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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Liver Reperfusion Injury
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Accession:DOID:9002159 term browser browse the term
Definition:Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the liver, including swelling; hemorrhage; necrosis; and damage from free radicals.
Synonyms:exact_synonym: Hepatic Ischemia-Reperfusion Injury;   Hepatic Reperfusion Injury;   Liver Ischemia-Reperfusion Injury


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Liver Reperfusion Injury term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing treatment IDA RGD PMID:23762489 RGD:8695935 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Adm adrenomedullin treatment IEP
ISO		 mRNA,protein:increased expression:liver,plasma: RGD PMID:19212187 PMID:19212187 RGD:7364958, RGD:7364958 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654 		JBrowse link
G Ager advanced glycosylation end product-specific receptor IEP mRNA:increased expression:liver RGD PMID:21431875 RGD:10402078 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member treatment ISO
IEP		 protein:altered expression:liver (mouse)
protein:altered expression:liver (rat)		 RGD PMID:30671488 PMID:29589772 RGD:15036807, RGD:14975297 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Atf6 activating transcription factor 6 ameliorates ISO RGD PMID:34144219 RGD:329812011 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Atg13 autophagy related 13 ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr 3:77,647,069...77,681,028
Ensembl chr 3:77,645,790...77,681,043 		JBrowse link
G Atg16l1 autophagy related 16-like 1 ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr 9:88,420,737...88,457,530
Ensembl chr 9:88,422,038...88,457,529 		JBrowse link
G Atg4d autophagy related 4D, cysteine peptidase ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr 8:19,807,733...19,817,321
Ensembl chr 8:19,807,766...19,817,321 		JBrowse link
G Atg7 autophagy related 7 ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Bad BCL2-associated agonist of cell death treatment IEP mRNA:increased expression:liver
associated with Non-alcoholic Fatty Liver Disease		 RGD PMID:22647552 PMID:22847887 RGD:10053673, RGD:10053710 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment
ameliorates		 IEP
ISO		 mRNA:increased expression:liver
associated with Non-alcoholic Fatty Liver Disease		 RGD PMID:22647552 PMID:22847887 PMID:21092002 PMID:34144219 RGD:10053673, RGD:10053710, RGD:5134995, RGD:329812011 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment
ameliorates		 IDA
IEP
ISO		 associated with Non-alcoholic Fatty Liver Disease RGD PMID:22847887 PMID:21092002 PMID:34144219 RGD:10053710, RGD:5134995, RGD:329812011 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 treatment IEP associated with Non-alcoholic Fatty Liver Disease RGD PMID:22847887 RGD:10053710 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Becn1 beclin 1 ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G C3 complement C3 treatment IEP RGD PMID:19854450 RGD:11040888 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Casp12 caspase 12 treatment IEP RGD PMID:29428101 RGD:13782166 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 ameliorates ISO RGD PMID:34144219 RGD:329812011 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 treatment IEP
ISO		 RGD PMID:23423194 PMID:15300206 RGD:8661760, RGD:14695087 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 treatment
ameliorates		 IEP
ISO		 RGD PMID:23364428 PMID:34144219 RGD:13782358, RGD:329812011 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 severity
treatment
ameliorates		 IEP
ISO		 mRNA, protein:increased expression:liver, serum (rat) RGD PMID:9500701 PMID:27229110 PMID:10630515 PMID:34400126 RGD:8549627, RGD:14995460, RGD:14995929, RGD:329902072 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 treatment
severity		 ISO RGD PMID:28623253 PMID:28623253 RGD:14995305, RGD:14995305 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303 		JBrowse link
G Ccn1 cellular communication network factor 1 ameliorates ISO RGD PMID:34144219 RGD:329812011 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Ccr1 C-C motif chemokine receptor 1 ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr 8:123,556,286...123,561,841 JBrowse link
G Ccr2 C-C motif chemokine receptor 2 severity ISO RGD PMID:27229110 RGD:14995460 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Cd14 CD14 molecule IDA RGD PMID:22564590 RGD:7183676 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cd40 CD40 molecule treatment IMP RGD PMID:14741776 RGD:8547795 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cfh complement factor H treatment IEP
ISO		 mRNA,protein:decreased expression:liver,plasma: RGD PMID:19212187 PMID:19212187 RGD:7364958, RGD:7364958 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
G Cs citrate synthase IDA RGD PMID:25416448 RGD:13504849 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421 		JBrowse link
G Cst3 cystatin C ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 treatment
ameliorates		 IDA
ISO		 RGD PMID:21092002 PMID:34400126 RGD:5134995, RGD:329902072 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 treatment
ameliorates		 ISO RGD PMID:18041715 PMID:34400126 RGD:27095942, RGD:329902072 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IEP mRNA:decreased expression:lung RGD PMID:19595018 RGD:2314952 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 ameliorates ISO RGD PMID:34144219 RGD:329812011 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ameliorates ISO RGD PMID:34144219 RGD:329812011 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Elane elastase, neutrophil expressed IMP RGD PMID:10588515 RGD:10450560 NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100 		JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:25769561 RGD:15090809 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Epor erythropoietin receptor IEP protein:increased phosphorylation:liver: RGD PMID:25769561 RGD:15090809 NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257 		JBrowse link
G F3 coagulation factor III, tissue factor treatment IMP RGD PMID:11750579 RGD:11341708 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fadd Fas associated via death domain treatment IEP RGD PMID:23423194 RGD:8661760 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fas Fas cell surface death receptor treatment IMP
IEP		 protein:increased expression:liver RGD PMID:17235585 PMID:16222447 PMID:18561025 RGD:2290283, RGD:1600351, RGD:14700680 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand treatment IMP RGD PMID:18561025 RGD:14700680 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fga fibrinogen alpha chain IEP mRNA:increased expression:liver (rat) RGD PMID:23503399 RGD:9685021 NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528 		JBrowse link
G Fn1 fibronectin 1 IDA RGD PMID:12651615 RGD:7205470 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Gpt glutamic--pyruvic transaminase treatment IEP RGD PMID:22564598 PMID:13678701 RGD:329970282, RGD:329970285 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta treatment IDA associated with nonalcoholic fatty liver disease RGD PMID:28807209 RGD:13792730 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 IEP mRNA:decreased expression:lung RGD PMID:19595018 RGD:2314952 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G H2ax H2A.X variant histone treatment IEP RGD PMID:23792534 RGD:8693718 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hmgb1 high mobility group box 1 treatment IMP
IEP		 mRNA, protein:increased expression, altered localization:serum, hepatocyte, cytoplasm
protein:increased oxidation:liver		 RGD PMID:24578610 PMID:21431875 PMID:22514737 RGD:10402068, RGD:10402078, RGD:10402175 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmox1 heme oxygenase 1 treatment IEP RGD PMID:20446775 RGD:10755725 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hp haptoglobin treatment IEP RGD PMID:17187421 PMID:21699906 RGD:1626366, RGD:11041815 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523 		JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment IMP
IEP		 associated with Intestinal Reperfusion Injury;protein:increased expression:liver RGD PMID:7884306 PMID:8780571 RGD:11520784, RGD:14402044 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 severity ISO RGD PMID:28938192 RGD:14985248 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma treatment IDA RGD PMID:22381173 RGD:12791280 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499 		JBrowse link
G Il10 interleukin 10 treatment IDA RGD PMID:21911118 RGD:7364839 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il18 interleukin 18 treatment IEP
ISO		 RGD PMID:25919765 PMID:14999688 RGD:14696667, RGD:14696668 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il18bp interleukin 18 binding protein IEP mRNA,protein:increased expression:liver RGD PMID:25919765 RGD:14696667 NCBI chr 1:156,372,923...156,374,963
Ensembl chr 1:156,372,883...156,374,963 		JBrowse link
G Il1a interleukin 1 alpha treatment IEP
IDA		 mRNA:increased expression:lung
protein:increased expression:serum		 RGD PMID:19595018 PMID:19283466 PMID:9840148 RGD:2314952, RGD:6907377, RGD:11059517 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta treatment
ameliorates		 IDA
ISO		 associated with Cholestasis RGD PMID:21468628 PMID:32155285 PMID:34400126 RGD:7175318, RGD:155260323, RGD:329902072 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rn interleukin 1 receptor antagonist treatment ISO
IMP		 rat model treated with human protein RGD PMID:9000676 PMID:12451245 RGD:6909138, RGD:8551710 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il6 interleukin 6 treatment
ameliorates		 IDA
ISO		 RGD PMID:24752458 PMID:32155285 PMID:34144219 PMID:34400126 RGD:11062134, RGD:155260323, RGD:329812011, RGD:329902072 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irf8 interferon regulatory factor 8 ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr19:48,790,581...48,812,363
Ensembl chr19:48,790,588...48,811,829 		JBrowse link
G Itgam integrin subunit alpha M treatment
exacerbates		 IMP
IEP		 protein:increased expression:neutrophil (rat) RGD PMID:8387952 PMID:11447039 RGD:329901847, RGD:329901849 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Jak2 Janus kinase 2 treatment IDA RGD PMID:22288937 RGD:10403073 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522 		JBrowse link
G Lbp lipopolysaccharide binding protein IEP mRNA, protein:increased expression:liver RGD PMID:12134092 RGD:9685192 NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 ameliorates
exacerbates		 ISO protein:increased phosphorylation:liver (mouse) RGD PMID:30076625 PMID:30622220 RGD:155804280, RGD:155882441 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 IEP protein:increased activity:liver: RGD PMID:11679968 RGD:10412680 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mfn2 mitofusin 2 treatment IEP mRNA, protein:decreased expression:liver (rat) RGD PMID:27363631 PMID:24898700 RGD:12910833, RGD:13204829 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Mir145 microRNA 145 IEP mRNA:decreased expression:small intestine (rat) RGD PMID:23166305 RGD:155230822 NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727 		JBrowse link
G Mir155 microRNA 155 ISO RGD PMID:28640790 RGD:21079442 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mir21 microRNA 21 IEP RNA:increased expression:liver RGD PMID:29187695 RGD:41410824 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mir210 microRNA 210 treatment ISO RGD PMID:32155285 RGD:155260323 NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454 		JBrowse link
G Mir223 microRNA 223 ISO RNA:increased expression:liver
RNA:increased expression:serum,liver		 RGD PMID:19104939 PMID:28646120 RGD:13831297, RGD:21408574 NCBI chr  X:61,141,887...61,141,996
Ensembl chr  X:61,141,887...61,141,996 		JBrowse link
G Mir34a microRNA 34a IEP miRNA:increased expression:liver RGD PMID:28963950 RGD:14695005 NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103 		JBrowse link
G Mmp15 matrix metallopeptidase 15 IEP mRNA:increased expression:lung RGD PMID:19595018 RGD:2314952 NCBI chr19:9,663,449...9,684,943
Ensembl chr19:9,663,449...9,684,943 		JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment IEP associated with Fatty Liver;mRNA, protein:decreased expression, decreased activity:liver RGD PMID:17255325 RGD:8547976 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Muc1 mucin 1, cell surface associated IEP mRNA, protein:decreased expression:bile duct RGD PMID:21775928 RGD:7364757 NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733 		JBrowse link
G Muc3 mucin 3 IEP mRNA, protein:decreased expression:bile duct RGD PMID:21775928 RGD:7364757 NCBI chr12:19,527,251...19,536,924
Ensembl chr12:19,527,321...19,538,522 		JBrowse link
G Muc4 mucin 4, cell surface associated IEP mRNA:decreased expression:bile duct RGD PMID:21775928 RGD:7364757 NCBI chr11:68,008,245...68,053,242 JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 ISO mRNA,protein:increased expression:liver: RGD PMID:36092961 RGD:268357360 NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 treatment IEP RGD PMID:22288937 PMID:31952110 RGD:10403073, RGD:21201304 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nos3 nitric oxide synthase 3 treatment IEP RGD PMID:28966130 RGD:13450941 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Pf4 platelet factor 4 exacerbates ISO RGD PMID:25440775 RGD:329901829 NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365 		JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa treatment ISO RGD PMID:12605111 PMID:18507760 RGD:11100021, RGD:11100046 NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133 		JBrowse link
G Rab10 RAB10, member RAS oncogene family ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr 6:26,267,081...26,319,739
Ensembl chr 6:26,266,859...26,320,193 		JBrowse link
G Rab8b RAB8B, member RAS oncogene family ameliorates ISO RGD PMID:34400126 RGD:329902072 NCBI chr 8:67,458,921...67,536,466
Ensembl chr 8:67,458,923...67,536,384 		JBrowse link
G Selplg selectin P ligand ameliorates IMP RGD PMID:16365457 RGD:401717523 NCBI chr12:42,796,690...42,809,908
Ensembl chr12:42,796,580...42,812,585 		JBrowse link
G Serpinc1 serpin family C member 1 treatment IEP
ISO		 RGD PMID:24726586 PMID:8589354 RGD:10450597, RGD:11038771 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293 		JBrowse link
G Serpine1 serpin family E member 1 IEP protein:increased activity:plasma (rat) RGD PMID:12353078 RGD:8547901 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Serping1 serpin family G member 1 treatment ISO RGD PMID:16367929 RGD:1580273 NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034 		JBrowse link
G Sirt1 sirtuin 1 treatment IEP RGD PMID:24557422 RGD:9497542 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor IEP RGD PMID:19595018 RGD:2314952 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
G Sod1 superoxide dismutase 1 treatment ISO human gene in a rat model RGD PMID:16555330 PMID:11779401 RGD:8655889, RGD:1581095 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod3 superoxide dismutase 3 treatment ISO human gene in a rat model RGD PMID:11779401 RGD:1581095 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990 		JBrowse link
G Tert telomerase reverse transcriptase treatment ISO RGD PMID:19545665 RGD:11038676 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tfpi tissue factor pathway inhibitor ISO RGD PMID:9921794 RGD:11062061 NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880 		JBrowse link
G Tlr2 toll-like receptor 2 treatment ISO
IEP		 RGD PMID:16038046 PMID:25769561 RGD:15090805, RGD:15090809 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 treatment
severity		 IEP
ISO		 mRNA:increased expression:liver
protein:increased expression:membrane raft:		 RGD PMID:21431875 PMID:27064547 PMID:23395256 PMID:22797797 PMID:21693218 RGD:10402078, RGD:14697698, RGD:14697699, RGD:14697702, RGD:5685379 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor treatment IEP
IMP
ISO		 protein:increased expression:serum (rat) RGD PMID:24726586 PMID:17164725 PMID:15457564 PMID:10454827 PMID:21125813 More... RGD:10450597, RGD:14696803, RGD:14985257, RGD:14985258, RGD:14995447, RGD:14995473, RGD:15039406, RGD:2325259, RGD:155260323 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A IEP protein:increased localization:mitochondrion RGD PMID:23423194 RGD:8661760 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tradd TNFRSF1A-associated via death domain treatment IEP RGD PMID:23423194 RGD:8661760 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638 		JBrowse link
G Ucp2 uncoupling protein 2 IEP mRNA:increased expression:liver RGD PMID:22195248 RGD:7175309 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
G Vegfa vascular endothelial growth factor A IEP RGD PMID:26451003 RGD:15036791 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Xdh xanthine dehydrogenase treatment IEP RGD PMID:24768926 RGD:13209011 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18969
    Nutritional and Metabolic Diseases 8246
      disease of metabolism 8246
        acquired metabolic disease 2481
          Reperfusion Injury 816
            Liver Reperfusion Injury 109
Path 2
Term Annotations click to browse term
  disease 18969
    disease of anatomical entity 18249
      gastrointestinal system disease 7095
        hepatobiliary disease 3069
          liver disease 2958
            Liver Injury 531
              Liver Reperfusion Injury 109
paths to the root