RGD Reference Report - Association of gene polymorphisms with chronic kidney disease in high- or low-risk subjects defined by conventional risk factors. - Rat Genome Database

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Association of gene polymorphisms with chronic kidney disease in high- or low-risk subjects defined by conventional risk factors.

Authors: Yoshida, T  Kato, K  Yokoi, K  Oguri, M  Watanabe, S  Metoki, N  Yoshida, H  Satoh, K  Aoyagi, Y  Nishigaki, Y  Nozawa, Y  Yamada, Y 
Citation: Yoshida T, etal., Int J Mol Med. 2009 Jun;23(6):785-92.
RGD ID: 7257553
Pubmed: PMID:19424605   (View Abstract at PubMed)

The purpose of the present study was to identify genetic variants which confer susceptibility to chronic kidney disease (CKD) in high- or low-risk subjects defined by conventional risk factors separately. The study population comprised 2828 Japanese individuals, including 434 subjects with CKD [estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m(2)] and 2394 controls (eGFR > or =60 ml/min/ 1.73 m(2)). The 1012 high-risk subjects had both hypertension and diabetes mellitus, and the 1816 low-risk subjects had none of these conditions. The genotypes for 296 polymorphisms of 202 candidate genes were determined. The Chi-square test, multivariable logistic regression analysis with adjustment for covariates, as well as a stepwise forward selection procedure revealed that ten different polymorphisms were associated (P<0.05) with the prevalence of CKD in high- or low-risk subjects: the -519Aright curved arrow G polymorphism of MMP1, the 1061Aright curved arrow G (Ile405Val) polymorphism of CETP, the Aright curved arrow G (Lys45Glu) polymorphism of MMP3, the -219Gright curved arrow T polymorphism of APOE, the Aright curved arrow G (Ile1205Val) polymorphism of COL3A1, the -863Cright curved arrow A polymorphism of TNF, and the 1454Cright curved arrow G (Leu125Val) polymorphism of PECAM1 in high-risk subjects; and the 1167Cright curved arrow T (Asn389Asn) polymorphism of TGFBR2, the 2386Aright curved arrow G (Ile796Val) polymorphism of SCAP, and the TAAAright curved arrow del polymorphism of PDE4D in low-risk subjects. Among these polymorphisms, the -519Aright curved arrow G polymorphism of MMP1 and the 1167Cright curved arrow T (Asn389Asn) polymorphism of TGFBR2 were most significantly associated with CKD in high- or low-risk individuals, respectively. These results suggest that polymorphisms associated with CKD may differ among high- or low-risk subjects. Stratification of subjects according to conventional risk factors may thus be important for personalized prevention of CKD based on genetic information.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
end stage renal disease  IAGP 7257553DNA:polymorphism: :p.I1205V (human)RGD 
end stage renal disease  ISOCOL3A1 (Homo sapiens)7257553; 7257553DNA:polymorphism: :p.I1205V (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Col3a1  (collagen type III alpha 1 chain)

Genes (Mus musculus)
Col3a1  (collagen, type III, alpha 1)

Genes (Homo sapiens)
COL3A1  (collagen type III alpha 1 chain)


Additional Information