Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:labdane diterpenoid
go back to main search page
Accession:CHEBI:36770 term browser browse the term
Definition:Any diterpenoid with a labdane skeleton.
Synonyms:related_synonym: labdane diterpenoids;   labdanes



show annotations for term's descendants           Sort by:
 
1,9-dideoxyforskolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity EXP 1,9-dideoxyforskolin results in decreased activity of ABCB1A protein CTD PMID:12202523 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B decreases activity EXP 1,9-dideoxyforskolin results in decreased activity of ABCB1B protein CTD PMID:12202523 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity EXP 1,9-dideoxyforskolin results in decreased activity of ABCB4 protein CTD PMID:12202523 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
andrographolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of ABCC4 mRNA CTD PMID:19737545 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions
EXP
ISO
andrographolide results in decreased expression of ACTA2 mRNA; andrographolide results in decreased expression of ACTA2 protein
andrographolide inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 mRNA]; andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 protein]; andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ACTA2 protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ACTA2 protein]]
andrographolide inhibits the reaction [Acetaminophen results in increased expression of ACTA2 mRNA]; andrographolide inhibits the reaction [Acetaminophen results in increased expression of ACTA2 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ACTA2 protein]; NFE2L2 gene mutant form inhibits the reaction [andrographolide inhibits the reaction [Acetaminophen results in increased expression of ACTA2 protein]]
CTD PMID:29355602 PMID:31128153 PMID:31706003 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of ADH7 mRNA CTD PMID:19737545 NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182
JBrowse link
G Ankrd1 ankyrin repeat domain 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of ANKRD1 mRNA CTD PMID:19737545 NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO andrographolide inhibits the reaction [cobaltous chloride results in increased expression of ATF2 protein modified form]; DUSP10 protein promotes the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of ATF2 protein modified form]] CTD PMID:29165873 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects folding
increases expression
multiple interactions
ISO andrographolide affects the folding of BAX protein
andrographolide results in increased expression of BAX mRNA; andrographolide results in increased expression of BAX protein
[andrographolide co-treated with Cisplatin] results in increased expression of BAX mRNA; andrographolide promotes the reaction [Cisplatin results in increased expression of BAX protein]; Fluorouracil promotes the reaction [andrographolide affects the folding of BAX protein]
CTD PMID:19097688 PMID:23845849 PMID:24563380 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO andrographolide results in decreased expression of BCL2 protein
[andrographolide co-treated with Cisplatin] results in decreased expression of BCL2 mRNA
CTD PMID:23845849 PMID:24563380 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of BHMT mRNA CTD PMID:19737545 NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
increases expression
EXP
ISO
andrographolide inhibits the reaction [Copper Sulfate results in decreased expression of and results in increased cleavage of BID protein]; andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in decreased expression of and results in increased cleavage of BID protein]]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in decreased expression of and results in increased cleavage of BID protein]]
[andrographolide co-treated with Cisplatin] results in increased expression of BID mRNA
andrographolide results in increased expression of BID mRNA; andrographolide results in increased expression of BID protein
CTD PMID:20946909 PMID:24563380 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO andrographolide results in decreased expression of BIRC5 protein CTD PMID:23845849 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Blvrb biliverdin reductase B multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of BLVRB mRNA CTD PMID:19737545 NCBI chr 1:82,738,646...82,756,312
Ensembl chr 1:82,738,695...82,770,375
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases expression
ISO
EXP
andrographolide results in increased activity of CASP3 protein
andrographolide inhibits the reaction [TGFB1 protein results in decreased cleavage of CASP3 protein]
andrographolide results in increased expression of CASP3 mRNA
[andrographolide co-treated with Cisplatin] results in increased expression of CASP3 mRNA; CASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP3 protein]]; Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP3 protein]
andrographolide inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]; andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]]
CTD PMID:19097688 PMID:20946909 PMID:24563380 PMID:31706003 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity
increases expression
multiple interactions
ISO
EXP
andrographolide results in increased activity of CASP8 protein
andrographolide results in increased expression of CASP8 mRNA
[andrographolide co-treated with Cisplatin] results in increased expression of CASP8 mRNA; CASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP3 protein]]; CASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP9 protein]]; CASP8 results in increased susceptibility to [andrographolide co-treated with Fluorouracil]; Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP8 protein]
andrographolide inhibits the reaction [Copper Sulfate results in increased activity of CASP8 protein]
CTD PMID:19097688 PMID:20946909 PMID:24563380 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity
increases expression
multiple interactions
ISO
EXP
andrographolide results in increased activity of CASP9 protein
andrographolide results in increased expression of CASP9 mRNA
andrographolide inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]; andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]]
[andrographolide co-treated with Cisplatin] results in increased expression of CASP9 mRNA; CASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP9 protein]]; Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP9 protein]
CTD PMID:19097688 PMID:20946909 PMID:24563380 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions ISO
EXP
[andrographolide co-treated with Polylactic Acid-Polyglycolic Acid Copolymer] inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; andrographolide inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
andrographolide inhibits the reaction [Freund's Adjuvant results in decreased activity of CAT protein]
CTD PMID:26485141 PMID:32061742 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cbr1 carbonyl reductase 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CBR1 mRNA CTD PMID:19737545 NCBI chr11:32,860,618...32,862,981
Ensembl chr11:32,908,950...32,911,393
JBrowse link
G Cbr3 carbonyl reductase 3 multiple interactions
increases expression
ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CBR3 mRNA
andrographolide results in increased expression of CBR3 mRNA
CTD PMID:19737545 NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CCL2 mRNA CTD PMID:19737545 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CCN2 mRNA CTD PMID:19737545 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccna2 cyclin A2 multiple interactions
decreases expression
ISO andrographolide inhibits the reaction [CCNA2 protein binds to CDK2 protein]
andrographolide results in decreased expression of CCNA2 protein
CTD PMID:18619950 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO andrographolide inhibits the reaction [CCND1 protein binds to CDK4 protein]
andrographolide results in decreased expression of CCND1 protein
CTD PMID:18619950 PMID:23845849 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccne1 cyclin E1 decreases expression
multiple interactions
ISO andrographolide results in decreased expression of CCNE1 protein
andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCNE1 protein]
CTD PMID:23845849 PMID:27475717 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO andrographolide inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]
andrographolide inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]]
CTD PMID:31128153 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh17 cadherin 17 decreases expression
multiple interactions
ISO andrographolide results in decreased expression of CDH17 mRNA
[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CDH17 mRNA
CTD PMID:19737545 NCBI chr 5:25,262,820...25,314,884
Ensembl chr 5:25,262,758...25,314,884
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein]
andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein]]
CTD PMID:31128153 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression
multiple interactions
ISO andrographolide results in decreased expression of CDK2 protein
andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CDK2 protein]
andrographolide inhibits the reaction [CCNA2 protein binds to CDK2 protein]
CTD PMID:18619950 PMID:27475717 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
decreases expression
ISO andrographolide inhibits the reaction [CCND1 protein binds to CDK4 protein]
andrographolide results in decreased expression of CDK4 protein
CTD PMID:18619950 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO andrographolide results in increased expression of CDKN1A protein CTD PMID:18619950 PMID:23845849 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO andrographolide affects the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] affects the expression of CEBPA mRNA]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CEBPA protein] CTD PMID:27475717 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO andrographolide affects the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] affects the expression of CEBPB mRNA]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of and results in increased phosphorylation of CEBPB protein] CTD PMID:27475717 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Ces3a carboxylesterase 3a multiple interactions
increases expression
ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CES3 mRNA
andrographolide results in increased expression of CES3 mRNA
CTD PMID:19737545 NCBI chr19:32,992,386...33,000,562 JBrowse link
G Cish cytokine inducible SH2-containing protein multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CISH mRNA CTD PMID:19737545 NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250
JBrowse link
G Cnn2 calponin 2 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CNN2 mRNA CTD PMID:19737545 NCBI chr 7:9,712,505...9,719,711
Ensembl chr 7:9,712,516...9,719,656
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression
ISO
EXP
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of COL1A1 mRNA]
andrographolide inhibits the reaction [Acetaminophen results in increased expression of COL1A1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]
andrographolide results in decreased expression of COL1A1 mRNA
CTD PMID:29355602 PMID:31706003 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col1a2 collagen type I alpha 2 chain decreases expression
multiple interactions
ISO
EXP
andrographolide results in decreased expression of COL1A2 mRNA
andrographolide inhibits the reaction [Acetaminophen results in increased expression of COL1A2 mRNA]
CTD PMID:29355602 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression
multiple interactions
EXP
ISO
andrographolide results in decreased expression of COL3A1 mRNA
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of COL3A1 mRNA]
andrographolide inhibits the reaction [Acetaminophen results in increased expression of COL3A1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 protein]
CTD PMID:29355602 PMID:31706003 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Crct1 cysteine-rich C-terminal 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CRCT1 mRNA CTD PMID:19737545 Ensembl chr 2:178,634,092...178,634,394 JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CXCL13 mRNA CTD PMID:19737545 NCBI chr14:13,608,894...13,613,965
Ensembl chr14:13,608,902...13,613,933
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions EXP andrographolide inhibits the reaction [Freund's Adjuvant results in increased expression of CXCL2 protein] CTD PMID:32061742 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CYP17A1 mRNA CTD PMID:19737545 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
increases activity
ISO [andrographolide co-treated with benz(a)anthracene] results in increased expression of CYP1A1 mRNA; [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CYP1A1 mRNA; [andrographolide co-treated with Tetrachlorodibenzodioxin] results in increased expression of CYP1A1 mRNA; Acetylcysteine affects the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; andrographolide promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Ascorbic Acid affects the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; beta-Naphthoflavone promotes the reaction [andrographolide results in increased expression of CYP1A1 mRNA]; Buthionine Sulfoximine promotes the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; Glutathione affects the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; Hydrogen Peroxide promotes the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; resveratrol inhibits the reaction [[andrographolide co-treated with benz(a)anthracene] results in increased expression of CYP1A1 mRNA]
andrographolide results in increased activity of CYP1A1 protein
CTD PMID:17825862 PMID:19737545 PMID:21094198 PMID:21963808 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression
multiple interactions
increases expression
ISO
EXP
andrographolide results in decreased expression of CYP1A2 mRNA
andrographolide affects the reaction [CYP1A2 protein results in increased metabolism of Theophylline]
andrographolide results in increased expression of CYP1A2 mRNA
[andrographolide co-treated with benz(a)anthracene] results in increased expression of CYP1A2 mRNA; [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CYP1A2 mRNA
CTD PMID:17825862 PMID:19041297 PMID:19737545 PMID:20096675 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO [andrographolide co-treated with benz(a)anthracene] results in increased expression of CYP1B1 mRNA; andrographolide promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1B1 mRNA] CTD PMID:17825862 PMID:19737545 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases activity
increases expression
multiple interactions
ISO andrographolide results in increased activity of CYP2B10 protein
andrographolide results in increased expression of CYP2B10 mRNA
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CYP2B10 mRNA
CTD PMID:19737545 PMID:21094198 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases expression
ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CYP2B9 mRNA
andrographolide results in increased expression of CYP2B9 mRNA
CTD PMID:19737545 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP andrographolide results in decreased expression of CYP2C11 mRNA; andrographolide results in decreased expression of CYP2C11 protein CTD PMID:19041297 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases expression ISO andrographolide results in decreased expression of CYP3A4 mRNA CTD PMID:19041297 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 decreases expression EXP andrographolide results in decreased expression of CYP3A23-3A1 mRNA CTD PMID:19041297 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 increases expression ISO andrographolide results in increased expression of CYP8B1 mRNA CTD PMID:19737545 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Ddc dopa decarboxylase multiple interactions
increases expression
ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of DDC mRNA
andrographolide results in increased expression of DDC mRNA
CTD PMID:19737545 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression
multiple interactions
ISO andrographolide results in increased expression of DUSP10 mRNA; andrographolide results in increased expression of DUSP10 protein
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [andrographolide results in increased expression of DUSP10 mRNA]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [andrographolide results in increased expression of DUSP10 protein]; DUSP10 protein promotes the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of ATF2 protein modified form]]; DUSP10 protein promotes the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; HMOX1 protein promotes the reaction [andrographolide results in increased expression of DUSP10 protein]; zinc protoporphyrin inhibits the reaction [andrographolide results in increased expression of DUSP10 mRNA]; zinc protoporphyrin inhibits the reaction [andrographolide results in increased expression of DUSP10 protein]
CTD PMID:29165873 NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO andrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]; andrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 protein]; Vanadates inhibits the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]]; Vanadates inhibits the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 protein]] CTD PMID:27297870 PMID:29165873 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 multiple interactions
increases expression
ISO EGLN1 mutant form inhibits the reaction [andrographolide results in decreased expression of HIF1A protein]; EGLN1 mutant form inhibits the reaction [andrographolide results in decreased expression of VEGFA protein]; TGFB1 protein inhibits the reaction [andrographolide results in increased expression of EGLN1 mRNA]; TGFB1 protein inhibits the reaction [andrographolide results in increased expression of EGLN1 protein]
andrographolide results in increased expression of EGLN1 mRNA; andrographolide results in increased expression of EGLN1 protein
CTD PMID:21134392 PMID:27297870 NCBI chr19:52,867,914...52,907,169 JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 increases expression ISO andrographolide results in increased expression of EGLN3 protein CTD PMID:27297870 NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766
JBrowse link
G Eid3 EP300 interacting inhibitor of differentiation 3 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of EID3 mRNA CTD PMID:19737545 NCBI chr 7:20,860,073...20,861,395 JBrowse link
G Elane elastase, neutrophil expressed multiple interactions EXP andrographolide inhibits the reaction [Freund's Adjuvant results in increased expression of ELANE protein] CTD PMID:32061742 NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit multiple interactions ISO andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EZH2 protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EZH2 protein]] CTD PMID:31128153 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362
JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression
ISO [andrographolide co-treated with Cisplatin] promotes the reaction [FAS protein binds to FASLG protein]; [andrographolide co-treated with Cisplatin] results in increased expression of FAS mRNA; [andrographolide co-treated with Cisplatin] results in increased expression of FAS protein; andrographolide promotes the reaction [FAS protein binds to FASLG protein]
andrographolide results in increased expression of FAS mRNA; andrographolide results in increased expression of FAS protein
CTD PMID:24563380 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand multiple interactions
increases expression
ISO [andrographolide co-treated with Cisplatin] promotes the reaction [FAS protein binds to FASLG protein]; [andrographolide co-treated with Cisplatin] results in increased expression of FASLG mRNA; [andrographolide co-treated with Cisplatin] results in increased expression of FASLG protein; andrographolide promotes the reaction [FAS protein binds to FASLG protein]
andrographolide results in increased expression of FASLG mRNA; andrographolide results in increased expression of FASLG protein
CTD PMID:24563380 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FASN mRNA]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FASN protein] CTD PMID:27475717 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 decreases expression ISO andrographolide results in decreased expression of FLT1 mRNA CTD PMID:28651835 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO andrographolide inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein] CTD PMID:31706003 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO andrographolide results in decreased localization of and results in decreased activity of FOS protein CTD PMID:19426720 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
EXP
ISO
andrographolide results in increased expression of GCLC mRNA; andrographolide results in increased expression of GCLC protein
andrographolide inhibits the reaction [Acetaminophen results in decreased expression of GCLC mRNA]
CTD PMID:25110055 PMID:29355602 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression
ISO
EXP
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of GCLM mRNA; andrographolide inhibits the reaction [Acetaminophen results in decreased expression of GCLM mRNA]
andrographolide results in increased expression of GCLM protein
andrographolide results in increased expression of GCLM mRNA; andrographolide results in increased expression of GCLM protein
CTD PMID:19737545 PMID:25110055 PMID:29355602 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [polylactic acid-polyglycolic acid copolymer co-treated with andrographolide] inhibits the reaction [sodium arsenite results in increased activity of GPT protein] CTD PMID:26485141 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of GSK3B protein] CTD PMID:27475717 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsr glutathione-disulfide reductase increases activity EXP andrographolide results in increased activity of GSR protein CTD PMID:25110055 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gstm2 glutathione S-transferase mu 2 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of GSTM2 mRNA CTD PMID:19737545 NCBI chr 2:195,624,015...195,628,774 JBrowse link
G Gstm4 glutathione S-transferase mu 4 increases expression
multiple interactions
ISO andrographolide results in increased expression of GSTM4 mRNA
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of GSTM4 mRNA
CTD PMID:19737545 NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression
multiple interactions
ISO andrographolide results in increased expression of GSTM3 mRNA
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of GSTM3 mRNA
CTD PMID:19737545 NCBI chr 2:195,531,627...195,534,562
Ensembl chr 2:195,531,495...195,534,553
JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO andrographolide results in decreased expression of HDAC1 protein CTD PMID:28651835 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression
increases expression
ISO [andrographolide co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of HIF1A protein; [andrographolide co-treated with cobaltous chloride] results in increased hydroxylation of HIF1A protein; andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]; andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; andrographolide inhibits the reaction [HIF1A protein binds to VEGFA promoter]; andrographolide results in decreased expression of and affects the localization of HIF1A protein; andrographolide results in decreased expression of and results in increased degradation of HIF1A protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [andrographolide results in decreased expression of HIF1A protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [andrographolide results in increased degradation of HIF1A protein]; DUSP10 protein promotes the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; EGLN1 mutant form inhibits the reaction [andrographolide results in decreased expression of HIF1A protein]; HMOX1 protein affects the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; NFE2L2 protein affects the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; pyrazolanthrone inhibits the reaction [andrographolide results in decreased expression of HIF1A protein]; Vanadates inhibits the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; Vanadates inhibits the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]]
andrographolide results in increased expression of HIF1A protein modified form
CTD PMID:21134392 PMID:27297870 PMID:28651835 PMID:29165873 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP
ISO
andrographolide results in increased expression of HMOX1 mRNA; andrographolide results in increased expression of HMOX1 protein
andrographolide inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 mRNA]
HMOX1 protein affects the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; HMOX1 protein promotes the reaction [andrographolide results in increased expression of DUSP10 protein]
CTD PMID:25110055 PMID:27297870 PMID:29165873 PMID:29355602 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hp haptoglobin multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of HP mRNA CTD PMID:19737545 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of HPGD mRNA CTD PMID:19737545 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of IKBKE mRNA CTD PMID:19737545 NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL6 protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ACTA2 protein]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EZH2 protein]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of HOTAIR mRNA]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM protein]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of STAT3 protein]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL6 protein]]
andrographolide inhibits the reaction [Freund's Adjuvant results in increased expression of IL6 protein]
andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of IL6 mRNA]; andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL6 protein]
CTD PMID:31128153 PMID:32061742 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO andrographolide results in decreased localization of and results in decreased activity of JUN protein CTD PMID:19426720 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kdr kinase insert domain receptor multiple interactions
decreases expression
ISO [andrographolide co-treated with KDR protein] inhibits the reaction [VEGFA protein binds to KDR protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]
andrographolide results in decreased expression of KDR mRNA
CTD PMID:24814888 PMID:28651835 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression ISO andrographolide results in decreased expression of KEAP1 protein CTD PMID:29355602 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Krt5 keratin 5 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of KRT5 mRNA CTD PMID:19737545 NCBI chr 7:132,846,355...132,851,986
Ensembl chr 7:132,846,136...132,851,850
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 multiple interactions ISO andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K4 protein] CTD PMID:24814888 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 multiple interactions ISO andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K6 protein] CTD PMID:24814888 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293
JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 multiple interactions ISO andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K7 protein] CTD PMID:24814888 NCBI chr12:2,591,312...2,604,211
Ensembl chr12:2,591,219...2,604,222
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP3K5 protein] CTD PMID:24814888 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]
andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK1 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]
CTD PMID:24814888 PMID:27475717 PMID:31706003 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]
andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:24814888 PMID:27475717 PMID:31706003 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO andrographolide inhibits the reaction [TGFB1 protein results in increased expression of MMP2 mRNA] CTD PMID:31706003 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression
multiple interactions
ISO andrographolide results in decreased expression of MMP7 mRNA
andrographolide results in decreased expression of and results in decreased activity of MMP7 protein
CTD PMID:19426720 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO andrographolide inhibits the reaction [TGFB1 protein results in increased expression of MMP9 mRNA] CTD PMID:31706003 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP andrographolide inhibits the reaction [Freund's Adjuvant results in increased expression of MPO protein] CTD PMID:32061742 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mta1 metastasis associated 1 decreases expression ISO andrographolide results in decreased expression of MTA1 mRNA; andrographolide results in decreased expression of MTA1 protein CTD PMID:28651835 NCBI chr 6:132,178,608...132,217,641
Ensembl chr 6:132,178,853...132,217,641
JBrowse link
G Myo18b myosin XVIIIb decreases expression ISO andrographolide results in decreased expression of MYO18B mRNA CTD PMID:19737545 NCBI chr12:43,747,003...43,953,694
Ensembl chr12:43,747,010...43,953,695
JBrowse link
G Necab1 N-terminal EF-hand calcium binding protein 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of NECAB1 mRNA CTD PMID:19737545 NCBI chr 5:28,357,859...28,578,642
Ensembl chr 5:28,357,859...28,578,642
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity
decreases response to substance
multiple interactions
EXP
ISO
andrographolide results in increased activity of NFE2L2 protein
NFE2L2 gene mutant form results in decreased susceptibility to andrographolide
NFE2L2 gene mutant form inhibits the reaction [andrographolide inhibits the reaction [Acetaminophen results in increased expression of ACTA2 protein]]
NFE2L2 protein affects the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]
CTD PMID:25110055 PMID:27297870 PMID:29355602 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Ngb neuroglobin multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of NGB mRNA CTD PMID:19737545 NCBI chr 6:106,744,378...106,749,830
Ensembl chr 6:106,744,378...106,749,830
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO
EXP
andrographolide results in increased expression of NQO1 mRNA
andrographolide results in increased expression of NQO1 protein
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of NQO1 mRNA; andrographolide promotes the reaction [Acetaminophen results in increased expression of NQO1 mRNA]
CTD PMID:19737545 PMID:29355602 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Olr878 olfactory receptor 878 decreases expression ISO andrographolide results in decreased expression of OLFR767 mRNA CTD PMID:19737545 NCBI chr 7:1,502,160...1,503,089
Ensembl chr 7:1,501,940...1,507,336
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO andrographolide inhibits the reaction [TGFB1 protein results in increased expression of PCNA protein] CTD PMID:31706003 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pdzrn3 PDZ domain containing RING finger 3 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of PDZRN3 mRNA CTD PMID:19737545 NCBI chr 4:133,770,736...133,996,959
Ensembl chr 4:133,770,736...133,996,959
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 decreases expression ISO andrographolide results in decreased expression of PECAM1 protein CTD PMID:28651835 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
JBrowse link
G Phospho1 phosphoethanolamine/phosphocholine phosphatase 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of PHOSPHO1 mRNA CTD PMID:19737545 NCBI chr10:80,762,062...80,769,596
Ensembl chr10:80,760,792...80,770,342
JBrowse link
G Plscr1 phospholipid scramblase 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of PLSCR1 mRNA CTD PMID:19737545 NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of POR mRNA CTD PMID:19737545 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein] CTD PMID:27475717 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of LTB4DH mRNA CTD PMID:19737545 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of RAF1 protein] CTD PMID:24814888 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO andrographolide results in decreased phosphorylation of RB1 protein CTD PMID:18619950 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G S100a4 S100 calcium-binding protein A4 multiple interactions EXP andrographolide inhibits the reaction [Bleomycin results in increased expression of S100A4 protein] CTD PMID:31706003 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of SCD1 mRNA]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of SCD1 protein] CTD PMID:27475717 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Serpina7 serpin family A member 7 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of SERPINA7 mRNA CTD PMID:19737545 NCBI chr  X:102,663,242...102,722,319
Ensembl chr  X:102,663,405...102,669,040
JBrowse link
G Slc1a4 solute carrier family 1 member 4 multiple interactions
increases expression
ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of SLC1A4 mRNA
andrographolide results in increased expression of SLC1A4 mRNA
CTD PMID:19737545 NCBI chr14:94,530,801...94,560,190
Ensembl chr14:94,529,084...94,560,418
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO andrographolide results in increased expression of SLC7A11 mRNA CTD PMID:19737545 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:31706003 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:31706003 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP andrographolide results in increased expression of SOD1 mRNA; andrographolide results in increased expression of SOD1 protein CTD PMID:25110055 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of SPP1 mRNA CTD PMID:19737545 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO andrographolide results in increased expression of SQSTM1 protein CTD PMID:29355602 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Srxn1 sulfiredoxin 1 multiple interactions
increases expression
ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of SRXN1 mRNA
andrographolide results in increased expression of SRXN1 mRNA
CTD PMID:19737545 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases activity
multiple interactions
ISO andrographolide results in decreased activity of STAT3 protein
andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of STAT3 protein]
andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of STAT3 protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of STAT3 protein]]
CTD PMID:23845849 PMID:31128153 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Steap4 STEAP4 metalloreductase multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of STEAP4 mRNA CTD PMID:19737545 NCBI chr 4:26,077,182...26,099,859
Ensembl chr 4:26,054,671...26,099,859
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase multiple interactions
increases expression
ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of TDO2 mRNA
andrographolide results in increased expression of TDO2 mRNA
CTD PMID:19737545 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions
ISO
EXP
andrographolide results in decreased expression of TGFB1 protein
andrographolide inhibits the reaction [TGFB1 protein results in decreased cleavage of CASP3 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of MMP2 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of MMP9 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of PCNA protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
andrographolide inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]
TGFB1 protein inhibits the reaction [andrographolide results in increased expression of EGLN1 mRNA]; TGFB1 protein inhibits the reaction [andrographolide results in increased expression of EGLN1 protein]
CTD PMID:21134392 PMID:31706003 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Thbs1 thrombospondin 1 multiple interactions
decreases expression
ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of THBS1 mRNA
andrographolide results in decreased expression of THBS1 mRNA
CTD PMID:19737545 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO andrographolide inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 mRNA] CTD PMID:31706003 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tmprss11f transmembrane serine protease 11F multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of TMPRSS11F mRNA CTD PMID:19737545 NCBI chr14:21,492,896...21,534,792
Ensembl chr14:21,429,418...21,534,809
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP andrographolide inhibits the reaction [Copper Sulfate results in increased expression of TNF protein]; andrographolide inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein] CTD PMID:20946909 PMID:32061742 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO andrographolide results in increased expression of and results in increased phosphorylation of TP53 protein; Fluorouracil promotes the reaction [andrographolide results in increased expression of TP53] CTD PMID:18619950 PMID:19097688 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions
increases expression
ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of UGT1A6 mRNA
andrographolide results in increased expression of UGT1A6 mRNA
CTD PMID:19737545 NCBI chr 9:88,747,229...88,808,465 JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of VCAM1 mRNA CTD PMID:19737545 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression
ISO [andrographolide co-treated with KDR protein] inhibits the reaction [VEGFA protein binds to KDR protein]; andrographolide inhibits the reaction [HIF1A protein binds to VEGFA promoter]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K4 protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K6 protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K7 protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP3K5 protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of RAF1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [andrographolide results in decreased expression of VEGFA mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [andrographolide results in decreased expression of VEGFA protein]; EGLN1 mutant form inhibits the reaction [andrographolide results in decreased expression of VEGFA protein]; pyrazolanthrone inhibits the reaction [andrographolide results in decreased expression of VEGFA mRNA]; pyrazolanthrone inhibits the reaction [andrographolide results in decreased expression of VEGFA protein]
andrographolide results in decreased expression of VEGFA mRNA; andrographolide results in decreased expression of VEGFA protein
CTD PMID:21134392 PMID:24814888 PMID:28651835 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vil1 villin 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of VIL1 mRNA CTD PMID:19737545 NCBI chr 9:75,991,141...76,018,860
Ensembl chr 9:75,991,141...76,018,858
JBrowse link
G Vim vimentin multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of VIM mRNA; andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM protein]
andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM protein]]
CTD PMID:19737545 PMID:31128153 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO andrographolide results in decreased expression of XIAP protein CTD PMID:23845849 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
G Zg16b zymogen granule protein 16B multiple interactions
decreases expression
ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of SBPL mRNA
andrographolide results in decreased expression of SBPL mRNA
CTD PMID:19737545 NCBI chr10:12,970,888...12,984,170
Ensembl chr10:12,979,020...12,983,572
JBrowse link
forskolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc6a4 solute carrier family 6 member 4 increases activity ISO forskolin increases activity of SLC6A4 protein in placental choriocarcinoma cells RGD PMID:8408014 RGD:36947876 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link
sclareol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions
decreases expression
ISO sclareol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein]
sclareol results in decreased expression of ACP5 mRNA; sclareol results in decreased expression of ACP5 protein
CTD PMID:33423118 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO sclareol results in decreased expression of and results in decreased phosphorylation of AKT1 protein
sclareol results in decreased phosphorylation of AKT1 protein
CTD PMID:33164868 PMID:33423118 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 decreases expression
multiple interactions
ISO sclareol results in decreased expression of ATP6V0D2 mRNA
sclareol inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA]
CTD PMID:33423118 NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression ISO sclareol results in increased expression of BGLAP mRNA CTD PMID:33423118 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Ccn1 cellular communication network factor 1 increases expression
multiple interactions
ISO sclareol results in increased expression of CCN1 mRNA; sclareol results in increased expression of CCN1 protein
[sclareol co-treated with SB 203580] results in increased expression of CCN1 protein; sclareol inhibits the reaction [TNFSF11 protein results in decreased expression of CCN1 protein]
CTD PMID:33423118 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Ctsk cathepsin K decreases expression
multiple interactions
ISO sclareol results in decreased expression of CTSK mRNA; sclareol results in decreased expression of CTSK protein
sclareol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK protein]
CTD PMID:33423118 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
JBrowse link
G Dcstamp dendrocyte expressed seven transmembrane protein decreases expression
multiple interactions
ISO sclareol results in decreased expression of DCSTAMP mRNA
sclareol inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]
CTD PMID:33423118 NCBI chr 7:70,807,455...70,822,067
Ensembl chr 7:70,807,581...70,822,078
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit multiple interactions
decreases expression
ISO [sclareol co-treated with Cisplatin] results in decreased expression of ERCC1 protein
sclareol results in decreased expression of ERCC1 protein
CTD PMID:33164868 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions
ISO sclareol results in decreased expression of FOS protein
sclareol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]
sclareol results in decreased expression of FOS mRNA; sclareol results in decreased expression of FOS protein
CTD PMID:33164868 PMID:33423118 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation ISO sclareol results in decreased phosphorylation of GSK3B protein CTD PMID:33164868 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression ISO sclareol results in decreased expression of JUN protein CTD PMID:33164868 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO [sclareol co-treated with TNFSF11 protein] results in decreased phosphorylation of MAPK1 protein
sclareol results in decreased phosphorylation of MAPK1 protein
CTD PMID:33423118 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
ISO sclareol results in decreased phosphorylation of MAPK3 protein
[sclareol co-treated with TNFSF11 protein] results in decreased phosphorylation of MAPK3 protein
CTD PMID:33423118 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 decreases expression
multiple interactions
ISO sclareol results in decreased expression of NFATC1 mRNA; sclareol results in decreased expression of NFATC1 protein
sclareol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]
CTD PMID:33423118 NCBI chr18:74,046,421...74,156,041
Ensembl chr18:74,046,904...74,156,028
JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression ISO sclareol results in increased expression of RUNX2 mRNA; sclareol results in increased expression of RUNX2 protein CTD PMID:33423118 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO sclareol results in decreased expression of SNAI1 protein CTD PMID:33164868 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO sclareol results in increased expression of SPP1 mRNA; sclareol results in increased expression of SPP1 protein CTD PMID:33423118 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO [sclareol co-treated with TNFSF11 protein] results in decreased phosphorylation of MAPK1 protein; [sclareol co-treated with TNFSF11 protein] results in decreased phosphorylation of MAPK3 protein; sclareol inhibits the reaction [TNFSF11 protein results in decreased expression of CCN1 protein]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK protein]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; sclareol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein] CTD PMID:33423118 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      atom 19799
        nonmetal atom 19686
          carbon atom 19609
            organic molecular entity 19609
              isoprenoid 12725
                terpenoid 12295
                  diterpenoid 11518
                    labdane diterpenoid 152
                      (+)-copalol 0
                      (-)-ent-copalol 0
                      (13E)-labda-7,13-dien-15-ol 0
                      (13R)-epi-8,13-epoxylabd-14-ene 0
                      (13R)-manoyl oxide 0
                      (13S)-vitexifolin A 0
                      (5S,9S,10S,13E)-labda-7,13-dien-15-yl diphosphate 0
                      1,9-dideoxyforskolin 3
                      13-epi-manool 0
                      6alpha-malonyloxymanoyl oxide 0
                      7alpha-hydroperoxy manool 0
                      8alpha,19-dihydroxylabd-13E-ene-15-oic acid 0
                      9,13(R)-epoxylabd-14-ene 0
                      9-deoxyforskolin 0
                      9-hydroxy hedychenone 0
                      andrographolide 136
                      cis-abienol 0
                      copal-8-ol diphosphate 0
                      copalyl diphosphate + 0
                      ent-copal-8-ol diphosphate 0
                      ent-manool 0
                      forskoditerpenoside C 0
                      forskoditerpenoside D 0
                      forskoditerpenoside E 0
                      forskolin + 4
                      hedychilactone D 0
                      labd-13(16),14-diene-9-ol 0
                      labd-13Z-ene-9,15,16-triol 0
                      manool 0
                      peregrinol + 0
                      peregrinol diphosphate 0
                      rotundifuran 0
                      sclareol 18
                      sterebin L 0
                      syn-copalol 0
                      viteagnusin D 0
                      viteagnusin I 0
                      vitetrifolin D 0
                      vitexilactone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    main group molecular entity 19698
                      s-block molecular entity 19479
                        hydrogen molecular entity 19471
                          hydrides 18834
                            organic hydride 18348
                              organic fundamental parent 18348
                                hydrocarbon 18059
                                  terpene 12725
                                    terpenoid 12295
                                      diterpenoid 11518
                                        labdane diterpenoid 152
                                          (+)-copalol 0
                                          (-)-ent-copalol 0
                                          (13E)-labda-7,13-dien-15-ol 0
                                          (13R)-epi-8,13-epoxylabd-14-ene 0
                                          (13R)-manoyl oxide 0
                                          (13S)-vitexifolin A 0
                                          (5S,9S,10S,13E)-labda-7,13-dien-15-yl diphosphate 0
                                          1,9-dideoxyforskolin 3
                                          13-epi-manool 0
                                          6alpha-malonyloxymanoyl oxide 0
                                          7alpha-hydroperoxy manool 0
                                          8alpha,19-dihydroxylabd-13E-ene-15-oic acid 0
                                          9,13(R)-epoxylabd-14-ene 0
                                          9-deoxyforskolin 0
                                          9-hydroxy hedychenone 0
                                          andrographolide 136
                                          cis-abienol 0
                                          copal-8-ol diphosphate 0
                                          copalyl diphosphate + 0
                                          ent-copal-8-ol diphosphate 0
                                          ent-manool 0
                                          forskoditerpenoside C 0
                                          forskoditerpenoside D 0
                                          forskoditerpenoside E 0
                                          forskolin + 4
                                          hedychilactone D 0
                                          labd-13(16),14-diene-9-ol 0
                                          labd-13Z-ene-9,15,16-triol 0
                                          manool 0
                                          peregrinol + 0
                                          peregrinol diphosphate 0
                                          rotundifuran 0
                                          sclareol 18
                                          sterebin L 0
                                          syn-copalol 0
                                          viteagnusin D 0
                                          viteagnusin I 0
                                          vitetrifolin D 0
                                          vitexilactone 0
paths to the root