903996Cfq5_mconditioned fear QTL 5 (mouse)1150606337159307464Mouse
4141346Skmw12_mskeletal muscle weight 12 (mouse)Not determined150756737184756922Mouse
1300969Sluc5_msusceptibility to lung cancer 5 (mouse)Not determined1151186243185186402Mouse
4142159Nba2_mNew Zealand Black autoimmunity 2 (mouse)Not determined151835111185835280Mouse
1357889Lprq3_mlipoprotein QTL 3 (mouse)Not determined1152038741186038913Mouse
1301301Sle1_msystemic lupus erythmatosus susceptibility 1 (mouse)Not determined1152038741186038913Mouse
1301025Lbw7_mlupus NZB x NZW 7 (mouse)Not determined1152038741186038913Mouse
1301614Cgnz1_mchronic glomerulonephritis in NZM 1 (mouse)Not determined1152038741186038913Mouse
4141554Cfmq1_mcystic fibrosis modifier QTL 1 (mouse)Not determined1152038741186038913Mouse
13464138Hdlq107_mHDL QTL 107 (mouse)1152132744186132744Mouse
11251722Ewc1_methanol withdrawal and consumption 1 (mouse)1152132744186132744Mouse

Markers in Region
AB002664  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381152,836,121 - 152,836,209UniSTSGRCm38
GRCm3813111,882,298 - 111,882,386UniSTSGRCm38
MGSCv371154,683,251 - 154,683,339UniSTSGRCm37
MGSCv3713112,672,506 - 112,672,594UniSTSGRCm37
Celera13116,185,240 - 116,185,328UniSTS
Celera1155,257,208 - 155,257,296UniSTS
Cytogenetic Map1G3UniSTS
Cytogenetic Map13D2.2UniSTS
cM Map176.1UniSTS
Whitehead/MRC_RH13969.7UniSTS
PMC156340P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381152,833,866 - 152,835,199UniSTSGRCm38
GRCm3813111,882,511 - 111,882,856UniSTSGRCm38
MGSCv371154,680,996 - 154,682,329UniSTSGRCm37
MGSCv3713112,672,719 - 112,673,064UniSTSGRCm37
Celera13116,185,453 - 116,185,800UniSTS
Celera1155,254,953 - 155,256,286UniSTS
Cytogenetic Map13D2.2UniSTS
Cytogenetic Map1G3UniSTS
cM Map176.1UniSTS
Ncf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1G3UniSTS
cM Map165.05UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001420384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001420385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001420386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001420387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB002664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC123613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK036379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC076609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC094056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY097838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ449939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000027754   ⟹   ENSMUSP00000027754
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1152,683,641 - 152,712,741 (+)Ensembl
GRCm38.p6 Ensembl1152,807,890 - 152,836,990 (+)Ensembl
RefSeq Acc Id: ENSMUST00000186568   ⟹   ENSMUSP00000140404
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1152,675,945 - 152,712,742 (+)Ensembl
GRCm38.p6 Ensembl1152,800,194 - 152,836,991 (+)Ensembl
RefSeq Acc Id: ENSMUST00000187235
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1152,699,320 - 152,700,235 (+)Ensembl
GRCm38.p6 Ensembl1152,823,569 - 152,824,484 (+)Ensembl
RefSeq Acc Id: ENSMUST00000187641
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1152,683,729 - 152,688,389 (+)Ensembl
GRCm38.p6 Ensembl1152,807,978 - 152,812,638 (+)Ensembl
RefSeq Acc Id: ENSMUST00000189135
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1152,686,641 - 152,700,042 (+)Ensembl
GRCm38.p6 Ensembl1152,810,890 - 152,824,291 (+)Ensembl
RefSeq Acc Id: ENSMUST00000190323   ⟹   ENSMUSP00000139774
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1152,683,588 - 152,700,043 (+)Ensembl
GRCm38.p6 Ensembl1152,807,837 - 152,824,292 (+)Ensembl
RefSeq Acc Id: NM_001420384   ⟹   NP_001407313
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391152,675,904 - 152,712,743 (+)NCBI
RefSeq Acc Id: NM_001420385   ⟹   NP_001407314
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391152,683,680 - 152,712,743 (+)NCBI
RefSeq Acc Id: NM_001420386   ⟹   NP_001407315
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391152,683,680 - 152,712,743 (+)NCBI
RefSeq Acc Id: NM_001420387   ⟹   NP_001407316
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391152,683,680 - 152,712,743 (+)NCBI
RefSeq Acc Id: NM_010877   ⟹   NP_035007
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391152,675,904 - 152,712,743 (+)NCBI
GRCm381152,800,153 - 152,836,990 (+)NCBI
MGSCv371154,655,020 - 154,684,120 (+)RGD
Celera1155,229,233 - 155,258,077 (+)RGD
cM Map1 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_035007   ⟸   NM_010877
- Peptide Label: isoform 1
- UniProtKB: Q3TC92 (UniProtKB/Swiss-Prot),   Q3U5S4 (UniProtKB/Swiss-Prot),   O70145 (UniProtKB/Swiss-Prot),   Q1PCS1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000027754   ⟸   ENSMUST00000027754
RefSeq Acc Id: ENSMUSP00000140404   ⟸   ENSMUST00000186568
RefSeq Acc Id: ENSMUSP00000139774   ⟸   ENSMUST00000190323
RefSeq Acc Id: NP_001407313   ⟸   NM_001420384
- Peptide Label: isoform 1
- UniProtKB: Q3U5S4 (UniProtKB/Swiss-Prot),   Q3TC92 (UniProtKB/Swiss-Prot),   O70145 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001407314   ⟸   NM_001420385
- Peptide Label: isoform 1
- UniProtKB: Q3U5S4 (UniProtKB/Swiss-Prot),   Q3TC92 (UniProtKB/Swiss-Prot),   O70145 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001407315   ⟸   NM_001420386
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001407316   ⟸   NM_001420387
- Peptide Label: isoform 3
Protein Domains
PB1   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70145-F1-model_v2 AlphaFold O70145 1-525 view protein structure

Promoters
RGD ID:6875250
Promoter ID:EPDNEW_M1076
Type:initiation region
Name:Ncf2_1
Description:Mus musculus neutrophil cytosolic factor 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381152,807,929 - 152,807,989EPDNEW
RGD ID:6818145
Promoter ID:MM_KWN:2431
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:UC007CZM.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361154,654,734 - 154,655,234 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97284 AgrOrtholog
Ensembl Genes ENSMUSG00000026480 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000027754.7 UniProtKB/Swiss-Prot
  ENSMUST00000186568 ENTREZGENE
  ENSMUST00000186568.7 UniProtKB/Swiss-Prot
  ENSMUST00000190323.7 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot
InterPro P67-PHOX UniProtKB/Swiss-Prot
  p67phox_SH3_1 UniProtKB/Swiss-Prot
  PB1_dom UniProtKB/Swiss-Prot
  PB1_P67 UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17970 UniProtKB/Swiss-Prot
MGD MGI:97284 ENTREZGENE
NCBI Gene 17970 ENTREZGENE
PANTHER NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15175:SF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PB1 UniProtKB/Swiss-Prot
  SH3_1 UniProtKB/Swiss-Prot
  TPR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ncf2 PhenoGen
PRINTS P67PHOX UniProtKB/Swiss-Prot
  SH3DOMAIN UniProtKB/Swiss-Prot
PROSITE PB1 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
  TPR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_REGION UniProtKB/Swiss-Prot
SMART PB1 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
  TPR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP CAD & PB1 domains UniProtKB/Swiss-Prot
  SSF48452 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot
UniProt A0A087WPH0_MOUSE UniProtKB/TrEMBL
  NCF2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q1PCS1 ENTREZGENE
  Q3TBY8_MOUSE UniProtKB/TrEMBL
  Q3TC92 ENTREZGENE
  Q3U5S4 ENTREZGENE
UniProt Secondary Q3TC92 UniProtKB/Swiss-Prot
  Q3U5S4 UniProtKB/Swiss-Prot