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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:andrographolide
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Accession:CHEBI:65408 term browser browse the term
Definition:A labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata that exhibits anti-HIV, anti-inflammatory and antineoplastic properties.
Synonyms:exact_synonym: (3E,4S)-4-hydroxy-3-{2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidenedecahydronaphthalen-1-yl]ethylidene}dihydrofuran-2(3H)-one
 related_synonym: (1R-(1-alpha(E(S)),4abeta,5alpha,6alpha,8aalpha))-3-(2-(decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethylidene)dihydro-4-hydroxy-2(3H)-furanone;   3-(2-(decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenenaphthyl)ethylidene)dihydro-4-hydroxyfuran-2(3H)-one;   3alpha,14,15,18-tetrahydroxy-5b,9bH,10a-labda-8(20),12-dien-16-oic acid gamma-Lactone;   Formula=C20H30O5;   InChI=1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15-,16+,17-,19+,20+/m1/s1;   InChIKey=BOJKULTULYSRAS-OTESTREVSA-N;   SMILES=[H][C@]12CCC(=C)[C@@H](C\\C=C3/[C@H](O)COC3=O)[C@]1(C)CC[C@@H](O)[C@@]2(C)CO
 xref: CAS:5508-58-7;   KEGG:C20214
 xref_mesh: MESH:C030419
 xref: PMID:15894448;   PMID:18464090;   PMID:19110075;   PMID:22026410;   PMID:22512591;   PMID:22858223;   Patent:CN102397273;   Patent:EP2411004;   Reaxys:5609598;   Wikipedia:Andrographolide


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andrographolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC4 ATP binding cassette subfamily C member 4 (PEL blood group) multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of ABCC4 mRNA CTD PMID:19737545 NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475 		JBrowse link
G ACTA2 actin alpha 2, smooth muscle multiple interactions
decreases expression		 EXP
ISO		 andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 mRNA]; andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 protein]; andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ACTA2 protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ACTA2 protein]]
andrographolide inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]
andrographolide results in decreased expression of ACTA2 mRNA; andrographolide results in decreased expression of ACTA2 protein
andrographolide inhibits the reaction [Acetaminophen results in increased expression of ACTA2 mRNA]; andrographolide inhibits the reaction [Acetaminophen results in increased expression of ACTA2 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ACTA2 protein]; NFE2L2 gene mutant form inhibits the reaction [andrographolide inhibits the reaction [Acetaminophen results in increased expression of ACTA2 protein]]		 CTD PMID:29355602 PMID:31128153 PMID:31706003 NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,934,822...88,991,339 		JBrowse link
G ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of ADH7 mRNA CTD PMID:19737545 NCBI chr 4:99,412,263...99,435,342
Ensembl chr 4:99,412,261...99,435,510 		JBrowse link
G ANKRD1 ankyrin repeat domain 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of ANKRD1 mRNA CTD PMID:19737545 NCBI chr10:90,912,096...90,921,087
Ensembl chr10:90,912,096...90,921,087 		JBrowse link
G AOX3P aldehyde oxidase 3, pseudogene multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of AOX3 mRNA CTD PMID:19737545 NCBI chr 2:200,695,723...200,738,781
Ensembl chr 2:200,678,233...200,732,539 		JBrowse link
G ATF2 activating transcription factor 2 multiple interactions EXP andrographolide inhibits the reaction [cobaltous chloride results in increased expression of ATF2 protein modified form]; DUSP10 protein promotes the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of ATF2 protein modified form]] CTD PMID:29165873 NCBI chr 2:175,072,259...175,168,203
Ensembl chr 2:175,072,250...175,168,382 		JBrowse link
G B4GALT1 beta-1,4-galactosyltransferase 1 increases expression EXP andrographolide results in increased expression of B4GALT1 mRNA CTD PMID:35724838 NCBI chr 9:33,104,077...33,185,089
Ensembl chr 9:33,104,082...33,167,356 		JBrowse link
G BAD BCL2 associated agonist of cell death increases expression EXP andrographolide results in increased expression of BAD protein CTD PMID:35917943 NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator affects folding
increases expression
multiple interactions		 EXP andrographolide affects the folding of BAX protein
andrographolide results in increased expression of BAX mRNA; andrographolide results in increased expression of BAX protein
[andrographolide co-treated with Cisplatin] results in increased expression of BAX mRNA; andrographolide promotes the reaction [Cisplatin results in increased expression of BAX protein]; Fluorouracil promotes the reaction [andrographolide affects the folding of BAX protein]		 CTD PMID:19097688 PMID:23845849 PMID:24563380 PMID:35917943 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BBC3 BCL2 binding component 3 increases expression EXP andrographolide results in increased expression of BBC3 mRNA CTD PMID:35724838 NCBI chr19:47,220,824...47,232,860
Ensembl chr19:47,220,822...47,232,766 		JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
multiple interactions		 EXP andrographolide results in decreased expression of BCL2 protein
[andrographolide co-treated with Cisplatin] results in decreased expression of BCL2 mRNA		 CTD PMID:23845849 PMID:24563380 PMID:35917943 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BHMT betaine--homocysteine S-methyltransferase multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of BHMT mRNA CTD PMID:19737545 NCBI chr 5:79,111,809...79,132,288
Ensembl chr 5:79,111,809...79,132,288 		JBrowse link
G BID BH3 interacting domain death agonist multiple interactions
increases expression		 ISO
EXP		 andrographolide inhibits the reaction [Copper Sulfate results in decreased expression of and results in increased cleavage of BID protein]; andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in decreased expression of and results in increased cleavage of BID protein]]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in decreased expression of and results in increased cleavage of BID protein]]
[andrographolide co-treated with Cisplatin] results in increased expression of BID mRNA
andrographolide results in increased expression of BID mRNA; andrographolide results in increased expression of BID protein		 CTD PMID:20946909 PMID:24563380 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770 		JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 multiple interactions
increases expression		 EXP [andrographolide co-treated with TNF protein] results in decreased expression of BIRC3 mRNA
andrographolide results in increased expression of BIRC3 mRNA		 CTD PMID:35724838 NCBI chr11:102,317,484...102,339,403
Ensembl chr11:102,317,484...102,339,403 		JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 decreases expression EXP andrographolide results in decreased expression of BIRC5 protein CTD PMID:23845849 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636 		JBrowse link
G BLVRB biliverdin reductase B multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of BLVRB mRNA CTD PMID:19737545 NCBI chr19:40,447,768...40,465,745
Ensembl chr19:40,447,765...40,465,764 		JBrowse link
G CASP3 caspase 3 increases activity
increases cleavage
multiple interactions
increases expression		 EXP
ISO		 andrographolide results in increased activity of CASP3 protein
andrographolide results in increased cleavage of CASP3 protein
andrographolide inhibits the reaction [TGFB1 protein results in decreased cleavage of CASP3 protein]
andrographolide results in increased expression of CASP3 mRNA
[andrographolide co-treated with Cisplatin] results in increased expression of CASP3 mRNA; CASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP3 protein]]; Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP3 protein]
andrographolide inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]; andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]]		 CTD PMID:19097688 PMID:20946909 PMID:24563380 PMID:31706003 PMID:35917943 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP8 caspase 8 increases activity
increases expression
multiple interactions		 EXP
ISO		 andrographolide results in increased activity of CASP8 protein
andrographolide results in increased expression of CASP8 mRNA
[andrographolide co-treated with Cisplatin] results in increased expression of CASP8 mRNA; CASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP3 protein]]; CASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP9 protein]]; CASP8 results in increased susceptibility to [andrographolide co-treated with Fluorouracil]; Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP8 protein]
andrographolide inhibits the reaction [Copper Sulfate results in increased activity of CASP8 protein]		 CTD PMID:19097688 PMID:20946909 PMID:24563380 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CASP9 caspase 9 increases activity
increases expression
multiple interactions		 EXP
ISO		 andrographolide results in increased activity of CASP9 protein
andrographolide results in increased expression of CASP9 mRNA
andrographolide inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]; andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]]
[andrographolide co-treated with Cisplatin] results in increased expression of CASP9 mRNA; CASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP9 protein]]; Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP9 protein]		 CTD PMID:19097688 PMID:20946909 PMID:24563380 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CAT catalase multiple interactions ISO [andrographolide co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; andrographolide inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
andrographolide inhibits the reaction [Freund's Adjuvant results in decreased activity of CAT protein]		 CTD PMID:26485141 PMID:32061742 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CBR1 carbonyl reductase 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CBR1 mRNA CTD PMID:19737545 NCBI chr21:36,070,024...36,073,164
Ensembl chr21:36,069,941...36,073,166 		JBrowse link
G CBR3 carbonyl reductase 3 multiple interactions
increases expression		 ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CBR3 mRNA
andrographolide results in increased expression of CBR3 mRNA		 CTD PMID:19737545 NCBI chr21:36,135,079...36,146,562
Ensembl chr21:36,135,079...36,146,562 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions
increases expression		 ISO
EXP		 [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CCL2 mRNA
andrographolide results in increased expression of CCL2 mRNA		 CTD PMID:19737545 PMID:35724838 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCL20 C-C motif chemokine ligand 20 increases expression EXP andrographolide results in increased expression of CCL20 mRNA CTD PMID:35724838 NCBI chr 2:227,813,842...227,817,556
Ensembl chr 2:227,805,739...227,817,564 		JBrowse link
G CCN2 cellular communication network factor 2 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CCN2 mRNA CTD PMID:19737545 NCBI chr 6:131,948,176...131,951,372
Ensembl chr 6:131,948,176...131,951,372 		JBrowse link
G CCNA2 cyclin A2 multiple interactions
decreases expression		 EXP andrographolide inhibits the reaction [CCNA2 protein binds to CDK2 protein]
andrographolide results in decreased expression of CCNA2 protein		 CTD PMID:18619950 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883 		JBrowse link
G CCND1 cyclin D1 multiple interactions
decreases expression		 EXP andrographolide inhibits the reaction [CCND1 protein binds to CDK4 protein]
andrographolide results in decreased expression of CCND1 protein		 CTD PMID:18619950 PMID:23845849 PMID:35917943 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CCNE1 cyclin E1 decreases expression
multiple interactions		 EXP
ISO		 andrographolide results in decreased expression of CCNE1 protein
andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCNE1 protein]		 CTD PMID:23845849 PMID:27475717 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312 		JBrowse link
G CDH1 cadherin 1 multiple interactions
increases expression		 EXP
ISO		 andrographolide inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]]
andrographolide results in increased expression of CDH1 protein		 CTD PMID:31128153 PMID:35917943 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537 		JBrowse link
G CDH17 cadherin 17 decreases expression
multiple interactions		 ISO andrographolide results in decreased expression of CDH17 mRNA
[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CDH17 mRNA		 CTD PMID:19737545 NCBI chr 8:94,127,162...94,217,278
Ensembl chr 8:94,127,162...94,217,303 		JBrowse link
G CDH2 cadherin 2 multiple interactions
decreases expression		 EXP
ISO		 andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein]]
andrographolide results in decreased expression of CDH2 protein		 CTD PMID:31128153 PMID:35917943 NCBI chr18:27,932,879...28,177,130
Ensembl chr18:27,932,879...28,177,946 		JBrowse link
G CDK2 cyclin dependent kinase 2 decreases expression
multiple interactions		 EXP
ISO		 andrographolide results in decreased expression of CDK2 protein
andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CDK2 protein]
andrographolide inhibits the reaction [CCNA2 protein binds to CDK2 protein]		 CTD PMID:18619950 PMID:27475717 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789 		JBrowse link
G CDK4 cyclin dependent kinase 4 multiple interactions
decreases expression		 EXP andrographolide inhibits the reaction [CCND1 protein binds to CDK4 protein]
andrographolide results in decreased expression of CDK4 protein		 CTD PMID:18619950 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP andrographolide results in increased expression of CDKN1A protein CTD PMID:18619950 PMID:23845849 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337 		JBrowse link
G CEBPA CCAAT enhancer binding protein alpha multiple interactions ISO andrographolide affects the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] affects the expression of CEBPA mRNA]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CEBPA protein] CTD PMID:27475717 NCBI chr19:33,299,934...33,302,534
Ensembl chr19:33,299,934...33,302,534 		JBrowse link
G CEBPB CCAAT enhancer binding protein beta multiple interactions ISO andrographolide affects the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] affects the expression of CEBPB mRNA]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of and results in increased phosphorylation of CEBPB protein] CTD PMID:27475717 NCBI chr20:50,190,583...50,192,690
Ensembl chr20:50,190,830...50,192,668 		JBrowse link
G CES3 carboxylesterase 3 multiple interactions
increases expression		 ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CES3 mRNA
andrographolide results in increased expression of CES3 mRNA		 CTD PMID:19737545 NCBI chr16:66,961,266...66,975,149
Ensembl chr16:66,961,245...66,975,149 		JBrowse link
G CISH cytokine inducible SH2 containing protein multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CISH mRNA CTD PMID:19737545 NCBI chr 3:50,606,489...50,611,774
Ensembl chr 3:50,606,489...50,611,774 		JBrowse link
G CNN2 calponin 2 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CNN2 mRNA CTD PMID:19737545 NCBI chr19:1,026,608...1,039,065
Ensembl chr19:1,026,586...1,039,068 		JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions
decreases expression		 EXP
ISO		 andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of COL1A1 mRNA]
andrographolide results in decreased expression of COL1A1 mRNA
andrographolide inhibits the reaction [Acetaminophen results in increased expression of COL1A1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]		 CTD PMID:29355602 PMID:31706003 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632 		JBrowse link
G COL1A2 collagen type I alpha 2 chain decreases expression
multiple interactions		 EXP
ISO		 andrographolide results in decreased expression of COL1A2 mRNA
andrographolide inhibits the reaction [Acetaminophen results in increased expression of COL1A2 mRNA]		 CTD PMID:29355602 NCBI chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227 		JBrowse link
G COL3A1 collagen type III alpha 1 chain decreases expression
multiple interactions		 ISO
EXP		 andrographolide results in decreased expression of COL3A1 mRNA
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of COL3A1 mRNA]
andrographolide inhibits the reaction [Acetaminophen results in increased expression of COL3A1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 protein]		 CTD PMID:29355602 PMID:31706003 NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746 		JBrowse link
G CRCT1 cysteine rich C-terminal 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CRCT1 mRNA CTD PMID:19737545 NCBI chr 1:152,514,482...152,516,008
Ensembl chr 1:152,514,482...152,516,008 		JBrowse link
G CTNNB1 catenin beta 1 decreases expression
multiple interactions		 EXP andrographolide results in decreased expression of CTNNB1 protein
KYA1797K promotes the reaction [andrographolide results in decreased expression of CTNNB1 protein]		 CTD PMID:35917943 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096 		JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 multiple interactions
increases expression		 EXP [andrographolide co-treated with TNF protein] results in decreased expression of CXCL1 mRNA
andrographolide results in increased expression of CXCL1 mRNA		 CTD PMID:35724838 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308 		JBrowse link
G CXCL13 C-X-C motif chemokine ligand 13 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CXCL13 mRNA CTD PMID:19737545 NCBI chr 4:77,511,753...77,611,834
Ensembl chr 4:77,511,753...77,611,834 		JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 multiple interactions
increases expression		 ISO
EXP		 andrographolide inhibits the reaction [Freund's Adjuvant results in increased expression of CXCL2 protein]
andrographolide results in increased expression of CXCL2 mRNA		 CTD PMID:32061742 PMID:35724838 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions ISO andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CXCL8 mRNA]; andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of CXCL8 protein] CTD PMID:31128153 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CYP17A1 mRNA CTD PMID:19737545 NCBI chr10:102,830,531...102,837,413
Ensembl chr10:102,830,531...102,837,472 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
increases expression
increases activity		 ISO [andrographolide co-treated with benz(a)anthracene] results in increased expression of CYP1A1 mRNA; [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CYP1A1 mRNA; [andrographolide co-treated with Tetrachlorodibenzodioxin] results in increased expression of CYP1A1 mRNA; Acetylcysteine affects the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; andrographolide promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Ascorbic Acid affects the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; beta-Naphthoflavone promotes the reaction [andrographolide results in increased expression of CYP1A1 mRNA]; Buthionine Sulfoximine promotes the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; Glutathione affects the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; Hydrogen Peroxide promotes the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; resveratrol inhibits the reaction [[andrographolide co-treated with benz(a)anthracene] results in increased expression of CYP1A1 mRNA]
andrographolide results in increased activity of CYP1A1 protein		 CTD PMID:17825862 PMID:19737545 PMID:21094198 PMID:21963808 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases expression
multiple interactions
increases expression		 EXP
ISO		 andrographolide results in decreased expression of CYP1A2 mRNA
andrographolide affects the reaction [CYP1A2 protein results in increased metabolism of Theophylline]
andrographolide results in increased expression of CYP1A2 mRNA
[andrographolide co-treated with benz(a)anthracene] results in increased expression of CYP1A2 mRNA; [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CYP1A2 mRNA		 CTD PMID:17825862 PMID:19041297 PMID:19737545 PMID:20096675 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 multiple interactions ISO [andrographolide co-treated with benz(a)anthracene] results in increased expression of CYP1B1 mRNA; andrographolide promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1B1 mRNA] CTD PMID:17825862 PMID:19737545 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G CYP2A7 cytochrome P450 family 2 subfamily A member 7 increases expression
multiple interactions		 ISO andrographolide results in increased expression of CYP2A4 mRNA
beta-Naphthoflavone promotes the reaction [andrographolide results in increased expression of CYP2A4 mRNA]		 CTD PMID:19737545 NCBI chr19:40,875,439...40,882,231
Ensembl chr19:40,875,439...40,882,752 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 increases activity
increases expression
multiple interactions		 ISO andrographolide results in increased activity of CYP2B10 protein
andrographolide results in increased expression of CYP2B10 mRNA
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CYP2B10 mRNA		 CTD PMID:19737545 PMID:21094198 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398 		JBrowse link
G CYP2C18 cytochrome P450 family 2 subfamily C member 18 decreases expression ISO andrographolide results in decreased expression of CYP2C11 mRNA; andrographolide results in decreased expression of CYP2C11 protein CTD PMID:19041297 NCBI chr10:94,683,729...94,736,190
Ensembl chr10:94,683,729...94,736,190 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 decreases expression EXP andrographolide results in decreased expression of CYP2C9 mRNA CTD PMID:19041297 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 decreases expression EXP andrographolide results in decreased expression of CYP3A4 mRNA CTD PMID:19041297 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G CYP8B1 cytochrome P450 family 8 subfamily B member 1 increases expression ISO andrographolide results in increased expression of CYP8B1 mRNA CTD PMID:19737545 NCBI chr 3:42,872,192...42,875,879
Ensembl chr 3:42,856,005...42,875,898 		JBrowse link
G DDC dopa decarboxylase multiple interactions
increases expression		 ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of DDC mRNA
andrographolide results in increased expression of DDC mRNA		 CTD PMID:19737545 NCBI chr 7:50,458,442...50,565,405
Ensembl chr 7:50,458,436...50,565,405 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression EXP andrographolide results in increased expression of DDIT3 protein CTD PMID:35724838 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737 		JBrowse link
G DUSP10 dual specificity phosphatase 10 increases expression
multiple interactions		 EXP andrographolide results in increased expression of DUSP10 mRNA; andrographolide results in increased expression of DUSP10 protein
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [andrographolide results in increased expression of DUSP10 mRNA]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [andrographolide results in increased expression of DUSP10 protein]; DUSP10 protein promotes the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of ATF2 protein modified form]]; DUSP10 protein promotes the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; HMOX1 protein promotes the reaction [andrographolide results in increased expression of DUSP10 protein]; zinc protoporphyrin inhibits the reaction [andrographolide results in increased expression of DUSP10 mRNA]; zinc protoporphyrin inhibits the reaction [andrographolide results in increased expression of DUSP10 protein]		 CTD PMID:29165873 NCBI chr 1:221,701,424...221,742,089
Ensembl chr 1:221,701,424...221,742,089 		JBrowse link
G EDN1 endothelin 1 multiple interactions
increases expression		 EXP andrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]; andrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 protein]; Vanadates inhibits the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]]; Vanadates inhibits the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 protein]]
andrographolide results in increased expression of EDN1 mRNA		 CTD PMID:27297870 PMID:29165873 PMID:35724838 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194 		JBrowse link
G EGLN1 egl-9 family hypoxia inducible factor 1 multiple interactions
increases expression		 EXP EGLN1 mutant form inhibits the reaction [andrographolide results in decreased expression of HIF1A protein]; EGLN1 mutant form inhibits the reaction [andrographolide results in decreased expression of VEGFA protein]; TGFB1 protein inhibits the reaction [andrographolide results in increased expression of EGLN1 mRNA]; TGFB1 protein inhibits the reaction [andrographolide results in increased expression of EGLN1 protein]
andrographolide results in increased expression of EGLN1 mRNA; andrographolide results in increased expression of EGLN1 protein		 CTD PMID:21134392 PMID:27297870 NCBI chr 1:231,363,756...231,422,287
Ensembl chr 1:231,363,751...231,422,287 		JBrowse link
G EGLN3 egl-9 family hypoxia inducible factor 3 increases expression EXP andrographolide results in increased expression of EGLN3 protein CTD PMID:27297870 NCBI chr14:33,924,227...33,951,074
Ensembl chr14:33,924,227...34,462,774 		JBrowse link
G EID3 EP300 interacting inhibitor of differentiation 3 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of EID3 mRNA CTD PMID:19737545 NCBI chr12:104,303,739...104,305,205
Ensembl chr12:104,303,739...104,305,205 		JBrowse link
G ELANE elastase, neutrophil expressed multiple interactions ISO andrographolide inhibits the reaction [Freund's Adjuvant results in increased expression of ELANE protein] CTD PMID:32061742 NCBI chr19:852,303...856,243
Ensembl chr19:851,014...856,247 		JBrowse link
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit multiple interactions ISO
EXP		 andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EZH2 protein]
andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EZH2 protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EZH2 protein]]		 CTD PMID:31128153 NCBI chr 7:148,807,383...148,884,291
Ensembl chr 7:148,807,257...148,884,321 		JBrowse link
G FAS Fas cell surface death receptor multiple interactions
increases expression		 EXP [andrographolide co-treated with Cisplatin] promotes the reaction [FAS protein binds to FASLG protein]; [andrographolide co-treated with Cisplatin] results in increased expression of FAS mRNA; [andrographolide co-treated with Cisplatin] results in increased expression of FAS protein; andrographolide promotes the reaction [FAS protein binds to FASLG protein]
andrographolide results in increased expression of FAS mRNA; andrographolide results in increased expression of FAS protein		 CTD PMID:24563380 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605 		JBrowse link
G FASLG Fas ligand multiple interactions
increases expression		 EXP [andrographolide co-treated with Cisplatin] promotes the reaction [FAS protein binds to FASLG protein]; [andrographolide co-treated with Cisplatin] results in increased expression of FASLG mRNA; [andrographolide co-treated with Cisplatin] results in increased expression of FASLG protein; andrographolide promotes the reaction [FAS protein binds to FASLG protein]
andrographolide results in increased expression of FASLG mRNA; andrographolide results in increased expression of FASLG protein		 CTD PMID:24563380 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876 		JBrowse link
G FASN fatty acid synthase multiple interactions ISO andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FASN mRNA]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FASN protein] CTD PMID:27475717 NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294 		JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 decreases expression EXP andrographolide results in decreased expression of FLT1 mRNA CTD PMID:28651835 NCBI chr13:28,300,346...28,495,128
Ensembl chr13:28,300,346...28,495,145 		JBrowse link
G FN1 fibronectin 1 multiple interactions ISO andrographolide inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein] CTD PMID:31706003 NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP andrographolide results in decreased localization of and results in decreased activity of FOS protein CTD PMID:19426720 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression
decreases expression
multiple interactions		 ISO
EXP		 andrographolide results in increased expression of GCLC mRNA; andrographolide results in increased expression of GCLC protein
andrographolide results in decreased expression of GCLC mRNA
[andrographolide co-treated with TNF protein] results in increased expression of GCLC mRNA
andrographolide inhibits the reaction [Acetaminophen results in decreased expression of GCLC mRNA]		 CTD PMID:25110055 PMID:29355602 PMID:35724838 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970 		JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit multiple interactions
decreases expression
increases expression		 ISO
EXP		 [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of GCLM mRNA; andrographolide inhibits the reaction [Acetaminophen results in decreased expression of GCLM mRNA]
andrographolide results in decreased expression of GCLM mRNA
[andrographolide co-treated with TNF protein] results in increased expression of GCLM mRNA
andrographolide results in increased expression of GCLM protein
andrographolide results in increased expression of GCLM mRNA; andrographolide results in increased expression of GCLM protein		 CTD PMID:19737545 PMID:25110055 PMID:29355602 PMID:35724838 NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456 		JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO [polylactic acid-polyglycolic acid copolymer co-treated with andrographolide] inhibits the reaction [sodium arsenite results in increased activity of GPT protein] CTD PMID:26485141 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions
decreases phosphorylation		 ISO
EXP		 andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of GSK3B protein]
andrographolide results in decreased phosphorylation of GSK3B protein		 CTD PMID:27475717 PMID:35917943 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994 		JBrowse link
G GSR glutathione-disulfide reductase increases activity ISO andrographolide results in increased activity of GSR protein CTD PMID:25110055 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846 		JBrowse link
G GSTM2 glutathione S-transferase mu 2 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of GSTM2 mRNA CTD PMID:19737545 NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,668,022...109,709,551 		JBrowse link
G GSTM3 glutathione S-transferase mu 3 increases expression
multiple interactions		 ISO andrographolide results in increased expression of GSTM3 mRNA
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of GSTM3 mRNA		 CTD PMID:19737545 NCBI chr 1:109,733,937...109,741,038
Ensembl chr 1:109,733,932...109,741,038 		JBrowse link
G GSTM4 glutathione S-transferase mu 4 increases expression
multiple interactions		 ISO andrographolide results in increased expression of GSTM4 mRNA
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of GSTM4 mRNA		 CTD PMID:19737545 NCBI chr 1:109,656,099...109,667,727
Ensembl chr 1:109,656,099...109,665,496 		JBrowse link
G HDAC1 histone deacetylase 1 decreases expression EXP andrographolide results in decreased expression of HDAC1 protein CTD PMID:28651835 NCBI chr 1:32,292,083...32,333,626
Ensembl chr 1:32,292,083...32,333,635 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression
increases expression		 EXP [andrographolide co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of HIF1A protein; [andrographolide co-treated with cobaltous chloride] results in increased hydroxylation of HIF1A protein; andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]; andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; andrographolide inhibits the reaction [HIF1A protein binds to VEGFA promoter]; andrographolide results in decreased expression of and affects the localization of HIF1A protein; andrographolide results in decreased expression of and results in increased degradation of HIF1A protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [andrographolide results in decreased expression of HIF1A protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [andrographolide results in increased degradation of HIF1A protein]; DUSP10 protein promotes the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; EGLN1 mutant form inhibits the reaction [andrographolide results in decreased expression of HIF1A protein]; HMOX1 protein affects the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; NFE2L2 protein affects the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; pyrazolanthrone inhibits the reaction [andrographolide results in decreased expression of HIF1A protein]; Vanadates inhibits the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; Vanadates inhibits the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]]
andrographolide results in increased expression of HIF1A protein modified form		 CTD PMID:21134392 PMID:27297870 PMID:28651835 PMID:29165873 NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259 		JBrowse link
G HMOX1 heme oxygenase 1 increases expression
decreases expression
multiple interactions		 ISO
EXP		 andrographolide results in increased expression of HMOX1 mRNA; andrographolide results in increased expression of HMOX1 protein
andrographolide results in decreased expression of HMOX1 mRNA
andrographolide inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 mRNA]
[andrographolide co-treated with TNF protein] results in increased expression of HMOX1 mRNA; HMOX1 protein affects the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; HMOX1 protein promotes the reaction [andrographolide results in increased expression of DUSP10 protein]		 CTD PMID:25110055 PMID:27297870 PMID:29165873 PMID:29355602 PMID:35724838 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HOTAIR HOX transcript antisense RNA multiple interactions ISO
EXP		 andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of HOTAIR mRNA]
andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of HOTAIR mRNA]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of HOTAIR mRNA]]		 CTD PMID:31128153 NCBI chr12:53,962,312...53,974,954
Ensembl chr12:53,962,308...53,974,956 		JBrowse link
G HP haptoglobin multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of HP mRNA CTD PMID:19737545 NCBI chr16:72,054,505...72,061,055
Ensembl chr16:72,054,505...72,061,055 		JBrowse link
G HPGD 15-hydroxyprostaglandin dehydrogenase multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of HPGD mRNA CTD PMID:19737545 NCBI chr 4:174,490,175...174,522,893
Ensembl chr 4:174,490,175...174,523,154 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions EXP [andrographolide co-treated with TNF protein] results in decreased expression of ICAM1 mRNA; andrographolide inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; andrographolide inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:35724838 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G IKBKE inhibitor of nuclear factor kappa B kinase subunit epsilon multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of IKBKE mRNA CTD PMID:19737545 NCBI chr 1:206,470,476...206,496,889
Ensembl chr 1:206,470,476...206,496,889 		JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP andrographolide inhibits the reaction [IL1B protein affects the localization of NFKBIA protein]; andrographolide inhibits the reaction [IL1B protein affects the localization of RELA protein]; andrographolide inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; andrographolide inhibits the reaction [IL1B protein results in increased expression of TNFAIP3 protein] CTD PMID:35724838 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 multiple interactions EXP
ISO		 andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL6 protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ACTA2 protein]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EZH2 protein]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of HOTAIR mRNA]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM protein]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of STAT3 protein]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL6 protein]]
andrographolide inhibits the reaction [Freund's Adjuvant results in increased expression of IL6 protein]
andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of IL6 mRNA]; andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL6 protein]		 CTD PMID:31128153 PMID:32061742 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G INS-IGF2 INS-IGF2 readthrough multiple interactions ISO andrographolide affects the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] affects the expression of CEBPA mRNA]; andrographolide affects the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] affects the expression of CEBPB mRNA]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of and results in increased phosphorylation of CEBPB protein]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCNE1 protein]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CDK2 protein]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CEBPA protein]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FASN mRNA]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FASN protein]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of SCD1 mRNA]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of SCD1 protein]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of GSK3B protein]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK1 protein]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein] CTD PMID:27475717 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP andrographolide results in decreased localization of and results in decreased activity of JUN protein CTD PMID:19426720 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048 		JBrowse link
G KDR kinase insert domain receptor multiple interactions
decreases expression		 EXP [andrographolide co-treated with KDR protein] inhibits the reaction [VEGFA protein binds to KDR protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]
andrographolide results in decreased expression of KDR mRNA		 CTD PMID:24814888 PMID:28651835 NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595 		JBrowse link
G KEAP1 kelch like ECH associated protein 1 decreases expression EXP andrographolide results in decreased expression of KEAP1 mRNA; andrographolide results in decreased expression of KEAP1 protein CTD PMID:29355602 PMID:35724838 NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558 		JBrowse link
G KRT5 keratin 5 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of KRT5 mRNA CTD PMID:19737545 NCBI chr12:52,514,575...52,520,394
Ensembl chr12:52,514,575...52,520,530 		JBrowse link
G MAFG MAF bZIP transcription factor G decreases expression EXP andrographolide results in decreased expression of MAFG mRNA CTD PMID:35724838 NCBI chr17:81,918,270...81,931,244
Ensembl chr17:81,918,270...81,927,735 		JBrowse link
G MAP2K4 mitogen-activated protein kinase kinase 4 multiple interactions EXP andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K4 protein] CTD PMID:24814888 NCBI chr17:12,020,877...12,143,828
Ensembl chr17:12,020,829...12,143,830 		JBrowse link
G MAP2K6 mitogen-activated protein kinase kinase 6 multiple interactions EXP andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K6 protein] CTD PMID:24814888 NCBI chr17:69,414,697...69,553,865
Ensembl chr17:69,414,697...69,553,865 		JBrowse link
G MAP2K7 mitogen-activated protein kinase kinase 7 multiple interactions EXP andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K7 protein] CTD PMID:24814888 NCBI chr19:7,903,877...7,914,478
Ensembl chr19:7,903,843...7,914,478 		JBrowse link
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 multiple interactions EXP andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP3K5 protein] CTD PMID:24814888 NCBI chr 6:136,557,046...136,793,091
Ensembl chr 6:136,557,046...136,793,097 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP
ISO		 andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]
andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK1 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]		 CTD PMID:24814888 PMID:27475717 PMID:31706003 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP
ISO		 andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]
andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]		 CTD PMID:24814888 PMID:27475717 PMID:31706003 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions
decreases expression		 ISO
EXP		 andrographolide inhibits the reaction [TGFB1 protein results in increased expression of MMP2 mRNA]
andrographolide results in decreased expression of MMP2 protein		 CTD PMID:31706003 PMID:35917943 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MMP7 matrix metallopeptidase 7 decreases expression
multiple interactions		 EXP andrographolide results in decreased expression of MMP7 mRNA; andrographolide results in decreased expression of MMP7 protein
andrographolide results in decreased expression of and results in decreased activity of MMP7 protein		 CTD PMID:19426720 PMID:35917943 NCBI chr11:102,520,508...102,530,747
Ensembl chr11:102,520,508...102,530,750 		JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions
decreases expression		 ISO
EXP		 andrographolide inhibits the reaction [TGFB1 protein results in increased expression of MMP9 mRNA]
andrographolide results in decreased expression of MMP9 protein		 CTD PMID:31706003 PMID:35917943 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MPO myeloperoxidase multiple interactions ISO andrographolide inhibits the reaction [Freund's Adjuvant results in increased expression of MPO protein] CTD PMID:32061742 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935 		JBrowse link
G MTA1 metastasis associated 1 decreases expression EXP andrographolide results in decreased expression of MTA1 mRNA; andrographolide results in decreased expression of MTA1 protein CTD PMID:28651835 NCBI chr14:105,419,827...105,470,729
Ensembl chr14:105,419,820...105,470,729 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor decreases expression EXP andrographolide results in decreased expression of MYC protein CTD PMID:35917943 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951 		JBrowse link
G MYO18B myosin XVIIIB decreases expression ISO andrographolide results in decreased expression of MYO18B mRNA CTD PMID:19737545 NCBI chr22:25,742,188...26,063,847
Ensembl chr22:25,742,144...26,031,045 		JBrowse link
G NECAB1 N-terminal EF-hand calcium binding protein 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of NECAB1 mRNA CTD PMID:19737545 NCBI chr 8:90,791,775...90,959,393
Ensembl chr 8:90,791,741...90,959,393 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 increases activity
multiple interactions
decreases response to substance		 ISO
EXP		 andrographolide results in increased activity of NFE2L2 protein
NFE2L2 gene mutant form inhibits the reaction [andrographolide inhibits the reaction [Acetaminophen results in increased expression of ACTA2 protein]]
NFE2L2 gene mutant form results in decreased susceptibility to andrographolide
andrographolide results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]		 CTD PMID:25110055 PMID:27297870 PMID:29355602 PMID:35724838 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP andrographolide inhibits the reaction [IL1B protein affects the localization of NFKBIA protein]; andrographolide inhibits the reaction [TNF protein affects the localization of NFKBIA protein] CTD PMID:35724838 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NFKBIE NFKB inhibitor epsilon increases expression EXP andrographolide results in increased expression of NFKBIE mRNA CTD PMID:35724838 NCBI chr 6:44,258,166...44,265,551
Ensembl chr 6:44,258,166...44,265,788 		JBrowse link
G NGB neuroglobin multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of NGB mRNA CTD PMID:19737545 NCBI chr14:77,265,483...77,271,206
Ensembl chr14:77,265,483...77,271,206 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression
decreases expression
multiple interactions		 ISO
EXP		 andrographolide results in increased expression of NQO1 mRNA
andrographolide results in decreased expression of NQO1 mRNA
andrographolide results in increased expression of NQO1 protein
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of NQO1 mRNA; andrographolide promotes the reaction [Acetaminophen results in increased expression of NQO1 mRNA]		 CTD PMID:19737545 PMID:29355602 PMID:35724838 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G OLR1 oxidized low density lipoprotein receptor 1 increases expression EXP andrographolide results in increased expression of OLR1 mRNA CTD PMID:35724838 NCBI chr12:10,158,301...10,176,266
Ensembl chr12:10,158,301...10,172,138 		JBrowse link
G OR2AP1 olfactory receptor family 2 subfamily AP member 1 decreases expression ISO andrographolide results in decreased expression of OR6C8 mRNA CTD PMID:19737545 NCBI chr12:55,572,468...55,575,612
Ensembl chr12:55,572,468...55,575,612 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage EXP andrographolide results in increased cleavage of PARP1 protein CTD PMID:35917943 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PCNA proliferating cell nuclear antigen multiple interactions
decreases expression		 ISO
EXP		 andrographolide inhibits the reaction [TGFB1 protein results in increased expression of PCNA protein]
andrographolide results in decreased expression of PCNA protein		 CTD PMID:31706003 PMID:35917943 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626 		JBrowse link
G PDGFB platelet derived growth factor subunit B increases expression EXP andrographolide results in increased expression of PDGFB mRNA CTD PMID:35724838 NCBI chr22:39,223,359...39,244,982
Ensembl chr22:39,223,359...39,244,982 		JBrowse link
G PDZRN3 PDZ domain containing ring finger 3 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of PDZRN3 mRNA CTD PMID:19737545 NCBI chr 3:73,382,431...73,624,941
Ensembl chr 3:73,382,431...73,624,941 		JBrowse link
G PECAM1 platelet and endothelial cell adhesion molecule 1 decreases expression EXP andrographolide results in decreased expression of PECAM1 protein CTD PMID:28651835 NCBI chr17:64,319,415...64,390,860
Ensembl chr17:64,319,415...64,413,776 		JBrowse link
G PHOSPHO1 phosphoethanolamine/phosphocholine phosphatase 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of PHOSPHO1 mRNA CTD PMID:19737545 NCBI chr17:49,223,366...49,230,787
Ensembl chr17:49,223,366...49,230,787 		JBrowse link
G PLAU plasminogen activator, urokinase increases expression EXP andrographolide results in increased expression of PLAU mRNA CTD PMID:35724838 NCBI chr10:73,909,164...73,917,494
Ensembl chr10:73,909,177...73,917,496 		JBrowse link
G PLSCR1 phospholipid scramblase 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of PLSCR1 mRNA CTD PMID:19737545 NCBI chr 3:146,515,180...146,544,607
Ensembl chr 3:146,515,180...146,544,856 		JBrowse link
G POR cytochrome p450 oxidoreductase multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of POR mRNA CTD PMID:19737545 NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein] CTD PMID:27475717 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PRKAG2 protein kinase AMP-activated non-catalytic subunit gamma 2 increases expression EXP andrographolide results in increased expression of PRKAG2 mRNA CTD PMID:35724838 NCBI chr 7:151,556,127...151,877,115
Ensembl chr 7:151,556,124...151,877,214 		JBrowse link
G PTGR1 prostaglandin reductase 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of PTGR1 mRNA CTD PMID:19737545 NCBI chr 9:111,549,722...111,599,647
Ensembl chr 9:111,549,722...111,599,893 		JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions EXP andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of RAF1 protein] CTD PMID:24814888 NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,582,101...12,664,201 		JBrowse link
G RB1 RB transcriptional corepressor 1 decreases phosphorylation EXP andrographolide results in decreased phosphorylation of RB1 protein CTD PMID:18619950 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP andrographolide inhibits the reaction [IL1B protein affects the localization of RELA protein]; andrographolide inhibits the reaction [TNF protein affects the localization of RELA protein]; andrographolide results in decreased expression of and results in decreased localization of RELA protein; pyrrolidine dithiocarbamic acid promotes the reaction [andrographolide results in decreased expression of and results in decreased localization of RELA protein] CTD PMID:35724838 PMID:35917943 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G S100A4 S100 calcium binding protein A4 multiple interactions ISO andrographolide inhibits the reaction [Bleomycin results in increased expression of S100A4 protein] CTD PMID:31706003 NCBI chr 1:153,543,621...153,545,806
Ensembl chr 1:153,543,613...153,550,136 		JBrowse link
G SERPINA7 serpin family A member 7 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of SERPINA7 mRNA CTD PMID:19737545 NCBI chr  X:106,032,435...106,038,727
Ensembl chr  X:106,032,435...106,038,727 		JBrowse link
G SLC1A4 solute carrier family 1 member 4 multiple interactions
increases expression		 ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of SLC1A4 mRNA
andrographolide results in increased expression of SLC1A4 mRNA		 CTD PMID:19737545 NCBI chr 2:64,988,479...65,023,865
Ensembl chr 2:64,988,477...65,023,865 		JBrowse link
G SLC3A2 solute carrier family 3 member 2 decreases expression EXP andrographolide results in decreased expression of SLC3A2 mRNA CTD PMID:35724838 NCBI chr11:62,856,109...62,888,860
Ensembl chr11:62,856,004...62,888,880 		JBrowse link
G SLC7A11 solute carrier family 7 member 11 increases expression ISO andrographolide results in increased expression of SLC7A11 mRNA CTD PMID:19737545 NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349 		JBrowse link
G SMAD2 SMAD family member 2 multiple interactions ISO andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:31706003 NCBI chr18:47,808,957...47,930,872
Ensembl chr18:47,808,957...47,931,146 		JBrowse link
G SMAD3 SMAD family member 3 multiple interactions ISO andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:31706003 NCBI chr15:67,065,602...67,195,169
Ensembl chr15:67,063,763...67,195,173 		JBrowse link
G SNAI1 snail family transcriptional repressor 1 decreases expression EXP andrographolide results in decreased expression of SNAI1 protein CTD PMID:35917943 NCBI chr20:49,982,980...49,988,886
Ensembl chr20:49,982,980...49,988,886 		JBrowse link
G SOD1 superoxide dismutase 1 increases expression ISO andrographolide results in increased expression of SOD1 mRNA; andrographolide results in increased expression of SOD1 protein CTD PMID:25110055 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G SPP1 secreted phosphoprotein 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of SPP1 mRNA CTD PMID:19737545 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532 		JBrowse link
G SQSTM1 sequestosome 1 increases expression
decreases expression		 EXP andrographolide results in increased expression of SQSTM1 protein
andrographolide results in decreased expression of SQSTM1 mRNA		 CTD PMID:29355602 PMID:35724838 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078 		JBrowse link
G SRXN1 sulfiredoxin 1 multiple interactions
decreases expression
increases expression		 ISO
EXP		 [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of SRXN1 mRNA
[andrographolide co-treated with TNF protein] results in increased expression of SRXN1 mRNA
andrographolide results in decreased expression of SRXN1 mRNA
andrographolide results in increased expression of SRXN1 protein
andrographolide results in increased expression of SRXN1 mRNA		 CTD PMID:19737545 PMID:35724838 NCBI chr20:646,615...653,200
Ensembl chr20:646,615...653,200 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 decreases activity
multiple interactions		 EXP
ISO		 andrographolide results in decreased activity of STAT3 protein
andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of STAT3 protein]
andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of STAT3 protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of STAT3 protein]]		 CTD PMID:23845849 PMID:31128153 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568 		JBrowse link
G STEAP4 STEAP4 metalloreductase multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of STEAP4 mRNA CTD PMID:19737545 NCBI chr 7:88,270,892...88,306,894
Ensembl chr 7:88,270,892...88,306,894 		JBrowse link
G TAP1 transporter 1, ATP binding cassette subfamily B member increases expression EXP andrographolide results in increased expression of TAP1 mRNA CTD PMID:35724838 NCBI chr 6:32,845,209...32,853,704
Ensembl chr 6:32,845,209...32,853,816 		JBrowse link
G TAS2R50 taste 2 receptor member 50 multiple interactions EXP andrographolide binds to and results in increased activity of TAS2R50 protein CTD PMID:19817411 NCBI chr12:10,985,913...10,986,912
Ensembl chr12:10,985,913...10,986,912 		JBrowse link
G TDO2 tryptophan 2,3-dioxygenase multiple interactions
increases expression		 ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of TDO2 mRNA
andrographolide results in increased expression of TDO2 mRNA		 CTD PMID:19737545 NCBI chr 4:155,903,696...155,920,406
Ensembl chr 4:155,854,738...155,920,406 		JBrowse link
G TGFB1 transforming growth factor beta 1 decreases expression
multiple interactions		 EXP
ISO		 andrographolide results in decreased expression of TGFB1 protein
andrographolide inhibits the reaction [TGFB1 protein results in decreased cleavage of CASP3 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of MMP2 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of MMP9 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of PCNA protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
andrographolide inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]
TGFB1 protein inhibits the reaction [andrographolide results in increased expression of EGLN1 mRNA]; TGFB1 protein inhibits the reaction [andrographolide results in increased expression of EGLN1 protein]		 CTD PMID:21134392 PMID:31706003 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G THBS1 thrombospondin 1 multiple interactions
decreases expression		 ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of THBS1 mRNA
andrographolide results in decreased expression of THBS1 mRNA		 CTD PMID:19737545 NCBI chr15:39,581,079...39,599,466
Ensembl chr15:39,581,079...39,599,466 		JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO andrographolide inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 mRNA] CTD PMID:31706003 NCBI chr  X:47,582,436...47,586,789
Ensembl chr  X:47,582,408...47,586,789 		JBrowse link
G TMPRSS11F transmembrane serine protease 11F multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of TMPRSS11F mRNA CTD PMID:19737545 NCBI chr 4:68,053,198...68,129,869
Ensembl chr 4:68,053,198...68,129,869 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO
EXP		 andrographolide inhibits the reaction [Copper Sulfate results in increased expression of TNF protein]; andrographolide inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]
[andrographolide co-treated with TNF protein] results in decreased expression of BIRC3 mRNA; [andrographolide co-treated with TNF protein] results in decreased expression of CXCL1 mRNA; [andrographolide co-treated with TNF protein] results in decreased expression of ICAM1 mRNA; [andrographolide co-treated with TNF protein] results in decreased expression of TNFAIP3 mRNA; [andrographolide co-treated with TNF protein] results in increased expression of GCLC mRNA; [andrographolide co-treated with TNF protein] results in increased expression of GCLM mRNA; [andrographolide co-treated with TNF protein] results in increased expression of HMOX1 mRNA; [andrographolide co-treated with TNF protein] results in increased expression of SRXN1 mRNA; andrographolide inhibits the reaction [TNF protein affects the localization of NFKBIA protein]; andrographolide inhibits the reaction [TNF protein affects the localization of RELA protein]; andrographolide inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; andrographolide inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]		 CTD PMID:20946909 PMID:32061742 PMID:35724838 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFAIP3 TNF alpha induced protein 3 multiple interactions
increases expression		 EXP [andrographolide co-treated with TNF protein] results in decreased expression of TNFAIP3 mRNA; andrographolide inhibits the reaction [IL1B protein results in increased expression of TNFAIP3 protein]; andrographolide inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]
andrographolide results in increased expression of TNFAIP3 mRNA; andrographolide results in increased expression of TNFAIP3 protein		 CTD PMID:35724838 NCBI chr 6:137,866,349...137,883,312
Ensembl chr 6:137,867,214...137,883,314 		JBrowse link
G TNFRSF9 TNF receptor superfamily member 9 increases expression EXP andrographolide results in increased expression of TNFRSF9 mRNA CTD PMID:35724838 NCBI chr 1:7,915,871...7,940,839
Ensembl chr 1:7,915,871...7,943,165 		JBrowse link
G TP53 tumor protein p53 multiple interactions
increases expression		 EXP andrographolide results in increased expression of and results in increased phosphorylation of TP53 protein; Fluorouracil promotes the reaction [andrographolide results in increased expression of TP53] CTD PMID:18619950 PMID:19097688 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546 		JBrowse link
G TRIB3 tribbles pseudokinase 3 decreases expression EXP andrographolide results in decreased expression of TRIB3 mRNA CTD PMID:35724838 NCBI chr20:380,760...397,559
Ensembl chr20:362,835...397,559 		JBrowse link
G TXNRD1 thioredoxin reductase 1 decreases expression EXP andrographolide results in decreased expression of TXNRD1 mRNA CTD PMID:35724838 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307 		JBrowse link
G UGT1A6 UDP glucuronosyltransferase family 1 member A6 multiple interactions
increases expression		 ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of UGT1A6 mRNA
andrographolide results in increased expression of UGT1A6 mRNA		 CTD PMID:19737545 NCBI chr 2:233,691,702...233,773,300
Ensembl chr 2:233,691,607...233,773,300 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions
increases expression		 ISO
EXP		 [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of VCAM1 mRNA
andrographolide results in increased expression of VCAM1 mRNA		 CTD PMID:19737545 PMID:35724838 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045 		JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions
decreases expression		 EXP [andrographolide co-treated with KDR protein] inhibits the reaction [VEGFA protein binds to KDR protein]; andrographolide inhibits the reaction [HIF1A protein binds to VEGFA promoter]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K4 protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K6 protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K7 protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP3K5 protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of RAF1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [andrographolide results in decreased expression of VEGFA mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [andrographolide results in decreased expression of VEGFA protein]; EGLN1 mutant form inhibits the reaction [andrographolide results in decreased expression of VEGFA protein]; pyrazolanthrone inhibits the reaction [andrographolide results in decreased expression of VEGFA mRNA]; pyrazolanthrone inhibits the reaction [andrographolide results in decreased expression of VEGFA protein]
andrographolide results in decreased expression of VEGFA mRNA; andrographolide results in decreased expression of VEGFA protein		 CTD PMID:21134392 PMID:24814888 PMID:28651835 PMID:35724838 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
G VIL1 villin 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of VIL1 mRNA CTD PMID:19737545 NCBI chr 2:218,419,123...218,453,295
Ensembl chr 2:218,419,121...218,453,295 		JBrowse link
G VIM vimentin multiple interactions
decreases expression		 ISO
EXP		 [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of VIM mRNA; andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM protein]
andrographolide results in decreased expression of VIM protein
andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM protein]]		 CTD PMID:19737545 PMID:31128153 PMID:35917943 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593 		JBrowse link
G XIAP X-linked inhibitor of apoptosis decreases expression EXP andrographolide results in decreased expression of XIAP protein CTD PMID:23845849 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,712...123,913,972 		JBrowse link
G ZFAND2A zinc finger AN1-type containing 2A decreases expression EXP andrographolide results in decreased expression of ZFAND2A mRNA CTD PMID:35724838 NCBI chr 7:1,148,850...1,160,196
Ensembl chr 7:1,152,071...1,160,759 		JBrowse link
G ZG16B zymogen granule protein 16B decreases expression
multiple interactions		 ISO andrographolide results in decreased expression of SBPL mRNA
[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of SBPL mRNA		 CTD PMID:19737545 NCBI chr16:2,830,303...2,832,276
Ensembl chr16:2,830,253...2,839,585 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26040
    role 25956
      biological role 25935
        biochemical role 25168
          metabolite 25098
            andrographolide 168
Path 2
Term Annotations click to browse term
  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    main group molecular entity 25840
                      s-block molecular entity 25160
                        hydrogen molecular entity 24758
                          hydrides 22970
                            organic hydride 21930
                              organic fundamental parent 21930
                                hydrocarbon 21357
                                  terpene 14706
                                    terpenoid 14343
                                      diterpenoid 13529
                                        labdane diterpenoid 188
                                          andrographolide 168
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