COL3A1 (collagen type III alpha 1 chain) - Rat Genome Database

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Gene: COL3A1 (collagen type III alpha 1 chain) Homo sapiens
Symbol: COL3A1
Name: collagen type III alpha 1 chain
RGD ID: 737225
HGNC Page HGNC:2201
Description: Enables integrin binding activity; platelet-derived growth factor binding activity; and protease binding activity. An extracellular matrix structural constituent. Involved in several processes, including cell surface receptor signaling pathway; cell-matrix adhesion; and collagen fibril organization. Located in collagen-containing extracellular matrix and extracellular space. Part of collagen type III trimer. Implicated in Ehlers-Danlos syndrome; Ehlers-Danlos syndrome hypermobility type; end stage renal disease; and vascular type Ehlers-Danlos syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: alpha-1 type III collagen; alpha1 (III) collagen; collagen alpha-1(III) chain; collagen type III alpha 1; collagen, fetal; collagen, type III, alpha 1; EDS4A; EDSVASC; Ehlers-Danlos syndrome type IV, autosomal dominant; FLJ34534; PMGEDSV
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382188,974,373 - 189,012,746 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2188,974,373 - 189,012,746 (+)EnsemblGRCh38hg38GRCh38
GRCh372189,839,099 - 189,877,472 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362189,547,344 - 189,585,717 (+)NCBINCBI36Build 36hg18NCBI36
Build 342189,664,604 - 189,702,978NCBI
Celera2183,433,958 - 183,472,272 (+)NCBICelera
Cytogenetic Map2q32.2NCBI
HuRef2181,698,732 - 181,737,119 (+)NCBIHuRef
CHM1_12189,845,032 - 189,883,377 (+)NCBICHM1_1
T2T-CHM13v2.02189,463,283 - 189,501,589 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Acute Otitis Media  (ISO)
alcoholic liver cirrhosis  (EXP)
Aneurysm  (IAGP)
aortic aneurysm  (IAGP)
aortic disease  (IAGP)
aortic valve insufficiency  (EXP)
bladder neck obstruction  (ISO)
Cardiac Fibrosis  (ISO)
Chemical and Drug Induced Liver Injury  (EXP)
connective tissue disease  (IAGP)
Contracture  (ISO)
Disproportionate Tall Stature  (IAGP)
Ehlers-Danlos syndrome  (EXP,IAGP,ISO)
Ehlers-Danlos syndrome classic type 1  (IAGP)
Ehlers-Danlos syndrome hypermobility type  (IAGP)
Ehlers-Danlos Syndrome Type 4  (IAGP)
end stage renal disease  (IAGP)
endomyocardial fibrosis  (EXP)
epilepsy  (IAGP)
Experimental Liver Cirrhosis  (EXP)
extrahepatic cholestasis  (EXP)
facioscapulohumeral muscular dystrophy  (EXP)
Familial Thoracic Aortic Aneurysm 1  (IAGP)
Familial Thoracic Aortic Aneurysm 2  (IAGP)
Fibrosis  (EXP)
genetic disease  (IAGP)
glomerulosclerosis  (ISO)
hereditary spastic paraplegia 4  (IAGP)
Hypercholesterolemia  (EXP)
hyperglycemia  (EXP)
hyperinsulinism  (EXP)
hypertension  (EXP)
immunodeficiency 31B  (IAGP)
Keloid  (EXP)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (EXP)
liver cirrhosis  (EXP)
liver disease  (EXP)
Loeys-Dietz syndrome  (IAGP)
Lung Reperfusion Injury  (ISO)
Marfan syndrome  (IAGP)
Marfanoid Hypermobility Syndrome  (IAGP)
Maxillofacial Abnormalities  (ISO)
megacolon  (IAGP)
Mycoplasma pneumoniae pneumonia  (HEP)
myocardial infarction  (ISO)
nephrosclerosis  (EXP)
Neurodevelopmental Disorders  (IAGP)
obesity  (ISO)
Polymicrogyria with or without Vascular-Type Ehlers-Danlos Syndrome  (IAGP)
pulmonary fibrosis  (EXP,ISO)
renal fibrosis  (ISO)
rheumatic heart disease  (ISO)
schizophrenia  (EXP)
steatotic liver disease  (EXP)
systemic scleroderma  (ISS)
thoracic aortic aneurysm  (IAGP)
Transplant Rejection  (IEP)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (EXP)
vascular type Ehlers-Danlos syndrome  (IAGP,ISS)
Ventral Hernia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-citrinin  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-selegiline  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
Ac-Ser-Asp-Lys-Pro-OH  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (EXP)
acrylamide  (ISO)
Activin A  (ISO)
adenine  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
ambroxol  (ISO)
ammonium chloride  (ISO)
amphibole asbestos  (ISO)
andrographolide  (EXP,ISO)
angiotensin II  (ISO)
anthocyanin  (ISO)
apocynin  (ISO)
arotinoid acid  (EXP)
arsenic acid  (ISO)
arsenite(3-)  (EXP,ISO)
atrazine  (ISO)
azelastine  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
berberine  (ISO)
beta-D-glucosamine  (ISO)
bilirubin IXalpha  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP,ISO)
bleomycin A2  (EXP,ISO)
boron nitride  (EXP)
bucladesine  (EXP)
buspirone  (ISO)
busulfan  (EXP)
C.I. Natural Red 20  (EXP)
cadmium atom  (EXP,ISO)