myocardial infarction - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	myocardial infarction	go back to main search page
Accession:	DOID:5844	browse the term
Definition:	A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia. (DO)
Synonyms:	exact_synonym:	Cardiovascular Stroke; Heart Attacks; Myocardial Infarct; Myocardial Infarctions; cardiovascular strokes; heart attack; myocardial infarcts
	narrow_synonym:	MCI1; MCI2; post-operative myocardial infarction
	broad_synonym:	F7-RELATED CONDITION
	related_synonym:	MYOCARDIAL INFARCTION, DECREASED SUSCEPTIBILITY TO; MYOCARDIAL INFARCTION, PROTECTION AGAINST; MYOCARDIAL INFARCTION, SUSCEPTIBILITY TO; MYOCARDIAL INFARCTION, SUSCEPTIBILITY TO, 1; MYOCARDIAL INFARCTION, SUSCEPTIBILITY TO, 2
	primary_id:	MESH:D009203
	alt_id:	MIM:608446; MIM:608557
	xref:	EFO:0000612; EFO:0009953; NCI:C27996
For additional species annotation, visit the Alliance of Genome Resources.

show annotations for term's descendants Sort by:
Rat (446) Mouse (443) Human (2014) Chinchilla (390) Bonobo (416) Dog (426) Squirrel (401) Pig (418) Green Monkey (410) Naked Mole-rat (387) All
Genes (416)

myocardial infarction

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 9

ClinVar Annotator: match by term: Myocardial infarction

PMID:16563363 PMID:18239147 PMID:20474083 PMID:21846889 PMID:23739550 More...

NCBI chr12:64,357,176...64,500,358
Ensembl chr12:66,960,888...67,102,496

G

angiotensin I converting enzyme

treatment
susceptibility

ClinVar Annotator: match by term: Myocardial infarction, susceptibility to
associated with Diabetes Mellitus, Type 1;DNA:deletion:intron:IVS16+1464-1751del (human)

PMID:1313972 PMID:1319114 PMID:1328889 PMID:1386652 PMID:1976655 More...

RGD:1558664 RGD:7829785 RGD:9685449

NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853

G

angiotensin converting enzyme 2

treatment

mRNA:increased expression:myocardium

PMID:15671045 PMID:23959549

RGD:1558664 RGD:9685449

NCBI chr X:8,189,267...8,229,415
Ensembl chr X:15,470,896...15,510,891

G

actin alpha 2, smooth muscle

CTD Direct Evidence: marker/mechanism

NCBI chr10:85,660,983...85,678,729
Ensembl chr10:89,164,344...89,182,080

G

activin A receptor type 2A

mRNA:decreased expression:myocardium (mouse)

NCBI chr2B:11,933,683...12,020,287
Ensembl chr2B:152,253,826...152,288,385

G

activin A receptor type 2B

mRNA:decreased expression:myocardium (mouse)

NCBI chr 3:38,350,838...38,389,839
Ensembl chr 3:38,633,093...38,662,063

G

ADAM metallopeptidase with thrombospondin type 1 motif 1

NCBI chr21:13,270,668...13,279,217
Ensembl chr21:26,656,370...26,665,485

G

adducin 1

no_association

DNA:missense mutation:cds:p.G460W (human)

PMID:16420563 PMID:17082469

RGD:5147995 RGD:5148001

NCBI chr 4:2,986,301...3,072,590
Ensembl chr 4:2,920,781...2,975,012

G

adiponectin, C1Q and collagen domain containing

disease_progression

NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885

G

adiponectin receptor 1

mRNA, protein:decreased expression:heart left ventricle

NCBI chr 1:178,542,496...178,560,055
Ensembl chr 1:182,837,589...182,854,782

G

adiponectin receptor 2

mRNA, protein:decreased expression:heart left ventricle

NCBI chr12:1,772,426...1,902,070
Ensembl chr12:1,817,620...1,852,251

G

adenosine A1 receptor

CTD Direct Evidence: therapeutic

NCBI chr 1:178,728,751...178,769,066
Ensembl chr 1:183,023,466...183,063,760

G

adrenoceptor alpha 2B

NCBI chr2A:103,198,432...103,202,506
Ensembl chr2A:97,040,126...97,041,472

G

adrenoceptor beta 1

NCBI chr10:110,642,491...110,646,595

G

adrenoceptor beta 2

susceptibility

mRNA:decreased expression:heart
DNA:polymorphisms: :p.G16R, p.Q27E, p.T164I

PMID:12400771 PMID:15520258

RGD:1601126 RGD:8548519

NCBI chr 5:144,259,756...144,398,421
Ensembl chr 5:150,267,554...150,315,892

G

advanced glycosylation end-product specific receptor

susceptibility

mRNA:increased expression:left ventricle myocardium (rat)
DNA:polymorphism:promoter:-429T>C (human)

PMID:16728681 PMID:19910580

RGD:1625333 RGD:2325647

NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641

G

angiotensinogen

susceptibility

associated with hypertension;DNA:polymorphism: :p.M235T
CTD Direct Evidence: marker/mechanism
associated with Coronary Artery Disease;DNA:polymorphism: :p.M235T (human)

PMID:1668233 PMID:11393670 PMID:16413583 PMID:17299437 PMID:21167013

RGD:1566452 RGD:1601132 RGD:5129191

NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044

G

angiotensin II receptor type 1

no_association
susceptibility

DNA:polymorphism:3' utr:1166A>C (human)

PMID:9652322 PMID:9857918 PMID:16061119

RGD:10047101 RGD:1566499 RGD:1601150

NCBI chr 3:145,722,475...145,767,550
Ensembl chr 3:153,341,947...153,345,380

G

alpha 2-HS glycoprotein

protein:increased expression:plasma

NCBI chr 3:183,644,223...183,652,620
Ensembl chr 3:192,110,770...192,119,915

G

aminoacyl tRNA synthetase complex interacting multifunctional protein 1

NCBI chr 4:98,796,320...98,830,095
Ensembl chr 4:109,404,352...109,436,566

G

adenylate kinase 1

treatment

NCBI chr 9:98,987,348...98,997,252
Ensembl chr 9:127,657,338...127,678,245

G

AKT serine/threonine kinase 1

protein:increased serine phosphorylation:platelet
protein:decreased serine phosphorylation:heart

PMID:20352476 PMID:20467748

RGD:10041035 RGD:5509094

NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756

G

aldehyde dehydrogenase 2 family member

DNA:missense mutation: :p.E487K (human)

NCBI chr12:109,343,020...109,385,060
Ensembl chr12:112,734,243...112,776,471

G

arachidonate 5-lipoxygenase activating protein

no_association

DNA:snps:multiple (human)

PMID:14770184 PMID:19046748

RGD:1578317 RGD:2313891

NCBI chr13:12,012,399...12,041,557
Ensembl chr13:30,425,510...30,476,607

G

angiogenin

NCBI chr14:1,548,693...1,558,528
Ensembl chr14:19,614,950...19,615,393

G

angiopoietin 1

mRNA, protein:decreased expression:myocardium

NCBI chr 8:103,893,234...104,137,661
Ensembl chr 8:106,042,041...106,286,783

G

angiopoietin 2

protein:increased expression:left ventricular wall, heart septum (rat)

NCBI chr 8:718,367...782,534
Ensembl chr 8:6,506,014...6,566,915

G

annexin A5

no_association
susceptibility

DNA:polymorphism: :-1C>T (human)
protein:altered localization:cardiac muscle cell, sarcolemma
protein:increased expression:plasma

PMID:8814351 PMID:12200370 PMID:16025836 PMID:16501019

RGD:1578384 RGD:2317541 RGD:2317542 RGD:2317543

NCBI chr 4:113,868,218...113,897,243
Ensembl chr 4:125,006,038...125,034,972

G

apurinic/apyrimidinic endodeoxyribonuclease 1

susceptibility

DNA:polymorphism:exon 5: G>A (human)

NCBI chr14:1,329,745...1,332,315
Ensembl chr14:19,381,911...19,384,542

G

apolipoprotein A1

treatment
no_association

DNA:polymorphisms

PMID:10428310 PMID:20176799 PMID:31734577

RGD:1578442 RGD:2325759 RGD:408418726

NCBI chr11:111,673,539...111,675,428
Ensembl chr11:115,606,136...115,608,122

G

apolipoprotein A4

no_association
susceptibility

DNA:mutation:intron:IVS2 (human)
associated with Diabetes Mellitus, Type 2; DNA:missense mutation:cds:p.Q360H (human)

PMID:7958503 PMID:10428310

RGD:1578442 RGD:5685678

NCBI chr11:111,659,186...111,661,790
Ensembl chr11:115,591,788...115,594,382

G

apolipoprotein C3

no_association

ClinVar Annotator: match by term: Myocardial infarction, susceptibility to

PMID:10428310 PMID:25741868

NCBI chr11:111,667,816...111,670,861
Ensembl chr11:115,600,416...115,603,460

G

apolipoprotein E

susceptibility

DNA:missense mutations, haplotype:cds:p.C112R, p.C158R (human)
DNA:missense mutations, haplotypes:cds:p.C112R, p.R158C (human)
CTD Direct Evidence: marker/mechanism

PMID:10090925 PMID:10587578 PMID:17217375

RGD:10449412 RGD:1601229

NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490

G

apolipoprotein H

PMID:12826288 PMID:15322656

RGD:10054111 RGD:2313985

NCBI chr17:60,154,389...60,171,762
Ensembl chr17:65,365,250...65,382,483

G

autophagy related 7

mRNA:increased expression:plantaris

NCBI chr 3:11,208,600...11,488,757
Ensembl chr 3:11,554,100...11,833,398

G

ATM serine/threonine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr11:103,109,979...103,256,405
Ensembl chr11:106,584,228...106,727,041

G

ATPase Na+/K+ transporting subunit alpha 1

CTD Direct Evidence: therapeutic

NCBI chr 1:86,162,401...86,193,883
Ensembl chr 1:121,212,488...121,243,099

G

ATP synthase F1 subunit delta

treatment

protein:decreased expression:myocardium (rat)

PMID:23809007 PMID:29300489

RGD:13792656 RGD:13792681

G

ATP synthase peripheral stalk subunit OSCP

treatment

NCBI chr21:20,270,442...20,282,865

G

arginine vasopressin receptor 1A

NCBI chr12:25,793,633...25,803,026
Ensembl chr12:26,065,882...26,075,972

G

BCL2 antagonist/killer 1

CTD Direct Evidence: marker/mechanism

NCBI chr 6:33,146,998...33,154,755
Ensembl chr 6:34,255,769...34,263,211

G

BCL2 associated X, apoptosis regulator

CTD Direct Evidence: marker/mechanism

PMID:20079142 PMID:25450231

NCBI chr19:45,955,926...45,962,870
Ensembl chr19:54,793,594...54,800,468

G

BCL2 apoptosis regulator

CTD Direct Evidence: marker/mechanism

NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100

G

BCL2 like 1

CTD Direct Evidence: marker/mechanism

PMID:17467744 PMID:20079142

NCBI chr20:27,955,688...28,015,950
Ensembl chr20:29,088,055...29,146,585

G

bradykinin receptor B1

mRNA:increased expression:heart

NCBI chr14:76,885,923...76,894,456

G

bradykinin receptor B2

mRNA:increased expression:heart

NCBI chr14:76,832,833...76,873,860
Ensembl chr14:96,156,494...96,196,253

G

beclin 1

treatment

CTD Direct Evidence: marker/mechanism

NCBI chr17:14,493,619...14,507,809
Ensembl chr17:14,719,781...14,733,286

G

baculoviral IAP repeat containing 5

NCBI chr17:72,292,332...72,303,493
Ensembl chr17:77,842,724...77,854,159

G

BCL2 interacting protein 3

mRNA:increased expression:plantaris

NCBI chr10:128,671,663...128,685,952
Ensembl chr10:132,858,211...132,871,634

G

BRCA1 associated protein

CTD Direct Evidence: marker/mechanism

NCBI chr12:109,216,171...109,263,160
Ensembl chr12:112,610,179...112,654,017

G

BMP/retinoic acid inducible neural specific 3

susceptibility

DNA:SNPs:3' end:

NCBI chr 1:165,586,510...165,972,173
Ensembl chr 1:169,873,541...170,258,015

G

complement C3

treatment

mRNA, protein:increased expression:myocardium

PMID:16996480 PMID:31734577

RGD:1600605 RGD:408418726

NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699

G

complement C7

Protein:increased activity:serum, myocardium

NCBI chr 5:69,405,041...69,478,445
Ensembl chr 5:74,447,559...74,520,649

G

complement C8 alpha chain

NCBI chr 1:56,137,596...56,201,975
Ensembl chr 1:57,847,726...57,912,392

G

complement C8 beta chain

NCBI chr 1:56,213,618...56,250,488
Ensembl chr 1:57,923,720...57,960,674

G

calcyclin binding protein

mRNA:increased expression:heart

NCBI chr 1:150,511,021...150,522,369
Ensembl chr 1:154,210,001...154,220,583

G

calcium/calmodulin dependent protein kinase II delta

treatment

mRNA, protein:splice variants, increased expression:heart left ventricle (rat)

NCBI chr 4:105,957,773...106,271,887
Ensembl chr 4:116,523,850...116,835,387

G

caspase 1

severity
ameliorates

PMID:17303764 PMID:33389498

RGD:2315913 RGD:242905187

NCBI chr11:99,965,964...99,975,640
Ensembl chr11:103,448,497...103,458,149
Ensembl chr11:103,448,497...103,458,149

G

caspase 3

ameliorates
treatment

CTD Direct Evidence: marker/mechanism

PMID:25450231 PMID:27904666 PMID:28622474

RGD:13782309 RGD:329333030

NCBI chr 4:176,793,190...176,815,023
Ensembl chr 4:189,018,422...189,040,185

G

calcium sensing receptor

protein:increased expression:myocardium (rat)

NCBI chr 3:119,278,071...119,383,901
Ensembl chr 3:126,252,765...126,285,268

G

catalase

CTD Direct Evidence: therapeutic

PMID:14575298 PMID:21600015

NCBI chr11:34,413,253...34,446,831
Ensembl chr11:34,289,603...34,323,160

G

caveolin 3

Protein:increased expression:cytosol
mRNA, protein; increased expression; myocardium (rat)

PMID:12566108 PMID:29438664

RGD:126925221 RGD:1599542

NCBI chr 3:8,684,829...8,697,731
Ensembl chr 3:8,928,069...8,940,942

G

C-C motif chemokine ligand 2

treatment

protein:increased expression:serum
DNA:snp:promoter:g.-2518A>G (human)

PMID:16116069 PMID:18459941 PMID:18753699

RGD:1581161 RGD:2307033 RGD:8549616

NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384

G

C-C motif chemokine ligand 5

mRNA:increased expression:heart (rat)

NCBI chr17:20,915,198...20,923,530
Ensembl chr17:21,210,798...21,219,172

G

cellular communication network factor 1

mRNA,protein:increased expression:myocardium (mouse)

NCBI chr 1:118,138,739...118,141,681
Ensembl chr 1:86,994,296...86,997,147

G

cellular communication network factor 2

treatment

mRNA:increased expression:left ventricle (rat)

PMID:18167060 PMID:29849775

RGD:2314623 RGD:35673318

NCBI chr 6:129,729,572...129,733,113
Ensembl chr 6:133,836,319...133,842,077

G

cyclin A2

protein:increased expression:cardiomyocyte:

NCBI chr 4:114,016,917...114,024,816
Ensembl chr 4:125,153,810...125,161,302

G

C-C motif chemokine receptor 2

PMID:12719858 PMID:12853162

RGD:1581174 RGD:1581177

NCBI chr 3:46,255,725...46,263,285
Ensembl chr 3:47,361,124...47,368,312

G

C-C motif chemokine receptor 3

NCBI chr 3:46,147,928...46,172,947
Ensembl chr 3:47,253,878...47,278,630

G

chaperonin containing TCP1 subunit 7

ClinVar Annotator: match by term: Myocardial infarction, susceptibility to, 1

NCBI chr2A:73,287,026...73,305,792
Ensembl chr2A:74,775,781...74,794,515

G

CD14 molecule

no_association

associated with Coronary Artery Disease;DNA:SNP:promoter

PMID:10195920 PMID:14587643 PMID:17436151

RGD:1580252 RGD:1580255 RGD:2314155

NCBI chr 5:135,996,265...135,997,909
Ensembl chr 5:142,113,082...142,118,966

G

CD36 molecule (CD36 blood group)

severity

NCBI chr 7:72,566,478...72,643,517
Ensembl chr 7:86,265,114...86,305,865

G

CD40 ligand

protein:increased expression:serum

NCBI chr X:125,776,138...125,788,820
Ensembl chr X:136,042,849...136,058,202

G

CD59 molecule (CD59 blood group)

protein:decreased expression:myocardium

NCBI chr11:33,680,580...33,708,479
Ensembl chr11:33,552,164...33,590,157

G

cyclin dependent kinase inhibitor 1B

treatment

NCBI chr12:12,742,258...12,747,404
Ensembl chr12:13,120,306...13,125,541

G

cofilin 1

treatment

NCBI chr11:61,215,092...61,218,628
Ensembl chr11:64,544,275...64,550,806

G

CF transmembrane conductance regulator

associated with Myocardial Reperfusion Injury

NCBI chr 7:109,449,847...109,633,023
Ensembl chr 7:122,129,798...122,327,864

G

chitinase 3 like 1

protein:increased secretion:serum (human)

NCBI chr 1:178,778,081...178,789,704
Ensembl chr 1:183,075,312...183,083,229

G

class II major histocompatibility complex transactivator

susceptibility
no_association

DNA:polymorphism:promoter:-168A>G

PMID:15821736 PMID:17183695

RGD:1358146 RGD:5491201

NCBI chr16:9,819,440...9,885,379
Ensembl chr16:11,041,434...11,090,485

G

creatine kinase B

CTD Direct Evidence: marker/mechanism

NCBI chr14:84,145,931...84,149,093

G

creatine kinase, M-type

CTD Direct Evidence: marker/mechanism

PMID:3279722 PMID:12359538

NCBI chr19:42,255,158...42,271,467
Ensembl chr19:50,854,556...50,870,366

G

clusterin

treatment

NCBI chr 8:26,867,973...26,884,838
Ensembl chr 8:24,070,053...24,083,523

G

collagen type I alpha 1 chain

treatment

NCBI chr17:44,274,349...44,291,764
Ensembl chr17:49,150,677...49,166,677

G

collagen type III alpha 1 chain

treatment

NCBI chr2B:76,285,115...76,322,703
Ensembl chr2B:194,204,613...194,242,956

G

collagen type IV alpha 1 chain

susceptibility

DNA:polymorphism: :p.Q1334H (human)

NCBI chr13:91,282,617...91,440,187
Ensembl chr13:110,407,009...110,562,529

G

collagen type VI alpha 3 chain

DNA:SNP:CDS:E1386K (rs146092501) (human)

NCBI chr2B:124,554,478...124,644,482

G

cAMP responsive element binding protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr2B:94,762,796...94,836,304
Ensembl chr2B:212,891,261...212,958,130

G

cAMP responsive element modulator

CTD Direct Evidence: marker/mechanism

NCBI chr10:35,247,426...35,335,545
Ensembl chr10:35,825,218...35,912,432

G

C-reactive protein

protein:increased expression:serum
associated with Angina, Unstable;

PMID:9761079 PMID:21046814 PMID:22446866

RGD:5131456 RGD:6482304 RGD:9491780

NCBI chr 1:135,062,102...135,064,402

G

citrate synthase

severity

protein:decreased expression:diaphragm, mitochondrion

PMID:1877670 PMID:34416105

RGD:243048469 RGD:243048471

NCBI chr12:32,614,982...32,643,719
Ensembl chr12:32,867,225...32,895,854

G

colony stimulating factor 2

NCBI chr 5:127,496,951...127,499,325
Ensembl chr 5:133,660,775...133,663,146

G

colony stimulating factor 3

treatment

NCBI chr17:17,271,074...17,273,493
Ensembl chr17:17,491,276...17,493,729

G

casein kinase 2 alpha 1

NCBI chr20:689,494...752,092
Ensembl chr20:456,629...521,126

G

casein kinase 2 beta

NCBI chr 6:31,327,250...31,331,250

G

cytotoxic T-lymphocyte associated protein 4

DNA:SNP:CDS:49A>G (human)

NCBI chr2B:91,054,917...91,106,234
Ensembl chr2B:209,239,417...209,244,498

G

cathepsin B

protein:increased activity:serum, heart (rat)

NCBI chr 8:7,333,498...7,359,264

G

C-X-C motif chemokine ligand 12

mRNA:increased expression:heart left ventricle

PMID:11820456 PMID:19187644

RGD:2306567 RGD:632503

NCBI chr10:41,296,975...41,384,864
Ensembl chr10:44,552,480...44,564,231

G

cytochrome P450 family 11 subfamily B member 1

NCBI chr 8:139,584,976...139,592,466
Ensembl chr 8:142,629,127...142,634,654

G

cytochrome P450 family 1 subfamily B member 1

ameliorates

NCBI chr2A:38,087,863...38,096,529
Ensembl chr2A:38,851,000...38,859,824

G

cytochrome P450 family 2 subfamily J member 2

susceptibility

DNA:polymorphism

NCBI chr 1:59,151,079...59,184,625
Ensembl chr 1:60,856,269...60,889,810

G

cytochrome P450 family 2 subfamily R member 1

DNA:SNP:CDS:rs2060793, rs1993116, rs10766197 (human)

NCBI chr11:14,960,651...14,989,083
Ensembl chr11:14,656,939...14,671,584

G

DAB adaptor protein 2

protein:increased expression:cardiomyocyte

PMID:20666606 PMID:21762377

RGD:7243156 RGD:7243158

NCBI chr 5:70,951,198...71,004,836
Ensembl chr 5:76,022,143...76,041,443

G

DAB2 interacting protein

onset

CTD Direct Evidence: marker/mechanism
DNA:SNP:CDS:intron 1 (rs7025486) (human)

NCBI chr 9:92,696,798...92,912,425
Ensembl chr 9:121,143,457...121,254,336

G

dystroglycan 1

treatment

NCBI chr 3:49,396,180...49,464,689
Ensembl chr 3:50,640,615...50,703,852

G

decorin

NCBI chr12:88,678,791...88,715,677
Ensembl chr12:91,994,129...92,031,413

G

DNA damage inducible transcript 3

CTD Direct Evidence: marker/mechanism

NCBI chr12:31,406,332...31,410,293
Ensembl chr12:31,664,743...31,668,701

G

diacylglycerol kinase zeta

CTD Direct Evidence: therapeutic

NCBI chr11:46,291,592...46,339,127
Ensembl chr11:46,841,605...46,889,763

G

dishevelled segment polarity protein 1

NCBI chr 1:92,469...106,748
Ensembl chr 1:1,292,052...1,301,008

G

dual specificity tyrosine phosphorylation regulated kinase 1A

treatment

associated with heart failure; protein:increased expression, increased activity:heart left ventricle (rat)

NCBI chr21:23,729,204...23,878,820
Ensembl chr21:37,137,253...37,231,987

G

endothelin converting enzyme 1

NCBI chr 1:20,166,019...20,290,803
Ensembl chr 1:21,206,199...21,278,909

G

endothelin 1

severity

mRNA:increased expression:heart left ventricle (rat)
protein:increased secretion:plasma (human)

PMID:10573185 PMID:17893002

RGD:1580921 RGD:4144880

NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545

G

endothelin 2

NCBI chr 1:40,777,582...40,783,410
Ensembl chr 1:42,092,811...42,098,721

G

endothelin receptor type A

NCBI chr 4:139,815,336...139,879,600
Ensembl chr 4:151,476,356...151,536,497

G

endothelin receptor type B

NCBI chr13:59,112,349...59,136,615
Ensembl chr13:78,153,020...78,177,286

G

egl-9 family hypoxia inducible factor 1

NCBI chr 1:206,915,541...206,976,656

G

egl-9 family hypoxia inducible factor 3

NCBI chr14:14,689,398...14,716,301
Ensembl chr14:32,880,324...32,907,241

G

endothelial PAS domain protein 1

PMID:15247145 PMID:18484163

RGD:1580977 RGD:5147886

NCBI chr2A:46,403,411...46,492,734
Ensembl chr2A:47,332,308...47,421,560

G

EPH receptor B1

ameliorates

NCBI chr 3:131,841,459...132,309,082
Ensembl chr 3:139,313,387...139,776,802

G

epoxide hydrolase 2

NCBI chr 8:26,761,090...26,818,436
Ensembl chr 8:23,964,094...24,017,749

G

erythropoietin

treatment

CTD Direct Evidence: marker/mechanism

PMID:19337937 PMID:21415704

NCBI chr 7:92,747,671...92,750,886
Ensembl chr 7:106,148,062...106,150,974

G

erythropoietin receptor

NCBI chr19:10,925,148...10,931,955
Ensembl chr19:11,635,248...11,642,383

G

erb-b2 receptor tyrosine kinase 2

treatment

NCBI chr17:17,560,337...17,600,808
Ensembl chr17:17,777,434...17,805,862

G

erb-b2 receptor tyrosine kinase 4

treatment

NCBI chr2B:98,625,630...99,795,371
Ensembl chr2B:217,069,644...218,272,006

G

estrogen receptor 1

susceptibility

ClinVar Annotator: match by term: Myocardial infarction, susceptibility to

PMID:11894143 PMID:11919305 PMID:14600184 PMID:15133719 PMID:25741868

NCBI chr 6:149,507,599...149,918,523
Ensembl chr 6:154,317,002...154,631,551

G

coagulation factor X

ClinVar Annotator: match by term: Myocardial infarction, decreased susceptibility to

PMID:10984565 PMID:12181036 PMID:25741868

NCBI chr13:94,263,202...94,289,612
Ensembl chr13:113,332,124...113,358,660

G

coagulation factor XII

susceptibility

DNA:polymorphism:promoter:-46C>T(human)

NCBI chr 5:172,703,724...172,711,618
Ensembl chr 5:179,766,243...179,773,485

G

coagulation factor XIII A chain

ClinVar Annotator: match by term: Myocardial infarction, protection against | ClinVar Annotator: match by term: Myocardial infarction, susceptibility to

PMID:8025280 PMID:9459313 PMID:9550516 PMID:10365735 PMID:10910914 More...

NCBI chr 6:5,978,505...6,156,705
Ensembl chr 6:6,157,926...6,513,961

G

coagulation factor II, thrombin

susceptibility

CTD Direct Evidence: marker/mechanism
DNA:polymorphism::20210G>A(human)

PMID:9292507 PMID:9531249 PMID:10027711 PMID:12480694

NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157

G

coagulation factor III, tissue factor

treatment

NCBI chr 1:97,190,381...97,203,076
Ensembl chr 1:95,918,502...95,931,050

G

coagulation factor V

no_association
susceptibility

DNA:mutation:cds:1691G>A (human)
CTD Direct Evidence: marker/mechanism

PMID:9531249 PMID:10590188 PMID:15131548

RGD:11564335 RGD:11564337

NCBI chr 1:144,996,757...145,070,046
Ensembl chr 1:148,718,897...148,790,915

G

coagulation factor VII

susceptibility

ClinVar Annotator: match by term: F7-related condition | ClinVar Annotator: match by term: Myocardial infarction, decreased susceptibility to | ClinVar Annotator: match by term: Myocardial infarction, susceptibility to

PMID:1634227 PMID:2070047 PMID:6812354 PMID:7919338 PMID:7974346 More...

NCBI chr13:94,246,694...94,261,133
Ensembl chr13:113,315,868...113,329,995

G

fatty acid binding protein 3

NCBI chr 1:30,640,595...30,653,450
Ensembl chr 1:31,665,270...31,673,689

G

fibrinogen alpha chain

treatment

NCBI chr 4:146,949,680...146,957,291

G

fibrinogen beta chain

NCBI chr 4:146,929,561...146,937,665
Ensembl chr 4:158,747,659...158,755,766

G

fibroblast growth factor 1

treatment

NCBI chr 5:137,949,100...138,054,553
Ensembl chr 5:144,056,387...144,078,001

G

fibroblast growth factor receptor 1

NCBI chr 8:37,713,133...37,773,098
Ensembl chr 8:34,890,147...34,948,904

G

fibroblast growth factor receptor 2

ameliorates

NCBI chr10:118,055,854...118,175,440
Ensembl chr10:121,469,735...121,588,815

G

fibrinogen gamma chain

treatment

NCBI chr 4:146,970,671...146,979,348
Ensembl chr 4:158,788,966...158,797,237

G

fission, mitochondrial 1

protein:increased expression:plantaris (rat)

NCBI chr 7:93,381,058...93,386,483
Ensembl chr 7:106,621,211...106,626,683

G

fms related receptor tyrosine kinase 1

NCBI chr13:9,584,850...9,779,542

G

fms related receptor tyrosine kinase 3 ligand

treatment

NCBI chr19:46,486,169...46,499,008

G

fibronectin 1

protein:decreased expression:heart

NCBI chr2B:102,623,568...102,698,747
Ensembl chr2B:221,208,431...221,284,003

G

Fos proto-oncogene, AP-1 transcription factor subunit

protein:increased expression:paraventricular nucleus hypothalamus, paraventricular nucleus thalamus

NCBI chr14:55,832,570...55,835,984
Ensembl chr14:74,676,316...74,679,766

G

FTO alpha-ketoglutarate dependent dioxygenase

treatment

DNA:SNP: :rs17817449 (human)
associated with type 2 diabetes mellitus;DNA:SNP:intron:rs9939609 (human)
mRNA, protein:decreased expression:heart

PMID:20031593 PMID:26772723 PMID:29997116

RGD:11555187 RGD:329812009 RGD:329901766

NCBI chr16:33,939,300...34,343,419
Ensembl chr16:53,023,425...53,490,231

G

frizzled class receptor 2

mRNA:increased expression:heart left ventricle

NCBI chr17:12,839,362...12,843,803

G

glucose-6-phosphate dehydrogenase

treatment

NCBI chr X:143,972,798...143,988,960
Ensembl chr X:153,843,092...153,860,674

G

GATA binding protein 4

treatment

CTD Direct Evidence: therapeutic

PMID:20200331 PMID:23948075

NCBI chr 8:7,442,921...7,526,731

G

glycine amidinotransferase

NCBI chr15:24,309,045...24,326,673
Ensembl chr15:42,639,597...42,657,209

G

GTP cyclohydrolase 1

treatment

PMID:26192027 PMID:32782412

RGD:329961570 RGD:329970290

NCBI chr14:35,428,676...35,489,359
Ensembl chr14:53,706,723...53,767,393

G

glutamate-cysteine ligase catalytic subunit

susceptibility

ClinVar Annotator: match by term: Myocardial infarction, susceptibility to

NCBI chr 6:53,052,145...53,102,794
Ensembl chr 6:54,687,315...54,734,994

G

glutamate-cysteine ligase modifier subunit

susceptibility

ClinVar Annotator: match by term: Myocardial infarction, susceptibility to

PMID:12081989 PMID:12975258

NCBI chr 1:96,548,850...96,573,273
Ensembl chr 1:95,278,665...95,297,893

G

gamma-glutamyltransferase 1

CTD Direct Evidence: marker/mechanism

NCBI chr22:5,424,334...5,469,705

G

growth hormone releasing hormone

treatment

NCBI chr20:33,573,001...33,583,699
Ensembl chr20:34,687,587...34,693,240

G

gap junction protein alpha 1

treatment

protein:decreased phosphorylation

PMID:22841862 PMID:22969867 PMID:29428663

RGD:13592597 RGD:7207261 RGD:7207262

NCBI chr 6:119,213,513...119,227,617

G

gap junction protein alpha 4

DNA:SNP:CDS:T allele of 1019C>T in Japanese men (p<0.001)
associated with coronary artery disease; DNA:SNP:CDS:C allele of 1019C>T, amino acid P319S (p = 0.0026) in a Swiss population

PMID:12477941 PMID:15982495 PMID:16677656

RGD:1580400 RGD:1626615 RGD:1626626

NCBI chr 1:34,059,901...34,063,181

G

gap junction protein alpha 5

treatment

NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413

G

glycoprotein Ib platelet subunit alpha

NCBI chr17:4,980,083...4,983,219

G

glycoprotein VI platelet

susceptibility
treatment
sexual_dimorphism
no_association
onset

DNA:SNP, missense mutation:promoter, CDS:c.-148C>T, c.13254T>C (p.S219P) (human)
human protein in a mouse model
DNA:missense mutation:CDS:c.13254T>C (p.S219P) (human)
DNA:missense mutation:CDS:c.13254T>C (p.S219P) (rs1613662) (human)
DNA:missense mutation:exon 7:c.645213C>T (p.T249A) (human)

PMID:11571236 PMID:12417295 PMID:20723028 PMID:22814400

RGD:401793749 RGD:401793754 RGD:401794407 RGD:401824647

NCBI chr19:52,051,138...52,071,673
Ensembl chr19:60,746,578...60,770,643

G

glutamic--pyruvic transaminase

treatment

Ensembl chr 8:144,259,991...144,263,737

G

glutathione peroxidase 1

susceptibility

NCBI chr 3:49,280,038...49,281,455
Ensembl chr 3:50,360,947...50,361,826

G

glycogen synthase kinase 3 beta

treatment

CTD Direct Evidence: marker/mechanism

PMID:16565311 PMID:16716347

NCBI chr 3:116,943,205...117,215,001
Ensembl chr 3:123,861,379...124,126,771

G

gelsolin

ameliorates

protein:decreased expression:blood serum (human)

PMID:9142022 PMID:28622474

RGD:329333022 RGD:329333030

NCBI chr 9:92,413,819...92,460,483
Ensembl chr 9:120,741,148...120,805,831

G

glutathione-disulfide reductase

treatment

NCBI chr 8:29,990,543...30,040,157
Ensembl chr 8:27,180,300...27,229,557

G

guanylate cyclase 1 soluble subunit alpha 1

ClinVar Annotator: match by term: Myocardial infarction, susceptibility to, 1

NCBI chr 4:148,032,167...148,102,757
Ensembl chr 4:159,850,107...159,913,338

G

hydroxyacyl-CoA dehydrogenase

NCBI chr 4:100,495,205...100,540,589
Ensembl chr 4:111,067,336...111,113,868

G

hepcidin antimicrobial peptide

mRNA:increased expression:heart

NCBI chr19:32,228,701...32,231,494
Ensembl chr19:40,964,445...40,968,861

G

homeostatic iron regulator

no_association
susceptibility

PMID:10491370 PMID:12850485

RGD:1582672 RGD:1582697

NCBI chr 6:25,921,663...25,930,852
Ensembl chr 6:26,580,358...26,588,591

G

hepatocyte growth factor

treatment

protein:increased expression:serum:

PMID:12419930 PMID:16570015

RGD:8548609 RGD:8548632

NCBI chr 7:73,667,618...73,738,960
Ensembl chr 7:87,327,798...87,397,811

G

hypoxia inducible factor 1 subunit alpha

ameliorates
treatment

mRNA:increased expression:heart left ventricle
human gene in a rat model

PMID:15247145 PMID:15999059 PMID:18484163 PMID:28622474

RGD:1580977 RGD:329333030 RGD:5147886 RGD:9068466

NCBI chr14:42,295,691...42,348,478
Ensembl chr14:60,552,374...60,604,885

G

high mobility group box 1

treatment

CTD Direct Evidence: marker/mechanism

PMID:21113057 PMID:23188125

NCBI chr13:11,737,942...11,894,923
Ensembl chr13:30,174,899...30,179,527

G

heme oxygenase 1

PMID:12392996 PMID:20925964

RGD:1598393 RGD:4145134

NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063

G

hydroxysteroid 11-beta dehydrogenase 1

ameliorates

PMID:26465199 PMID:28522730

RGD:11087531 RGD:329902054

NCBI chr 1:185,262,599...185,311,417
Ensembl chr 1:190,086,449...190,116,765

G

hydroxysteroid 11-beta dehydrogenase 2

mRNA:increased expression:heart
CTD Direct Evidence: marker/mechanism

NCBI chr16:47,776,118...47,782,861
Ensembl chr16:67,165,215...67,171,417

G

heat shock protein family A (Hsp70) member 5

CTD Direct Evidence: marker/mechanism

NCBI chr 9:96,351,645...96,356,761
Ensembl chr 9:124,865,211...124,870,458

G

heat shock protein family D (Hsp60) member 1

NCBI chr2B:84,729,615...84,743,352
Ensembl chr2B:202,623,497...202,636,959

G

intercellular adhesion molecule 1

treatment

CTD Direct Evidence: marker/mechanism

PMID:10070497 PMID:23139358

NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605

G

insulin like growth factor 1

severity

mRNA, protein:increased expression:myocardium

PMID:16635594 PMID:19295919

RGD:1598421 RGD:2306696

NCBI chr12:99,986,887...100,066,773
Ensembl chr12:103,385,911...103,462,177

G

insulin like growth factor 1 receptor

mRNA,protein:increased expression:myocyte:

NCBI chr15:77,332,926...77,648,474
Ensembl chr15:96,535,164...96,832,974

G

interleukin 10

susceptibility

CTD Direct Evidence: marker/mechanism

PMID:15466015 PMID:15883752 PMID:16310260

NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371

G

interleukin 17A

mRNA, protein:increased expression:heart left ventricle (rat)

NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074

G

interleukin 18

ameliorates

NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371

G

interleukin 18 binding protein

NCBI chr11:67,078,251...67,083,043
Ensembl chr11:70,302,923...70,307,511

G

interleukin 1 beta

ameliorates

CTD Direct Evidence: marker/mechanism
protein:increased expression:serum (rat)

PMID:11743230 PMID:15883752 PMID:16310260 PMID:23143013 PMID:23237935 More...

RGD:242905187 RGD:7175553 RGD:7204425

NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424

G

interleukin 1 receptor antagonist

CTD Direct Evidence: therapeutic

PMID:18474815 PMID:19005744

NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839

G

interleukin 4 receptor

mRNA:increased expression:heart

Ensembl chr16:27,642,702...27,737,445

G

interleukin 6

treatment

CTD Direct Evidence: marker/mechanism

PMID:15883752 PMID:16310260 PMID:31734577

NCBI chr 7:23,415,922...23,420,767

G

interleukin 6 receptor

NCBI chr 1:129,761,914...129,824,386
Ensembl chr 1:133,374,078...133,433,089

G

inhibin subunit beta A

mRNA:increased expression:heart (rat)
mRNA:increased expression:myocardium (mouse)

PMID:14993131 PMID:32427381

RGD:1580888 RGD:329849118

NCBI chr 7:42,538,591...42,556,578
Ensembl chr 7:42,580,730...42,595,097

G

inhibin subunit beta B

mRNA:increased expression:myocardium (mouse)

NCBI chr2B:7,278,944...7,284,632

G

ISL LIM homeobox 1

ameliorates

PMID:22727192 PMID:29482621

RGD:243048463 RGD:243048464

NCBI chr 5:62,635,095...62,650,141
Ensembl chr 5:64,252,715...64,264,674

G

integrin subunit alpha 2

no_association
susceptibility

PMID:10194421 PMID:15227729 PMID:16697311

RGD:1581029 RGD:1582294 RGD:1582296

NCBI chr 5:60,935,452...61,040,726
Ensembl chr 5:62,555,370...62,659,720

G

integrin subunit alpha 3

protein:increased expression:myocardium (rat)

NCBI chr17:44,145,974...44,181,343
Ensembl chr17:49,019,892...49,055,245

G

integrin subunit alpha M

treatment

NCBI chr16:23,634,476...23,707,147
Ensembl chr16:31,630,146...31,702,406

G

integrin subunit beta 1

treatment

NCBI chr10:33,023,573...33,081,384
Ensembl chr10:33,608,978...33,644,031

G

integrin subunit beta 3

no_association
susceptibility

DNA:polymorphism:exon:
ClinVar Annotator: match by term: Myocardial infarction, susceptibility to

RGD
OMIM
ClinVar

PMID:2014236 PMID:7570918 PMID:8598867 PMID:8667943 PMID:8838346 More...

RGD:5128481 RGD:5128498

NCBI chr17:10,134,450...10,194,596
Ensembl chr17:10,353,111...10,392,382

G

inter-alpha-trypsin inhibitor heavy chain 4

NCBI chr 3:52,754,664...52,774,867
Ensembl chr 3:53,980,668...53,998,038

G

Janus kinase 2

susceptibility

associated with Myocardial Reperfusion Injury

NCBI chr 9:4,820,303...4,971,867
Ensembl chr 9:5,006,271...5,156,626

G

potassium inwardly rectifying channel subfamily J member 2

treatment

NCBI chr17:64,097,908...64,112,914
Ensembl chr17:69,487,846...69,489,129

G

potassium two pore domain channel subfamily K member 2

mRNA:decreased expression:heart left ventricle, epicardium, endocardium (rat)

NCBI chr 1:190,576,180...190,807,367
Ensembl chr 1:195,430,994...195,662,840

G

potassium calcium-activated channel subfamily N member 4

susceptibility

DNA:SNPs,haplotypes:introns:multiple

NCBI chr19:40,715,621...40,735,025
Ensembl chr19:49,321,403...49,335,900

G

lysine demethylase 5B

ameliorates

NCBI chr 1:178,323,073...178,406,608
Ensembl chr 1:182,622,425...182,702,994

G

lysine demethylase 6A

mRNA:increased expression:myocardium (rat)

NCBI chr X:37,313,000...37,548,630
Ensembl chr X:45,127,382...45,362,029

G

kinase insert domain receptor

treatment

PMID:16698275 PMID:25936512

RGD:126925214 RGD:1581717

NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109

G

kinesin family member 6

no_association
treatment

DNA:SNP: :p.W719R (rs20455) (human)
CTD Direct Evidence: marker/mechanism
DNA:SNP: :rs20455 (human)

PMID:18222354 PMID:19371834 PMID:20403483 PMID:20927332 PMID:21943003 More...

RGD:11097528 RGD:243048446 RGD:243048447 RGD:243048449 RGD:243048450

NCBI chr 6:38,917,083...39,306,190
Ensembl chr 6:40,234,426...40,616,738

G

KLF transcription factor 13

CTD Direct Evidence: marker/mechanism

NCBI chr15:9,818,294...9,964,912

G

kallikrein 1

CTD Direct Evidence: therapeutic

PMID:12411458 PMID:17022964

NCBI chr19:47,784,368...47,789,004
Ensembl chr19:56,677,579...56,682,216

G

lysosomal associated membrane protein 2

mRNA:increased expression:plantaris

NCBI chr X:109,700,185...109,743,579
Ensembl chr X:119,886,982...119,929,896

G

lecithin-cholesterol acyltransferase

NCBI chr16:48,278,137...48,285,305
Ensembl chr16:67,668,646...67,673,127

G

lipocalin 2

ameliorates

NCBI chr 9:99,259,278...99,274,494
Ensembl chr 9:127,940,799...127,944,798

G

lactate dehydrogenase A

CTD Direct Evidence: marker/mechanism

NCBI chr11:18,432,347...18,445,694
Ensembl chr11:18,115,250...18,128,400

G

galectin 2

susceptibility

ClinVar Annotator: match by term: Myocardial infarction, susceptibility to

NCBI chr22:18,488,257...18,498,401
Ensembl chr22:36,320,775...36,330,281

G

galectin 3

CTD Direct Evidence: marker/mechanism

NCBI chr14:35,715,850...35,732,263
Ensembl chr14:53,990,023...54,006,412

G

lipase G, endothelial type

susceptibility

DNA:polymorphism: :584C>T (human)

NCBI chr18:42,942,132...42,972,112
Ensembl chr18:46,292,154...46,320,652

G

left-right determination factor 1

ameliorates

NCBI chr 1:201,347,411...201,351,295
Ensembl chr 1:206,348,419...206,350,787

G

somatotropin

treatment

NCBI chr17:58,010,848...58,013,421
Ensembl chr17:63,103,332...63,105,067

G

interferon alpha-2

CTD Direct Evidence: marker/mechanism

NCBI chr 9:21,245,017...21,246,210
Ensembl chr 9:21,863,062...21,863,736

G

myosin-7

CTD Direct Evidence: marker/mechanism

PMID:11743230 PMID:15090263

NCBI chr14:4,231,344...4,254,295
Ensembl chr14:22,325,812...22,348,763

G

adenosine receptor A3

CTD Direct Evidence: therapeutic

PMID:12160945 PMID:20132822

NCBI chr 1:114,144,642...114,225,407
Ensembl chr 1:126,122,352...126,202,396

G

cytochrome b-245 heavy chain

mRNA:increase expression:ventricle myocardium

NCBI chr X:30,230,394...30,267,379
Ensembl chr X:37,939,704...37,973,183

G

cytochrome b-245 light chain

mRNA:increased expression:myocardium
mRNA:increase expression:ventricle myocardium:

PMID:11243862 PMID:18762777

RGD:1599690 RGD:2317860

NCBI chr16:69,356,396...69,364,225
Ensembl chr16:89,016,349...89,024,719

G

lysyl oxidase

NCBI chr 5:117,450,833...117,464,957
Ensembl chr 5:123,234,662...123,248,717

G

lipoprotein(a)

DNA:SNP:CDS:rs3798220, g.160961137T>C, p.Ile1891Met

NCBI chr 6:158,434,394...158,628,028

G

lipoprotein lipase

susceptibility

associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:SNP: :p.D9N (rs1801177) (human)

NCBI chr 8:19,164,541...19,193,100
Ensembl chr 8:16,113,415...16,142,966

G

LDL receptor related protein 1

susceptibility

NCBI chr12:31,713,938...31,799,287
Ensembl chr12:31,966,149...32,051,979

G

LDL receptor related protein 8

susceptibility
onset
no_association

ClinVar Annotator: match by term: Myocardial infarction, susceptibility to, 1
DNA:missense mutation:cds:p.R952Q (human)

OMIM
ClinVar
RGD

PMID:17847002 PMID:18592168

RGD:2306124 RGD:2306125

NCBI chr 1:52,515,534...52,600,390
Ensembl chr 1:54,114,909...54,199,452

G

LDL receptor related protein associated protein 1

susceptibility

NCBI chr 4:3,663,649...3,683,450
Ensembl chr 4:3,646,179...3,666,098

G

lymphotoxin alpha

susceptibility
severity
no_association

ClinVar Annotator: match by term: Myocardial infarction, susceptibility to
DNA:SNP:exon:804C>A (p.T26N) (human)

OMIM
ClinVar
RGD

PMID:12426569 PMID:12746914 PMID:14681301 PMID:15175864 PMID:15266304 More...

RGD:1581940 RGD:8548841

NCBI chr 6:31,233,411...31,235,409
Ensembl chr 6:32,123,353...32,125,375

G

microtubule associated protein 1 light chain 3 alpha

treatment

NCBI chr20:30,887,345...30,888,986
Ensembl chr20:32,010,284...32,020,411

G

mitogen-activated protein kinase kinase kinase 5

treatment

NCBI chr 6:134,316,841...134,582,843
Ensembl chr 6:138,406,398...138,641,727

G

mitogen-activated protein kinase kinase kinase 7

treatment

mRNA, protein:increased expression:myocardium (rat)

PMID:16183734 PMID:27121011

RGD:11073666 RGD:2298758

NCBI chr 6:88,398,329...88,470,926
Ensembl chr 6:91,664,263...91,737,468

G

mitogen-activated protein kinase 1

NCBI chr22:3,883,119...3,990,368
Ensembl chr22:20,365,487...20,450,335

G

mitogen-activated protein kinase 14

ameliorates

NCBI chr 6:35,586,847...35,683,041
Ensembl chr 6:36,788,233...36,871,114

G

mitogen-activated protein kinase 8

ameliorates

NCBI chr10:45,806,748...45,936,362

G

malate dehydrogenase 2

NCBI chr 7:67,953,759...67,973,270
Ensembl chr 7:82,497,800...82,516,526

G

midkine

NCBI chr11:46,339,365...46,342,388
Ensembl chr11:46,891,540...46,893,254

G

myocyte enhancer factor 2C

treatment

NCBI chr 5:26,480,489...26,650,813
Ensembl chr 5:26,681,700...26,786,426

G

mesenchyme homeobox 2

protein:decreased expression:heart (rat)

NCBI chr 7:16,268,225...16,343,914
Ensembl chr 7:15,598,466...15,673,935

G

mesoderm posterior bHLH transcription factor 1

treatment

human gene and cell line in a rat model

NCBI chr15:68,440,626...68,441,935
Ensembl chr15:87,645,768...87,647,210

G

mitochondrial fission factor

treatment

CTD Direct Evidence: marker/mechanism

NCBI chr2B:114,569,893...114,602,158
Ensembl chr2B:233,381,466...233,413,778

G

mitofusin 2

treatment

NCBI chr 1:10,729,933...10,764,865
Ensembl chr 1:11,945,880...11,981,077

G

matrix Gla protein

susceptibility

NCBI chr12:14,887,806...14,891,796
Ensembl chr12:15,284,883...15,288,523

G

MIA SH3 domain ER export factor 3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:198,291,200...198,339,502
Ensembl chr 1:203,304,237...203,354,919

G

macrophage migration inhibitory factor

protein:increased expression:plasma
mRNA, protein:increased expression:myocardium

PMID:11589847 PMID:12704210

RGD:1642003 RGD:1642008

NCBI chr22:4,646,986...4,647,831
Ensembl chr22:22,730,807...22,732,009

G

MLX interacting protein like

susceptibility

DNA:SNP:cd: C771G, p.Q241H (rs3812316) (human)

Ensembl chr 7:80,745,765...80,776,153

G

matrix metallopeptidase 1

susceptibility

protein:increased expression, increased activity:heart left ventricle (rat)
associated with Coronary Artery Disease; DNA:snps, haplotype:promoter:g.-519A>G, g.-340T>C (human)
human gene in rat model

PMID:8531210 PMID:11179039 PMID:15009768 PMID:16210545 PMID:19797822

RGD:1582520 RGD:1582535 RGD:7207135 RGD:7207136 RGD:7207198

NCBI chr11:97,730,545...97,739,190
Ensembl chr11:101,221,393...101,230,104

G

matrix metallopeptidase 13

NCBI chr11:97,890,811...97,902,778
Ensembl chr11:101,377,001...101,387,679

G

matrix metallopeptidase 14

PMID:10773235 PMID:16461815

RGD:1582569 RGD:1582587

NCBI chr14:3,654,125...3,665,158
Ensembl chr14:21,753,305...21,764,058

G

matrix metallopeptidase 2

CTD Direct Evidence: marker/mechanism

PMID:10773235 PMID:11179039 PMID:16310260 PMID:24358288

RGD:1582587 RGD:7207136

NCBI chr16:35,711,866...35,738,881
Ensembl chr16:54,812,694...54,844,279

G

matrix metallopeptidase 3

NCBI chr11:97,776,729...97,784,549
Ensembl chr11:101,267,566...101,275,354

G

matrix metallopeptidase 7

NCBI chr11:97,467,037...97,477,305
Ensembl chr11:100,960,032...100,971,099

G

matrix metallopeptidase 9

susceptibility

protein:increased expression:heart left ventricle
CTD Direct Evidence: marker/mechanism
protein:increased expression, increased activity:heart left ventricle (rat)
DNA:snps:promoter, exon:g.-1562C>T, p.R279Q (rs3918242, rs2664538) (human)
protein:increased expression:coronary artery, plasma (human)

PMID:8531210 PMID:14729404 PMID:15118287 PMID:16310260 PMID:16845718 More...

RGD:13204799 RGD:1582639 RGD:1582645 RGD:1582653 RGD:7207049 RGD:7207198

NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129

G

myostatin

mRNA:decreased expression:myocardium (mouse)

NCBI chr2B:77,364,927...77,452,426
Ensembl chr2B:195,283,903...195,290,922

G

methylenetetrahydrofolate reductase

susceptibility

DNA:SNP: :677C>T (human)
associated with Kidney Failure, Chronic; DNA:transition:cds:g.677C>T rs1801133 (human)

PMID:10090925 PMID:19272686

RGD:10449412 RGD:6893548

NCBI chr 1:10,548,196...10,568,174
Ensembl chr 1:11,766,334...11,785,419

G

mechanistic target of rapamycin kinase

treatment

protein:decreased serine phosphorylation:heart
associated with Diabetes Mellitus, Experimental

PMID:20352476 PMID:23773982

RGD:10041035 RGD:10041040

NCBI chr 1:9,871,700...10,028,704
Ensembl chr 1:11,093,765...11,249,841

G

myosin heavy chain 6

NCBI chr14:4,200,616...4,226,193
Ensembl chr14:22,294,965...22,321,331

G

neural cell adhesion molecule 1

mRNA, protein:increased expression:heart
protein:alternative form, increased expression:myocardium

PMID:19853610 PMID:23462508

RGD:2325979 RGD:40924663

NCBI chr11:107,845,507...108,160,441
Ensembl chr11:111,925,677...112,000,401

G

NADH:ubiquinone oxidoreductase subunit B5

treatment

NCBI chr 3:176,636,937...176,659,813
Ensembl chr 3:184,807,246...184,827,011

G

NFE2 like bZIP transcription factor 2

treatment

PMID:23290949 PMID:24915518

RGD:10412734 RGD:10412738

NCBI chr2B:64,509,446...64,544,600
Ensembl chr2B:182,214,116...182,248,085

G

NFKB inhibitor alpha

treatment

NCBI chr14:16,155,331...16,158,588

G

nerve growth factor

treatment

protein:increased expression:myocardium

NCBI chr 1:87,223,597...87,276,759

G

nemo like kinase

mRNA, protein:decreased expression:heart

NCBI chr17:28,586,894...28,740,252

G

NLR family pyrin domain containing 3

ameliorates

NCBI chr 1:223,052,307...223,084,736
Ensembl chr 1:228,505,147...228,537,216

G

non-POU domain containing octamer binding

ameliorates

NCBI chr X:60,547,277...60,564,845
Ensembl chr X:70,602,456...70,619,956

G

nitric oxide synthase 2

treatment

CTD Direct Evidence: marker/mechanism

PMID:10090345 PMID:11489778 PMID:26192027

NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093

G

nitric oxide synthase 3

susceptibility
treatment

protein:decreased expression:aorta (rat)
DNA:repeats:intron
human gene in rat model
DNA:duplication:intron:IVS4?-?+27 (human)
CTD Direct Evidence: marker/mechanism

PMID:10510054 PMID:10531147 PMID:11903359 PMID:12362496 PMID:16337503 More...

RGD:13450930 RGD:13503346 RGD:1580283 RGD:1580284 RGD:5128481 RGD:7771561 RGD:7771563

NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233

G

nucleophosmin 1

protein:increased expression:cardiomyocyte:

NCBI chr 5:166,735,904...166,756,321
Ensembl chr 5:173,490,197...173,510,656

G

natriuretic peptide A

CTD Direct Evidence: marker/mechanism|therapeutic
DNA:snp:cds:c.2238T>C (human)

PMID:9527094 PMID:11743230 PMID:12514664 PMID:16087130

RGD:1579982 RGD:1580000

NCBI chr 1:10,608,025...10,610,287
Ensembl chr 1:11,825,072...11,827,373

G

natriuretic peptide B

PMID:17256064 PMID:17639095 PMID:19858735

RGD:1642266 RGD:2324680 RGD:7247724

NCBI chr 1:10,621,416...10,622,960
Ensembl chr 1:11,838,518...11,839,995

G

natriuretic peptide receptor 1

susceptibility

DNA:missense mutation:cds:p.M341I (human)

NCBI chr 1:129,034,972...129,050,439
Ensembl chr 1:132,664,948...132,679,327

G

nuclear receptor subfamily 1 group H member 3

susceptibility

DNA:SNPs, haplotype:promoter:c.-115G>A, c.-840C>A (rs12221497, rs61896015) (human)

NCBI chr11:47,195,122...47,215,277
Ensembl chr11:47,748,353...47,768,672

G

nuclear receptor subfamily 3 group C member 2

CTD Direct Evidence: marker/mechanism

PMID:16413583 PMID:17587755

NCBI chr 4:140,418,624...140,785,180
Ensembl chr 4:152,108,508...152,430,298

G

neuregulin 1

treatment

PMID:24200746 PMID:26892146 PMID:27993643

RGD:10449026 RGD:11522702 RGD:405145704

NCBI chr 8:30,954,852...32,084,411
Ensembl chr 8:29,050,222...29,263,977

G

nuclear receptor interacting protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr21:1,565,149...1,801,358
Ensembl chr21:15,065,197...15,068,673

G

oxidized low density lipoprotein receptor 1

susceptibility

ClinVar Annotator: match by term: Myocardial infarction, susceptibility to

PMID:12646194 PMID:12810610 PMID:14684693

NCBI chr12:10,196,712...10,210,432
Ensembl chr12:10,445,202...10,461,071

G

OPA1 mitochondrial dynamin like GTPase

treatment

NCBI chr 3:190,890,242...190,995,133
Ensembl chr 3:201,207,607...201,312,358

G

opioid receptor delta 1

PMID:12798419 PMID:15076225

RGD:2316587 RGD:9831425

NCBI chr 1:28,068,053...28,143,053
Ensembl chr 1:29,112,152...29,163,464

G

opioid receptor kappa 1

NCBI chr 8:49,650,844...49,677,494
Ensembl chr 8:47,029,313...47,056,577

G

purinergic receptor P2Y12

CTD Direct Evidence: marker/mechanism

NCBI chr 3:148,364,151...148,412,231

G

pappalysin 1

susceptibility

DNA:polymorphism:intron
CTD Direct Evidence: marker/mechanism

PMID:11586954 PMID:17700210

NCBI chr 9:87,287,289...87,535,414
Ensembl chr 9:115,671,212...115,883,435

G

poly(ADP-ribose) polymerase 1

protein:altered processing:left ventricle (mouse)

NCBI chr 1:201,820,355...201,867,673
Ensembl chr 1:206,812,981...206,860,356

G

proprotein convertase subtilisin/kexin type 2

DNA:SNP:intron: (rs6080699) (human)

NCBI chr20:17,184,878...17,443,355
Ensembl chr20:17,163,675...17,421,157

G

phosphodiesterase 3A

CTD Direct Evidence: marker/mechanism

NCBI chr12:20,380,213...20,690,540
Ensembl chr12:20,763,999...21,064,391

G

phosphodiesterase 5A

NCBI chr 4:111,682,772...111,817,234
Ensembl chr 4:122,832,175...122,966,636

G

platelet derived growth factor D

mRNA,protein:altered expression:myocardium:

NCBI chr11:98,852,652...99,110,147
Ensembl chr11:102,357,079...102,593,273

G

phosphatidylethanolamine binding protein 1

protein:decreased expression:right heart ventricle, ventricular septum

NCBI chr12:115,716,953...115,726,412
Ensembl chr12:119,093,952...119,105,054

G

platelet and endothelial cell adhesion molecule 1

onset
no_association

DNA:missense mutation:cds:p.R643G (human)
DNA:polymorphisms: :p.N563S, p.G670R (human)
DNA:missense mutations:cds:p.L125V, p.S563N (human)

PMID:11795274 PMID:15265022 PMID:15488875

RGD:1581009 RGD:2311656 RGD:6771224

NCBI chr17:58,417,134...58,526,409
Ensembl chr17:63,511,784...63,579,067

G

placental growth factor

PMID:20649603 PMID:21329947 PMID:22114497

RGD:6483584 RGD:6483773 RGD:6483777

NCBI chr14:55,494,152...55,508,066
Ensembl chr14:74,338,976...74,352,964

G

phosphatase and actin regulator 1

susceptibility
severity
no_association

CTD Direct Evidence: marker/mechanism
DNA:SNP:intron: (rs9369640) (human)
DNA:SNPs:multiple (human)
DNA:SNP:intron:(rs12526453) (human)
mRNA:increased expression:peripheral blood mononuclear cells (human)
DNA:SNPs:intron 3: (rs9349379, rs2026458, rs2876300) (human)
DNA:SNP:intron:g.13035530G>C (rs12526453) (human)
mRNA, protein:decreased expression:heart left ventricle (rat)

PMID:19198609 PMID:25738804 PMID:25838425 PMID:26086777 PMID:26098115 More...

RGD:11052493 RGD:11052994 RGD:11053274 RGD:11056926 RGD:401851907 RGD:401900171

NCBI chr 6:12,560,862...13,136,126
Ensembl chr 6:12,922,871...13,505,609

G

pleckstrin homology like domain family A member 3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:177,063,775...177,067,714
Ensembl chr 1:181,367,976...181,368,359

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

NCBI chr 7:98,841,974...98,885,446
Ensembl chr 7:111,570,148...111,611,614

G

phospholipase A2 group VII

protein:decreased expression:serum

NCBI chr 6:46,264,262...46,318,487
Ensembl chr 6:47,558,861...47,590,212

G

plasminogen activator, tissue type

treatment

CTD Direct Evidence: therapeutic
DNA:snp:enhancer:g.-7351C>T (human)

PMID:1430592 PMID:1492007 PMID:1898952 PMID:1899364 PMID:1900011 More...

RGD:11541077 RGD:1580881

NCBI chr 8:41,419,415...41,451,951
Ensembl chr 8:38,864,918...38,897,779

G

plasminogen activator, urokinase

mRNA, protein:increased expression:myocardium
DNA:SNP:3' utr:c.*141C>T (rs4065) (human)
CTD Direct Evidence: marker/mechanism|therapeutic

PMID:1908371 PMID:2174952 PMID:2382605 PMID:3068399 PMID:3984876 More...

RGD:6484126 RGD:6484133 RGD:6484145

NCBI chr10:70,433,340...70,441,569
Ensembl chr10:73,105,895...73,113,136

G

plasminogen activator, urokinase receptor

NCBI chr19:40,588,100...40,616,479
Ensembl chr19:49,197,341...49,222,561
Ensembl chr19:49,197,341...49,222,561

G

phospholipase C beta 1

protein:increased expression:heart

NCBI chr20:8,106,665...8,858,572
Ensembl chr20:7,887,960...8,636,019

G

phospholipase C beta 3

protein:increased expression:heart

NCBI chr11:59,608,651...59,626,289
Ensembl chr11:62,953,587...62,971,393

G

phospholamban

treatment

CTD Direct Evidence: marker/mechanism
protein:decreased expression:heart left ventricle (rat)

PMID:16026515 PMID:16162791 PMID:23781262 PMID:26067684

RGD:11097969 RGD:7327176

NCBI chr 6:116,357,335...116,370,382
Ensembl chr 6:120,509,510...120,509,668

G

paraoxonase 1

PMID:10610741 PMID:10978258

RGD:1580198 RGD:1580202

NCBI chr 7:87,253,476...87,279,650
Ensembl chr 7:100,841,286...100,867,493

G

periostin

protein:increased expression:heart:

NCBI chr13:18,779,297...18,815,207
Ensembl chr13:37,368,030...37,407,212

G

peroxisome proliferator activated receptor alpha

DNA:SNP:intron:rs4253623, minor allele associated with increased risk

Ensembl chr22:45,218,364...45,302,970

G

PPARG coactivator 1 alpha

protein:decreased expression:heart (rat)
CTD Direct Evidence: marker/mechanism

PMID:22087236 PMID:22503866

RGD:6484266 RGD:7242181

NCBI chr 4:18,196,431...18,876,889
Ensembl chr 4:23,483,377...23,581,212

G

protein kinase C epsilon

CTD Direct Evidence: therapeutic
RNA:decreased expression:myocardium:

PMID:16782078 PMID:28887629

NCBI chr2A:45,757,629...46,294,064
Ensembl chr2A:46,688,436...47,220,313

G

protein kinase D1

treatment

NCBI chr14:10,353,284...10,707,841
Ensembl chr14:28,496,282...28,650,030

G

protein C, inactivator of coagulation factors Va and VIIIa

NCBI chr2B:32,846,899...32,859,060
Ensembl chr2B:128,083,794...128,094,625

G

proteasome 20S subunit alpha 6

susceptibility

ClinVar Annotator: match by term: Myocardial infarction, susceptibility to

PMID:16845397 PMID:19282875

NCBI chr14:16,044,300...16,069,521
Ensembl chr14:34,214,271...34,252,347

G

prostaglandin I2 synthase

susceptibility

DNA:SNP::1117C>A (human)
DNA:silent mutation:exon 8:1117C>A (human)
DNA:SNP:CDS: (rs5629) (human)

PMID:12040339 PMID:19040046 PMID:19046748 PMID:19327107

RGD:2313891 RGD:401901147 RGD:401901155 RGD:401901268

NCBI chr20:45,841,238...45,905,641
Ensembl chr20:46,905,665...46,971,612

G

prostaglandin-endoperoxide synthase 2

NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519

G

pleiotrophin

protein:increased expression:myocardium (rat)

NCBI chr 7:129,184,786...129,300,815
Ensembl chr 7:141,701,430...141,705,623

G

RAD50 double strand break repair protein

treatment

NCBI chr 5:127,972,630...128,059,911
Ensembl chr 5:134,134,495...134,222,261

G

RAN binding protein 1

protein:decreased expression:heart ventricle, cytoplasm (rat)

NCBI chr22:2,877,954...2,888,035
Ensembl chr22:18,549,055...18,560,573

G

retinol binding protein 4

protein:increased expression:blood serum (human)

NCBI chr10:90,337,879...90,347,530
Ensembl chr10:93,848,166...93,857,887

G

renin

susceptibility

CTD Direct Evidence: marker/mechanism
associated with Hypertension; protein:increased activity:plasma (human)

PMID:1668233 PMID:1759997

NCBI chr 1:179,757,653...179,769,530
Ensembl chr 1:184,046,117...184,057,393

G

resistin

protein:increased expression:plasma

NCBI chr19:6,958,536...6,960,032
Ensembl chr19:7,812,942...7,814,909

G

ribosomal protein S6 kinase B1

protein:increased threonine phosphorylation:heart left ventricle

NCBI chr17:53,958,807...54,014,752
Ensembl chr17:58,799,069...58,853,653

G

ryanodine receptor 1

protein:hyperphosphorylation:extensor digitorum longus:

NCBI chr19:35,527,466...35,685,446
Ensembl chr19:44,106,036...44,256,327

G

S100 calcium binding protein B

CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:left ventricle myocardium, plasma

PMID:9788975 PMID:19910580

NCBI chr21:33,063,845...33,070,073
Ensembl chr21:46,197,750...46,203,953

G

syndecan 1

mRNA:increased expression:myocardium

NCBI chr2A:20,187,249...20,211,567
Ensembl chr2A:20,302,589...20,309,848

G

syndecan 4

protein:increased expression:plasma

NCBI chr20:41,656,406...41,679,549
Ensembl chr20:42,746,281...42,769,737

G

selectin L

CTD Direct Evidence: marker/mechanism

NCBI chr 1:145,173,700...145,194,927
Ensembl chr 1:148,895,373...148,916,393

G

selectin P

susceptibility

protein:increased expression:serum
DNA:polymorphisms, haplotypes:cds:p.S290N, p.N562D, p.T715P (human)
associated with Hypertension;protein:increased expression:plasma

PMID:12165563 PMID:17391113 PMID:21162967 PMID:21567088

RGD:1580075 RGD:2312304 RGD:6218991 RGD:6219003

NCBI chr 1:145,071,094...145,112,851
Ensembl chr 1:148,793,677...148,834,701

G

serpin family E member 1

susceptibility

DNA:deletion:promoter:g.-676_-674delG (human)

PMID:12477941 PMID:16053971

RGD:1626626 RGD:8547882

NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450

G

secreted frizzled related protein 2

PMID:19079247 PMID:19109969

RGD:155883169 RGD:4107088

NCBI chr 4:146,123,075...146,131,543
Ensembl chr 4:157,944,733...157,953,258

G

SH2B adaptor protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr12:108,977,344...109,024,029

G

sonic hedgehog signaling molecule

treatment

NCBI chr 7:147,400,112...147,414,036
Ensembl chr 7:159,114,666...159,126,651

G

sirtuin 1

protein:altered localization:nucleus

NCBI chr10:64,368,878...64,401,684
Ensembl chr10:66,681,598...66,715,069

G

sirtuin 3

treatment

NCBI chr11:210,052...233,969
Ensembl chr11:255,191...278,732

G

solute carrier family 27 member 1

protein:decreased expression:infarcted heart

NCBI chr19:16,956,000...16,993,429
Ensembl chr19:17,929,785...17,966,171

G

solute carrier family 27 member 6

protein:decreased expression:heart

NCBI chr 5:124,378,721...124,447,729
Ensembl chr 5:130,140,967...130,212,940

G

secretory leukocyte peptidase inhibitor

treatment

NCBI chr20:41,583,429...41,585,773
Ensembl chr20:42,673,417...42,675,773

G

SMAD family member 2

treatment
ameliorates

PMID:11087260 PMID:33409963

RGD:12903276 RGD:401794430

NCBI chr18:41,213,001...41,309,902
Ensembl chr18:44,580,905...44,668,530

G

SMAD family member 3

ameliorates

NCBI chr15:46,013,764...46,143,126
Ensembl chr15:64,284,949...64,414,185

G

SMAD family member 4

treatment

NCBI chr18:44,402,112...44,456,779
Ensembl chr18:47,764,568...47,797,359

G

suppressor of cytokine signaling 1

protein:increased expression:heart

NCBI chr16:10,196,432...10,198,205

G

superoxide dismutase 1

treatment

CTD Direct Evidence: therapeutic
human gene in a rat model

PMID:11864929 PMID:21600015 PMID:22006090

RGD:1581222 RGD:8655953

NCBI chr21:18,029,831...18,037,526

G

superoxide dismutase 2

CTD Direct Evidence: therapeutic

PMID:2313102 PMID:9250167 PMID:12160945 PMID:14575298

RGD:1580839 RGD:1580840 RGD:1581148

NCBI chr 6:157,562,814...157,610,155
Ensembl chr 6:162,576,082...162,589,960

G

superoxide dismutase 3

NCBI chr 4:19,195,941...19,201,298
Ensembl chr 4:24,485,059...24,485,781

G

secreted protein acidic and cysteine rich

mRNA:increased expression:heart

NCBI chr 5:147,087,903...147,112,466
Ensembl chr 5:153,090,181...153,115,750

G

secreted phosphoprotein 1

PMID:12939547 PMID:14500723

RGD:1581325 RGD:1581386

NCBI chr 4:80,263,711...80,271,466
Ensembl chr 4:90,988,200...90,995,935

G

serine and arginine rich splicing factor 1

treatment

protein:increased phosphorylation:heart left ventricle(rat)

NCBI chr17:52,083,676...52,087,454
Ensembl chr17:56,937,295...56,944,425

G

T-box transcription factor 3

NCBI chr12:112,240,050...112,254,299
Ensembl chr12:115,620,002...115,631,316

G

T-box transcription factor 5

treatment

NCBI chr12:111,954,222...112,009,261
Ensembl chr12:115,333,609...115,389,739

G

TEK receptor tyrosine kinase

protein:increased expression:ventricle myocardium

NCBI chr 9:26,955,339...27,077,809
Ensembl chr 9:27,561,421...27,683,572

G

tissue factor pathway inhibitor

treatment

mRNA,protein:increased expression:heart:

PMID:14656922 PMID:15630488 PMID:21229253

RGD:11060131 RGD:11060139 RGD:11062083

NCBI chr2B:74,744,154...74,834,338
Ensembl chr2B:192,541,881...192,581,384

G

transforming growth factor beta 1

susceptibility

mRNA,protein:increased expression:heart:
associated with Coronary Disease;DNA:polymorphism:promoter:-509C>T (human)
CTD Direct Evidence: marker/mechanism

PMID:16310260 PMID:16543493 PMID:27121011

RGD:11073666 RGD:1601560

NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973

G

transforming growth factor beta 2

NCBI chr 1:193,907,398...194,005,800
Ensembl chr 1:198,758,751...198,859,041

G

transforming growth factor beta receptor 1

NCBI chr 9:70,195,007...70,243,514
Ensembl chr 9:98,332,739...98,362,748

G

transforming growth factor beta receptor 2

protein:increased expression:myocardium

NCBI chr 3:30,536,187...30,623,653
Ensembl chr 3:30,854,460...30,938,856

G

tyrosine hydroxylase

no_association

DNA:polymorphism:intron:g.1170_1173dupTCAT (human)

NCBI chr11:2,204,820...2,212,750
Ensembl chr11:2,231,248...2,242,433

G

thrombomodulin

CTD Direct Evidence: marker/mechanism

PMID:9843165 PMID:10627464

NCBI chr20:22,992,341...22,996,415
Ensembl chr20:23,345,917...23,347,812

G

thrombospondin 1

mRNA, protein:increased expression:myocardium

NCBI chr15:18,521,802...18,538,172
Ensembl chr15:36,776,756...36,793,170

G

TIMP metallopeptidase inhibitor 2

CTD Direct Evidence: marker/mechanism

NCBI chr17:72,928,692...73,001,892
Ensembl chr17:78,476,807...78,495,649

G

toll like receptor 4

DNA:SNP:intron:rs1927911, minor allele associated with decreased risk

PMID:15864121 PMID:18549840

RGD:1580734 RGD:5562819

NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711

G

transmembrane 6 superfamily member 2

CTD Direct Evidence: marker/mechanism

NCBI chr19:18,703,075...18,712,056
Ensembl chr19:19,706,235...19,715,096

G

tenascin C

protein:increased expression:heart, fibroblast

NCBI chr 9:86,125,672...86,222,804
Ensembl chr 9:114,486,778...114,584,299

G

tumor necrosis factor

CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:left ventricle myocardium, plasma

PMID:15883752 PMID:16310260 PMID:21362018

NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381

G

TNF receptor superfamily member 11b

NCBI chr 8:115,614,778...115,643,387
Ensembl chr 8:118,134,305...118,162,422

G

TNF receptor superfamily member 12A

CTD Direct Evidence: marker/mechanism

NCBI chr16:1,962,179...1,964,223
Ensembl chr16:3,134,577...3,136,581

G

TNF receptor superfamily member 14

protein:increased expression:heart, cardiomyocyte, endothelial cell (rat)

NCBI chr 1:1,288,493...1,296,532
Ensembl chr 1:2,427,631...2,435,615

G

TNF receptor superfamily member 1A

mRNA, protein:increased expression:left ventricle myocardium (rat)

PMID:15117889 PMID:20651834 PMID:21362018

RGD:1624194 RGD:5130892 RGD:5130975

NCBI chr12:6,457,617...6,470,969
Ensembl chr12:6,374,257...6,387,613

G

TNF receptor superfamily member 1B

mRNA, protein:decreased expression:left ventricle myocardium (rat)

NCBI chr 1:10,915,743...10,957,765
Ensembl chr 1:12,130,663...12,172,646

G

TNF superfamily member 11

protein:increased expression:serum

NCBI chr13:23,750,835...23,784,740

G

TNF superfamily member 4

susceptibility

CTD Direct Evidence: marker/mechanism

NCBI chr 1:148,684,689...148,989,775
Ensembl chr 1:152,391,450...152,415,845
Ensembl chr 1:152,391,450...152,415,845

G

troponin I3, cardiac type

CTD Direct Evidence: marker/mechanism

NCBI chr19:52,193,061...52,198,782
Ensembl chr19:60,887,630...60,894,219

G

troponin T2, cardiac type

NCBI chr 1:176,957,298...176,976,033

G

tumor protein p53

CTD Direct Evidence: marker/mechanism

NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120

G

triggering receptor expressed on myeloid cells 1

disease_progression
ameliorates

NCBI chr 6:40,861,283...40,874,446
Ensembl chr 6:42,163,337...42,183,091

G

transient receptor potential cation channel subfamily V member 1

NCBI chr17:3,612,781...3,658,608
Ensembl chr17:3,609,952...3,637,579

G

titin

NCBI chr2B:65,783,512...66,064,618

G

thioredoxin

NCBI chr 9:81,399,056...81,411,607
Ensembl chr 9:109,565,557...109,578,311

G

thioredoxin reductase 1

mRNA:decreased expression:heart left ventricle (rat)

NCBI chr12:101,862,703...101,925,104
Ensembl chr12:105,187,128...105,321,112

G

ubiquitin D

associated with induced myocardial infarction

NCBI chr 6:29,359,680...29,364,014
Ensembl chr 6:30,018,444...30,022,814

G

urotensin 2

associated with Heart Failure, Congestive;mRNA:increased expression:heart ventricle

NCBI chr 1:6,609,104...6,616,966
Ensembl chr 1:7,854,687...7,864,688

G

urotensin 2 receptor

associated with Heart Failure, Congestive;mRNA:increased expression:heart ventricle

NCBI chr17:76,783,432...76,788,639
Ensembl chr17:82,592,312...82,593,702

G

versican

NCBI chr 5:31,699,278...31,810,169
Ensembl chr 5:32,019,709...32,130,351

G

voltage dependent anion channel 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:129,375,267...129,408,230
Ensembl chr 5:135,529,173...135,560,005

G

voltage dependent anion channel 2

treatment

NCBI chr10:71,739,395...71,763,835

G

vascular endothelial growth factor A

treatment

protein:increased expression:serum,platelet:

PMID:10652191 PMID:25936512

RGD:126925214 RGD:7483604

NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353

G

vascular endothelial growth factor B

NCBI chr11:59,591,750...59,595,926

G

von Willebrand factor

protein:increased expression:heart:

NCBI chr12:6,073,836...6,249,806
Ensembl chr12:5,990,612...6,165,153

G

WD repeat domain 12

CTD Direct Evidence: marker/mechanism

PMID:19198609 PMID:25915632

NCBI chr2B:90,112,037...90,145,520
Ensembl chr2B:208,260,696...208,291,783

G

WRN RecQ like helicase

NCBI chr 8:30,353,643...30,492,978
Ensembl chr 8:27,541,145...27,679,855

G

X-ray repair cross complementing 3

susceptibility

DNA:polymorphism:: (human)

NCBI chr14:84,323,644...84,341,763
Ensembl chr14:104,131,903...104,149,037

G

zinc finger E-box binding homeobox 2

protein:increased expression:heart (rat)

NCBI chr2B:15,325,094...15,460,908
Ensembl chr2B:148,460,904...148,596,500

acute myocardial infarction

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Rho GTPase activating protein 17

ameliorates

Ensembl chr16:25,161,229...25,220,151

G

BCL2 associated X, apoptosis regulator

ameliorates

NCBI chr19:45,955,926...45,962,870
Ensembl chr19:54,793,594...54,800,468

G

complement C3

NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699

G

calcium voltage-gated channel auxiliary subunit gamma 4

mRNA:decreased expression:blood:

NCBI chr17:60,900,645...60,969,659

G

caspase 3

treatment

NCBI chr 4:176,793,190...176,815,023
Ensembl chr 4:189,018,422...189,040,185

G

caspase 7

treatment

NCBI chr10:110,273,318...110,324,800
Ensembl chr10:113,707,780...113,758,626

G

cellular communication network factor 1

ameliorates

NCBI chr 1:118,138,739...118,141,681
Ensembl chr 1:86,994,296...86,997,147

G

DNA damage regulated autophagy modulator 1

ameliorates

mRNA,protein:decreased expression:heart

NCBI chr12:99,464,540...99,509,793
Ensembl chr12:102,862,707...102,907,385

G

desmocollin 2

ameliorates

NCBI chr18:24,296,505...24,332,997
Ensembl chr18:27,894,603...27,930,843

G

Fos proto-oncogene, AP-1 transcription factor subunit

treatment

NCBI chr14:55,832,570...55,835,984
Ensembl chr14:74,676,316...74,679,766

G

FTO alpha-ketoglutarate dependent dioxygenase

mRNA:increased expression:blood

NCBI chr16:33,939,300...34,343,419
Ensembl chr16:53,023,425...53,490,231

G

GATA binding protein 5

susceptibility

DNA:SNPs:promoter:rs80197101, rs77067995 (human)

Ensembl chr20:60,148,359...60,158,886

G

glycoprotein VI platelet

sexual_dimorphism
ameliorates

DNA:missense mutation:intron 1, intron 5: (rs1671207, rs11084382) (human)
DNA:missense mutation:CDS:p.S219P (rs1613662) (human)

NCBI chr19:52,051,138...52,071,673
Ensembl chr19:60,746,578...60,770,643

G

glutathione peroxidase 3

protein:increased expression:plasma

NCBI chr 5:146,447,939...146,456,476

G

glycogen synthase kinase 3 beta

treatment
ameliorates

PMID:26591365 PMID:32068187

RGD:13792778 RGD:267358468

NCBI chr 3:116,943,205...117,215,001
Ensembl chr 3:123,861,379...124,126,771

G

isocitrate dehydrogenase (NADP(+)) 2

ClinVar Annotator: match by term: Acute myocardial infarction

PMID:20946881 PMID:21250968 PMID:21596855 PMID:21997850 PMID:22160010 More...

NCBI chr15:68,771,050...68,790,523
Ensembl chr15:87,972,889...87,991,276

G

interferon gamma

ameliorates

NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829

G

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

ameliorates

NCBI chr X:143,988,720...144,010,078
Ensembl chr X:153,854,493...153,876,092

G

interleukin 10

ameliorates

NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371

G

interleukin 17A

ameliorates

NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074

G

interleukin 1 beta

ameliorates

NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424

G

interleukin 1 receptor like 1

G

interleukin 33

NCBI chr 9:6,027,014...6,069,540
Ensembl chr 9:6,234,178...6,248,624

G

interleukin 4

ameliorates

NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581

G

interleukin 6

ameliorates

NCBI chr 7:23,415,922...23,420,767

G

integrin subunit alpha M

treatment

NCBI chr16:23,634,476...23,707,147
Ensembl chr16:31,630,146...31,702,406

G

kinesin family member 6

DNA:SNP: :p.W719R (rs20455) (human)

NCBI chr 6:38,917,083...39,306,190
Ensembl chr 6:40,234,426...40,616,738

G

microtubule associated protein 1 light chain 3 alpha

treatment

NCBI chr20:30,887,345...30,888,986
Ensembl chr20:32,010,284...32,020,411

G

NADH:ubiquinone oxidoreductase subunit B5

ameliorates

associated with obesity

NCBI chr 3:176,636,937...176,659,813
Ensembl chr 3:184,807,246...184,827,011

G

platelet factor 4

treatment

NCBI chr 4:50,208,806...50,210,570
Ensembl chr 4:56,041,833...56,043,750

G

phospholipase C gamma 1

ameliorates

NCBI chr20:37,477,077...37,515,854
Ensembl chr20:38,572,709...38,615,145

G

pro-platelet basic protein

treatment

NCBI chr 4:50,203,168...50,204,303
Ensembl chr 4:56,035,060...56,037,702

G

phosphatase and tensin homolog

ameliorates

mRNA:decreased expression:heart left ventricle (rat)
RNA:increased expression:serum

PMID:26973267 PMID:29990866 PMID:32595526

RGD:11526378 RGD:155882565 RGD:401851053

NCBI chr10:84,587,841...84,689,043
Ensembl chr10:88,093,539...88,194,605

G

ras homolog family member A

ameliorates

NCBI chr 3:49,282,009...49,339,887

G

Ras like without CAAX 2

ameliorates

NCBI chr18:36,008,302...36,381,259
Ensembl chr18:39,557,814...39,930,393

G

succinate dehydrogenase complex iron sulfur subunit B

ameliorates

associated with obesity

NCBI chr 1:15,962,383...15,998,056
Ensembl chr 1:17,018,542...17,054,509

G

serpin family G member 1

mRNA:increased expression:heart

NCBI chr11:52,838,502...52,855,781
Ensembl chr11:56,309,686...56,326,639

G

sequestosome 1

treatment

NCBI chr 5:174,960,727...174,989,946
Ensembl chr 5:182,284,436...182,299,093

G

T-box transcription factor 1

treatment

NCBI chr22:2,521,080...2,541,267

G

tumor necrosis factor

ameliorates

NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381

G

zinc finger E-box binding homeobox 1

ameliorates

NCBI chr10:31,449,202...31,659,534
Ensembl chr10:32,046,491...32,253,550

anterolateral myocardial infarction

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

endothelin 1

protein:increased expression:aortic root, coronary sinus, plasma (human)

NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545

G

serpin family E member 1

disease_progression

protein:decreased expression, decreased activity:heart:

NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450

Cardiogenic Shock

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

erythropoietin

CTD Direct Evidence: marker/mechanism

NCBI chr 7:92,747,671...92,750,886
Ensembl chr 7:106,148,062...106,150,974

G

plasminogen activator, tissue type

CTD Direct Evidence: therapeutic

NCBI chr 8:41,419,415...41,451,951
Ensembl chr 8:38,864,918...38,897,779

G

superoxide dismutase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:157,562,814...157,610,155
Ensembl chr 6:162,576,082...162,589,960

Coronary Artery Disease, Autosomal Dominant 1

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

myocyte enhancer factor 2A

ClinVar Annotator: match by term: Coronary artery disease, autosomal dominant, 1 | ClinVar Annotator: match by term: Coronary artery disease/myocardial infarction

PMID:14645853 PMID:15496429 PMID:15841183 PMID:25741868

NCBI chr15:78,246,439...78,396,720
Ensembl chr15:97,428,744...97,579,092

Coronary Artery Disease, Autosomal Dominant 2

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

ClinVar Annotator: match by term: Coronary artery disease, autosomal dominant 2

PMID:25741868 PMID:28492532

NCBI chr2A:27,218,699...27,245,156
Ensembl chr2A:27,306,527...27,332,804

G

LDL receptor related protein 6

ClinVar Annotator: match by term: Coronary artery disease, autosomal dominant 2

PMID:17332414 PMID:23703864 PMID:25741868 PMID:28492532

NCBI chr12:12,121,411...12,288,590
Ensembl chr12:12,508,108...12,657,973

myocardial stunning

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

CTD Direct Evidence: marker/mechanism

NCBI chr12:107,857,009...107,924,938
Ensembl chr12:111,246,508...111,311,923

G

nitric oxide synthase 2

CTD Direct Evidence: marker/mechanism

NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093

G

phospholamban

CTD Direct Evidence: marker/mechanism

NCBI chr 6:116,357,335...116,370,382
Ensembl chr 6:120,509,510...120,509,668

G

tumor necrosis factor

CTD Direct Evidence: marker/mechanism

NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381

No-Reflow Phenomenon

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cadherin 5

CTD Direct Evidence: therapeutic

NCBI chr16:46,684,545...46,722,740
Ensembl chr16:65,787,370...65,825,360

G

catenin beta 1

CTD Direct Evidence: therapeutic

NCBI chr 3:41,104,940...41,145,934
Ensembl chr 3:41,373,726...41,414,030

G

junction plakoglobin

CTD Direct Evidence: therapeutic

NCBI chr17:15,527,115...15,559,251
Ensembl chr17:15,747,163...15,777,479

ST Elevation Myocardial Infarction

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

treatment

DNA:SNPs: :rs1045642,rs7779562(human)

NCBI chr 7:79,497,536...79,706,277
Ensembl chr 7:93,147,950...93,243,238

G

ATP synthase membrane subunit c locus 2

severity

NCBI chr12:35,078,290...35,089,480

G

cellular communication network factor 1

sexual_dimorphism

protein:increased expression:blood serum (human)

NCBI chr 1:118,138,739...118,141,681
Ensembl chr 1:86,994,296...86,997,147

G

galectin 3

CTD Direct Evidence: marker/mechanism

NCBI chr14:35,715,850...35,732,263
Ensembl chr14:53,990,023...54,006,412

Term paths to the root

Path 1
Term	Annotations
disease	15805
disease of anatomical entity	0
cardiovascular system disease	4467
heart disease	3180
Myocardial Ischemia	854
myocardial infarction	416
Cardiogenic Shock	3
Coronary Artery Disease, Autosomal Dominant 1	1
Coronary Artery Disease, Autosomal Dominant 2	2
No-Reflow Phenomenon	3
Non-ST Elevated Myocardial Infarction	0
ST Elevation Myocardial Infarction	4
acute myocardial infarction +	41
anterolateral myocardial infarction +	2
apical myocardial infarction	0
inferior myocardial infarction	0
inferolateral myocardial infarct	0
lateral myocardial infarction	0
myocardial stunning	4
posterior myocardial infarction	0
posteroinferior myocardial infarction	0
posterolateral myocardial infarction	0
septal myocardial infarction	0
silent myocardial infarction	0
subendocardial myocardial infarction	0
Path 2
Term	Annotations
disease	15805
disease of anatomical entity	0
cardiovascular system disease	4467
vascular disease	3056
ischemia	1371
Myocardial Ischemia	854
Coronary Disease	594
coronary artery disease	569
myocardial infarction	416
Cardiogenic Shock	3
Coronary Artery Disease, Autosomal Dominant 1	1
Coronary Artery Disease, Autosomal Dominant 2	2
No-Reflow Phenomenon	3
Non-ST Elevated Myocardial Infarction	0
ST Elevation Myocardial Infarction	4
acute myocardial infarction +	41
anterolateral myocardial infarction +	2
apical myocardial infarction	0
inferior myocardial infarction	0
inferolateral myocardial infarct	0
lateral myocardial infarction	0
myocardial stunning	4
posterior myocardial infarction	0
posteroinferior myocardial infarction	0
posterolateral myocardial infarction	0
septal myocardial infarction	0
silent myocardial infarction	0
subendocardial myocardial infarction	0

paths to the root