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Gene: DDC (dopa decarboxylase) Homo sapiens
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Symbol: DDC
Name: dopa decarboxylase
Description: Exhibits L-dopa decarboxylase activity and enzyme binding activity. Predicted to be involved in catecholamine biosynthetic process and indolalkylamine biosynthetic process. Localizes to the extracellular exosome. Implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; and inherited metabolic disorder. Biomarker of hyperinsulinism.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AADC; aromatic L-amino acid decarboxylase; aromatic-L-amino-acid decarboxylase; dopa decarboxylase (aromatic L-amino acid decarboxylase)
Orthologs:
Mus musculus (house mouse) : Ddc (dopa decarboxylase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ddc (dopa decarboxylase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ddc (dopa decarboxylase)
Pan paniscus (bonobo/pygmy chimpanzee) : DDC (dopa decarboxylase)
Canis lupus familiaris (dog) : DDC (dopa decarboxylase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ddc (dopa decarboxylase)
Sus scrofa (pig) : DDC (dopa decarboxylase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl750,458,436 - 50,565,405 (-)Ensembl
GRCh38750,458,436 - 50,565,460 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37750,526,134 - 50,633,154 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36750,493,628 - 50,600,648 (-)NCBINCBI36hg18NCBI36
Build 34750,300,344 - 50,402,960NCBI
Celera750,591,055 - 50,698,048 (-)NCBI
Cytogenetic Map7p12.2-p12.1NCBI
HuRef750,376,100 - 50,483,099 (-)NCBIHuRef
CHM1_1750,528,427 - 50,635,428 (-)NCBICHM1_1
CRA_TCAGchr7v2750,532,205 - 50,639,203 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on DDC
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 734177
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-01-14
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.